Keskin, Cumali

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Profile URL
https://hdl.handle.net/20.500.12514/7084
Name Variants
Keskin, C.
Cumali Keskin
Keskin, Cumali
Job Title
Profesör
Email Address
cumalikeskin@artuklu.edu.tr
Main Affiliation
Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Status
Website
ORCID ID
0000-0003-3758-0654
Scopus Author ID
57819807000
Turkish CoHE Profile ID
100584
Google Scholar ID
psFlP5IAAAAJ
WoS Researcher ID
C-1551-2018
Files
cv_A-021_ingilizce.pdf (122.98 KB)
cv_A-021_turkce.pdf (123.09 KB)

Sustainable Development Goals

NO POVERTY1
NO POVERTY
0
Research Products
ZERO HUNGER2
ZERO HUNGER
0
Research Products
GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
32
Research Products
QUALITY EDUCATION4
QUALITY EDUCATION
0
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GENDER EQUALITY5
GENDER EQUALITY
0
Research Products
CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
4
Research Products
AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
1
Research Products
DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
5
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REDUCED INEQUALITIES10
REDUCED INEQUALITIES
0
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SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
2
Research Products
RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
1
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CLIMATE ACTION13
CLIMATE ACTION
0
Research Products
LIFE BELOW WATER14
LIFE BELOW WATER
2
Research Products
LIFE ON LAND15
LIFE ON LAND
1
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PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
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PARTNERSHIPS FOR THE GOALS17
PARTNERSHIPS FOR THE GOALS
0
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Documents

