Orhan, Özhan
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Orhan, Ozhan
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Dr. Öğr. Üyesi
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Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
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Current Staff
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Scholarly Output
17
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17
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0
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0
17 results
Scholarly Output Search Results
Now showing 1 - 10 of 17
Article Citation - WoS: 0Citation - Scopus: 0Methemoglobinemia and acute ıntravascular hemolysis after naphthalene poisoning in a pediatric patient(SciELO Argentina, 2023) Orhan, Özhan; Talay, Mehmet Nur; Department of Internal Medical Sciences / Dahili Tıp Bilimleri BölümüPoisoning by naphthalene is uncommon in children. It is a type of poisoning brought on by ingesting, inhaling, or coming into touch with naphthalene-containing substances on the skin. Patients typically present with an initial onset of dark brown urine, watery diarrhea, and bile vomit. The signs include fever, tachycardia, hypotension, and low pulse oximetry readings even with oxygen support. Hemolytic anemia, methemoglobinemia, renal failure, and hyperbilirubinemia are all detected in blood tests. Erythrocyte transfusion, ascorbic acid, methylene blue, and N-acetylcysteine (NAC) therapies are provided to inpatients in addition to symptomatic treatment. We present a 23-month-old male patient who developed methemoglobinemia and acute ıntravascular hemolysis, who was followed up in the intensive care unit for five days due to naphthalene intoxication. Although naphthalene poisoning is very rare, it should be known that it has fatal consequences, and more care should be taken in its use and saleArticle Citation - WoS: 0Citation - Scopus: 0Assessment of Iron Metabolism and Inflammation in Children With Cerebral Palsy(Mdpi, 2025) Orhan, Özhan; Gökdemir, Gül Şahika; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü; Department of Basic Medical Sciences / Temel Tıp Bilimleri BölümüBackground/Objectives: Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. Methods: A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. Results: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children (p < 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Conclusions: Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients.Article Citation - WoS: 0Citation - Scopus: 0Our Treatment Experience in Poisoning With Calcium Channel Blockers: a Series of Twelve Cases(Briefland, 2024) Talay, Mehmet Nur; Orhan, Ozhan; Orhan, Özhan; Özbek, Mehmet Nuri; Turanli, Ese Eda; Department of Internal Medical Sciences / Dahili Tıp Bilimleri BölümüBackground: Intoxications with cardiovascular system drugs constitute a small percentage of all poisoning cases. Calcium Channel Blockers (CCBs) are the most common drug poisoning in this group. Objectives: We aimed to evaluate the effectiveness of treatments for CCB poisoning and add to the current body of literature by outlining the clinical treatments we employ for bradyarrhythmia, hypotension, and resistant vasodilation resulting from CCB poisoning, as well as sharing our clinical insights in this field. Methods: Twelve patients, ranging in age from 1 month to 18 years, were admitted to the Tertiary Paediatric Intensive Care Unit (PICU) for treatment of medication poisoning related to the CCB group. Patients who ingested several drugs that caused CCB were not allowed to participate in the trial. Results: Twelve patients were followed up in the PICU due to poisoning with CCB group drugs. Of the patients, 7 were male and 5 were female. Five of the patients had taken CCB medication with the purpose of committing suicide, and 7 of them accidentally. All of the patients who received CCB to commit suicide had taken verapamil. Five patients whose hypotension and bradycardia continued were administered inotropes. In addition to PI, calcium gluconate, intravenous lipid, glucagon, insulin, bicarbonate, and methylene blue were given as therapy to our symptomatic patients. Plasmapheresis was applied to a patient who was hospitalized in the PICU due to a sudden loss of consciousness. Conclusions: In the management of patients with CCB poisoning, the use of hyperinsulinemia euglycemia, intravenous lipid emulsion treatment, glucagon treatments, and treatments including methylene blue and extracorporeal life support should be considered in cases of resistant hypotension, bradycardia, and coma in the early period.Article Citation - WoS: 0Acute Cyanide Poisoning Due To Ingestion of Apricot Seeds(Soc Argentina Pediatria, 2024) Talay, Mehmet Nur; Orhan, Özhan; Orhan, Ozhan; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü[No Abstract Available]Article Citation - WoS: 0Citation - Scopus: 0Epidemiology, Clinical and Laboratory Findings of Pediatric Leptospirosis in Southeastern Turkey(Briefland, 2024) Orhan, Özhan; Elci, Huseyin; Department of Internal Medical Sciences / Dahili Tıp Bilimleri BölümüBackground: Leptospirosis is a significant zoonotic infection caused by Leptospira spirochetes, which are distributed globally. Infection typically occurs through exposure to water or soil contaminated by the urine of mammals, including dogs, cattle, pigs, or rodents. Objectives: The objective of this study was to elucidate the epidemiological, clinical, and laboratory