Yıldız, Reşit

Yıldız, Reşit

Job Title

Prof. Dr.

Email Address

ryildiz80@gmail.com, resityildiz@artuklu.edu.tr

Main Affiliation

Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü

Scholarly Output

44

Articles

33

Citation Count

801

Supervised Theses

2 Scholarly Output Search Results

Now showing 1 - 10 of 44

Green Synthesis of Silver Nanoparticles Derived from Papaver rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties
(MDPI, 2023) İpek, Polat; Yıldız, Reşit; Baran, Mehmet Fırat; Hatipoğlu, Abdülkerim; Baran, Ayşe; Sufianov, Albert; Beylerli, Ozal; Yıldız, Reşit
In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet-visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and atomic force microscope (AFM)), structural (X-ray diffractometer (XRD) and zetasizer), and analytic (thermogravimetric/differential thermal analyzer (TGA-DTA)) characterization of the silver nanoparticles (AgNPs) produced from Papaver rhoeas (PR) L. leaf extract are presented. PR-AgNPs are generally spherical and have a maximum surface plasmon resonance of 464.03 nm. The dimensions of the manufactured nanomaterial are in the range of 1.47-7.31 nm. PR-AgNPs have high thermal stability and a zeta potential of 36.1 mV. The minimum inhibitory concentration (MIC) values (mg L-1) of PR-AgNPs on Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans are 1.50, 0.75, 3.00, 6.00, and 0.37, respectively. In the study, the cytotoxic and proliferative effects of PR-AgNPs using the MTT (3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium bromide) method on various cancer cell lines (CACO-2 (human colon adenocarcinoma cell), MCF-7 (human breast cancer cell), T98-G (glioblastoma multiforme cell), and healthy HUVEC (human umbilical vein endothelial cell)) cell lines are presented. After 24 and 48 h of the application, the half-maximum inhibitory concentration (IC50) values (mu g mL(-1)) of PR-AgNPs on HUVEC, CACO-2, MCF-7, and T98-G lines are 2.365 and 2.380; 2.526 and 2.521; 3.274 and 3.318; 3.472 and 3.526, respectively. Comprehensive in vivo research of PR-AgNPs is proposed to reveal their potential for usage in sectors such as nanomedicine and nanochemistry.
Trans-Chalcone Attenuate Arsenic-Induced Toxicity in 3t3 Embryonic Fibroblast Cells; An In Vitro And In Silico Study
(Elsevier, 2024) Unsal, Velid; Yildiz, Resit; Cicek, Mustafa; Gungor, Meltem; Kurutas, Ergul Belge; Yıldız, Reşit
This study investigated the curative role of trans-chalcone, a flanovide, against arsenic toxicity using in vitro and computer-based analyses. MTT and LDH methods were used to assess the cytotoxicity and viability of cells, spectrophotometric methods to evaluate SOD, GSH-px, MDA and PC biomarkers, and ELISA method to evaluate TNF-a IL-1(3 levels. Bax, Bcl-2 levels and Caspase-3 activity were measured by qRT-PCR technique, while TUNEL staining was performed to detect DNA breaks and DAPI staining was performed to visualize nuclear changes. In addition, computer-based analyses of trans-chalcone and Dimercaprol molecules were analyzed using SwissADME, ADMETlab, DFT web tools. Trans-chalcone treatment rescued 3T3 embryonic fibroblast cells, reduced oxidative stress. Again, trans-chalcone treatment showed positive effects on TNF-alpha, IL-1(3 levels and apoptotic markers. In conclusion, trans-chalcone showed antioxidant, anti-inflammatory, and anti-apoptotic effects against cellular toxicity caused by arsenic, as well as DFT, ADMET, drug similarity, molecular docking profiles predicted trans-chalcone to be a promising ligand. This research, based on in vitro and in silico analyses, may be useful in the development of promising drug(s) to reduce toxicity.
Biosynthesis of silver nanoparticles from Arum dioscoridis plant leaf aqueous extract: anticancer and antimicrobial properties
(Gültekin ÖZDEMİR, 2023) İpek, Polat; Baran, Mehmet Fırta; Yıldız, Reşit; Hatipoğlu, Abdulkerim; Yıldız, Reşit
This study was carried out to synthesize silver nanoparticles (AgNPs) from Arum dioscoridis (AD) leaf extract and to investigate the cytotoxic and antipathogenic effects of them. The plant material had a reducing and stabilizing effect on the synthesized nanomaterial. During the plant-mediated synthesis of nanomaterials, no substances that would cause environmental pollution were used. For the structural characterization of AD-AgNPs, Ultraviolet-visible (UV-vis) Spectroscopy, Field Emission Scanning Electron Microscopy (FE-SEM), Electron Dispersive X-ray (EDX) Spectroscopy, Fourier Transform Infrared (FT-IR) Spectroscopy, Transmission Electron Microscopy (TEM), X-ray Diffractometer (XRD), Atomic Force