Dündar, Ahmet
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| Journal | Count |
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| Arq Neuropsiquiatr | 2 |
| Analytical and Quantitative Cytopathology and Histopathology | 1 |
| Arquivos de Neuro-Psiquiatria | 1 |
| Interdisciplinary medical journal | 1 |
| International Journal of Retina and Vitreous | 1 |
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Article Citation - WoS: 6Citation - Scopus: 6Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine(Taylor & Francis Online, 2022) Dündar, Ahmet; Cafer, Vugar; Aslanhan, Hamza; Özdemir, Hasan Hüseyin; Yilmaz, Ahmet; Çevik, Mehmet UğurBackground: Migraine is a type of primary headache caused by changes in the trigeminal system and has been reported to be associated with neurovascular inflammation of cerebral and extracerebral vessels. Objective: It is known that inflammation is an important process in the pathogenesis of migraine. It has been shown that the molecules of visinin-like protein 1 (Vilip-1), YKL-40, lipocalin-2 and interleukin (IL)-23 play a role in the inflammatory process. Our aim is to investigate the role of this molecule in the metabolic pathway of migraine disease. Methods: Fifty migraine patients with and without aura in the interictal period were included in the study. Vilip-1, YKL-40, lipocalin-2, and IL-23 levels were measured by ELISA method. Results: Serum vilip-1, YKL-40, lipocalin-2, and IL-23 levels were found to be significantly higher in migraine patients compared to the control group. We found that this molecule increased significantly in migraine subgroups compared to the control group (p < 0.001). A positive significant correlation was found between vilip-1 level and YKL-40 and lipocalin-2 levels in migraine patients. In addition, a positive correlation was observed between visual analogue scale score, number of days with pain and vilip-1 level (p < 0.01). The results of our study showed that activation of inflammatory mediators may play a role in the pathogenesis of migraine disease. In addition, our study is valuable in that inflammatory molecules are high in the interictal period and these biomarkers have never been analyzed in migraine patients. However, we still believe that larger studies are needed to explain the role of vilip-1, YKL-40, lipocalin-2, and IL-23 in the molecular mechanism of migraine disease.Master Thesis Investigation of the Role of Visinin-Like Protein-1 and Prestin Biomarkers in the Physiopathology of Covid-19 Patients(2025) Farhat, Sibel; Dündar, AhmetKorona virüs hastalığı-19 (Covid-19) viral bir enfeksiyon hastalığıdır. Covid-19 birçok semptoma neden olmaktadır. Covid-19'dan kaynaklı olan geçici işitme kaybı, baş dönmesi, bilinç bulanıklığı, tat ve koku kaybı gibi nörolojik semptomlardan kaynaklanan geçici veya kalıcı rahatsızlıkların mekanizması tam olarak bilinmemektedir. Bu nedenle bu çalışmadaki amacımız covid-19 fizyopatolojisinde nöronal hasar belirteci olan visinin-like protein-1 (vilip-1) ve prestin moleküllerinin rolünü araştırmaktır. Çalışma Mardin Eğitim ve Araştırma Hastanesinde 01.01.2022-31.03.2022 tarihleri arasında gelen hastalarda reverse transkriptaz polimeraz zincir reaksiyonu (RT-PCR) pozitif çıkan ve hastaneye yatırılan covid-19 hastalarından 60 hasta çalışmaya dahil edildi. Grup II: RT-PCR sonucu negatif olan kişiler kontrol grubu olarak çalışmaya dahil edildi (n=60). Vilip-1 ve prestin düzeyleri Eliza yöntemiyle tayin edildi. Serum AST, ALT, LDH, ve CRP düzeyleri kolorimetrik yöntem ile çalışıldı. Cinsiyetler arasında istatistiksel olarak farklılık bulunmadı. Covid-19 hastalarında serum vilip-1 düzeylerinin kontrol grubuna göre yükseldiği ve istatistiksel olarak anlamlı olduğu bulundu (p=0.001). Covid-19 hastalarında serum prestin düzeylerinin kontrol grubuna göre yükseldiği ancak istatistiksel olarak anlamlı olmadığı gözlendi (p=0.470). Covid-19 hasta grubunda serum AST, ALT, LDH ve CRP düzeylerinin kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı olduğu tespit edildi (p=0.001). Yapılan korelasyon analizlerinde covid-19 hastalarında