Dündar, Ahmet
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Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
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Scholarly Output
7
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6
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66
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1
7 results
Scholarly Output Search Results
Now showing 1 - 7 of 7
Article Evaluation of Serum Adipocytokine and Interleukin-18 Levels in Patients With Epilepsy(2023) Dündar, Ahmet; Jafar, Vugar; Ayan, Orhan; Çevik, Mehmet Uğur; Aslanhan, Hamza; Dündar, Ahmet; Yılmaz, Ahmet; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüObjective: Epilepsy is a neurological disease characterized by recurrent seizures. The underlying pathophysiological mechanisms in epilepsy are not fully known. Our aim is to investigate the relationship between serum adipocytokine and interleukin (IL)-18 levels in epilepsy patients receiving and not receiving antiepileptic therapy. Method: Our study was established as three groups. I: Epilepsy patients receiving antiepileptic therapy (n=30), II: Newly diagnosed epilepsy patients (n=30) and III: Control group (n=30). Serum adipocytokine and IL-18 levels were measured by enzyme-linked immunoassorbent assay method. Results: It was determined that serum adipocytokine and IL-18 levels were increased in epilepsy patients who received topiramate treatment and did not receive antiepileptic therapy compared to the control group. Serum glucose, total protein, cholesterol and albumin concentrations of patients who received antiepileptic treatment were decreased compared to the control group (p0.05). It was found that the body mass index (BMI) ratio of epilepsy patients who received antiepileptic treatment decreased and was significant compared to the control group and the group that did not receive treatment (pArticle Citation - WoS: 4Citation - Scopus: 4Increased visinin-like protein-1, YKL-40, lipocalin-2, and IL-23 levels in patients with migraine(Taylor & Francis Online, 2022) Dündar, Ahmet; Cafer, Vugar; Aslanhan, Hamza; Özdemir, Hasan Hüseyin; Yilmaz, Ahmet; Çevik, Mehmet Uğur; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüBackground: Migraine is a type of primary headache caused by changes in the trigeminal system and has been reported to be associated with neurovascular inflammation of cerebral and extracerebral vessels. Objective: It is known that inflammation is an important process in the pathogenesis of migraine. It has been shown that the molecules of visinin-like protein 1 (Vilip-1), YKL-40, lipocalin-2 and interleukin (IL)-23 play a role in the inflammatory process. Our aim is to investigate the role of this molecule in the metabolic pathway of migraine disease. Methods: Fifty migraine patients with and without aura in the interictal period were included in the study. Vilip-1, YKL-40, lipocalin-2, and IL-23 levels were measured by ELISA method. Results: Serum vilip-1, YKL-40, lipocalin-2, and IL-23 levels were found to be significantly higher in migraine patients compared to the control group. We found that this molecule increased significantly in migraine subgroups compared to the control group (p < 0.001). A positive significant correlation was found between vilip-1 level and YKL-40 and lipocalin-2 levels in migraine patients. In addition, a positive correlation was observed between visual analogue scale score, number of days with pain and vilip-1 level (p < 0.01). The results of our study showed that activation of inflammatory mediators may play a role in the pathogenesis of migraine disease. In addition, our study is valuable in that inflammatory molecules are high in the interictal period and these biomarkers have never been analyzed in migraine patients. However, we still believe that larger studies are needed to explain the role of vilip-1, YKL-40, lipocalin-2, and IL-23 in the molecular mechanism of migraine disease.Article Citation - WoS: 0Citation - Scopus: 0Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension(Arquivos de Neuro-Psiquiatria, 2022) Dündar, Ahmet; Arıkanoğlu, Adalet; Özdemir, Hasan Hüseyin; Aslanhan, Hamza; Çevik, Mehmet Uğur; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüBackground Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleukin-33 (IL-33) are among the factors involved in inflammatory processes. Objective To investigate the CSF levels of sortilin-1, lipocalin-2, autotaxin, decorin, and IL-33 in patients with IIH. Methods A total of 24 IIH patients and 21 healthy controls were included in the study. Demographic characteristics of the patients and of the control group as well as CSF pressures were evaluated. Sortilin-1, lipocalin-2, autotaxin, decorin and IL-33 levels in the CSF were measured. Results The CSF levels