Fakülteler

Permanent URI for this communityhttps://hdl.handle.net/20.500.12514/14

Browse

Now showing 1 - 20 of 130

Citation - WoS: 18
Citation - Scopus: 16
Alpha-lipoic acid may ameliorate testicular damage by targeting dox-induced altered antioxidant parameters, mitofusin-2 and apoptotic gene expression
(Andrologia, 2021) Güzel, Elif Erdem; Kaya Tektemur, Nalan; Tektemur, Ahmet
In the study, the ameliorating effects of alfa lipoic acid (ALA) against doxorubicin-induced testicular apoptosis, oxidative stress and disrupted mitochondrial fusion were investigated in male rats. Rats were divided into four groups as control, doxorubicin (DOX), DOX + ALA and ALA. A single dose of 15 mg/kg DOX was administered i.p to the DOX and DOX + ALA groups. 50 mg/kg ALA was given to the DOX + ALA and ALA groups by oral gavage every other day. After 28 days, rat testes and serum samples were collected and analysed. Administration of DOX alone caused a decrease in body and relative testicular weights, seminiferous tubule diameter and germinal epithelium thickness, Johnsen's score and serum testosterone levels. DOX treatment led to severe testicular damage such as tubular degeneration, and atrophic tubules. Also, the activities of superoxide dismutase and glutathione peroxidase were reduced, while the level of malondialdehyde was increased in the testis. The mRNA levels of apoptotic-related genes (CASP3, TP53, BAX, BCL2) and apoptotic index were increased, while mitofusin-2 decreased. DOX caused an increase in CASP3 and a decrease in mitofusin-2 immunoreactivities. Treatment with ALA markedly improved all of DOX-induced biochemical, histochemical and molecular alterations in rat testis. Consequently, ALA has a therapeutic role in ameliorating DOX-induced testicular damage in rats.
Citation - WoS: 33
Citation - Scopus: 40
An analysis of age-standardized suicide rates in Muslim-majority countries in 2000-2019
(BMC Public Health, 2022) Zeyrek-Rios, Emek Yüce; Bob Lew; Lester, David; Kõlves, Kairi; Yip, Paul S. F.; Ibrahim, Norhayati
Background: This study examines the 20-year trend of suicide in 46 Muslim-majority countries throughout the world and compares their suicide rates and trends with the global average. Ecological-level associations between the proportion of the Muslim population, the age-standardized suicide rates, male-to-female suicide rate ratio, and the Human Development Index (HDI) in 2019 were examined. Methods: Age-standardized suicide rates were extracted from the WHO Global Health Estimates database for the period between 2000 and 2019. The rates in each country were compared with the age-standardized global average during the past 20 years. The countries were further grouped according to their regions/sub-regions to calculate the regional and sub-regional weighted age-standardized suicide rates involving Muslim-majority countries. Correlation analyses were conducted between the proportion of Muslims, age-standardized suicide rate, male: female suicide rate ratio, and the HDI in all countries. Joinpoint regression was used to analyze the age-standardized suicide rates in 2000-2019. Results: The 46 countries retained for analysis included an estimated 1.39 billion Muslims from a total worldwide Muslim population of 1.57 billion. Of these countries, eleven (23.9%) had an age-standardized suicide rate above the global average in 2019. In terms of regional/sub-regional suicide rates, Muslim-majority countries in the Sub-Saharan region recorded the highest weighted average age-standardized suicide rate of 10.02/100,000 population, and Southeastern Asia recorded the lowest rate (2.58/100,000 population). There were significant correlations between the Muslim population proportion and male-to-female rate ratios (r=-0.324, p=0.028), HDI index and age-standardized suicide rates (r=-0.506, p<0.001), and HDI index and male-to-female rate ratios (r=0.503, p<0.001) in 2019. Joinpoint analysis revealed that seven Muslim-majority countries (15.2%) recorded an increase in the average annual percentage change regarding age-standardized suicide rates during 2000-2019. Conclusions: Most Muslim-majority countries had lower age-standardized suicide rates than the global average, which might reflect religious belief and practice or due to Muslim laws in their judicial and social structure which may lead to underreporting. This finding needs further in-depth country and region-specific study with regard to its implication for public policy.