vilip-1, prestin, CRP ve LDH düzeyleri arasında pozitif korelasyon olduğu göstermiştir. Sonuç olarak çalışmamızda covid-19 hastalarında serum vilip-1, CRP, AST, ALT, LDH düzeylerinin kontrol grubuna göre yükseldiği gösterilmiştir. Koklear hasar belirteci olan prestin düzeylerinde yükselme olduğu ancak istatistiksel olarak anlamlı olmadığı bulunmuştur. Çalışmamızda dikkatleri çeken bir diğer sonuç ise nöronal hasar biyobelirteç olan vilip-1 biyomolekülü ve CRP düzeyleri arasında pozitif korelasyon göstermesi ve literatürde böyle bir bulgunun olmayışı açısından çalışmamızı değerli kılmıştır. Bu bilgiler ışığında nörolojik belirtiler olmaksızın bile akut dönemdeki covid-19 hastalarında nöronal hasarın olabileceğini göstermiştir. Ancak yine de vilip-1 ve prestin moleküllerinin covid-19 hastalığındaki patofizyolojik rolünü açıklayacak geniş çaplı çalışmaların yapılmasına ihtiyaç duyulmaktadır.Article Kynurenine Pathway Metabolites as Potential Biomarkers in Age-Related Macular Degeneration: An ELISA-Based Prospective Study(BMC, 2025) Dundar, Ahmet; Cetik Yildiz, SongulObjectivesAge-related macular degeneration (AMD), in which oxidative stress, inflammation and metabolic imbalances play a role in its pathogenesis, is one of the leading causes of irreversible vision loss. The kynurenine (KYN) pathway, one of the principal routes of tryptophan (TRP) metabolism, constitutes an important mechanism in retinal neurodegeneration. Based on this information, our study aimed to compare the serum TRP, KYN, kynurenic acid (KYNA), 3-hydroxykynurenine (3HK), 3-hydroxyanthranilic acid (3HAA) and, quinolinic acid (QA) levels of AMD patients and to investigate the diagnostic values of these biomarkers.MethodsSerum samples were collected from AMD patients and control groups. TRP, KYN, KYNA, 3HK, 3HAA, and QA levels were measured using a commercial ELISA method. KYN pathway activity, KYN/TRP and, KYNA/3HK ratios were also assessed. Mann-Whitney U test, ROC analysis, Spearman correlation were applied for statistical comparisons.ResultsAccording to our results, 3HK was significantly higher in the AMD group, while TRP, KYN, QA, and KYNA/3HK ratio were higher in the control. ROC analysis revealed 3HK to be the strongest discriminatory marker. The KYNA/3HK ratio also provided significant diagnostic value. Correlation analysis revealed strong negative correlations between 3HK and KYN, QA, and especially KYNA/3HK. Conversely, strong positive correlations were found between KYN and KYNA/3HK, and between TRP, KYN, QA, and KYNA.ConclusionKYN pathway metabolites exhibit significant alterations in patients with AMD. 3HK levels and the reduction of the KYNA/3HK ratio suggest a disruption of the neurotoxic-neuroprotective balance and imply that KYN pathway dysfunction may play a role in the pathogenesis of AMD. Among the biomarkers examined, 3HK displayed the highest diagnostic performance, while the KYNA/3HK ratio emerged as an additional biological indicator. These findings indicate that 3HK and the KYNA/3HK ratio may serve as potential biomarker candidates for the early diagnosis and monitoring of AMD.Article Citation - WoS: 19Citation - Scopus: 19Serum YKL-40 levels in patients with multiple sclerosis(Arq Neuropsiquiatr, 2021) Dönder, Ahmet; Özdemir, Hasan HüseyinBackground: Multiple sclerosis (MS) is a chronic inflammatory disease affecting the central nervous system. The YKL-40 protein, which is secreted from various cells that contribute to inflammation and infection, plays a role in immune regulation. Objective: This study investigated the serum YKL-40 levels of patients with clinically isolated syndrome (CIS) and MS. Methods: The participants was divided into three groups: 1) patients with CIS (n = 20); 2) patients with relapsing-remitting MS (RRMS; n = 39); and 3) healthy individuals (n = 35). The YKL-40 levels in serum samples obtained from the participants were measured using enzyme-linked immunoassays. Results: The median serum YKL-40 level was 20.2 ng/mL (range 9.8-75.9 ng/mL) in the patients with CIS, 22.7 ng/mL (range 13.4-57.9 ng/mL) in the patients with RRMS and 11.0 