Gökdemir, Mehmet Tahir
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Gokdemir, Mehmet Tahir
Gökdemir,Mehmet Tahir
Gökdemir,Mehmet Tahir
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Prof. Dr.
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tahirgokdemir@artuklu.edu.tr
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Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
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Current Staff
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1
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8
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7
AFFORDABLE AND CLEAN ENERGY
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17
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13
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2
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4
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3
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3
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9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
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16
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5
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12
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10
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14
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11
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15
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6
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Documents
44
Citations
238
h-index
9
Documents
60
Citations
264
Scholarly Output
9
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6
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8/5
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WoS Citation Count
3
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2
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1
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1
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0
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2
WoS Citations per Publication
0.33
Scopus Citations per Publication
0.22
Open Access Source
7
Supervised Theses
0
| Journal | Count |
|---|---|
| ENDOKRİN ACİLLER | 2 |
| KİTAP | 1 |
| Medicine | 1 |
| Medicine Science | 1 |
| Psychopharmacology | 1 |
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9 results
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Now showing 1 - 9 of 9
Article EFFECT OF METFORMIN ON MUSCLE ATROPHY IN EXPERIMENTAL DIABETIC RATS(2023) Gökdemir.Gül Şahika; Keşim, Dilek Aygül; Gökdemir, Mehmet Tahir; Baylan,MukadderBackground: Although first-line biguanide metformin is frequently administered to T2DM patients, the effects of long-term use on muscle are unknown. This study aimed to examine the effect of metformin-treated diabetes on muscle atrophy in experimental diabetic rats. Materials and methods: Twenty-one Wistar albino male rats in 3 groups were included in our research. Insulin resistance HOMA-IR, mTOR, and Myostatin levels and gastrocnemius weight were measured. Results: Myostatin level was significantly higher in the non-medicated diabetes group than in the healthy control group (p<0.001). Moreover, myostatin level was significantly lower in the metformin group (p=0.001). The weight of gastrocnemius was significantly lower in both the metformin-treated and non-metformin-treated diabetic groups compared to the control group (p<0.001 for both groups). Moreover, the gastrocnemius weight was significantly higher in the metformin group than in the non-medicated group (p=0.004). The HOME-IR level had a significantly negative correlation with the mTOR level (R=-0.783; P<0.001) and a positive correlation with the myostatin level (R=0.622; P=0.003). Conclusion: Our evidence and data support that metformin may be effective in preventing muscle wasting. To conclude, this study showed that metformin has anti-atrophic effects on muscles in diabetes and that metformin can prevent muscle mass loss.Book Part HIPERKALSEMI(AKADEMİSYEN YAYINEVİ, 2023) Gökdemir,Mehmet TahirParatiroid bezleri, insan boynunda tiroid bezi arkasında farklı yerlerde gizlenen küçük dört adet endokrin bezlerdir. Bazı kişilerde altı, sekiz hatta daha fazla paratiroid bezi olabilir. Nadiren paratiroid bezleri tiroid bezinin kendisinde, göğüste ve hatta timusta olabilir. Paratiroid bezi, kandaki ve kemiklerdeki kalsiyum miktarının düzenlenmesinde kilit rol oynayan düşük kan kalsiyumuna yanıt olarak paratiroid hormonu (PTH) üretir ve salgılar. Paratiroid bezleri, tiroid bezine benzer olarak, aynı arterler olan üst tiroid arteri, alt tiroid arteri ile beslemesini, venöz drenajını üst tiroid, orta