Citation - WoS: 32
Citation - Scopus: 31
Ancient DNA from Mesopotamia suggests distinct Pre-Pottery and Pottery Neolithic migrations into Anatolia
(Science, 2022) Acar, Ayşe; Lazaridis, Iosif; Alpaslan-Roodenberg, Songül; Açıkkol, Ayşen; Agelarakis, Anagnostis; Davtyan, Ruben
We present the first ancient DNA data from the Pre-Pottery Neolithic of Mesopotamia (Southeastern Turkey and Northern Iraq), Cyprus, and the Northwestern Zagros, along with the first data from Neolithic Armenia. We show that these and neighboring populations were formed through admixture of pre-Neolithic sources related to Anatolian, Caucasus, and Levantine hunter-gatherers, forming a Neolithic continuum of ancestry mirroring the geography of West Asia. By analyzing Pre-Pottery and Pottery Neolithic populations of Anatolia, we show that the former were derived from admixture between Mesopotamian-related and local Epipaleolithic-related sources, but the latter experienced additional Levantine-related gene flow, thus documenting at least two pulses of migration from the Fertile Crescent heartland to the early farmers of Anatolia.
Animal exploitation at the Olympos, southwestern Anatolia: Zooarchaeological analysis
(ScienceDirect, 2022) Onar, Vedat; Olcay-Uçkan, B. Yelda; Öztaşkin, Muradiye; Sıddıq, Abu Bakar; Öncü, Emre; Öztaşkin, Gökçen K.; Chrószcz, Aleksanderf
This study presents analysis of animal remains unearthed from 2006 to 2021 excavations at Olympos, an important city of ancient Lycia, southwestern Turkey. Seven faunal assemblages were unearthed from seven distinct areas of the city. Each of them was studied according to their distinct archaeological contexts. The zooarchaeological observation was based on taxonomic identification, species diversity, kill-off patterns, nature of bone modification, including taphonomic and anthropogenic marks, and type of species exploitation at the site. The results demonstrated that the majority of the specimens were consumption residues, comprising mainly of ungulate and carnivore mammals, birds and marine fish and mollusks. Goat remains were the most common in all the assemblages, which is consistent with common animal exploitation patterns in Anatolia. Fish bones mostly represented bonito (Sarda sarda), tuna (Thunnus thynnus) and shark (Carcharhinidae sp.). Among the mollusks, the shells of Triton trumpet, rarely found in the Roman-Byzantine Anatolia, were clearly used as trumpets. As Olympos was an important harbour with a strategic location by the Mediterranean Sea, its faunal remains shed new light on the coastal dietary habbit, animal economy, and cultural contacts in the Roman and Early Byzantine periods in Anatolia.
Citation - WoS: 10
Citation - Scopus: 14
The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats
(Wiley, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Tektemur, Ahmet; Acay, Hilal; Yıldırım, Ayfer
This study was conducted to evaluate the protective role of Pleurotus eryngii extract (PE) and Pleurotus eryngii extract-loaded chitosan nanoparticles (PE-CSNP) against doxorubicin (DOX)-induced testicular toxicity in rats. Male rats were divided into six groups: control (DMSO/ethanol), PE (200 mg/kg PE), PE-CSNP (30 mg/kg PECSNP), DOX (10 mg/kg DOX, a single dose, i.p), DOX+PE (10 mg/kg DOX+200 mg/ kg PE) and DOX+PE-CSNP (10 mg/kg DOX+30 mg/kg PE-CSNP). PE and PE-CSNP were administered by oral gavage every other day for 21 days. DOX-treated rats showed histopathological impairment compared with the control group. There was an increase in the apoptotic index, caspase 3 (CASP3), BCL2-associated X apoptosis regulator (BAX), dynamin-related protein 1 (DRP1) expression and total oxidative status (TOS) in the DOX group, while mitofusin-2 (MFN2), total antioxidative status (TAS) and serum testosterone levels of the DOX group reduced when compared with the other groups. PE and PE-CSNP treatments provided significant protection against DOX-induced oxidative stress by reducing TOS levels and increasing TAS levels. CASP3, BAX, apoptotic index and DRP1-MFN2 expressions were restored by PE and PE-CSNP. However, the PE-CSNP showed higher antioxidant and anti-apoptotic efficacy compared with PE. Thus, our results provide evidence that CSNP and PE could synergistically have a potent antioxidant and anti-apoptotic therapy against DOX-induced testicular damage in male rats.