Microscopy (AFM) and Zetasizer analyses were performed. The produced AgNPs showed maximum surface plasmon resonance at 431.67 nm and had mostly spherical morphology. The zeta potential value of the nanomaterial was -9.76 mV and the average powder crystal size was 31.48 nm. The minimum inhibitory concentration (MIC) values (mg/L) of AD-AgNPs on Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans were 0.25, 2.00, 0.125, 4.00, and 1.00, respectively. After 24 and 48 hours of application by MTT [3-(4,5-dimetiltiazol-2-il)-2,5-difeniltetrazolium bromid] assay, the half-maximal inhibitory concentrations (IC50: μg/mL) of AD-AgNPs on human colon adenocarcinoma cell (CACO-2), human breast cancer cell (MCF-7), glioblastoma multiforme cell (T98-G), and healthy human umbilical vein endothelial cell (HUVEC) lines were determined as 2.977, 2.801, 5.694, 4.392; 2.115, 2.300, 2.612, 4.091, respectively.
YUMUŞAK ÇELİK KORUMA İÇİN KOROZYON İNHİBİTÖRÜ OLARAK SULFANİLAMİD KULLANIMI
(2018) Yıldız, Reşit; Toprak Döşlü, Serap; Dehri, İlyas; Yıldız, Reşit
Bu çalışmada, Sulfanilamide 0,5 M HCl çözeltisinde yumuşak çeliğin (YÇ) yüzeyine adsorpsiyonu ve korozyon inhibisyon mekanizması çalışılmıştır. Bu amaçla elektrokimyasal teknik kullanılmıştır. Elde edilen sonuçlara göre; Sulfanilamid’nın inhibisyon etkinliği artan Sulfanilamid derişimi ile artış göstermiştir. 10 mM Sulfanilamide içeren 0,5 M HCl çözeltisinde inhibisyon etkinliği % 87 olarak tespit edilmiştir. İnhibitör içeren ve içermeyen korozif ortamlar ile maruz bırakılmış yumuşak çelik yüzeyleri taramalı elektron mikroskopu (SEM) ile incelenmiştir. Elde edilen sonuçlar Sulfanilamide metal yüzeyinde homojen dağılımlı, sıkı bir film oluşturarak koruma sağladığı belirlenmiştir.
The Adsorption and Inhibition Efficiency of 2-Amino for Corrosion of Mild Steel in Hydrochloric Acid Solution
(Emerald Group Publishing Ltd, 2023) Okten, Veysi; Yildiz, Resit; Sigircik, Goekmen; Yıldız, Reşit
PurposeThis study aims to prevent mild steel (MS) against corrosion in 0.5 M HCl solution, 2-amino-4-methoxy-6-methyl-1,3,5-triazine was used. The effectiveness of the compound as a corrosion inhibitor was studied via electrochemical, surface and theoretical calculation techniques. Design/methodology/approachFor concentrations ranging from 0.5 to 10.0 mM, almost similar polarization resistances were obtained from electrochemical impedance spectroscopy (EIS) and linear polarization resistance tests. It also investigated inhibitive activity of 2-amino-4-methoxy-6-methyl-1,3,5-triazine on the steel surface using scanning electron and atomic force microscope instruments. Langmuir adsorption is the best matched isotherm for the adsorption of the inhibitor to the steel surface. FindingsEIS method was used to determine inhibition efficiency, which was determined to be 95.7% for 10.0 mM inhibitor containing acid solution. Density functional theory's predictions for quantum chemistry agreed well with the other experimental results. Originality/valueThe methods used in this study are effective and applicable; the used organic inhibitor is 2-amino-4-methoxy-6-methyl-1,3,5-triazine; and protective effectiveness is important, which is crucial for the task of MS corrosion prevention.
Synthesis of TiO2 doped poly (MA-co-IN)
(4rd Internatıonal Turkıc World Conference on Chemıcal Scıences and Technologıes (ITWCCST2018), 2018) Yıldız, Reşit; Toprak Döşlü, Serap; Yıldız, Reşit
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POLİÜRETAN KAPLAMALI GALVANİZE ÇELİĞİN KESİLMİŞ KENAR KOROZYONU: FARKLI SÜRE VE BAĞIL NEMLERDE SO2 GAZININ ETKİSİ
(2017) Yıldız, Reşit; Dehri, İlyas; Yıldız, Reşit
Bu çalışmada kesilmiş kenar poliüretan kaplamalı galvanize çelik örneklerin atmosferik korozyonuna farklı bağıl nemliliklerde SO2 gazının etkisi araştırılmıştır. Bu amaçla örnekler bağıl nemlilikleri %70 , %80 , %90 ve %100 e ayarlanmış test hücrelerinde 20, 40 ve 60 gün süreyle SO2 gazı etkisinde bırakılmıştır. Çalışma da test hücresinden çıkarılan örneklerin, impedans ölçümleri yapılmış, Nyquist diyagramları, Lineer Polarizasyon Direnci ve Anodik akım potansiyel eğrileri elde edilmiştir. Elde edilen sonuçlara göre kesilmiş kenar poliüretan kaplamalar genel olarak %70 bağıl nemde koruyuculuğunu çok az kaybetmiştir ancak %80, %90 ve %100 bağıl nemliliklerde organik kaplamanın koruyuculuğun bağıl neme bağlı olarak büyük oranda kaybolduğu görülmüştür
4,4'-Diaminobifenil’in Yumuşak Çeliğin Hidroklorik Asitteki Korozyonuna Karşı İnhibisyon Etkisi Ve Kuantum Hesaplamaları
(Fırat Üniversitesi Mühendislik Bilimleri Dergisi, 2018) Yıldız, Reşit; Dehri, İlyas; Yıldız, Reşit
