Karahan, Mehmet Zülkif

Karahan, Mehmet Zülkif

Job Title

Prof. Dr.

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Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü

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Current Staff

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Scholarly Output

23

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21

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0

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Kardiyovasküler Hastalıklarda Beslenme
(2023) Kayan, Fethullah; Karahan, Mehmet Zülkif; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Bölüm 20 - Kardiyovasküler Hastalıklarda Beslenme ............................................................ 399 Fethullah Kayan - M. Zülkif Karahan 1. Genel Bakış ........................................................................................................................ 400 2. Besinler .............................................................................................................................. 403 3. Gıdalar ............................................................................................................................... 405 xv 4. Hipertansiyon ve Beslenme................................................................................................ 408 5. Obezite-Diyabetüs Mellitüs ve Beslenme ........................................................................... 409 6. Kalp Yetmezliği ve Beslenme.............................................................................................. 410 7. Koroner Arter Hastalığı ve Beslenme .................................................................................. 411 Kaynaklar................................................................................................................................... 413
Citation - WoS: 0
Citation - Scopus: 0
Is Atrial Fibrillation a Risk Factor for Hearing Loss
(verduci Publisher, 2023) Karahan, M. Z.; Karahan, Mehmet Zülkif; Can, S.; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
OBJECTIVE: In the present study, we sought to evaluate the results of hearing loss in AF patients. PATIENTS AND METHODS: This study involved 50 patients with AF, as determined by means of electrocardiogram, and 50 patients without AF. The pure-tone audiometry (PTA) threshold values were measured at low, medium and high frequencies for both ears. The signal-to-noise ratio (SNR) DPOAEs and TEOAEs were also analyzed for both ears separately. RESULTS: Both the airway and bone conduction PTA thresholds at 3, 4 and 6 kHz (kilohertz) were significantly lower in the AF group than in the control group (p<0.05). The AF patients exhibited worse hearing and worse TEO-AE results at 1, 2, 3 and 4 kHz. In fact, the TEO-AE amplitudes of the AF group were significantly lower in both the right and left ears at 2, 3 and 4 kHz when compared with the control group (p<0.05). Moreover, the DPOAE amplitudes in the AF group were statistically significantly lower at 3.4 kHz in both ears when compared with the control group (p<0.05). CONCLUSIONS: In light of these findings, we believe that AF is a risk factor for hearing.
Citation - WoS: 2
The Significance of Frontal Plane QRS-T Angle for Estimating Non-Dipper Hypertension
(Cureus, 2022) Karahan, Mehmet Zülkif; Karahan, Mehmet Zülkif; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Objective: The frontal QRS-T angle (fQRS-T) is linked to myocardial ischemia and ventricular arrhythmias. On the other hand, non-dipper hypertension is a risk factor for cardiac adverse events. The objective of this research was to determine whether the fQRS-T, a marker of ventricular heterogeneity, could be used to predict non-dipper hypertensive individuals in the lack of left ventricular hypertrophy. Methods: The observational study was carried out retrospectively. Patients diagnosed with hypertension were included in this study. Blood tests were routinely conducted for all patients. Electrocardiography (ECG) was conducted for each patient and echocardiography was performed. Blood pressure (BP) values were collected from the ambulatory Holter records. According to ambulatory Holter monitoring, the individuals were separated into two groups. The association between fQRS-T and hypertension was investigated. Results: The research involved 123 patients, with an average age of 51.85±8.22 years, comprising 76 women (61.8%) and 47 males (38.2%). According to ambulatory Holter