45

Citations

1247

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Documents

51

Citations

1102

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Scholarly Output

74

Articles

57

Views / Downloads

398/5107

Supervised MSc Theses

7

Supervised PhD Theses

1

WoS Citation Count

818

Scopus Citation Count

959

Patents

0

Projects

7

WoS Citations per Publication

11.05

Scopus Citations per Publication

12.96

Open Access Source

49

Supervised Theses

8

JournalCount
Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi3
International Journal of Agriculture, Environment and Food Sciences3
Kahramanmaraş Sütçü İmam Üniversitesi Tarım ve Doğa Dergisi3
Cukurova Medical Journal2
Journal of Nanomaterials2
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Now showing 1 - 10 of 74
  • Thumbnail Image
    Article
    Citation - WoS: 12
    Citation - Scopus: 13
    The Investigation of the Chemical Composition and Applicability of Gold Nanoparticles Synthesized with Amygdalus communis (Almond) Leaf Aqueous Extract as Antimicrobial and Anticancer Agents
    (Molecules, 2023) Keskin, Cumali; Mehmet Fırat Baran, Cumali Keskin, Ayşe Baran, Aziz Eftekhari, Sabina Omarova, Rovshan Khalilov, Mehmet Tevfik Adican, Gvozden Rosić, Dragica Selakovic, Mahmut Yıldıztekin, Kadri Kurt, Canan Aytuğ Ava, Mehmet Nuri Atalar; Baran, Mehmet Firat; Atalar, Mehmet Nuri; Eftekhari, Aziz; Khalilov, Rovshan; Baran, Ayse; Omarova, Sabina
    The current work’s main objective was to determine the chemical composition of Amygdalus communis (AC) leaf extract and examine the antibacterial and cytotoxic properties of biosynthesized gold nanoparticles (AuNPs). The chemical composition of AC leaf extract was determined using LC-ESI/MS/MS to detect compounds that may be responsible for the reducing, stabilizing, and capping steps in the synthesis of nanoparticles and their biological activities. The AC-AuNPs were spherical, with a particle size lower than 100 nm and a face-centered cubic structure. The EDX spectrum confirmed the formation of AuNPs and a negative zeta potential value (−27.7 mV) suggested their physicochemical stability. The in vitro cytotoxic efficacy of the AC-AuNPs against colorectal adenocarcinoma (Caco-2), glioma (U118), and ovarian (Skov-3) cancer cell lines and human dermal fibroblasts (HDFs) was evaluated by MTT assay. CaCo-2 cell proliferation was effectively inhibited by the AC-AuNPs at concentrations between 25 and 100 g mL−1. The AC-AuNPs exerted preeminent antimicrobial activity against Bacillus subtilis with an MIC of 0.02 μg/mL, whilst good activity was shown against Staphylococcus aureus bacteria and Candida albicans yeast with an MIC of 0.12 μg/mL. Ultimately, the results support the high antibacterial and anticancer potential of biosynthesized AuNPs from AC leaf extract.
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    Article
    Citation - WoS: 27
    Citation - Scopus: 33
    Green Synthesis and Characterization of Silver Nanoparticles Using Anchusa Officinalis: Antimicrobial and Cytotoxic Potential
    (Dove Medical Press Ltd, 2025) Keskin, Cumali; Aslan, Seyhan; Baran, Mehmet Firat; Baran, Ayse; Eftekhari, Aziz; Adican, Mehmet Tevfik; Mohamed, Ali Jimale
    Objective: Anchusa officinalis L. (A. officinalis) is a herbaceous traditional medicinal plant used in the treatment of some diseases. The presence of its medicinal properties suggested that A. officinalis (AO) leaf extract could be used as a coating agent for the environmentally friendly production of silver nanoparticles (AgNPs). Methods: The synthesized biogenic silver nanoparticles (AO-AgNPs) were characterized using different techniques. The antimicrobial activity of AgNPs against common bacterial pathogenic strains was determined by the minimum inhibitory concentration (MIC) method. The presence of phytochemicals was determined by LSMS/MS. The MTT assay was used to investigate AO-AgNPs' cytotoxic activity in malignant (LnCap, Caco2, MDA-MB2, A549) and healthy (HEK-293) cell lines. Results: LC-MS/MS analysis detected the presence of rich phytochemicals that may be responsible for reduction reactions. Biogenic AO-AgNPs exhibited effective inhibition of the growth of pathogenic microorganisms at low concentrations. The most effective antimicrobial activity was measured as 0.5 mu g/mL MIC against S. aureus, E. coli, and C. albicans. Moreover, AO-AgNPs showed significant inhibition on the growth of cancerous cell lines, especially at a concentration of 25 mu g/mL. On the contrary, it was determined that the inhibition rate decreased in the growth of healthy cell lines due to the increase in concentration. The lowest EC50 values were determined as 15.15 mu g/mL in A549 cells. Conclusion: The obtained results showed that AO could be an important source for the synthesis of AgNPs. Especially their ability to inhibit the growth of antibiotic-resistant pathogenic bacteria at low concentrations compared to common antibiotics indicates that AOAgNPs can be used as biomedical agents in various areas. Moreover, their suppressive effect on cancerous cell lines showed that they have the potential to be used as an anticancer agent, but due to their proliferative effect on healthy cell lines, care should be taken in determining the appropriate dose.