tiroid ve alt tiroid venleri ile lenfatik drenajını ise pretrakeal, prelaringeal, jugulodigastrik lenfleri ile yapmak tadır. Pratiroid bezinin sinir inervasyomu da, yine tiroid bezinin siniri ile ortak olan orta servikal ganglion, alt servikal gangliondan oluşmaktadır. Gerçek toplam plazma kalsiyum seviyesini he saplama formülü: Düzeltilmiş [Ca] = ölçülen [Ca] + (0,8 × [4,5-albümin düzeyi]). Primer hiperparatiroidizm (PHPT) ve malignite, hiperkalsemi vakalarının %90’ını oluşturur. Yavaş gelişen hafif bir artışı olanlarda tipik olarak hiçbir semptom görülmez. Daha yüksek seviyeli veya hızlı başlangıçlı olanlarda semptomlara yol açar.Article Importance of Curcumin Effect and Asprosin Level on Glucose Metabolism in Diabetic Rats(2023) Gökdemir, Mehmet Tahir; Taşdemir, Ezel; Yokus, Beran; Atmaca, Mukadder; Gokdemir, Gul SahikaAsprosin is a new hormone secreted mainly from white adipose tissue. It may be associated with the pathogenesis of obesity, diabetes and some metabolic diseases. The changes in plasma asprosin levels of experimental diabetic rats and the relation of these changes with liver glucose metabolism and some diabetes parameters were investigated, and the effects of metformin, gliclazide or curcumin treatment on plasma asprosin levels were tried. The study was designed as an animal model in diabetic rats The albino rats were divided into five groups. To induce diabetes, a single dose of STZ was injected intraperitoneally. Diabetics rats were treated intragastrically with metformin (D+Metformin group), gliclazide (D+Giliclazide group) or 20 curcumin (D+Curcumin group) for eight weeks. Fasting blood glucose, insulin levels and other parameters were measured. Plasma asporsin levels of untreated diabetic rats increased significantly (P<.001). Although the plasma asprosin levels of diabetic rats treated with the rugs were significantly lower (P<.001). Fasting blood glucose levels of diabetic rats treated with the drugs were found to be remarkably lower than the diabetic control values (P<.001, respectively). There was no significant difference in the insulin levels and HOMA- IR between these three groups. Curcumin treatment provides significant improvements in plasma asprosin level and diabetes parameters. The increase in plasma asprosin level in diabetic rats may be one of the main reasons that facilitate the development of the disease or is responsible for its pathogenesis. Our findings support the idea that curcumin may be an important treatment option for diabetes.Book ENDOKRİN ACİLLER(AKADEMİSYEN YAYINEVİ, 2023) Gökdemir, Mehmet TahirEndokrinoloji, günümüzde tıbbın karşı karşıya olduğu en yaygın durumlarından olan ciddi acil sağlık sorunlarından bazılarını kapsar. Endokrin sistem, hormonların haberci sistemi olarak önemli bir rol oynar ve vücuttaki metabolik işleyişi kontrol eder. Bir endokrin bezin akut veya kronik yetmezliği hastalıklara ve hatta ölüme neden olabilir. Pankreas, tiroid, paratiroid ve sürrenal bezlerin bozuklukları gibi endokrin hastalıkların komplikasyonları klinik olarak sinsidir ve hayati önemdedir. Bu hastalıklar toplam nüfusun %10'undan fazladır. Bilinen endokrin organ hastalıklarının yanı sıra bu hastalıkların acil durumlarının değerlendirilmesi ve yönetimi kritik önemdedir. Endokrin acil durumlar genellikle travma, cerrahi, yeni hastalık veya enfeksiyon gibi akut bir olayla tetiklenir. Normal işleyişteki aksamalar yaşamı tehdit eden acil durumlar yaratabilir ve acil müdahale gerektirebilir. Bu nedenle, endokrin acil durumları tanımak ve uygun şekilde yönetmek önemlidir. Semptomları belirsiz olabileceğinden ve diğer durumları taklit edebildiğinden, endokrin acil durumları başlangıçta tespit etmek zor olabilir. Endokrin acil durumlar, acil servislerde klinik iş yükünün büyük bir bölümünü oluşturur. Bu kitabın amacı, güncel endokrin acil durumları değerlendirmeyi ve kritik hasta yönetiminin endokrin yönlerini kapsamaktır. Endokrin Aciller kitabı, uzman hekimlere, acil tıp başta olmak üzere diğer tıp asistanlarına, pratisyen hekimlere ve tıp öğrencilerine faydalı olabilecek referans bir çalışmadır. Kitap, klinisyenin karşılaşabileceği yüksek riskli endokrin acil olguların yönetimine katkı sağlayacaktır. Her bölümde acil duruma genel bakış, semptomlar, tanı ve tedaviyle ilgili bölümler bulunur. Kitabımızın hazırlanma aşamasında gösterdikleri özverili çalışmalarından dolayı bölüm yazarlarımıza ve Akademisyen yayınevi çalışanlarına teşekkür ederim. Kitabımızın Acil Tıp ve diğer tüm klinik alanda çalışan hekimlerimize, öğrencilerimize ve hastalarımıza faydalı olması en büyük arzumuzdur.Article Citation - WoS: 1Citation - Scopus: 1Antidepressant-Like Effects of Ashwagandha (Withania Somnifera) on Chronic Unpredictable Mild Stress-Induced Depression