monitoring, patients were separated into dippers (n=65) and non-dippers (n=58). There were no statistically significant in the laboratory and echocardiographic variables (p>0.05). QT dispersion (QTd) and fQRS-T were substantially greater in the non-dipper group than in the dipper group (p=0.043 and p<0.001, respectively). Independent determinants of non-dipper status were determined by univariate and multivariate logistic regression analyses. fQRS-T was found to be the only independent indicator of non-dipper status (OR: 1.03, 95%CI: 1.02-1.06, p<0.001). Conclusion: The fQRS-T may be a useful marker for estimating non-dipper hypertensive individuals in the lack of left ventricular hypertrophy.
Citation - Scopus: 5
The effect of coronary slow flow on ventricular repolarization parameters
(ScienceDirect, 2023) Karahan, Mehmet Zülkif; Aktan, Adem; Günlü, Serhat; Kılıç, Raif; Kılıç, Raif; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Introduction: Ischemia due to microvascular dysfunction may be responsible for the heterogeneity of ventricular repolarization in coronary slow flow. To our knowledge, there is no study in which QT interval, Tp-Te interval, index of cardiac-electrophysiological balance (iCEB), and frontal QRS-T angle were evaluated together in patients with CSF. In this study, we examined for the first time the relationship between all these myocardial repolarization parameters and CSF. Materials and methods: The study group included 178 patients (99 female, mean age: 50.6 ± 8.6 years) with isolated CSF without stenotic lesions and with angiographically proven normal coronary arteries. The control group included 120 patients (71 female, mean age: 49.3 ± 9.4 years) with normal coronary angiography. QRS duration, QT interval, QTc interval, Tp-Te interval, Tp-Te/QT, Tp- Te/QTc, iCEB score, and frontal QRS-T angle were calculated from 12‑lead ECGs. Results: There was no significant difference in demographic parameters between the two groups. Compared with the control group, patients with CSF had significantly longer QTmax duration, QT dispersion, Tp-Te interval, and higher iCEB score, wider frontal QRS-T angle. Conclusion: In our study, we found that many of the ventricular repolarization parameters were adversely affected in patients with CSF. Impaired parameters may be associated with the risk of malignant ventricular arrhythmias.
Citation - WoS: 7
Citation - Scopus: 7
Comparison of Pain Levels of Traditional Radial, Distal Radial, and Transfemoral Coronary Catheterization
(Assoc Medica Brasileira, 2023) Günlü, Serhat; Kılıç, Raif; Kilic, Raif; Guzel, Tuncay; Aktan, Adem; Aktan, Adem; Arslan, Bayram; Karahan, Mehmet Zülkif; Aslan, Muzaffer; Gunlu, Serhat; Karahan, Mehmet Zulkuf; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
OBJECTIVE: The aim of our study was to compare the traditional radial artery, distal radial artery, and transfemoral artery, which are vascular access sites for coronary angiography, in terms of pain level using the visual analog scale.METHODS: Between April 2021 and May 2022, consecutive patients from three centers were included in our study. A total of 540 patients, 180 from each of the traditional radial artery, distal radial artery , and transfemoral artery groups, were included. The visual analog scale was applied to the patients as soon as they were taken to bed. RESULTS: When the visual analog scale was compared between the groups, it was found to be significantly different (transfemoral artery: 2.7 & PLUSMN;1.6, traditional radial artery: 3.9 & PLUSMN;1.9, and distal radial artery: 4.9 & PLUSMN;2.1, respectively, p<0.001). When the patients were classified as mild, moderate, and severe based on the visual analog scale score, a significant difference was found between the groups in terms of body mass index, process time, access time, and number of punctures (p<0.001). Based on the receiver operating characteristic analysis, body mass index>29.8 kg/m2 predicted severe pain with 72.5% sensitivity and 73.2% specificity [(area under the curve: 0.770, 95%CI: 0.724-0.815, p<0.0001)].CONCLUSION: In our study, we found that the femoral approach caused less access site pain and a high body mass index predicts severe pain.
Vatanından Uzakta Ölmek” Palyatif Bakım Kliniğinde Ölen 7 Suriye Uyruklu Hasta ve Ülkemizin Sığınmacıların Sağlık İhtiyaçlarını Karşılamadaki Rolü