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    Presentation
    Acanthus dioscoridis L. var. dioscoridis’ in total yağ asidi, fosfolipit ve triaçilgliserol kompozisyonlarının belirlenmesi
    (2014) Keskin, Cumali; Yavuz, Murat; Kaçar, Semra
    Özet: Yağ asitleri fosfolipitler, trigliseritler ve monogliseritler gibi lipitlerin temel bileşenleridir. Doymuş, tekli doymamış veya çoklu doymamış olabilirler. Acanthus dioscoridis’in total lipit, fosfolipit ve triaçilgliserol yağ asidi kompozisyonları gaz kromatografisi (GC) ile belirlendi. A. dioscoridis’in total lipit ve TLC yöntemiyle ayrılan fosfolipit ve triaçilgliserol fraksiyonlarında 9 farklı yağ asidi tespit edildi. A. dioscoridis’in toprak üstü kısımlarından ekstrakte edilen total lipit, fosfolipit ve triaçilgliserol fraksiyonlarından elde edilen metil esterlerinde; doymuş yağ asitleri içinde C14:0, C15:0, C16:0, C17:0 ve C18:0 tekli doymamış yağ asitleri içinde C16:1ω-7 ve C18:1 ω-9, çoklu doymamış yağ asitleri içinde C18:2ω-2 ve C18:3 ω-3 temel bileşenler olarak belirlenmiştir. Total lipit, fosfolipit ve triaçilgliserolde sırasıyla doymuş yağ asitlerinden majör bileşen olarak palmitik asit (C16:0), stearik asit (C18:0) ve miristik asit (C14:0) tespit edildi. Total doymamış yağ asitleri (∑SFA) (%42.66) en fazla fosfolipit fraksiyonunda saptandı. Oleik asit (C18:1n-9) (%26.33) en fazla triaçilgliserol fraksiyonunda tespit edildi. Palmitoleik asit (C16:1n-7) (%13.67) ve total MUFA (%40.00) oranı; triaçilgliserol fraksiyonunda diğerlerine oranla belirgin miktarda yüksek bulundu. Temel yağ asitlerinden linoleik asit (C18:2n-6) (%16.26) ve linolenik asit (C18:3n-3) (%35.25) yüksek oranda total lipitte saptandı. Total doymamış yağ asitleri (∑PUFA) en fazla total lipitte (%51.51) diğer taraftan en düşük triaçilgliserol fraksiyonunda (%35.45) saptandı. Sonuç olarak A. dioscoridis’in total lipit, fosfolipit, triaçilgliserol fraksiyonlarının kalitatif olarak benzer olduğu fakat kantitatif olarak farklılık gösterdiği tespit edilmiştir.
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    Presentation
    Herbs used in Traditional Foods: Coriandrum sativum and Rhus coriaria
    (The 4th International Symposium on “Traditional Foods from Adriatic to Caucasus” 19-21 April 2018 Abstract Book, 2018) Gürbüz, Semra; Çelikel, Aslı; Keskin, Cumali
    Traditional foods are products made from locally available raw materials depending on the culture and tradition of the region. The majority of countries and regions have their own traditional foods and traditional cuisine depending on local consumption habits, methods of cooking and preparation as well as food ingredients. The herbs grown in the region have an important contribution to the rich culinary culture of the Southeastern Anatolia Region. Coriander sativum "Coriander" and Rhus coriaria "Sumac", which have been known since ancient times, are often used for traditional food and beverages in the region's cuisine due to their intensive cultivation in the Southeastern Anatolian region.These herbs, which constitute an integral component of the Southeastern Anatolia cuisine, are also effective in suppressing some undesirable effects andpreserving food for long periods of time as well as imparting flavor, aroma and flavor to food.These herbs, which are used in the traditional foods in Turkey as well as in the traditional foods in other countries wherethey are grown,are widely usedin traditional medical practices because of their antimicrobial, anti-diabetic, antioxidant properties.The aim of this study is to evaluate the use of Coriander sativum and Rhus coriariain traditional foods, their functions and their health effects.
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    Article
    Citation - WoS: 22
    Citation - Scopus: 25
    Determination of Antimicrobial and Toxic Metal Removal Activities of Plant-Based Synthesized (capsicum Annuum L. Leaves), Ecofriendly, Gold Nanomaterials
    (Wiley-v C H verlag Gmbh, 2020) Baran, Mehmet Firat; Acay, Hilal; Keskin, Cumali