ng/mL (range 10.0-17.3 ng/mL) in the control group (p < 0.001). The serum YKL-40 levels in the patients with RRMS were correlated with the patients’ expanded disability status scale scores and ages (p < 0.05). No relationships were determined between the serum YKL-40 levels and the other variables (p > 0.05). The serum YKL-40 levels were higher in the CIS group than in the MS group. These findings show that the serum YKL-40 levels were high even at the beginning of the disease. The serum YKL-40 levels were also not involved in the progression to clinically definite MS. Conclusions: The findings from this study suggested that YKL-40 may be a useful marker for the inflammatory process of MS.Article Evaluation of Serum Adipocytokine and Interleukin-18 Levels in Patients With Epilepsy(2023) Kılınç, Derya; Jafar, Vugar; Ayan, Orhan; Çevik, Mehmet Uğur; Aslanhan, Hamza; Dündar, Ahmet; Yılmaz, AhmetObjective: Epilepsy is a neurological disease characterized by recurrent seizures. The underlying pathophysiological mechanisms in epilepsy are not fully known. Our aim is to investigate the relationship between serum adipocytokine and interleukin (IL)-18 levels in epilepsy patients receiving and not receiving antiepileptic therapy. Method: Our study was established as three groups. I: Epilepsy patients receiving antiepileptic therapy (n=30), II: Newly diagnosed epilepsy patients (n=30) and III: Control group (n=30). Serum adipocytokine and IL-18 levels were measured by enzyme-linked immunoassorbent assay method. Results: It was determined that serum adipocytokine and IL-18 levels were increased in epilepsy patients who received topiramate treatment and did not receive antiepileptic therapy compared to the control group. Serum glucose, total protein, cholesterol and albumin concentrations of patients who received antiepileptic treatment were decreased compared to the control group (p0.05). It was found that the body mass index (BMI) ratio of epilepsy patients who received antiepileptic treatment decreased and was significant compared to the control group and the group that did not receive treatment (pArticle Ganoderma Lucidum Alleviates Ischemia-Reperfusion–induced Renal Injury in Wistar Rats(Science Printers and Publishers Inc., 2021) Dönder, A.; Aşır, F.OBJECTIVE: To investigate effects of Ganoderma lucidum (G. lucidum) kidney sections of rats induced by ischemiareperfusion (I/R) injury. STUDY DESIGN: A total of 40 rats were assigned to 4 groups: control (Sham), I/R, G. lucidum, and I/R+G. lucidum groups. Prior to animal experiments, 20 mL/kg G. lucidum was administered to the G. lucidum–treated groups for 7 days. The control and I/R groups received only saline solution. The kidney was exposed to hypoxia for 1 hour by clamping renal vessels and was then allowed to reoxygenate for 6 hours. Blood was taken to measure for serum MDA, MPO, and GSH. Kidney tissues were resected for histological paraffin tissue protocol. Hematoxylineosin and immunohistochemical staining were performed. RESULTS: MDA and MPO levels were highest in the I/R group but were close to the levels of the control group in the I/R+G. lucidum group. Unlike MDA and MPO values, GSH values were the lowest in the I/R group, but after G. lucidum treatment, GSH levels increased in the I/R+G. lucidum group. In kidney sections of hematoxylineosin staining, the control group showed no pathology. In the I/R group, atrophic glomeruli, degenerated tubular cells, and mononuclear cell infiltration with dilated and congested vessels were observed. In the I/R+G. lucidum group, I/R pathology was mostly recovered. In the G. lucidum group, ADAMTS4 expression was moderately expressed in glomerular and tubular cells. The I/R group showed positive ADAMTS4 expression in mostly inflammatory cells. In the I/R+G. lucidum group, ADAMTS4 was positively expressed only in glomerular structures. In the G. lucidum group, caspase3 expression was observed in glomerular and tubular cells. The I/R group showed strong caspase3 activity in glomerular and tubular cells, in vascular cells, and inflammatory cells. The I/R+G. lucidum