lipocalin-2, sortilin-1, autotaxin, IL-33 and CSF pressure were significantly higher in the patients group compared with the control group (p < 0.001). Decorin levels were reduced in patients (p < 0.05). There was no correlation between the autotaxin and IL-33 levels and age, gender, CSF pressure, and body mass index. The results of our study showed that inflammatory activation plays an important role in the development of the pathophysiology of IIH. In addition, the fact that the markers used in our study have never been studied in the etiopathogenesis of IIH is important in explaining the molecular mechanism of this disease. Conclusion Studies are needed to evaluate the role of these cytokines in the pathophysiology of the disease. It is necessary to evaluate the effects of these molecules on this process. © 2022. Academia Brasileira de Neurologia. All rights reserved.Article The effect of body mass index and anxiety status on blood pressure in patients admitted to family medicine outpatient clinic(Aile Hekimliği ve Palyatif Bakım, 2022) Dündar, Ahmet; Yilmaz, Ahmet; Dündar, Ahmet; Demir Pervane, Vasfiye; Kuyumcu, Mahir; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüIntroduction: Hypertension is a global public health problem that is the leading cause of preventable death in the world and a disease which can cause many morbidities and mortality if not controlled or treated effectively. In many studies, it has been determined that anxiety and body mass index(BMI) are among the factors affecting hypertension. However, different results have been obtained in many studies in terms of the relationship between anxiety and hypertension. This study was carried out with the aim to evaluate the effect of body mass index and anxiety on blood pressure and the factors affecting blood pressure in patients who applied to outpatient clinic of family medicine at Dicle University Faculty of Medicine. Methods: 403 patients aged between 18- 65 years, who applied to outpatient clinic of family medicine at Dicle University Faculty of Medicine between 01.04.2018 and 01.07.2018, were included in this cross-sectional study. The population of the study was the province where the study was carried out, and the sample size was calculated with a power of 80%. The patients' body mass index and anxiety scores from Beck anxiety scale were calculated and measurements of arterial blood pressure were performed. The relationship between BMI, Beck anxiety scores and blood pressure of patients were investigated. Results: Of the participants, 50.1% were male, 49.9% were female and the average age was 34.11 in years. Of the patients, the mean BMI as 25.52 kg/m², the mean anxiety score as 7.40 and the arterial blood pressures as 117.80/75.54 mmHg were measured. It was found that arterial blood pressure raised significantly as the BMI group increased. While the relationship between the severity of anxiety and systolic blood pressure was significant, its relationship with diastolic blood pressure was not significant. There was a positive correlation between BMI, anxiety score and systolic and diastolic blood pressure. Conclusions: According to the results of this study, it was found that the increase in BMI and Beck anxiety scores may be related with increase in arterial blood pressure. This result showed that common health problems in primary care such as anxiety, obesity and hypertension may be associated with each other, and it can be effectively fought against hypertension and its complications with the perspective of family medicine and biopsychosocial approach.Article Evaluation of Serum Vitamin D Levels According To Season, Age, and Gender in Mardin Province and Its Surroundings(2022) Dündar, Ahmet; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüVitamin D is a steroid in character and fat-soluble vitamin. It is produced primarily from cholesterol in the skin and is also taken up in a small amount in the diet. 25(OH)D3 levels are used as an indirect measure of vitamin D levels. Our aim was to investigate the variation in serum 25(OH)D3 levels of patients admitted to the hospital in and around Mardin based on gender, season, and age. 25(OH)D3 concentrations were evaluated at Mardin Training and Research Hospital between 01.01.2017 and 31.12.2019. Our study established subgroups according to gender, season, age, and 25(OH)D3 status. 25(OH)D3 concentration was measured using the chemiluminescence method. A significant decrease was observed in the 25(OH)D3 levels of female (13.62±11.53 ng/ml) patients compared to male patients (12.14±9.38 ng/ml). A significant increase was detected in the summer and autumn seasons compared to winter and spring (p<0.001). There was no significant difference between age and serum 25(OH)D3 concentration (p>0.05). 