Orhan, Özhan
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Orhan, Ozhan
Job Title
Doç. Dr.
Email Address
ozhanorhan@artuklu.edu.tr
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Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
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Current Staff
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17
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0
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2
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1
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5
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0
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6
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1
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13
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10
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1
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16
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8
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15
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3
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6
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9
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0
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14
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2
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4
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1
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7
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11
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0
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12
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Documents
18
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9
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2
Documents
23
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13
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24
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22
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87/493
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7
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9
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2
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2
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0.29
Scopus Citations per Publication
0.38
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19
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| Journal | Count |
|---|---|
| Archivos Argentinos de Pediatria | 5 |
| Annals of Medical Research | 2 |
| Pediatric Pulmonology | 2 |
| Iranian Journal of Pediatrics | 2 |
| The European Research Journal | 2 |
Current Page: 1 / 3
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24 results
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Now showing 1 - 10 of 24
Article Methemoglobinemia and acute ıntravascular hemolysis after naphthalene poisoning in a pediatric patient(SciELO Argentina, 2023) Orhan, Özhan; Talay, Mehmet NurPoisoning by naphthalene is uncommon in children. It is a type of poisoning brought on by ingesting, inhaling, or coming into touch with naphthalene-containing substances on the skin. Patients typically present with an initial onset of dark brown urine, watery diarrhea, and bile vomit. The signs include fever, tachycardia, hypotension, and low pulse oximetry readings even with oxygen support. Hemolytic anemia, methemoglobinemia, renal failure, and hyperbilirubinemia are all detected in blood tests. Erythrocyte transfusion, ascorbic acid, methylene blue, and N-acetylcysteine (NAC) therapies are provided to inpatients in addition to symptomatic treatment. We present a 23-month-old male patient who developed methemoglobinemia and acute ıntravascular hemolysis, who was followed up in the intensive care unit for five days due to naphthalene intoxication. Although naphthalene poisoning is very rare, it should be known that it has fatal consequences, and more care should be taken in its use and saleArticle Our Treatment Experience in Poisoning With Calcium Channel Blockers: a Series of Twelve Cases(Briefland, 2024) Talay, Mehmet Nur; Orhan, Ozhan; Ozbek, Mehmet Nuri; Kangin, Murat; Turanli, Ese EdaBackground: Intoxications with cardiovascular system drugs constitute a small percentage of all poisoning cases. Calcium Channel Blockers (CCBs) are the most common drug poisoning in this group. Objectives: We aimed to evaluate the effectiveness of treatments for CCB poisoning and add to the current body of literature by outlining the clinical treatments we employ for bradyarrhythmia, hypotension, and resistant vasodilation resulting from CCB poisoning, as well as sharing our clinical insights in this field. Methods: Twelve patients, ranging in age from 1 month to 18 years, were admitted to the Tertiary Paediatric Intensive Care Unit (PICU) for treatment of medication poisoning related to the CCB group. Patients who ingested several drugs that caused CCB were not allowed to participate in the trial. Results: Twelve patients were followed up in the PICU due to poisoning with CCB group drugs. Of the patients, 7 were male and 5 were female. Five of the patients had taken CCB medication with the purpose of committing suicide, and 7 of them accidentally. All of the patients who received CCB to commit suicide had taken verapamil. Five patients whose hypotension and bradycardia continued were administered inotropes. In addition to PI, calcium gluconate, intravenous lipid, glucagon, insulin, bicarbonate, and methylene blue were given as therapy to our symptomatic patients. Plasmapheresis was applied to a patient who was hospitalized in the PICU due to a sudden loss of