group showed weak caspase3 expression. CONCLUSION: Ischemiareperfusion injury caused histopathological and biochemical alterations in renal tissue; G. lucidum protected tissue structure and integrity by its antioxidant and antiinflammatory properties. © Science Printers and Publishers, Inc.Article Citation - WoS: 1Citation - Scopus: 1Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension(Arquivos de Neuro-Psiquiatria, 2022) Dündar, Ahmet; Arıkanoğlu, Adalet; Özdemir, Hasan Hüseyin; Aslanhan, Hamza; Çevik, Mehmet UğurBackground Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleukin-33 (IL-33) are among the factors involved in inflammatory processes. Objective To investigate the CSF levels of sortilin-1, lipocalin-2, autotaxin, decorin, and IL-33 in patients with IIH. Methods A total of 24 IIH patients and 21 healthy controls were included in the study. Demographic characteristics of the patients and of the control group as well as CSF pressures were evaluated. Sortilin-1, lipocalin-2, autotaxin, decorin and IL-33 levels in the CSF were measured. Results The CSF levels lipocalin-2, sortilin-1, autotaxin, IL-33 and CSF pressure were significantly higher in the patients group compared with the control group (p < 0.001). Decorin levels were reduced in patients (p < 0.05). There was no correlation between the autotaxin and IL-33 levels and age, gender, CSF pressure, and body mass index. The results of our study showed that inflammatory activation plays an important role in the development of the pathophysiology of IIH. In addition, the fact that the markers used in our study have never been studied in the etiopathogenesis of IIH is important in explaining the molecular mechanism of this disease. Conclusion Studies are needed to evaluate the role of these cytokines in the pathophysiology of the disease. It is necessary to evaluate the effects of these molecules on this process. © 2022. Academia Brasileira de Neurologia. All rights reserved.Article The effect of body mass index and anxiety status on blood pressure in patients admitted to family medicine outpatient clinic(Aile Hekimliği ve Palyatif Bakım, 2022) Ayan, Orhan; Yilmaz, Ahmet; Dündar, Ahmet; Demir Pervane, Vasfiye; Kuyumcu, Mahir; Demir, VasfiyeIntroduction: Hypertension is a global public health problem that is the leading cause of preventable death in the world and a disease which can cause many morbidities and mortality if not controlled or treated effectively. In many studies, it has been determined that anxiety and body mass index(BMI) are among the factors affecting hypertension. However, different results have been obtained in many studies in terms of the relationship between anxiety and hypertension. This study was carried out with the aim to evaluate the effect of body mass index and anxiety on blood pressure and the factors affecting blood pressure in patients who applied to outpatient clinic of family medicine at Dicle University Faculty of Medicine. Methods: 403 patients aged between 18- 65 years, who applied to outpatient clinic of family medicine at Dicle University Faculty of Medicine between 01.04.2018 and 01.07.2018, were included in this cross-sectional study. The population of the study was the province where the study was carried out, and the sample size was calculated with a power of 80%. The patients' body mass index and anxiety scores from Beck anxiety scale were calculated and measurements of arterial blood pressure were performed. The relationship between BMI, Beck anxiety scores and blood pressure of patients were investigated. Results: Of the participants, 50.1% were male, 49.9% were female and the average age was 34.11 in years. Of the patients, the mean BMI as 25.52 kg/m², the mean anxiety score as 7.40 and the arterial blood pressures as 117.80/75.54 mmHg were measured. It was found that arterial blood pressure raised significantly as the BMI group increased. While the relationship between the severity of anxiety and systolic blood pressure was significant, its relationship with diastolic blood pressure was not significant. There was a positive