Citation - WoS: 8
Citation - Scopus: 10
Attitudes promoting coping with death anxiety among parents of children with disabilities
(Taylor and Francis Online, 2021) Kaçan, Havva; Sakız, Halis; Bayram Deger, Vasfiye
We investigated death anxiety among parents of children with disabilities and its associations with coping attitudes and psycho-demographic factors. Surveys were administered to 382 parents of children who possess a severe disability and data were analyzed via descriptive and inferential statistics. Findings revealed that parents experienced high levels of death anxiety; the level of death anxiety changed according to some psycho-demographic factors, such as external support, type of disability, and death-related beliefs; and death anxiety was significantly explained by demographic variables, death-related thoughts, and experiences, and adaptive and maladaptive coping attitudes.
Citation - WoS: 7
Citation - Scopus: 7
Biochemical components, enzyme inhibitory, antioxidant and antimicrobial activities in endemic plant Scilla mesopotamica speta
(Wiley, 2021) Aktepe, Necmettin; Keskin, Cumali; Baran, Ayşe; Atalar, Mehmet Nuri; Baran, Mehmet Fırat; Akmeşe, Şükrü
In this study, in vitro antioxidant, antimicrobial, anticholinesterase and phenolic profile of different solvent extracts of Scilla mesopotamica speta were determined in detail. In vitro antioxidant activities and total phenolic and flavonoid contents of plant extracts obtained with different solvents were tested in terms of 2.2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activities. The highest total phenolic and total flavonoid contents were determined in the ethyl acetate extract (62.24 mu g GAE/mg) and chloroform extract (87.72 mu g QE/mg) respectively. The highest DPPH radical scavenging activity was detected in ethyl acetate extracts. Antimicrobial and antifungal activities were investigated by MIC method. The inhibitory activities of the extracts on the acetyl cholinesterase enzyme were investigated. Liquid chromatography (LC) tandem mass spectrometry LC-MS/MS was used to determine the phenolic component content of extracts. Thirty-one different components were identified in the analyses and their amounts were measured. Practical applications Scilla mesopotamica speta is an endemic and medicinal plant. It was determined that the extracts of this plant had a very rich content in terms of phenolic compounds, especially caffeic and ferulic acids. However, this plant was remarkable for its antioxidant, anticholinesterase, and antimicrobial activities. Considering the strong antioxidant, antimicrobial, and enzyme inhibition activities of the Scilla mesopotamica speta it can be suggested as a source of anticancer, antimicrobial, and antiviral drugs.
Citation - Scopus: 1
Biography as allegory
(ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2013) Krausmüller, Dirk
Through comparison with Dante's Divine Comedy and with Late Antique allegorical interpretations of the Bible this article makes the case that Byzantine hagiographers encoded an allegorical dimension into their texts and that they did so in order to make value judgements that complement explicit evaluations of the behaviour of saints.
Citation - WoS: 6
Citation - Scopus: 7
Bodily Boundaries Transgressed: Corporal Alteration Through Ornamentation in the Pre-Pottery Neolithic at Boncuklu Tarla, Turkiye
(Cambridge Univ Press, 2024) Kodas, Ergul; Baysal, Emma L.; Ozkan, Kazim
Lack of contextual evidence for the use of small personal ornaments means that much of our understanding of ornamentation traditions within archaeological cultures is reconstructed from ethnographic comparisons. New in situ finds from the areas around the ears and mouth in burials at Boncuklu Tarla, a Neolithic settlement in Turkiye, add a novel dimension to the interpretation of stone 'tokens' or 'plugs'. This article presents a new typology for these artefacts and argues for their use as ear ornaments or labrets in a practice involving significant and lasting corporal alteration.
