Baran, Ayşe
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Baran, Ayse
Baran, A.
Baran, Ayşe
Baran, A.
Baran, A.
Baran, Ayşe
Baran, A.
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Dr. Öğr. Üyesi
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BİTKİSEL VE HAYVANSAL ÜRETİM
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Scholarly Output
61
Articles
58
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0
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1
61 results
Scholarly Output Search Results
Now showing 1 - 10 of 61
Article Synthesis, Characterization and Evaluation of Antimicrobial Activities of Silver Nanoparticles Obtained From Rumex Acetosella L. (sorrel) Plant(2022) Aktepe, Necmettin; Keskin, Cumali; Baran, Ayşe; Baran, Mehmet Fırat; Baran, Mehmet Fırat; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; Department of Nursing / Hemşirelik BölümüRumex acetosella L. (sorrel) is a plant belonging to the Polygonaceous family and is a species that grows naturally across Turkey. In this study, the characterization of silver nanoparticles (AgNPs) obtained from the Rumex acetocella L. (RA) plant using the green synthesis method was performed and their antimicrobial activities were investigated. AgNPs were successfully synthesized in the first stage of the study using plant extract taken from plant samples collected from the natural growing environment. Characterization of synthesized AgNPs was performed using appropriate analytical methods (UV-vis, FT-IR, XRD, SEM-EDX, TEM, Zeta Potential and Zeta Sizer). According to the analysis results, it was determined that AgNPs had a maximum absorbance at 476 nm wavelength, a pentagonal, hexagonal, and spherical appearance, a size of 29.16 nm, and a zeta potential of -9.88 mV. The antimicrobial activities of AgNPs were tested using the microdilution technique, in which Minimum Inhibition Concentration (MIC) values were determined on gram-positive Staphylococcus aureus, Bacillus subtilis and gram-negative Pseudomonas aeruginosa, Escherichia coli bacteria and Candida albicans fungus. It showed a very strong antimicrobial effect on C. albicans, S. aureus and P. aeruginosa. Consequently, AgNPs had stronger antimicrobial activity at low concentrations and when compared to commercial antibiotics.Article Citation - WoS: 0Citation - Scopus: 0Green Synthesis and Characterization of Silver Nanoparticles Using Anchusa Officinalis: Antimicrobial and Cytotoxic Potential(Dove Medical Press Ltd, 2025) Keskin, Cumali; Baran, Mehmet Fırat; Baran, Ayşe; Baran, Ayse; Eftekhari, Aziz; Adican, Mehmet Tevfik; Mohamed, Ali Jimale; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüObjective: Anchusa officinalis L. (A. officinalis) is a herbaceous traditional medicinal plant used in the treatment of some diseases. The presence of its medicinal properties suggested that A. officinalis (AO) leaf extract could be used as a coating agent for the environmentally friendly production of silver nanoparticles (AgNPs). Methods: The synthesized biogenic silver nanoparticles (AO-AgNPs) were characterized using different techniques. The antimicrobial activity of AgNPs against common bacterial pathogenic strains was determined by the minimum inhibitory concentration (MIC) method. The presence of phytochemicals was determined by LSMS/MS. The MTT assay was used to investigate AO-AgNPs' cytotoxic activity in malignant (LnCap, Caco2, MDA-MB2, A549) and healthy (HEK-293) cell lines. Results: LC-MS/MS analysis detected the presence of rich phytochemicals that may be responsible for reduction reactions. Biogenic AO-AgNPs exhibited effective inhibition of the growth of pathogenic microorganisms at low concentrations. The most effective antimicrobial activity was measured as 0.5 mu g/mL MIC against S. aureus, E. coli, and C. albicans. Moreover, AO-AgNPs showed significant inhibition on the growth of cancerous cell lines, especially at a concentration of 25 mu g/mL. On the contrary, it was determined that the inhibition rate decreased in the growth of healthy cell lines due to the increase in concentration. The lowest EC50 values were determined as 15.15 mu g/mL in A549 cells. Conclusion: The obtained results showed that AO could be an important source for the synthesis of AgNPs. Especially their ability to inhibit the growth of antibiotic-resistant pathogenic bacteria at low concentrations compared to common antibiotics indicates that AOAgNPs can be used as biomedical agents in various areas. Moreover, their suppressive effect on cancerous cell lines showed that they have the potential to be used as an anticancer agent, but due to their proliferative effect on healthy cell lines, care should be taken in determining the appropriate dose.Article Citation - WoS: 4Citation - Scopus: 4Green Synthesis Study: Adsorption of Congo Red Dye With Selenium Nanoparticles Obtained From prunus Armeniaca L. Leaf Waste(Wiley-v C H verlag Gmbh, 2024) Baran, Ayşe; Solmaz, Alper; Baran, AyseIn this study, it was aimed to remove Congo Red (CR) dye in aqueous solution by biosynthesized Selenium Nanoparticles from Prunus armeniaca L. (PAL-SeNPs) leaf wastes by green synthesis method. The characteristic structure of PAL-SeNPs was determined by UV-vis spectroscopy, X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), scanning electron microscope (SEM), energy dispersive X-ray (EDX), fourier transform infrared spectroscopy (FTIR), thermogravimetry-differential thermal analysis (TGA-DTA), dynamic light scattering (DLS), zetasizer, and point of zero charge (pHpzc). The effects of pH, adsorbent amount, time, initial concentration, and temperature were investigated by batch adsorption studies. 