Keskin, Cumali
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Keskin, C.
Cumali Keskin
Keskin, Cumali
Cumali Keskin
Keskin, Cumali
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cumalikeskin@artuklu.edu.tr
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Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
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Scholarly Output
69
Articles
55
Citation Count
877
Supervised Theses
6
68 results
Scholarly Output Search Results
Now showing 1 - 10 of 68
Presentation Acanthus dioscoridis L. var. dioscoridis’ in total yağ asidi, fosfolipit ve triaçilgliserol kompozisyonlarının belirlenmesi(2014) Keskin, Cumali; Kaçar, Semra; Kaçar, Semra; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik BölümüÖzet: Yağ asitleri fosfolipitler, trigliseritler ve monogliseritler gibi lipitlerin temel bileşenleridir. Doymuş, tekli doymamış veya çoklu doymamış olabilirler. Acanthus dioscoridis’in total lipit, fosfolipit ve triaçilgliserol yağ asidi kompozisyonları gaz kromatografisi (GC) ile belirlendi. A. dioscoridis’in total lipit ve TLC yöntemiyle ayrılan fosfolipit ve triaçilgliserol fraksiyonlarında 9 farklı yağ asidi tespit edildi. A. dioscoridis’in toprak üstü kısımlarından ekstrakte edilen total lipit, fosfolipit ve triaçilgliserol fraksiyonlarından elde edilen metil esterlerinde; doymuş yağ asitleri içinde C14:0, C15:0, C16:0, C17:0 ve C18:0 tekli doymamış yağ asitleri içinde C16:1ω-7 ve C18:1 ω-9, çoklu doymamış yağ asitleri içinde C18:2ω-2 ve C18:3 ω-3 temel bileşenler olarak belirlenmiştir. Total lipit, fosfolipit ve triaçilgliserolde sırasıyla doymuş yağ asitlerinden majör bileşen olarak palmitik asit (C16:0), stearik asit (C18:0) ve miristik asit (C14:0) tespit edildi. Total doymamış yağ asitleri (∑SFA) (%42.66) en fazla fosfolipit fraksiyonunda saptandı. Oleik asit (C18:1n-9) (%26.33) en fazla triaçilgliserol fraksiyonunda tespit edildi. Palmitoleik asit (C16:1n-7) (%13.67) ve total MUFA (%40.00) oranı; triaçilgliserol fraksiyonunda diğerlerine oranla belirgin miktarda yüksek bulundu. Temel yağ asitlerinden linoleik asit (C18:2n-6) (%16.26) ve linolenik asit (C18:3n-3) (%35.25) yüksek oranda total lipitte saptandı. Total doymamış yağ asitleri (∑PUFA) en fazla total lipitte (%51.51) diğer taraftan en düşük triaçilgliserol fraksiyonunda (%35.45) saptandı. Sonuç olarak A. dioscoridis’in total lipit, fosfolipit, triaçilgliserol fraksiyonlarının kalitatif olarak benzer olduğu fakat kantitatif olarak farklılık gösterdiği tespit edilmiştir.Presentation Herbs used in Traditional Foods: Coriandrum sativum and Rhus coriaria(The 4th International Symposium on “Traditional Foods from Adriatic to Caucasus” 19-21 April 2018 Abstract Book, 2018) Keskin, Cumali; Gürbüz, Semra; Çelikel Güngör, Aslı; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; Department of Gastronomy and Culinary Arts / Gastronomi ve Mutfak Sanatları BölümüTraditional foods are products made from locally available raw materials depending on the culture and tradition of the region. The majority of countries and regions have their own traditional foods and traditional cuisine depending on local consumption habits, methods of cooking and preparation as well as food ingredients. The herbs grown in the region have an important contribution to the rich culinary culture of the Southeastern Anatolia Region. Coriander sativum "Coriander" and Rhus coriaria "Sumac", which have been known since ancient times, are often used for traditional food and beverages in the region's cuisine due to their intensive cultivation in the Southeastern Anatolian region.These herbs, which constitute an integral component of the Southeastern Anatolia cuisine, are also effective in suppressing some undesirable effects andpreserving food for long periods of time as well as imparting flavor, aroma and flavor to food.These herbs, which are used in the traditional foods in Turkey as well as in the traditional foods in other countries wherethey are grown,are widely usedin traditional medical practices because of their antimicrobial, anti-diabetic, antioxidant properties.The aim of this study is to evaluate the use of Coriander sativum and Rhus coriariain traditional foods, their functions and their health effects.Article Citation - WoS: 21Citation - Scopus: 24Determination of Antimicrobial and Toxic Metal Removal Activities of Plant-Based Synthesized (capsicum Annuum L. Leaves), Ecofriendly, Gold Nanomaterials(Wiley-v C H verlag Gmbh, 2020) Acay, Hilal; Keskin, Cumali; Baran, Mehmet Fırat; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüNanoparticles are valuable materials with widespread use. The fact that these materials