Citation - WoS: 5
Citation - Scopus: 6
Bronchiectasis in Türkiye: Data From a Multicenter Registry (Turkish Adult Bronchiectasis Database)
(Galenos Publ House, 2024) Edis, Ebru Cakir; Cilli, Aykut; Kizilirmak, Deniz; Coskun, Ayson Sakar; Guler, Nurcan; Cicek, Sedat; Sayiner, Abdullah; Gülmez, İnci; Çağlayan, Benan; Niksarlioglu, Elif Yelda Ozgun; Researchers, Tebveb
Background: Bronchiectasis is a chronic lung disease characterized by permanent bronchial wall dilatation. Although it has been known as an orphan disease, it has recently gained attention because of registry -based studies and drug research. Aims: We aimed to use a multicenter database to analyze and compare data regarding the etiology, associated comorbidities, microbiological characteristics, and preventive strategies of bronchiectasis in T & uuml;rkiye to those of other countries. Study Design: A multicenter prospective cohort study. Methods: The multicenter, prospective cohort study was conducted between March 2019 and January 2022 using the Turkish Adult Bronchiectasis Database, in which 25 centers in T & uuml;rkiye participated. Patients aged > 18 years who presented with respiratory symptoms such as cough, sputum, and dyspnea and were diagnosed with non -cystic fibrosis bronchiectasis using computed tomography were included in the study. Demographic information, etiologies, comorbidities, pulmonary functions, and microbiological, radiological, and clinical data were collected from the patients. Results: Of the 1,035 study participants, 518 (50%) were females. The mean age of the patients was 56.1 +/- 16.1 years. The underlying etiology was detected in 565 (54.6%) patients. While postinfectious origin was the most common cause of bronchiectasis (39.5%), tuberculosis was identified in 11.3% of the patients. An additional comorbidity was detected in 688 (66.5%) patients. The most common comorbidity was cardiovascular disease, and chronic obstructive pulmonary disease (COPD) and bronchiectasis was identified in 19.5% of the patients. The most commonly detected microbiological agent was Pseudomonas aeruginosa (29.4%). Inhaled corticosteroids (ICS) were used in 70.1% of the patients, and the frequency of exacerbations in the last year was significantly higher in patients using ICS than in nonusers (p < 0.0001). Age [odds ratio (OR): 1.028; 95% confidence interval (CI): 1.005-1.051], cachexia (OR: 4.774; 95% CI: 2,054-11,097), high modified medical research council dyspnea scale score (OR: 1,952; 95% CI: 1,459-2,611), presence of chronic renal failure (OR: 4,172; 95% CI: 1,249-13,938) and use of inhaled steroids (OR: 2,587; 95% CI: 1,098-6,098) were significant risk factors for mortality. Mortality rates were higher in patients with COPD than in those with no COPD (21.7-9.1%, p = 0.016). Patients with bronchiectasis and COPD exhibited more frequent exacerbations, exacerbation -related hospitalizations, and hospitalization in the intensive care unit in the previous year than patients without COPD. Conclusion: This is the first multicenter study of bronchiectasis in T & uuml;rkiye. The study results will provide important data that can guide the development of health policies in T & uuml;rkiye on issues such as infection control, vaccination, and the unnecessary use of antibiotics and steroids.
Byzantium in the Iconoclast Era, c.680-850: A History
(OXFORD UNIV PRESS, 2012) Krausmüller, Dirk
Although the title refers to the period between 680 and 850 as the ‘Iconoclast era’, the main aim of this book is to demonstrate that previous scholarship has exaggerated the importance of the controversy about religious images. The authors argue, firstly, that Iconoclasm was only one aspect in a much broader process of transformation, and secondly, that Iconoclasm itself was less significant than Iconophile sources would have us believe. The book is clearly intended to be a comprehensive treatment of the period. Owing to the specialisations of the two authors, the focus is on art history and on social, economic and administrative history, whereas literature is barely mentioned.