correlation between BMI, anxiety score and systolic and diastolic blood pressure. Conclusions: According to the results of this study, it was found that the increase in BMI and Beck anxiety scores may be related with increase in arterial blood pressure. This result showed that common health problems in primary care such as anxiety, obesity and hypertension may be associated with each other, and it can be effectively fought against hypertension and its complications with the perspective of family medicine and biopsychosocial approach.Article Citation - WoS: 4Citation - Scopus: 6Evaluation of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and C-Reactive Protein in Tension-Type Headache Patients(Journal of Neurosciences in Rural Practice, 2021) Özdemir, Hasan Hüseyin; Dönder, AhmetObjectives A tension headache is the most common type of headache, and its causes are multifactorial. A relationship has been shown between migraine headaches and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP). In this study, we investigated the NLR, PLR, and serum CRP levels in frequent episodic tension-type headache (FETTH) and chronic tension-type headache (CTTH) patients. Materials and Methods This retrospective study included 64 patients with FETTH, 80 patients with CTTH, and 60 healthy controls who were followed up in the neurology clinic. Hematological parameters were compared between the patient and control groups. Results In CTTH patients, platelets, NLR, PLR, and CRP values were statistically higher than in FETTH patients and patients in the control group. In FETTH patients, the PLR value was higher than in patients in the control group, but there was no statistically significant difference in NLR and CRP values between FETTH patients and patients in the control group. Also, there was no correlation between these values and age and gender. Conclusion Increase platelet count might have an effect on tension-type headache pathophysiology. Systemic inflammation parameters were shown to be significantly higher in CTTH patients. More comprehensive studies are needed to evaluate the effect of systemic inflammation on the chronicity of tension headaches.Article Citation - WoS: 7Citation - Scopus: 7Investigation of serum vaspin, visfatin, chemerin and IL-18 levels in migraine patients(Arq Neuropsiquiatr, 2021) Dönder, Ahmet; Cafer, Vugar; Yilmaz, Ahmet; Aslanhan, Hamza; Arikanoğlu, AdaletBackground: Migraines are headaches caused by changes in the trigeminovascular metabolic pathway. Migraine headache attacks are associated with neurovascular inflammation, but their pathophysiological mechanisms have not been fully explained. Objective: To investigate the relationship between serum vaspin, visfatin, chemerin and interleukin-18 (IL-18) levels and the frequency of attacks in migraine headache. Methods: Three groups were established: migraine with aura (n = 50), migraine without aura (n = 50) and control group (n = 50). The migraine diagnosis was made in accordance with the International Classification of Headache Disorders-III beta diagnostic criteria. The analyses on serum vaspin, visfatin, chemerin and IL-18 levels were performed using the enzyme-linked immunosorbent assay method. Results: The serum vaspin, visfatin, chemerin and IL-18 levels were found to be significantly higher in the migraine patients than in the control group (p < 0.01). No statistically significant differences in serum vaspin, visfatin, chemerin and IL-18 levels were found among the migraine patients during attacks or in the interictal period (p>0.05). The serum visfatin and chemerin levels of the migraine patients were positively correlated with their serum IL-18 levels (p < 0.01), while their serum chemerin and visfatin levels were positively correlated with their serum vaspin levels (p < 0.05). Conclusions: This study showed that these biomarkers may be related to migraine pathogenesis. Nonetheless, we believe that more comprehensive studies are needed in order to further understand the role of vaspin, visfatin, chemerin and IL-18 levels in the pathophysiology of migraine headaches