are obtained by biological resources with an environmentally friendly method contributes to the development of studies in this field. Gold nanoparticles (AuNPs) from waste vegetable sources (green leaves of Capsicum annum L.) are economically and easily synthesized. The obtained particles are characterized by UV-vis spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) analysis. The antimicrobial activity of the particles on the pathogenic microorganisms Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus subtilis bacteria, and Candida albicans yeast are found to have a significant suppressive effect. The removal activities of eight toxic metals (Pd, Cd, Fe, Ni, Co, Mn, Zn, Pb) in Diyarbakir drinking water and artificially prepared water within different pHs are investigated. Gold nanoparticles synthesized from Capsicum annuum L. leaves are found to be effective in toxic metal removal in water samples.Article Synthesis, Characterization and Evaluation of Antimicrobial Activities of Silver Nanoparticles Obtained From Rumex Acetosella L. (sorrel) Plant(2022) Aktepe, Necmettin; Keskin, Cumali; Baran, Ayşe; Baran, Mehmet Fırat; Baran, Mehmet Fırat; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; Department of Nursing / Hemşirelik BölümüRumex acetosella L. (sorrel) is a plant belonging to the Polygonaceous family and is a species that grows naturally across Turkey. In this study, the characterization of silver nanoparticles (AgNPs) obtained from the Rumex acetocella L. (RA) plant using the green synthesis method was performed and their antimicrobial activities were investigated. AgNPs were successfully synthesized in the first stage of the study using plant extract taken from plant samples collected from the natural growing environment. Characterization of synthesized AgNPs was performed using appropriate analytical methods (UV-vis, FT-IR, XRD, SEM-EDX, TEM, Zeta Potential and Zeta Sizer). According to the analysis results, it was determined that AgNPs had a maximum absorbance at 476 nm wavelength, a pentagonal, hexagonal, and spherical appearance, a size of 29.16 nm, and a zeta potential of -9.88 mV. The antimicrobial activities of AgNPs were tested using the microdilution technique, in which Minimum Inhibition Concentration (MIC) values were determined on gram-positive Staphylococcus aureus, Bacillus subtilis and gram-negative Pseudomonas aeruginosa, Escherichia coli bacteria and Candida albicans fungus. It showed a very strong antimicrobial effect on C. albicans, S. aureus and P. aeruginosa. Consequently, AgNPs had stronger antimicrobial activity at low concentrations and when compared to commercial antibiotics.Article The Protective and Antiapoptotic Effects of Hypericum Triquetrifolium Turra Against Cyclophosphamide-Induced Lung Injury in Rats: in Vitro Evaluation(2024) Keskin, Cumali; Şahintürk, Varol; Çetik Yıldız, Songül; Ayhancı, Adnan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüObjectives: Hypericum triquetrifolium Turra (HTT) has been traditionally used in medical treatments due to its sedative, antiseptic, antiinflammatory, and anthelmintic properties. The present study aims to investigate the lung-protective and antiapoptotic effects of HTT against cyclophosphamide (CP)-induced lung injury in rats. Methods: Thirty-five Sprague Dawley rats were categorized into 5 groups, each consisting of seven members. Phenolic acid and flavonoid contents of this plant were determined. The lung tissue samples cultivated from the rats were examined in histopathological and immunohistochemically for the apoptosis markers of Caspase-3, Bax, and Bcl-2. Results: Histopathological results indicated that structural defects, bleeding areas, and edema had occurred in the lungs of the CP-Alone Group. Besides, Caspase-3 and Bax positivity of the lung cells had also increased while Bcl-2 positivity had decreased. On the other hand, in the HTT+CP Group, HTT was shown to have reversed the aforementioned changes positively. Conclusion: Based on in vivo results, HTT could be a strong protective candidate for CP-induced lung injury and apoptosisArticle Citation - WoS: 10Citation - Scopus: 11The Investigation of the Chemical Composition and Applicability of Gold Nanoparticles Synthesized with Amygdalus communis (Almond) Leaf Aqueous Extract as Antimicrobial and Anticancer Agents(Molecules, 2023) Keskin, Cumali; Mehmet Fırat Baran, Cumali Keskin, Ayşe Baran, Aziz Eftekhari, Sabina Omarova, Rovshan Khalilov, Mehmet Tevfik Adican, Gvozden Rosić, Dragica Selakovic, Mahmut Yıldıztekin, Kadri Kurt, Canan Aytuğ Ava, Mehmet Nuri Atalar; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüThe current work’s main