Citation - WoS: 6
Citation - Scopus: 6
Can deep learning replace histopathological examinations in the differential diagnosis of cervical lymphadenopathy?
(Springer, 2024) Can, Sermin; Türk, Ömer; Ayral, Muhammed; Kozan, Günay; Arı, Hamza; Akdağ, Mehmet; Yıldırım Baylan, Müzeyyen; Baylan, Muezeyyen Yildirim
Introduction: We aimed to develop a diagnostic deep learning model using contrast-enhanced CT images and to investigate whether cervical lymphadenopathies can be diagnosed with these deep learning methods without radiologist interpretations and histopathological examinations. Material method: A total of 400 patients who underwent surgery for lymphadenopathy in the neck between 2010 and 2022 were retrospectively analyzed. They were examined in four groups of 100 patients: the granulomatous diseases group, the lymphoma group, the squamous cell tumor group, and the reactive hyperplasia group. The diagnoses of the patients were confirmed histopathologically. Two CT images from all the patients in each group were used in the study. The CT images were classified using ResNet50, NASNetMobile, and DenseNet121 architecture input. Results: The classification accuracies obtained with ResNet50, DenseNet121, and NASNetMobile were 92.5%, 90.62, and 87.5, respectively. Conclusion: Deep learning is a useful diagnostic tool in diagnosing cervical lymphadenopathy. In the near future, many diseases could be diagnosed with deep learning models without radiologist interpretations and invasive examinations such as histopathological examinations. However, further studies with much larger case series are needed to develop accurate deep-learning models.
Citation - WoS: 22
Citation - Scopus: 29
Can entrepreneurial knowledge boost the entrepreneurial intent of French students? The mediation role of behavioral antecedents
(Emerald, 2022) Alkhalaf, Taher; Durrah, Omar; Almohammad, Dawoud; Ahmed, Faisal
Purpose: Entrepreneurial knowledge occupies a significant place in policy discourse and practice, especially in developed economies. This study aims to examine the effect of entrepreneurial knowledge on the components of entrepreneurial intent of undergraduate students. The authors seek to decipher a deeper understanding of their orientation for engaging in new ventures. In addition, we analyze the mediating role of behavioral antecedents between entrepreneurial knowledge and entrepreneurial intent. Design/methodology/approach: The authors collected the primary data of 400 undergraduate students from French universities and used structural equation modeling through Smart PLS software for testing several pertinent hypotheses. Findings: The study’s results revealed that entrepreneurial knowledge negatively affects students’ attitudes in choosing entrepreneurship in favor of a corporate job. In addition, entrepreneurial knowledge does not affect the social norms and self-efficacy that shape entrepreneurial intent. Interestingly, our study also revealed no mediating role between entrepreneurial knowledge and students’ self-efficacy. Originality/value: The findings of this study will contribute to the academic discourse on the role of entrepreneurial knowledge and its potential effect in promoting entrepreneurship. Furthermore, this study has policy implications and solicits developing entrepreneurship programs to enhance entrepreneurial intent among young people.
Citation - WoS: 32
Citation - Scopus: 50
Case Study as a Research Method in Hospitality and Tourism Research: a Systematic Literature Review (1974-2020)
(Sage Publications inc, 2021) Cakar, Kadir; Aykol, Sehmus
This systematic literature review aimed to investigate the use of case study method in hospitality and tourism research to increase the awareness about the use of case study as a research method. Data were collected (n = 871) from 10 leading hospitality and tourism journals published between 1974 and 2020. A thematic analysis of the data was conducted using Leximancer as a computer-aided analysis software. The study findings reveal an overall mislabel and misuse of the case study method. Suggestions are provided to improve case study method applications and increase case study research for more theory development in hospitality and tourism research.