25(OH)D3 status was shown to be 60.5% in the severe deficiency group. As a result, it has been shown that the vitamin D profile in Mardin and its surroundings is low in all seasons and in all age groups. For this reason, consuming food sources rich in vitamin D and taking supplements indicate that the importance of sunlight in vitamin D metabolism should be emphasized.Article Citation - WoS: 3Citation - Scopus: 3Investigation of serum ischemic-modified albumin, galectin-3, paraoxonase-1, and myeloperoxidase activity levels in patients with acute brucellosis(Taylor & Francis, 2023) Dündar, Ahmet; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüObjectives: Infection remains current as an important discussion topic in the etiological factors of atherosclerosis. Ischemic-modified albumin (IMA), galectin-3 (gal-3), paraoxonase-1 (PON-1), and myeloperoxidase (MPO) are biomolecules that play an important role in the pathogenesis of atherosclerosis. Our aim is to investigate serum IMA, gal-3, PON-1, and MPO activity in acute brucellosis infection. Materials and methods: Forty patients with acute brucellosis and 40 healthy individuals were included in the study. Serum IMA, gal-3, PON-1, and MPO activity were analyzed by the ELISA method. Results: In acute brucellosis infection, serum gal-3, IMA, and MPO activities were found to be significantly increased compared to the control group, and PON-1 activity was found to be significantly decreased compared to the control group (p < 0.001). There was a positive correlation between serum IMA, and MPO activity (r = 0.707 p = 0.000) and a negative correlation (r = -0.943, p = 0.000) between PON-1 activity. There was a positive correlation between serum gal-3 and MPO activity (r = 0.683, p = 0.000) and IMA level (r = 0.927, p = 0.000) and a negative correlation between PON-1 activity (r = -0.951, p = 0.000).Conclusion, it was found that serum gal-3, IMA levels and MPO activity increased, while PON-1 activity decreased. These results showed that the oxidant-anti-oxidant balance is impaired in acute brucellosis infection. In addition, these results indicate that brucella infection may be increase the risk of atherosclerosis. Further studies are needed to support our findings.Master Thesis Investigation of the Role of Visinin-Like Protein-1 and Prestin Biomarkers in the Physiopathology of Covid-19 Patients(2025) Dündar, Ahmet; Dündar, Ahmet; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüKorona virüs hastalığı-19 (Covid-19) viral bir enfeksiyon hastalığıdır. Covid-19 birçok semptoma neden olmaktadır. Covid-19'dan kaynaklı olan geçici işitme kaybı, baş dönmesi, bilinç bulanıklığı, tat ve koku kaybı gibi nörolojik semptomlardan kaynaklanan geçici veya kalıcı rahatsızlıkların mekanizması tam olarak bilinmemektedir. Bu nedenle bu çalışmadaki amacımız covid-19 fizyopatolojisinde nöronal hasar belirteci olan visinin-like protein-1 (vilip-1) ve prestin moleküllerinin rolünü araştırmaktır. Çalışma Mardin Eğitim ve Araştırma Hastanesinde 01.01.2022-31.03.2022 tarihleri arasında gelen hastalarda reverse transkriptaz polimeraz zincir reaksiyonu (RT-PCR) pozitif çıkan ve hastaneye yatırılan covid-19 hastalarından 60 hasta çalışmaya dahil edildi. Grup II: RT-PCR sonucu negatif olan kişiler kontrol grubu olarak çalışmaya dahil edildi (n=60). Vilip-1 ve prestin düzeyleri Eliza yöntemiyle tayin edildi. Serum AST, ALT, LDH, ve CRP düzeyleri kolorimetrik yöntem ile çalışıldı. Cinsiyetler arasında istatistiksel olarak farklılık bulunmadı. Covid-19 hastalarında serum vilip-1 düzeylerinin kontrol grubuna göre yükseldiği ve istatistiksel olarak anlamlı olduğu bulundu (p=0.001). Covid-19 hastalarında serum prestin düzeylerinin kontrol grubuna göre yükseldiği ancak istatistiksel olarak anlamlı olmadığı gözlendi (p=0.470). Covid-19 hasta grubunda serum AST, ALT, LDH ve CRP düzeylerinin kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı olduğu tespit edildi (p=0.001). Yapılan korelasyon analizlerinde covid-19 hastalarında vilip-1, prestin, CRP ve LDH düzeyleri arasında pozitif korelasyon olduğu göstermiştir. Sonuç olarak çalışmamızda covid-19 hastalarında serum vilip-1, CRP, AST, ALT, LDH düzeylerinin kontrol grubuna göre yükseldiği gösterilmiştir. Koklear hasar belirteci olan prestin düzeylerinde yükselme olduğu ancak istatistiksel olarak anlamlı olmadığı bulunmuştur. Çalışmamızda dikkatleri çeken bir diğer sonuç ise nöronal hasar biyobelirteç olan vilip-1 biyomolekülü ve CRP düzeyleri arasında pozitif korelasyon göstermesi ve literatürde böyle bir bulgunun olmayışı açısından çalışmamızı değerli kılmıştır. Bu bilgiler ışığında nörolojik belirtiler olmaksızın bile akut dönemdeki covid-19 hastalarında nöronal hasarın olabileceğini göstermiştir. Ancak yine de vilip-1 ve prestin moleküllerinin covid-19 hastalığındaki patofizyolojik rolünü açıklayacak geniş çaplı çalışmaların yapılmasına ihtiyaç duyulmaktadır.