characteristics of leptospirosis cases in Turkey. Methods: In a retrospective review, we analyzed the clinical and laboratory data of all individuals under 18 years diagnosed with leptospirosis at a secondary care center in Southeast Turkey from the beginning of 2020 to the end of 2O22. Results: Over the two-year period, 36 confirmed cases of leptospirosis in individuals under 18 were identified. All patients had been engaged in activities at wells in cornfields, assisting their families with irrigation or related to well operations. Of these patients, 3 (8%) resided in urban areas, while 33 (92%) lived in rural settings. None required intensive care, and there were no fatalities reported. The most common symptoms at presentation were fatigue (83%), fever (75%), and nausea/vomiting (75%). Laboratory tests revealed that all patients had positive C-reactive protein (CRP) levels, with a significant portion (61%) showing Conclusions: In conclusion, leptospirosis should be considered by clinicians when evaluating patients, especially those with risk factors like occupational exposure. Prompt testing for the disease is advisable under these circumstances.Article Citation - WoS: 1Citation - Scopus: 1Evaluation of the Results of the Patients Who Underwent Plasmapheresis in the Pediatric Intensive Care Unit(Tubitak Scientific & Technological Research Council Turkey, 2024) Talay, Mehmet Nur; Orhan, Ozhan; Orhan, Özhan; Özbek, Mehmet Nuri; Ozbek, Mehmet Nuri; Department of Internal Medical Sciences / Dahili Tıp Bilimleri BölümüBackground/aim: Therapeutic plasma exchange (TPE) is an extracorporeal treatment method that removes large molecular weight substances from plasma. In our study, we aimed to retrospectively examine the indications and procedural methods of the patients who had undergone TPE, and the complications that occurred during the procedure. Materials and methods: Forty-one patients who were monitored in thePICU of Gazi Ya & scedil;argil Training and Research Hospital and had indications for TPE between 2017 and 2021 were included in the study. Laboratory parameters were checked before and after the TPE procedure. In addition to these, patients' diagnosis, weight, type of procedure and type of device, where the procedure was performed, duration of the procedure, amount of blood and plasma processed, complications, number of procedures, and death during the procedure or independent of the procedure were evaluated. Results: The median age was 93.0 (14.0-167.0) months. Hemolytic uremic syndrome (HUS) was the most common TPE indication with nine patients. The most common complication related to TPE was fever (11 patients), while no complication was observed in 18 patients. When laboratory results were evaluated according to American Society for Apheresis (ASFA) categories, a significant improvement was observed in the values of platelet, AST, ALT, LDH, urea, and creatinine in ASFA1 after TPE. No significant improvement was observed in ASFA2 (p > 0.05). In ASFA3, a significant improvement was observed in INR, AST, ALT, LDH, total bilirubin, creatinine, pH, and lactate values after TPE (p < 0.05). Five patients died from ASFA1, one from ASFA2, and three patients from ASFA3. Conclusion: Since significant adjustments are observed in clinical and laboratory values in sepsis-MOF, which is in the ASFA3 category, we believe that it should be evaluated in the ASFA2 or ASFA1 category in the early treatment of these diseases. In addition, we think that MIS -C cases, which have not been in any category according to ASFA, should be included in the ASFA2 or ASFA3 category, considering our TPE results.Article Investigation of Vitamin D, Vitamin B12 and Ferritin Levels in Children Receiving Home Health Care Services in Southeastern Türkiye(2023) Orhan, Özhan; Solmaz, Murat; Department of Internal Medical Sciences / Dahili Tıp Bilimleri BölümüAim: For proper nutrition of children followed by the Home Health Care (HHC) unit, a close follow-up is extremely important. Vitamin deficiencies are common in children in this group who need parental or caregiver-dependent nutrition. The purpose of this study conducted in Batman Province, was to investigate vitamin D, vitamin B12 and ferritin levels of individuals under 18 years of age who are followed by the HHC unit and continue their lives and treatments at home, except for emergencies. Materials and Methods: This study was derived from the files of 416 pediatric patients who were followed up in Batman Province HHC unit between January 1, 2022, and December 31, 2022. It was designed as a retrospective, single-center study evaluating 25-hydroxyvitamin D (OH) levels, vitamin B12 levels, ferritin levels, and demographic variables from individuals followed by HHC unit. The data were collected from the HHC unit’s files. IBM-SPSS version 24 was used for analysis. Results: The mean age of the 416 children receiving home health care services included in the study was 10.38±4.37 years. 