Citation - WoS: 4
Citation - Scopus: 6
A cat skeleton from the balatlar church excavation, sinop, Turkey
(MDPI AG, 2021) Sıddıq, Abu Bakar; Onar, Vedat; Köroğlu, Gülgün; Armutak, Altan; Öncü, Öğül Emre; Chrószcz, Aleksander
In the 2015 excavation season, an east–west oriented burial (2015-Grave-14) built with large dimension stone blocks was unearthed on the south edge of “Area IVi” at the Balatlar Church in Sinop, on the northeastern Black Sea coast of Turkey. In this grave, which is dated between the end of the 6th century AD and the first half of the 7th century AD, a human skeleton was found with the head to the west and a cat skeleton was carefully placed next to the right femur. This study on the burial and the cat skeleton within it shows that, compared to the Roman period, the status of cats reached a higher level during the Byzantine period. It was found that alongside of being a pet, the Balatlar cat was a young healthy female individual that instinctively hunted rodents and birds, given that the remains of a rat and a sparrow were found in the region of the abdominal cavity, corresponding with the stomach location in the living animal. The grave presents the most significant direct archaeological evidence of a pet–human bond recorded at any Byzantine site so far.
Citation - WoS: 9
Citation - Scopus: 18
The cathedral complex at Nisibis
(CAMBRIDGE UNIV PRESS, 2013) Keser Kayaalp, Elif; Erdoğan, Nihat
The cathedral complex at Nisibis sits within what is currently a large excavation site. The excavations, continuing on and off over the last 12 years, have yielded exciting discoveries. This article is not a report of the excavations as such, but, in the light of them, it revisits the cathedral complex in an attempt to reconstruct the possible cathedral on the site and to establish the building phases of the only standing structure on the site, known as the 'Church of Mor Yaqub', which was the baptistery of the cathedral.
Citation - WoS: 63
Citation - Scopus: 71
Changes in volatile compounds, sugars and organic acids of different spices of peppers (Capsicum annuum L.) during storage
(FOOD CHEMISTRY, 2020) Korkmaz, Aziz; Atasoy, Ahmet Ferit; Hayaloglu, Ali Adnan
Changes in sugars, organic acids and volatile compounds (VC) of red pepper flakes (RPF), traditional (TRI), and industrial (INI) isot peppers were evaluated during one year storage at the room condition. The changes in the flavor components were significantly affected by the production methods and storage time. Glucose content decreased gradually along storage and reduced by about 21.23, 47.22 and 56.65% for TRI, INI and RPF, respectively. However, fructose decreased significantly only in RPF (11.29%). Citric and succinic acids exhibited slight changes, but malic acid showed an increasing trend, especially in RPF (4-fold). Most of the VC in all samples decreased or disappeared after storage. The major quantitative losses in these compounds were found in TRI during the first 3 months as 81.76%. The storage was found to be caused deterioration flavor properties in red pepper spices and revealed the importance of appropriate storage conditions.