(2022) Akelma, Hakan; Karahan, Mehmet Zülkif; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Savaşlar, iç çatışmalar telafisi mümkün olmayan yıkımlara neden olup, en çok da sivilleri etkilemektedir. Yıkımın etkisi başta ikincil şahıslara ihtiyaç duyan çocuk, yaşlı ve kadınlar için daha belirgindir. Şu anda dünyadaki sığınmacıların yarısından fazlası Suriye’de hayatlarını kurtarmak için ülkelerinden ayrılmak zorunda kalan sığınmacılardan oluşmaktadır. Siyasal, sosyal, kültürel ve ekonomik açıdan toplumu ve bireyleri etkileyen yurdundan edilme durumu sağlık sorunlarını da beraberinde getirmektedir. Sığınmacılar zor yaşam koşulları, barınma, beslenme, şiddet ve psikolojik travmalar gibi birçok neden ile sağlık bakım sisteminde en kırılgan ve savunmasız gruplardandır. Kendi yaşam alanlarından zorunlu olarak ayrılan bireylerin yaşam konforlarının azalması ve yaşadıkları psikolojik yıkım, beraberinde bulaşıcı hastalıklar, kardiyovasküler hastalıklar, diyabet, kanser ve akciğer hastalıkları gibi kronik hastalıkların riskini artırmaktadır. Bu hastalıklara bağlı palyatif bakım ünitelerine yatışlar artmakta ve bu kliniklerde yaşam koşullarından daha iyi şartlarda sağlık hizmeti almakta ancak hastalıklarının şiddetine göre ölümler gerçekleşmektedir. Türkiye, sığınmacılara mümkün olan en iyi yaşam koşullarını ve kapsamlı insani yardımı sağlamaktadır. Sığınmacılar hem kamplarda hem de barındıkları iskânlarda tüm sağlık hizmetlerini sürdürmektedir. Bu sığınmacılar aynı şekilde gerekli durumlarda palyatif bakım hizmetlerinden faydalanmaktadır. Bu çalışmanın amacı palyatif bakım kliniklerde özellikle kanser, diyabet ve diğer kronik hastalıklar sonucu hayatını kaybeden sığınmacı hastaların değerlendirilmesi ve bunun yanında ülkemiz sağlık bakımındaki desteğini vurgulamaktır.
Citation - Scopus: 1
The predictive effect of shock index on mortality in patients with acute heart failure
(AME Publishing, 2023) Günlü, Serhat; Kayan, Fethullah; Karahan, Mehmet Zülkif; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Background: The predictive usefulness of the shock index (SI), which is determined as a proportion of heart rate (HR) to systolic blood pressure (SBP), and age-adjusted SI (SI × age) for clinical outcomes other than mortality in acute heart failure (AHF) is not well established. This research aimed to examine whether SI and SI × age measured non-invasively at a patient’s bedside can identify mortality risk in patients admitted to the coronary care unit (CCU) with AHF. Methods: This research was carried out as a retrospective case-control study. Indices were calculated. The receiving operating characteristic (ROC) and Youden index were applied to calculate the optimal SI and SI × age cut-off for estimating mortality. Using multivariate analysis to determine independent indicators of mortality in patients with AHF. Results: A total of 1,468 patients who were hospitalized at the CCU with AHF were included. The population’s median age was 81 (73–91) years and 53.7% were male. In the survivor group, the median SI was 0.6 (0.5–0.75), and the median SI × age was 46 (38–58). In the non-survivor group, the median SI was 0.62 (0.55–0.81) and the median SI × age was 53 (44–66). According to the Youden index, the best value of SI was 0.56 with a specificity of 46% and a sensitivity of 70%, and the best value of SI × age was 44.8 with a specificity of 48% and a sensitivity of 76%. In the multivariate analysis, the power of SI × age to predict mortality was 2.39 times greater than other independent predictors. Conclusions: SI and SI × age calculated in the CCU may be valuable prognostic markers for identifying AHF patients at high risk for adverse outcomes.
KRONİK HASTALIĞI OLAN BİREY VE AİLE İLE İLETİŞİM
(2023) Aktan, Adem; Karahan, Mehmet Zülkif; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Kronik hastalık, uzun süreli tedavi gerektiren ve hayatı boyunca sürebilecek bir sağlık durumunu ifade eder. Bunlar, diyabet, hipertansiyon, kalp hastalığı, kanser, multipl skleroz gibi bir dizi farklı hastalığı içerebilir. Kronik hastalık tanısı alan bireylerin ve ailelerin yaşamlarında büyük bir etkiye sahip olabilir ve duygusal, sosyal ve fiziksel zorluklara neden olabilir. Bu nedenle, kronik hastalık tanısı almış bireylerle ve aileleriyle iletişim kurarken dikkatli ve duyarlı olmak önemlidir (1). İletişim, bireylerin duygularını ifade etmelerine, endişelerini paylaşmalarına ve birbirleriyle destek sağlamalarına yardımcı olabilir. Kronik hastalıkla ilgili iletişim becerileri, bireylerin sağlıklı bir şekilde başa çıkmalarına ve daha iyi sonuçlar elde etmelerine yardımcı olabilir. Kronik