234 (56.2%) of the participants were male and 182 (43.8%) were female. The 25(OH)D level was 18.47±5.41 ng/mL for all ages, and the ferritin level was 34.90 (33.08) ng/mL. The vitamin B12 level was 480.31±190.38 ng/L. The 25-OH-D vitamin levels of the children in the study were significantly low. Conclusion: Patients followed within the scope of home health care services are at risk for malnutrition and vitamin deficiencies, and annual follow-up of the patients in this regard and personalized diet programs should be created. Vitamin D insufficiency and deficiency are common in children in this group, who cannot leave the house except for compulsory situations and cannot benefit from sunlight sufficiently. We think that these children with chronic diseases should take vitamin D prophylaxis.Article Citation - WoS: 0Metahemoglobinemia y hemolisis intravascular aguda despues de una intoxicacion por naftaleno en un paciente pediatrico(Soc Argentina Pediatria, 2023) Orhan, Özhan; Talay, Mehmet Nur; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü[No Abstract Available]Article Evaluation of Admissions and Inappropriate Referrals To Pediatric Gastroenterology, Hepatology and Nutrition Outpatient Clinics(2025) Orhan, Özhan; Orhan, Özhan; Department of Internal Medical Sciences / Dahili Tıp Bilimleri BölümüObjective: The aim of this study was to examine the diagnostic profiles of patients admitted to pediatric gastroenterology, hepatology, and nutrition outpatient clinics within the scope of the state service obligation and to determine the reasons for inappropriate referrals. Methods: A total of 10,235 patients admitted to the pediatric gastroenterology, hepatology and nutrition outpatient clinics of Mardin Training and Research Hospital between 2022 and 2023 were retrospectively analyzed. Data were analyzed using SPSS 21.0 software according to demographic and clinical variables such as age, gender, reasons for admission and diagnoses. Results: Of the patients examined, 49.1% were girls and 50.9% were boys, and the most common reason for presentation was inadequate weight gain with a rate of 46%. However, malnutrition or another nutritional disorder was not detected in 28% of the patients referred with a diagnosis of inadequate weight gain. Malnutrition was diagnosed in a total of 1,710 cases, of which 8.2% were mild malnutrition, 5.3% were moderate malnutrition, and 4.2% were severe malnutrition. No pathological findings were found in 40.8% of the applicants. It was also found that most of the complaints of constipation and diarrhea, which are common reasons for admission, can be effectively treated in primary and secondary health care services. Conclusions: The results of the study show that a significant proportion of referrals to pediatric gastroenterology outpatient clinics are unnecessary and that referrals can be reduced by evaluating these patients in primary and secondary care, thereby increasing the efficiency of health care services.Article Evaluation of Pediatric Patients Installed Due To Acute Gastroenteritis(2023) Orhan, Özhan; Bulut, Mehmet; Department of Internal Medical Sciences / Dahili Tıp Bilimleri BölümüObjectives: Acute gastroenteritis is one of the most prevalent causes of death and morbidity in children and a significant health issue in Turkey, as well as developed and developing nations. The purpose of this study is to analyze retrospectively the patients with acute gastroenteritis who sought treatment at the Kızıltepe State Hospital in Mardin. Methods: This study was designed as a single-center retrospective study in which demographic variables were evaluated by taking fresh stool samples from the patients who applied to the Mardin Province Kızıltepe State Hospital between 01/11/2020 and 31/10/2021 with the complaint of diarrhea. The information of rotavirus, enteric adenovirus and amoeba viruses in stool samples was investigated by qualitative immunochromatographic test. The researcher assessed the research data utilizing the hospital's file archive materials and three factors set by the researcher. The researcher extracted the information about these factors from the patient files and stored it in a Microsoft Office Excel file. Results: According to the gender variable of the research participants, Amoeba positive rates were considerably higher in males than in girls (35.8% versus 22.6%, p = 0.046, respectively). According to the age groups variable, rotavirus antigen positive was statistically significantly greater in the 5-24 month age group compared to other age groups (p = 0.034). Similarly, Amoeba positive was statistically substantially higher in the 5-24 month age group compared to other age groups (p = 0.001). There was no significant variation between age groups in the distribution of adenovirus. According to the seasonal variable, rotavirus antigen positivity was most prevalent in the spring, and the difference between the spring and other seasons was statistically significant (p = 0.001), whereas amoeba positivity was most prevalent in the summer, with no statistically significant difference between the seasons (p = 0.003). The frequency of undiscovered variables was greater during the spring-summer months, and a statistically significant difference (p = 0.041) was identified between the groups. The seasonal variation in the prevalence of Adenovirus antigen positive was not statistically significant (p = 0.394). Conclusions: As a result, in poor and underdeveloped nations, it is among the top five causes of death in children under the age of five, in relation to acute gastroenteritis. Furthermore, the majority of these deaths may be minimized by preventative and prevention strategies. It is the responsibility of governments, health professionals, and families to foster a safe and healthy environment for all infants and children during their infancy and development. Community-based health strategies should be undertaken to lower the morbidity and death rates of millions of people worldwide who are exposed to harmful environmental conditions and malnutrition.