Citation - WoS: 26
Citation - Scopus: 25
Characterization and Comparison of Extra Virgin Olive Oils of Turkish Olive Cultivars
(Molecules, 2023) Korkmaz, Aziz
Extra virgin olive oils (EVOOs) obtained from five Turkish olive cultivars widely produced in the Aegean and Marmara regions were investigated based on their total antioxidant capacity (TAC), total phenolic content (TPC), pigment contents, fatty acid (FA) profiles, phenolic compounds (PC), volatile compounds (VC), and sensory properties. The results showed that all properties of EVOO samples were significantly affected by the olive cultivar used. The pigment contents in Ayvalık (9.90 mg·kg−1) and Uslu (9.00 mg·kg−1) oils were higher than the others (p < 0.05). The greatest values for oleic acid (74.13%) and TPC (350.6 mg·kg−1) were observed in Gemlik and Domat oils, respectively (p < 0.05). Edincik oil showed the maximum hydroxytyrosol content (48.022 mg·kg−1) and TAC value (515.36 mg TE·kg−1) (p < 0.05). The Edincik, Domat, and Uslu oils were significantly not different for the total content of C6 compounds derived by lipoxygenase, which are the main volatiles responsible for the typical aroma of EVOOs (p > 0.05). Domat oil also exhibited the highest scores for bitterness and pungency perceptions (p < 0.05). The fruitiness scores of the oil samples (except for Ayvalık oil) were close to each other, even if they were statistically different (p < 0.05). Principal component analysis (PCA) indicated that the Ayvalık oil was separated from the others due to its poor-quality characteristics. As a result, it can be stated that Domat olive oil has better quality than the others
Citation - WoS: 52
Citation - Scopus: 65
The Cittaslow Philosophy in the Context of Sustainable Tourism Development; The Case of Turkey
(Tourism Management, 2014) Ekinci, Mehmet Behzat
This paper studies the Cittaslow (slow city) philosophy in terms of sustainable tourism development (STD); and in this context research was undertaken for the case of Turkey. Cittaslow, a movement rooted in STD philosophy, aims to encourage the development of tranquil cities already known for their historical, natural, socio-cultural, and touristic features and the intention is to offer a significant contribution to systematic and rapid implementation of STD on a global scale. This paper, which makes a particular study of the practice of STD in Turkey, offers new candidate cities (Uzungöl, Hasankeyf, Safranbolu, Ürgüp, and İznik) and, thus, endeavours to contribute to the spread of STD throughout the whole country. In this study, above-named cities were found to be particularly good candidates for Cittaslow membership. In addition to these: Tatvan, Midyat, Alanya, and Fethiye were also found to be potential Cittaslows even though they fail to meet the population criterion.
Citation - WoS: 21
Citation - Scopus: 20
Clinical features of generalized lipodystrophy in Turkey: a cohort analysis
(Wiley Online Library, 2023) Özbek, Mehmet Nuri; Yildirim Simsir, Ilgin; Tuysuz, Beyhan; Tanrikulu, Seher; Celik Guler, Merve; Akinci, Baris; Karhan, Asuman Nur
Aim: To describe the Turkish generalized lipodystrophy (GL) cohort with the frequency of each complication and the death rate during the period of the follow-up. Methods: This study reports on 72 patients with GL (47 families) registered at different centres in Turkey that cover all regions of the country. The mean ± SD follow-up was 86 ± 78 months. Results: The Kaplan-Meier estimate of the median time to diagnosis of diabetes and/or prediabetes was 16 years. Hyperglycaemia was not controlled in 37 of 45 patients (82.2%) with diabetes. Hypertriglyceridaemia developed in 65 patients (90.3%). The Kaplan-Meier estimate of the median time to diagnosis of hypertriglyceridaemia was 14 years. Hypertriglyceridaemia was severe (≥ 500 mg/dl) in 38 patients (52.8%). Seven (9.7%) patients suffered from pancreatitis. The Kaplan-Meier estimate of the median time to diagnosis of hepatic steatosis was 15 years. Liver disease progressed to cirrhosis in nine patients (12.5%). Liver disease was more severe in congenital lipodystrophy type 2 (CGL2). Proteinuric chronic kidney disease (CKD) developed in 32 patients (44.4%) and cardiac disease in 23 patients (31.9%). Kaplan-Meier estimates of the median time to diagnosis of CKD and cardiac disease were 25 and 45 years, respectively. Females appeared to have a more severe metabolic disease, with an earlier onset of metabolic abnormalities. Ten patients died during the follow-up period. Causes of death were end-stage renal disease, sepsis (because of recurrent intestinal perforations, coronavirus disease, diabetic foot infection and following coronary artery bypass graft surgery), myocardial infarction, heart failure because of dilated cardiomyopathy, stroke, liver complications and angiosarcoma. Conclusions: Standard treatment approaches have only a limited impact and do not prevent the development of severe metabolic abnormalities and early onset of organ complications in GL.

Browse

Browsing Fakülteler by Scopus Q "Q1"