consciousness. Conclusions: In the management of patients with CCB poisoning, the use of hyperinsulinemia euglycemia, intravenous lipid emulsion treatment, glucagon treatments, and treatments including methylene blue and extracorporeal life support should be considered in cases of resistant hypotension, bradycardia, and coma in the early period.Article Retrospective Investigation of Children Presented With Febrile Convulsion(2024) Orhan, Ozhan; Talay, Mehmet Nur; Solmaz, MuratAim: In this study, we aimed to determine the characteristics of patients admitted with the diagnosis of febrile convulsion (FC) and to evaluate the most common diagnosis and the most frequent months of presentation. Materials and Methods: A total of 172 children who were admitted to the pediatric emergency unit in the last one year due to FC and were admitted for observation were included in the study. The age range of the children included in the study was 5 months - 6 years (72 months). Patients were analyzed in terms of age, gender, diagnosis at presentation, type of FC, month of presentation, whether brain tomography was performed, sodium level, CRP level, white blood cell (WBC) count, and glucose level. SPSS (Statistical Package for Social Sciences) for Windows 22.0 program was used for statistical analysis. Results: The median age of the patients was 20 (11-34) months and 58.7% were male. Upper respiratory tract infections were the most common cause of convulsions with 72.7%. Acute gastroenteritis followed with 20.9%. Simple febrile convulsion was present in 89.5% of cases. Brain tomography was required in 33.1% of the patients admitted due to FC. The most common month of presentation was November with 16.3%. Mean WBC level was 13.4±6.0 (x103 /µL), mean CRP level was 24.2±35.3 (mg/L), mean Glucose level was 117±29.8 (mg/dL), mean Sodium level was 137±13.9 (mmol/L). Conclusion: In the management of this condition, which is uncomplicated and has no long-term effects in most patients, it is important to avoid unnecessary examinations and to provide accurate information to families.Article Acute Cyanide Intoxication Due To Apricot Seed Ingestion(Soc Argentina Pediatria, 2024) Talay, Mehmet N.; Gungor, Emre; Orhan, OzhanIntroduction : Cyanide poisoning, whether it be accidental or intentional, remains a significant danger to adults and children, especially in societies where agriculture is a primary source of income. We examined the clinical follow-up, complications, and results of cyanide poisoning cases that occurred after eating the pits and seeds of plants containing cyanide glycosides, such as apricot kernels and almonds. Methods : Between 01/01/2017 and 01/08/2022, 14 children aged 1-18 years who were followed up with a prediagnosis of cyanide poisoning in our Paediatric Intensive Care Unit (PICU) were retrospectively analysed. Results : Eight of the patients followed with a preliminary diagnosis of cyanide poisoning were female and six were male. The most common admission month was July (42.8%) coinciding with the agricultural season. The most common symptoms at presentation were weakness and fatigue (n = 7). In the PICU, 4 patients presented lip cyanosis; 3, altered level of consciousness. Vomiting, seizure, headache, dizziness and palpitatons were less frequent. Four patients were treated with hydroxocobalamin (Cyanokit (R) ) as an antidote due to acidosis in their blood gases. All patients treated for cyanide poisoning were discharged. Conclusions : Cyanide poisoning should be considered in paediatric patients with suspicious findings, sudden loss of consciousness, increased anion gap acidosis and lactic acidosis. The history of eating the seeds of plants such as apricot and almonds should be investigated .Article Citation - Scopus: 4Evaluation of Breastfeeding Behaviors and Complementary Feeding Practices of Turkish and Syrian Refugee Mothers(Soc Argentina Pediatria, 2023) Orhan, Ozhan; Elci, HuseyinObjectives: The purpose of this study was to compare breastfeeding and related factors (age, level of education, age at first pregnancy, etc.), and complementary feeding practices between Syrian refugee and native Turkish mothers.Material and methods: This descriptive-comparative study examined the nutritional characteristics of infants aged 9 to 60 months whose mothers were Turkish or Syrian refugees who attended Kiziltepe Results: 204 mothers (126 Turkish and 78 Syrian) who had a child aged 9-60 months were included. The average age of the mothers was 27.60 & PLUSMN; 5.17 years for Turkish citizens and 28.91 & PLUSMN; 5.62 for Syrian refugees, without significant difference between the two groups (p: 0.091). Postpartum breastfeeding was 91.3% and breastfeeding duration was 12 (0-24) months in Turkish citizens; in Syrian refugees, breastfeeding was 84.6% and average breastfeeding time was 9 (0- 24) months (respectively, breast milk intake p: 0.144, uptake time p: 0.161; no statistical difference). Breastfeeding training was received by 23.8% of Turkish citizens and 5.1% of Syrian refugees; there was a significant difference between the two groups (p: 0.001).Conclusion: In refugee groups, infant and maternal nutrition practices are disrupted. Working in conjunction with local and international organizations and state agencies that give help to refugee groups, the appropriate interventions, initiatives, supports, and awareness-raising activities would strive to improve practices in mother and baby nutrition and narrow gaps.Article Acute Cyanide Poisoning Due To Ingestion of Apricot Seeds(Soc Argentina Pediatria, 2024) Talay, Mehmet N.; Gungor, Emre; Orhan, Ozhan[No Abstract Available]Article Çocukluk Çağında Yeni Tanı Almış 140 Diyabet Olgusunun Tanı Tipleri ve Klinik Özellikleri: Tek Merkez Deneyimi(2025) Yıldırım, Ruken; Ozbek, Mehmet