hastalık tanısı almış bireyler ve aileleri arasındaki iletişim, aşağıdaki bazı temel prensiplere dikkat ederek etkili bir şekilde gerçekleştirilebilir: Açık iletişim kurma: Kronik hastalık tanısı almış bir bireyin ve ailesinin duygularını ve deneyimlerini anlamak için empati kurmak önemlidir. Açık iletişim, dürüst, saygılı ve etkili bir iletişim tarzını içerir. Kronik hastalık tanısı almış bir birey ve ailesiyle iletişim kurarken açık ve net olmak önemlidir. VII. Sonuç Kronik hastalık tanısı almış bireyler ve aileleriyle etkili iletişim kurmak önemlidir. Etkili iletişim, hastaların sağlık sonuçlarını, yaşam kalitesini ve memnuniyetini artırabilir. Ailelerin de katılımıyla birlikte, uygun tıbbi bakım sağlanabilir ve sağlıklı bir iyileşme süreci desteklenebilir. Bu nedenle, sağlık profesyonellerive diğer ilgili paydaşlar, hastalarla etkili iletişim kurma becerilerini geliştirmek için yönlendirilmelidir. Kronik hastalık yönetiminde etkili iletişim, hastaların ve ailelerinin gereksinimlerini anlamak ve onları desteklemek için vazgeçilmez bir araçtır.
Citation - WoS: 0
The Importance of Frontal QRS-T Angle in Predicting the Effectiveness and Success of Thrombolytic Therapy in Patients With Acute Pulmonary Embolism
(Cureus, 2023) Karahan, Mehmet Zülkif; Karahan, Mehmet Zülkif; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Objective: The frontal QRS-T angle (fQRS-T) is associated with myocardial ischemia and ventricular arrhythmias. On the other hand, acute pulmonary embolism (APE) is a major risk factor for cardiac adverse events. This research aimed to determine whether the fQRS-T, a marker of ventricular heterogeneity, can be used to predict successful thrombolytic therapy in patients with APE. Methods: This was a retrospective observational study. Patients diagnosed with APE and hospitalized in the intensive care unit between 2020 and 2022 were included in the research. A total of 136 individuals with APEs were enrolled in this research. The patients were divided into two groups: thrombolytic-treated (n=64) and non-treated (moderate to severe risk, n=72). An ECG was conducted for each patient, and echocardiography was performed. Results: The mean age of the thrombolytic group was 58.2±17.6 years, with 35 females (55.1% of the group) and 29 males (44.9%). The non-thrombolytic group had a mean age of 63.1±16.2, with 41 females (56.5%) and 31 males (43.5%). Respiratory rate, heart rate, and fQRS-T were higher in the thrombolytic group, and oxygen saturation ratio and systolic and diastolic blood pressure were higher in the non-thrombolytic group (p=0.006, p<0.001, p=0.021; p<0.001, p=0.015, p<0.001, respectively). In the thrombolytic therapy group, comparing pre- and post-treatment ECG data revealed a statistically significant change in the fQRS-T value (p=0.019). Conclusion: The fQRS-T may provide important clues for the successful treatment of APEs
An Evaluation of Cardiovascular Risk Factors Among Military Personnel: A Study Conducted in Turkey
(2022) Günlü, Serhat; Karahan, Mehmet Zülkif; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Background: Cardiovascular (CV) risk factors are associated with high morbidity and mortality rates; however, prevalence data for Turkish military members are unknown. Aim: This study determines how common cardiovascular risk factors are among military members in the Corps Command Military Unit and how they relate to socio-demographic parameters. Materials and Methods: A cross-sectional research was conducted with 25222 active-duty individuals. A questionnaire was used to assess cardiovascular risk factors. This study included patients with more than two risk factors or current cardiac complaints. ECGs, echocardiograms, and biochemical testing were performed. Results: The study employed 835 individuals with an average age of 19.43±2.12 years. 19.6% of them had hypertension, 5.6% had dyslipidemia, 39.6% were smokers, 2.4% had diabetes mellitus, and 9.8% had a positive family history. Physical activity frequency was not observed in 54% of the patients before enlisting in the military. There was a significant positive correlation between smoking and mental stress (r=1.07, p<0.001). Conclusion: In terms of cardiovascular risk, hypertension and smoking were found to be the most prevalent among the Corps command staff. Therefore, this study provides compelling evidence that military healthcare providers should conduct annual periodic checks on those at risk for cardiovascular diseases.