in Adolescent Rats(Springer, 2025) Gokdemir, Gul Sahika; Seker, Ugur; Baksi, Nazan; Baylan, Mukadder; Demirtas, Berjan; Gokdemir, Mehmet TahirRationaleAdolescent depression is often linked to biological changes associated with stress. However, new approaches and treatment strategies for early intervention and prevention of depression in children and adolescents are still limited. Ashwagandha is an Ayurvedic herb widely used in the management of anxiety and stress. However, there is no information in the current literature on its potential effect on adolescent depression.ObjectivesThis study aimed to investigate the effects of depression on proapoptotic proteins and neuroinflammation and the antidepressant effect of Ashwagandha on depression-like symptoms in adolescent rats exposed to the Chronic Unpredictable Mild Stress (CUMS) model.MethodsIn the study, CUMS model was used to induce depression in adolescent rats. Rats were treated with Ashwagandha or Sertraline. To evaluate the antidepressant effects, behavioral tests as well as biochemical and histological analyses were performed. Forced Swim Test (FST), Sucrose Test and Elevated Plus Maze Test were performed as behavioral tests. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were measured by the ELISA method in the fronto-parietal cortex. Proapoptotic proteins (Bax and Caspase-3) and inflammatory markers (TNF-alpha and IL-1 beta), as well as glial fibrillary acidic protein (GFAP), were evaluated immunohistochemically in the fronto-parietal cortex.ResultsProapoptotic proteins (Bax and Caspase-3) and inflammatory markers (TNF-alpha and IL-1 beta) were increased in the CUMS group. BDNF and GFAP levels were decreased. Ashwagandha treatment was more effective than Sertraline in reducing the levels of these proteins and markers. Additionally, Ashwagandha prevented weight loss.ConclusionsAshwagandha showed antidepressant-like effects in adolescent rats, reducing apoptosis, inflammation, and neuroinflammation, suggesting potential for treating adolescent depression.Article Citation - WoS: 1Citation - Scopus: 1Prognostic Significance of the Chemerin Level in Coronavirus Disease 2019 Patients(Lippincott Williams & Wilkins, 2024) Arac, Songul; Yokus, Beran; Gokdemir, Guel Sahika; Gokdemir, Mehmet TahirIncreased serum chemerin levels have been reported in several inflammatory diseases. Few studies have investigated the relationship between chemerin and clinical features of COVID-19. Thus, chemerin may modulate the development and progression of COVID-19. We compared the serum chemerin concentration between patients with and without SARS-CoV-2 infection and its association with the severity and prognosis of COVID-19 pneumonia. This is a prospective, single-center, cross-sectional study. We enrolled COVID-19 patients who presented to our tertiary hospital and healthy controls. The COVID-19 patients were conducted and the dates of symptom onset were recorded. After admission to the hospital and stabilization, blood samples were obtained for routine hemogram, biochemistry, and chemerin. The chemerin level was 37.93 +/- 17.3 ng/mL in patients followed in the ICU, 29.41 +/- 12.79 ng/mL in inpatients, 30.48 +/- 10.86 ng/mL in outpatients, and 25.12 +/- 9.82 ng/mL in healthy controls. The difference between patients treated in the ICU and healthy controls was significant (P < .001). The high-sensitivity C-reactive protein (hs-CRP), ferritin, procalcitonin (PCT), and D-dimer levels were significantly higher in the intensive care unit (ICU) group (P < .001). Moreover, the chemerin level of patients who died was significantly higher than that of those who survived (P < .001). The chemerin level was increased in COVID-19 patients and also increased with increasing disease severity. The chemerin level was higher in the COVID-19 patients than healthy controls and was significantly higher in patients who died compared to those who did not.Book Part LAKTIK ASIDOZ(AKADEMİSYEN YAYINEVİ, 2023) Gökdemir,Mehmet TahirLaktik asidoz, vücutta laktat ve proton birikimi sonucu meydana gelen ve prognozu kötü olabilecek bir fizyopatolojik bozukluktur. Laktik asit, fizyolojik olarak normal süreçlerde ve hastalık durumlarında yaygın bir bulgu olarak üretilir. Artan üretim, azalan klirens ile birlikte görüldüğünde, klinik seyrin şiddeti artar. Laktik asidoz, sepsise eşlik ettiğinde ölüm oranı yaklaşık üç kat artar ve laktat düzeyi ne kadar yüksekse sonuç o kadar kötü olur. Hiperlaktatemi sıklıkla doku hipoksisine bağlı olmakla beraber, başka faktörlerde neden olabilir. Tetikleyici koşulların kontrol edilmesi laktik asidozun tedavisini de bir şekilde sağlayacaktır. Patofizyolojik olarak hücresel işlev bozukluğuna neden olan faktörlerin anlaşılmasındaki ilerlemeler