In this study, 4,4′-Diamınobıphenyl (4-DB) is investigated usage of inhibitor molecule. Electrochemical techniques (EIS and polarization measurements) and quantum chemical calculations ((DFT) with the B3LYP/6- 311++G (d, p)) were obtained. The results showed that; inhibition efficiencies increase with increasing concentration of 4-DB. It is found that 4-DB retards anodic reactions according to polarization measurements. The inhibition efficiency of 4-DB is attributed to the high value of EHOMO (–0,189 eV), dipole moment μ (0,6121 D) and low value of ELUMO (-0.019 eV). This inhibitor functions through adsorption following Langmuir isotherm. The value of adsorption free energy of (∆G°ads) was also calculated.
Comparison of New Secondgeneration H1 Receptor Blockers With Some Molecules; a Study Involving Dft, Molecular Docking, Admet, Biological Target and Activity
(Bmc, 2025) Unsal, Velid; Oner, Erkan; Yildiz, Resit; Mert, Basak Dogru; Yıldız, Reşit
Although the antiallergic properties of compounds such as CAPE, Melatonin, Curcumin, and Vitamin C have been poorly discussed by experimental studies, the antiallergic properties of these famous molecules have never been discussed with calculations. The histamine-1 receptor (H1R) belongs to the family of rhodopsin-like G-protein-coupled receptors expressed in cells that mediate allergies and other pathophysiological diseases. In this study, pharmacological activities of FDA-approved second generation H1 antihistamines (Levocetirizine, desloratadine and fexofenadine) and molecules such as CAPE, Melatonin, Curcumin, Vitamin C, ADMET (Absorption, Distribution, Metabolism, Excretion, Toxicity) profiles, density functional theory (DFT), molecular docking, biological targets and activities were compared by calculating. Since drug development is an extremely risky, costly and time-consuming process, the data obtained in this study will facilitate and guide future studies. It will also enable researchers to focus on the most promising compounds, providing an effective design strategy. Their pharmacological activity was carried out using computer-based computational techniques including DFT, molecular docking, ADMET analysis, biological targeting, and activity methods. The best binding sites of Desloratadine, Levocetirizine, Fexofenadine, CAPE, Quercetin, Melatonin, curcumin, Vitamin C ligands to Desmoglein 1, Human Histamine H1 receptor, IgE and IL13 protons were determined by molecular docking method and binding energy and interaction states were analyzed. Fexofenadine and Quercetin ligand showed the most effective binding affinity. Melatonin had the best Caco-2 permeability PPB values of Quercetin, CAPE and Curcumin were at optimal levels. On the OATP1B1 and OATP1B3 of curcumin and CAPE, Quercetin was found to have strong inhibition effects on BCRP. Melatonin and CAPE were found to have the highest inhibition values on CYP1A2, while CAPE had the highest inhibition values on CYP2C19 and CYP2C9. Vitamin C and Quercetin were found to be safer in terms of cardiac toxicity and mutagenic risks, while Desloratadine and Levocetirizine carried high risks of neurotoxicity and hematotoxicity, while CAPE was noted for its high enzyme inhibitory activities and low toxicity profiles, while the hERG blockade, DILI, and cytotoxicity values of other compounds pointed to various safety concerns. This study demonstrated the potential of machine learning methods in understanding and discovering H1 receptor blockers. The results obtained provide important clues in the development of important strategies in the clinical use of H1 receptor blockers. In the light of these data, CAPE and Quercetin are remarkable molecules.
Adsorption and inhibition effect of 2,4-diamino-6-hydroxypyrimidine for mild steel corrosion in HCl medium: experimental and theoretical investigation
(SPRINGER HEIDELBERG, 2019) Yildiz, Resit; Yıldız, Reşit
2,4-Diamino-6-hydroxypyrimidine (2D6H) was examined as corrosion inhibitor of mild steel (MS) in 0.1M HCl using potentiodynamic measurements, linear polarization resistance (LPR), scanning electron microscopy, electrochemical experiments, and quantum chemical calculations. All measurements show that the corrosion inhibition effectiveness is forthright compared to the concentration of 2D6H ranging from 0.5 to 10.0mM. Adsorption of 2D6H on the MS surface in the presence of HCl is determined to obey Langmuir adsorption isotherm. The electronic features elucidated by quantum chemical calculations were associated with the experimental inhibition productivities. The mechanism of inhibition was revealed by E-pzc measurements.