    Nanoparticles are valuable materials with widespread use. The fact that these materials are obtained by biological resources with an environmentally friendly method contributes to the development of studies in this field. Gold nanoparticles (AuNPs) from waste vegetable sources (green leaves of Capsicum annum L.) are economically and easily synthesized. The obtained particles are characterized by UV-vis spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) analysis. The antimicrobial activity of the particles on the pathogenic microorganisms Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus subtilis bacteria, and Candida albicans yeast are found to have a significant suppressive effect. The removal activities of eight toxic metals (Pd, Cd, Fe, Ni, Co, Mn, Zn, Pb) in Diyarbakir drinking water and artificially prepared water within different pHs are investigated. Gold nanoparticles synthesized from Capsicum annuum L. leaves are found to be effective in toxic metal removal in water samples.
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    Article
    Synthesis, Characterization and Evaluation of Antimicrobial Activities of Silver Nanoparticles Obtained From Rumex Acetosella L. (sorrel) Plant
    (2022) Aktepe, Necmettin; Bütüner, Hafize; Baran, Ayşe; Keskin, Cumali; Baran, Mehmet Fırat
    Rumex acetosella L. (sorrel) is a plant belonging to the Polygonaceous family and is a species that grows naturally across Turkey. In this study, the characterization of silver nanoparticles (AgNPs) obtained from the Rumex acetocella L. (RA) plant using the green synthesis method was performed and their antimicrobial activities were investigated. AgNPs were successfully synthesized in the first stage of the study using plant extract taken from plant samples collected from the natural growing environment. Characterization of synthesized AgNPs was performed using appropriate analytical methods (UV-vis, FT-IR, XRD, SEM-EDX, TEM, Zeta Potential and Zeta Sizer). According to the analysis results, it was determined that AgNPs had a maximum absorbance at 476 nm wavelength, a pentagonal, hexagonal, and spherical appearance, a size of 29.16 nm, and a zeta potential of -9.88 mV. The antimicrobial activities of AgNPs were tested using the microdilution technique, in which Minimum Inhibition Concentration (MIC) values were determined on gram-positive Staphylococcus aureus, Bacillus subtilis and gram-negative Pseudomonas aeruginosa, Escherichia coli bacteria and Candida albicans fungus. It showed a very strong antimicrobial effect on C. albicans, S. aureus and P. aeruginosa. Consequently, AgNPs had stronger antimicrobial activity at low concentrations and when compared to commercial antibiotics.
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    Article
    Citation - WoS: 25
    Citation - Scopus: 33
    Green Synthesis, Characterization of Gold Nanomaterials using Gundelia tournefortii Leaf Extract, and Determination of Their Nanomedicinal (Antibacterial, Antifungal, and Cytotoxic) Potential
    (Hindawi, 2022) Keskin, Cumali; Baran, Ayşe; Baran, Mehmet Fırat; Hatipoğlu, Abdulkerim; Adican, Mehmet Tevfik; Atalar, Mehmet Nuri; Huseynova, Irada; Khalilov, Rovshan; Ahmadian, Elham; Yavuz, Ömer; Kandemir, Sevgi İrtegün; Eftekhari, Aziz
    Introduction. Fighting against cancer and antibiotic resistance are important challenges of healthcare systems, and developing new treatment methods has become the most concentrated area of researchers. Method and Materials. Green synthesis, characterization, and some biological activities of gold nanomaterials (AuNPs) obtained with Gundelia tournefortii (kenger) leaf extract were investigated in this study. Fourier scanning electron microscope, UV-visible spectrophotometer, Fourier transform ınfrared spectroscopy, energy-dispersive X-ray spectrophotometer, X-ray diffraction diffractometer, transmission electron microscope, and Zetasizer instrument data were used to elucidate the structures of nanoparticles. Results. The maximum surface plasmon resonance was observed at 532.15 nm after 1 hour. With the powder XRD model, the mean cubic crystallite size was determined as 23.53 nm. It was observed that the shapes of the obtained AuNPs were spherical, and the dimensions were 5-40 nm and hexagonal. Surface charges (-27 mV) and average size (365.3 nm) of gold nanoparticles were measured with a zeta analyzer. Conclusion. The suppressive effects of AuNPs on the growth of pathogenic microorganisms and healthy and cancer cell lines were determined using the MIC and MTT methods, respectively.
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    Article
    Citation - WoS: 8
    Citation - Scopus: 8
    Analysis of bioactive compounds using LC-ESI-MS/MS, cytotoxic, antimicrobial effects, and enzyme activities from Cyclotrichium origanifolium