yeni tedavilere yol açabilir . Ciddi şekilde yükselmiş laktik asit seviyelerinin etkileri derin hemodinamik sonuçlara sahip olabilir ve ölüme yol açabilir. Serum laktat seviyeleri hem bir risk belirteci hem de terapötik bir hedef olabilir. Yüksek serum laktat düzeyinin seviyesi ne kadar yüksekse ve normalleşme süresi ne kadar uzun olursa, ölüm riski o kadar yüksek olur. Klinisyenler, yeterli doku perfüzyonu ve oksijenasyon varlığında hiperlaktateminin oluşabileceğinin farkında olmalıdır. Laktik asidoz ise genellikle yetersiz doku per füzyonu, karbonhidrat metabolizmasındaki anormallikler ve bazı ilaçların kullanımı ile ortaya çıkar. Laktik asidozun patofizyolojisi ve asideminin vücut üzerindeki etkileri hakkında çok şey bilinmesine rağmen, bugüne kadar sodyum bikarbonat ile tedavisi ve bunun klinik sonuçlar üzerindeki etkileri hakkında az sayıda insan çalışması yapılmıştır. Laktik asidoz, doku hipoksisi olan (tip A) ve doku hipoksisinin olmadığı bozukluk (tip B) olarak ikiye ayrılırlar. Kardiyojenik veya hipovolemik şok, şiddetli kalp yetmezliği, şiddetli travma ve sepsis, vakaların büyük çoğunluğunu oluşturan laktik asidozun en yaygın nedenleridir.Article Citation - WoS: 1The Effect of Acute Carbon Monoxide Intoxication on Cardiac Necrosis in Rats: in Relation To Adiponectin Levels(Univ Zulia, Facultad Ciencias veterinarias, 2025) Gokdemir, Gul Sahika; Cakmak, Sumeyye; Demirtas, Berjan; Gokdemir, Mehmet Tahir; Sogut, Ozgur; Canpolat-Erkan, Revsa Evin; Yokus, BeranIn order to investigate the effects of acute CO poisoning and subsequent oxygen therapy on cardiac necrosis in rats, with a specific focus on adiponectin levels, twenty-one male Wistar albino rats were divided into three groups (Control, CO, CO+O-2). The Control group was placed in a container and exposed to room air for 30 min. Acute CO poisoning was induced in the CO group and CO+O-2 group by exposing the rats to CO gas for 30 min. Following CO exposure, the CO+O-2 group received oxygen therapy for 30 min, while the CO group did not receive any additional intervention. The animals were euthanized by cardiac puncture under anesthesia, following the approved ethical procedures. Carboxyhemoglobin (COHb), serum levels of creatine kinase (CK), creatine kinase myocardial band (CK-MB), C-reactive protein (CRP) and lactate dehydrogenase (LDH), as well as cardiac and serum adiponectin levels were measured. CO poisoning caused necrosis in cardiac tissue however, oxygen therapy alleviated the negative effect of CO on cardiac injury. COHb and LDH levels in CO group were increased, whereas both cardiac and serum adiponectin levels were decreased (all, P<0.05). There were no changes in CK, CK-MB, CRP levels among groups (all, P>0.05). Oxygen therapy decreased COHb, but increased both cardiac and serum adiponectin levels (all, P<0.05). Adiponectin and LDH may serve as potential biomarkers for early diagnosis of cardiac necrosis caused by acute CO poisoning. The assessment or quantification of adiponectin can also be useful for the early prognosis of cardiac necrosis after oxygen therapy.Article High-Flow Nasal Cannula Oxygen Versus Conventional Oxygen Therapy in a Rat Model of Severe Carbon Monoxide Toxicity(MRE Press, 2025) Cakmak, Sumeyye; Gokdemir, Gul Sahika; Gokdemir, Mehmet Tahir; Sogut, Ozgur; Erkan, Revsa Evin CanpolatBackground: This study compared the efficacy of high-flow nasal cannula (HFNC) oxygen therapy with conventional oxygen therapy (COT) using a simple face mask for clearing carbon monoxide (CO) from the bloodstream in a rat model of severe CO poisoning. Methods: Twenty-eight male Wistar rats were assigned to four groups: severe CO intoxication treated with HFNC, a sham group (no intoxication or treatment), severe CO intoxication treated with COT, and a control group with severe CO intoxication receiving no treatment. Their arterial blood gas and metabolic parameters were analyzed and compared to determine treatment effectiveness. Results: Significant differences were observed among the groups in terms of carboxyhemoglobin (COHb), pH, bicarbonate (HCO3), hemoglobin, sodium (Na), potassium (K), calcium (Ca), glucose and lactate levels. Both treatment groups had lower COHb and lactate levels compared to the untreated control group, with COHb clearance being significantly higher in the HFNC group than in the COT group (20.33% +/- 3.58% vs. 41.17% +/- 6.49%; p < 0.001). Additionally, pH levels were higher in the HFNC group than in the COT group (7.32 +/- 0.07 vs. 7.27 +/- 0.05; p = 0.486). Conclusions: HFNC oxygen therapy was found to be more effective than COT in promoting CO elimination and improving arterial blood gas parameters, indicating its potential as a superior treatment strategy for severe CO poisoning.