Nuri; Trabzon, Gül; Orhan, Özhan; Karakaya, Amine AktarAmaç: Çocukluk çağındaki diyabetes mellitusun (DM) çoğunluğunu tip 1 diyabet (T1DM) oluşturur. Ancak son yıllarda tip 2 diyabetes mellitus (T2DM) sıklığında ve monogenik diyabet (MD) tanısı koymada artış gözlenmektedir. Bu çalışmada 0-18 yaş arasında tanı konulan diyabetli hastalarda klinik ve laboratuvar bulgularının, DM tiplerinin değerlendirilmesi amaçlandı. Gereç ve yöntem: Çalışmada kliniğimizde DM tanısı alan 140 hasta retrospektif olarak değerlendirildi. Bulgular: Üç yıllık süreçte 140 hastaya (76 erkek, %54,3) diyabet tanısı konuldu. Hastaların ortalama tanı yaşı 10±4,19 yıldı. Hastaların %93,6'sına T1DM, %2,8'ine T2DM, %3,6'sına MD tanısı konuldu. Tip 1 diyabetes mellitus vakalarının 5-9 (%36,6) ve 10-14 (%37,4) yaş gruplarında zirve yaptığı görüldü. Diyabetik ketoasidoz (DKA) prevalansı %61,8 idi. Yine bu olguların %64,9'u sonbahar/kış aylarında tanı aldı. Tip2 diyabetli hastaların %75'i kadındı ve ortalama tanı yaşı 15,05±1,11 idi. Monogenik diyabetli olgularının ikisi neonatal DM, ikisi GCK-MODY ve biri CEL-MODY idi. Sonuç: Çocukluk çağı diyabet vakalarının çoğunluğu T1DM olmasına rağmen, özellikle obez ergenlerde T2DM sıklığı artma eğilimindedir. Otoantikor pozitif T1DM’li hastalarda da obezitenin olabileceği akılda tutulmalıdır. Tip1 diyabet olgularının daha çok kış mevsiminde, 10-14 yaş grubunda başvurduğu ve DKA sıklığının yüksek olduğu saptandı. Monogenik diyabet şüphesi olan olgulara genetik inceleme yapılmalıdır.Article Citation - WoS: 2Citation - Scopus: 2Assessment of Iron Metabolism and Inflammation in Children With Cerebral Palsy(Mdpi, 2025) Orhan, Ozhan; Gokdemir, Gul SahikaBackground/Objectives: Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. Methods: A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. Results: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children (p < 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Conclusions: Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients.Article Impact of Iron Deficiency Anemia on Electrocardiographic Markers in Pediatric Patients(Wiley, 2025) Orhan, Ozhan; Aktan, AdemBackground Iron deficiency anemia (IDA) is a condition in which healthy red blood cells are inadequately produced in children and, if left untreated, can lead to serious health problems. The impact of IDA on electrocardiographic (ECG) markers in children has not been sufficiently investigated, emphasizing the need for more comprehensive studies in this regard.Methods This study, conducted in our clinic, includes 75 children diagnosed with anemia and a control group of 77 healthy children. ECG analysis was employed to assess depolarization and repolarization parameters, including measurements such as QT interval, Tp-e interval (Tp-e), cardiac electrophysiological balance index (iCEB), and frontal QRS-T angle.Results The ECG parameters of children with IDA and ferritin levels below 15 ng/mL were contrasted with those of healthy children having ferritin levels exceeding 25 ng/mL. The anemic group exhibited significantly higher values for QT interval, corrected QT (QTc), Tp-e, P-wave dispersion (PWd), QT dispersion (QTd), corrected QTd, Tp-e dispersion, iCEB, and corrected iCEB compared to the control group. In the Pearson correlation analysis, a weak and negative correlation was found between ferritin levels and QT dispersion (p = 0.002) and QTc dispersion (p = 0.039). No significant relationship was detected between other parameters. These observations imply that IDA in children might induce alterations in depolarization and repolarization, potentially elevating the susceptibility to arrhythmias.Conclusions Our study demonstrated significant alterations in certain electrocardiographic parameters in children with IDA. These findings suggest that iron deficiency may influence cardiac repolarization and highlight the potential role of ECG monitoring in the early stages.Article Evaluation of Admissions and Inappropriate Referrals To Pediatric Gastroenterology, Hepatology and Nutrition Outpatient Clinics(2025) Şeker, Gül; Orhan, ÖzhanObjective: The aim of this study was to examine the diagnostic profiles of patients admitted to pediatric gastroenterology, hepatology, and nutrition outpatient clinics within the scope of the state service obligation and to determine the reasons for inappropriate referrals. Methods: A total of 10,235 patients admitted to the pediatric gastroenterology, hepatology and nutrition outpatient clinics of Mardin Training and Research Hospital between 2022 and 2023 were retrospectively analyzed. Data were analyzed using SPSS 21.0 software according to demographic and clinical variables such as age, gender, reasons for admission and diagnoses. Results: Of the patients examined, 49.1% were girls and 50.9% were boys, and the most common reason for presentation was inadequate weight gain with a rate of 46%. However, malnutrition or another nutritional disorder was not detected in 28% of the patients referred with a diagnosis of inadequate weight gain. Malnutrition was diagnosed in a total of 1,710 cases, of which 8.2% were mild malnutrition, 5.3% were moderate malnutrition, and 4.2% were severe malnutrition. No pathological findings were found in 40.8% of the applicants. It was also found that most of the complaints of constipation and diarrhea, which are common reasons for admission, can be effectively treated in primary and secondary health care services. Conclusions: The results of the study show that a significant proportion of referrals to pediatric gastroenterology outpatient clinics are unnecessary and that referrals can be reduced by evaluating these patients in primary and secondary care, thereby increasing the efficiency of health care services.
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