objective was to determine the chemical composition of Amygdalus communis (AC) leaf extract and examine the antibacterial and cytotoxic properties of biosynthesized gold nanoparticles (AuNPs). The chemical composition of AC leaf extract was determined using LC-ESI/MS/MS to detect compounds that may be responsible for the reducing, stabilizing, and capping steps in the synthesis of nanoparticles and their biological activities. The AC-AuNPs were spherical, with a particle size lower than 100 nm and a face-centered cubic structure. The EDX spectrum confirmed the formation of AuNPs and a negative zeta potential value (−27.7 mV) suggested their physicochemical stability. The in vitro cytotoxic efficacy of the AC-AuNPs against colorectal adenocarcinoma (Caco-2), glioma (U118), and ovarian (Skov-3) cancer cell lines and human dermal fibroblasts (HDFs) was evaluated by MTT assay. CaCo-2 cell proliferation was effectively inhibited by the AC-AuNPs at concentrations between 25 and 100 g mL−1. The AC-AuNPs exerted preeminent antimicrobial activity against Bacillus subtilis with an MIC of 0.02 μg/mL, whilst good activity was shown against Staphylococcus aureus bacteria and Candida albicans yeast with an MIC of 0.12 μg/mL. Ultimately, the results support the high antibacterial and anticancer potential of biosynthesized AuNPs from AC leaf extract.Article Citation - WoS: 0Citation - Scopus: 0Green Synthesis and Characterization of Silver Nanoparticles Using Anchusa Officinalis: Antimicrobial and Cytotoxic Potential(Dove Medical Press Ltd, 2025) Keskin, Cumali; Baran, Mehmet Fırat; Baran, Ayşe; Baran, Ayse; Eftekhari, Aziz; Adican, Mehmet Tevfik; Mohamed, Ali Jimale; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüObjective: Anchusa officinalis L. (A. officinalis) is a herbaceous traditional medicinal plant used in the treatment of some diseases. The presence of its medicinal properties suggested that A. officinalis (AO) leaf extract could be used as a coating agent for the environmentally friendly production of silver nanoparticles (AgNPs). Methods: The synthesized biogenic silver nanoparticles (AO-AgNPs) were characterized using different techniques. The antimicrobial activity of AgNPs against common bacterial pathogenic strains was determined by the minimum inhibitory concentration (MIC) method. The presence of phytochemicals was determined by LSMS/MS. The MTT assay was used to investigate AO-AgNPs' cytotoxic activity in malignant (LnCap, Caco2, MDA-MB2, A549) and healthy (HEK-293) cell lines. Results: LC-MS/MS analysis detected the presence of rich phytochemicals that may be responsible for reduction reactions. Biogenic AO-AgNPs exhibited effective inhibition of the growth of pathogenic microorganisms at low concentrations. The most effective antimicrobial activity was measured as 0.5 mu g/mL MIC against S. aureus, E. coli, and C. albicans. Moreover, AO-AgNPs showed significant inhibition on the growth of cancerous cell lines, especially at a concentration of 25 mu g/mL. On the contrary, it was determined that the inhibition rate decreased in the growth of healthy cell lines due to the increase in concentration. The lowest EC50 values were determined as 15.15 mu g/mL in A549 cells. Conclusion: The obtained results showed that AO could be an important source for the synthesis of AgNPs. Especially their ability to inhibit the growth of antibiotic-resistant pathogenic bacteria at low concentrations compared to common antibiotics indicates that AOAgNPs can be used as biomedical agents in various areas. Moreover, their suppressive effect on cancerous cell lines showed that they have the potential to be used as an anticancer agent, but due to their proliferative effect on healthy cell lines, care should be taken in determining the appropriate dose.Article Synthesis, Characterization, and Evaluation of the Antimicrobial Activities of Silver Nanoparticles From Cyclotrichium Origanifolium L.(2022) Keskin, Cumali; Aktepe, Necmettin; Baran, Ayşe; Aktepe, Necmettin; Baran, Ayşe; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; Department of Nursing / Hemşirelik BölümüCyclotricium origanifolium is a plant belonging to the Lamiaceae family and is a species that grows in the Western and Southern Anatolian regions of Turkey. In our study, the antimicrobial activities of silver nanoparticles (AgNP) were investigated through Cyclotricium origanifolium plant extract. Characterization processes of the obtained AgNPs, suitable spectral analysis methods; Uv-Vis was determined by FT-IR, SEM-EDX, XRD. According to the results of the analysis, it was determined that the AgNPs were spherical in shape and had an average diameter of 