    (Wiley Online Library, 2022) Aktepe, Necmettin; Baran, Ayşe; Atalar, Mehmet Nuri; Baran, Mehmet Fırat; Keskin, Cumali; Taşkin, Abdullah; Yavuz, Ömer; Demirtaş, İbrahim; Oğuz, Ercan; Jahan, Israt
    Cyclotrichium origanifolium is a medicinal plant belonging to the Lamiaceae family. In this study, phenolic content analysis, antimicrobial effects, and cytotoxic effects of extracts of C. origanifolium were investigated. In the extracts, phenolic compound analysis by the liquid chromatography–electrospray ionization– tandem mass spectrometry method, antimicrobial effect by the minimum inhibition concentration method, and cytotoxic effect on human dermal fibroblasts (HDF), glioblastoma cell (U87), ovarian adenocarcinoma cell (Skov-3), and human colorectal adenocarcinoma cell (CaCo-2) cancer cell lines were investigated. Cytotoxicity analyses were performed by the MTT method. In addition, the GST and AChE enzyme activities of the extracts were also measured. Around 18 compounds were detected in both the methanol and ethanol extract. It was found that the best antimicrobial effect on Gram-negative Pseudomonas aeruginosa was on methanol extract, while the ethanol extract was on Candida albicans fungus (respectively, 2.50mg/ml, 5.0 μg/ml). A 500μg/ml of methanol extract has been shown to have cytotoxic activity high effect on HDF cells. GST and AChE activity were found to decrease in a concentration-dependent manner.
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    Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Trace Metal Determination in the Medicinal Plant Hyoscyamus (Solanaceae) by Inductively Coupled Plasma Optical Emission Spectrometry
    (Perkin - Elmer Corp., 2014) Keskin, C.; Keskin, Cumali; Kisin, E.; Yavuz, M.; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
    The concentrations of Cd, Ni, Cu, Pb, Cr, Fe, B, and A1 were determined in four different medicinal plants of the Hyoscyamus species: Hyoscyamus reticulums L, Hyoscyamus leptocalyx STAPF, Hyoscyamus aureus L, and Hyoscyamus albus L by ICP-OES. By considering the sensitivity of ICP-OES with respect to the trace level determination of Cd, Ni, Cu, Pb, Cr, Fe, B, and Al in the studied plant samples and the limitations of sample amount possible in a microwave digestion procedure, the ashing method was applied before analysis and proved the quantitative measurements of the elements.The accuracy of the method was verified by comparison to the certified reference sample NCSZC 73014 Tea Leaves. The RSD values were between 0.14-10.4%, while the error values were in the 90-107% range. The results show that with the proposed method higher concentrations of Ni, Cr, Pb, Fe, and B were determined in H. aureus. Interestingly, the concentration of Cu in H. reticulatus was approximately 48.5 times higher than the mean Cu values of the other three Hyoscyamus species, while the Pb concentration levels in H. aureus were 17.8 times higher than in the H. reticulatus L, H. leptocalyx STAPF, and H. albus L species.
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    Article
    Citation - Scopus: 1
    Determination of the Protective Effect of Curcumin Against Tartrazine-Induced DNA Damage and HSP 70 in the Rat Brain
    (Springer, 2025) Yavas, Mehmet Cihan; Tan, Fazile Canturk; Tur, Kardelen; Keskin, Cumali; Basmaci, Guldidar
    Tartrazine is a widely used food dye, and children often consume large amounts of food products containing this additive due to their appealing appearance. Curcumin, on the other hand, is known for its antioxidant properties. The aim of this study was to investigate the protective effects of curcumin on brain tissue and biochemical parameters in rats exposed to short-term tartrazine administration. Male Wistar albino rats were randomly divided into five equal groups. Group 1 served as the control; Group 2 received tartrazine (10 mg/kg); Group 3 received tartrazine (100 mg/kg); Group 4 received tartrazine (10 mg/kg) along with curcumin (20 mg/kg); and Group 5 received tartrazine (100 mg/kg) along with curcumin (20 mg/kg). All substances were administered via oral gavage. The study lasted for 21 days. Serum samples were analyzed for heat shock protein 70 (HSP70) levels using the ELISA method. Brain tissues were subjected to histopathological examination and DNA damage assessment using the comet assay. Although HSP70 levels increased in the tartrazine groups, the differences were not statistically significant (p = 0.065). Partial damage was observed in the histopathological analysis. Comet assay results indicated a dose-dependent increase in DNA tail percentage with tartrazine, which was reduced following curcumin administration. These findings suggest that curcumin may alleviate tartrazine-induced damage in brain tissue and may have a regulatory effect on serum HSP70 levels in rats.