17.60 nm. The antimicrobial effect of AgNPs was determined by the minimum inhibition concentration (MIC) method. Gram positive as test microorganisms; Staphylococcus aureus, Bacillus subtilis and gram negative; Escherichia coli, Pseudomonas aeruginosa bacteria, and Candida albicans fungal pathogen species were used. The suppression of microorganism growth was investigated by comparing the efficacy of standard antibiotics used in our study with AgNPs produced by the green synthesis method. It has been observed that the obtained AgNPs have a very strong effect on gram-positive B. subtilis and gram-negative E. coli bacteria, and are more effective against C. albicans than the normal antifungal drug. It was determined that the antimicrobial activity of AgNPs produced from C. origanifolium L. plants showed a stronger effect than standard antibiotics.Article Citation - WoS: 7Determination of in vitro antioxidant and antimicrobial properties of shoot and root extracts of Astragalus diphtherites FENZL var. diphtherites and Astragalus gymnalopecias RECH. FIL. obtained by different solvents(KAHRAMANMARAS SUTCU IMAM UNIV, 2018) Keskin, Cumali; Ozen, Hasan Cetin; Toker, Zuhal; Kizil, Goksel; Kizil, Murat; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüObjective of this study was to investigate the antioxidant and antimicrobial properties of shoot and and root parts of Astragalus diphtherites var. diphtherites (A. diphtherites) and Astragalus gymnalopecias (A.gymnalopecias) species which were subjected to solvent series with different polarity. Total phenolic, total flavonoid, 2.2-diphenyl - 1 - picryl-hydrazyl (DPPH). metal chelating, reducing power and hydroxy radicals scavenging activities of the extracts were tested to determine antioxidant. properties. The highest total phenolic content of A. diphtherites. was obtained from the methanol extract of shoots and the acetone extract of root parts. On the other Antimicrobial. hand. the highest total phenolic content in A. gymnalopecias were achieved from methanol extract of shoot parts and the ethyl acetate extract of the root part. The highest amount of total flavonoids and reducing power activities of A. diphtherites and A. gymnalopecias were obtained from the acetone extracts in the shoot. part and from the ethyl acetate extracts in the root part. While the highest DPPH radical scavenging activity was determined in the methanol extract in the shoot part and the acetone extract in the root part of A. diphtherites. The highest DPPH radical scavenging activity for A. gymnalopecias was determined in the methanol extract of the shoot part and the ethyl acetate extract of the root part. The highest metal chelating activity was seen in the methanol extracts from shoot parts and in the hexane extracts from the root part of A. diphtherites. The ethyl acetate extracts of the shoot and root part in both species showed the highest hydroxyl radical scavenging activity. It. was determined that. acetone and methanol extracts of the shoot part of A. gymnalopecias have inhibition effect on the growth of Streptococcus pyogenes.Article Wistar Albino Sıçanlarında Hypericum Triquetrifolium Turra. Tohum Metanol Ekstraktlarının Siklofosfamid-nedenli Mesane Hemorajik Sistiti ve Nefrotoksisitesi Üzerine Üroprotektif Etkilerinin İncelenmesi(2020) Keskin, Cumali; Yıldız, Songul Çetik; Sahinturk, Varol; Keskin, Cumali; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüAmaç: Bu çalışmada, Hypericum triquetrifolium Turra (HT) tohum metanol ekstraktlarının (25,50,100 mg/kg, i.p., 6 gün boyunca) siklofosfamid (CYP) nedenli (150 mg/kg, tek doz, i.p.) akut mesane hemorajik sistit (HC) ve nefrotoksisiteye karşı olası üroprotektif etkileri araştırıldı. Gereç ve Yöntem: Bu çalışmada kullanılan Wistar albino sıçanlar, her biri yedi sıçan olmak üzere dokuz gruba ayrıldı. Grup 1 (kontrol) 0.5ml salin (SF) ile muamele edildi ve Grup 2, CYP (150 mg/kg) ile muamele edildi. Grup 3, 4, 5 sırasıyla 25, 50, 100 mg/kg HT ile tedavi edilirken, grup 6, 7, 8 sırasıyla 25, 50, 100 mg/kg HT + CYP ile tedavi edildi. Son olarak, Grup 9 (kontrol-2) 0.5ml-% 0.2 dimetil sülfoksit (DMSO) ile muamele edildi. Kan serumunda serum kreatinin, kan üre azotu (BUN), süperoksit dismutaz (SOD) ve katalaz (CAT) seviyeleri ölçüldü. Bulgular: CYP ile tedavi edilen sıçanların histopatolojik olarak hafif-orta derecede mesane ve böbrek yaralanmaları vardı. Böbrek hasarının biyokimyasal belirteçleri olan serum kreatinin ve BUN düzeyleri, kontrol grubuna göre önemli ölçüde artmıştır. Sonuç: HT, enflamasyonu ve apoptozu inhibe ederek sıçanlarda CYP ile ilişkili mesane HC'si ve nefrotoksisite üzerinde koruyucu bir etki göstermiştir.