2 different kinetic and 4 isotherm models were tested and error analysis functions were determined for the most suitable model. Accordingly, the particle size, crystallinity, pHpzc value and average surface charge of PAL-SeNPs were determined as 9.969 nm, 48.50 %, 3.47, and -23.6 mV, respectively. Also, the most suitable kinetic and isotherm models for the removal of CR dye with PAL-SeNPs were found as Pseudo-second-order and Freundlich, with R2 values of 0.996, respectively. Also, where the optimum pH was 7.00, the maximum adsorption capacity was calculated as 96.59 mgCR/gPAL-SeNPs. The results obtained show that environmentally friendly and low-cost PAL-SeNPs produced by the green synthesis method are a suitable alternative for the removal of CR dye.Article Citation - WoS: 6Citation - Scopus: 6Determination of Chemical Components of the Endemic Species allium Turcicum L. Plant Extract by Lc-ms/Ms and Evaluation of Medicinal Potentials(Cell Press, 2024) Baran, Ayşe; Baran, Mehmet Fırat; Baran, Ayse; Baran, Mehmet Firat; Ommati, Mohammad Mehdi; Karadag, Musa; Khalilov, Rovshan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüThe Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer, antioxidant, and antibacterial prospectives of Zuzubak methanol extract. Reported results show that the extract is rich in bioactive compounds and has anticancer activity with breast cancer cells (MCF-7), human prostate cancer cells (DU -145), and Human osteosarcoma cancer Cell lines of (IC50) in dose dependent manner in the concentration range of 31.25 mu g/mL and 2000 mu g/mL for 24 and 48 h. Western blotting results determined that the extract significantly suppressed the growth of U2OS, MCF-7, and DU -145 cancer cells by down expression of Ang-1 (angiogenic protein) and Beclin-1 (autophagy protein) and overexpression of Bax (a proapoptotic protein). The oxidative stress indices showed a reduction in RPE-1 and MCF-7 cells and an upsurge in U2OS and DU -145 cells. Additionally, the antimicrobial assay showed suppression of the growth of various pathogenic microorganisms in 4.00 - 8.00 mu g/concentrations of Zuzubak extract using the microdilution method. The phytochemicals identified showed promising anticancer, antioxidant effects, and antimicrobial properties, representing a valuable herbal source for drug development studies.Article Gümüş Nano Malzemelerin Çevre Dostu, Hızlı Sentezi ve Biomedikal Uygulamaları(2021) Baran, AyşeBu çalışmada, ceviz yaprakları kullanılarak hazırlanan özüt ile gümüş nano malzemeler çevre dostu hızlı ve basit bir şekilde sentezlendi. Elde edilen bu malzemelerin karakterizasyonu UV-visiblespektrofotometre (UV-Vis.), Fourier dönüşümü kızılötesi spektroskopisi (FTIR), X- Işınımı Kırınımı Difraktrometresi(XRD), Taramalı Elektron Mikroskobu (SEM), zeta potansiyeli analiz verileri ile belirlendi. Gümüş nano malzemelerin 454.01 nm dalga boyunda maksimum absorbans, 23.66 nm kristal nano boyut, küresel görünüm ve -11.53 mV zeta potansiyeline sahip oldukları belirlendi. Biomedikal ugulamalar için anti-mikrobiyal etkileri patojen türler üzerinde incelendi. Bu türler üzerinde Minumum İnhibisyon Konsantrasyonları (MİK) 0.25-1.0 mg/L olarak mikrodilusyon yöntemi ile belirlendi.Article Citation - Scopus: 4Inhibitory effects of gold nanoparticles biosynthesized by redox reaction using Rheum ribes lam fruit peels on pathogen strains and cancer cells(Particulate Science and Technology, 2023) Baran, AyşeGold nanoparticles (AuNPs) are very valuable materials used in many fields, especially in biomedical applications. In this study Rheum ribes Lam-derived AuNPs (Rrib AuNPs) were synthesized in an environmentally friendly, easy and low-cost method using the extract obtained from the waste skin of the fruit known as Rheum ribes Lam (Kurdish banana). Functional groups of phytochemicals responsible for redox reactions were determined by FTIR data. Properties of synthesized Rrib AuNPs UV-vis, TEM, FE-SEM, Zeta potential, XRD, AFM, TGA-DTA), EDX), Zetasizer devices. In the characterization data, it was determined that Rrib AuNPs had an average size distribution of 58.27 nm, a spherical appearance morphology, a maximum absorbance of 543.96 nm, a surface charge of 23.0 mV, a monodisperse and stable structure. It was determined by microdilution that the synthesized Rrib AuNPs had antibacterial and anti-fungal effects with 0.03–0.50 mg ml1 Minimum Inhibition Concentration amounts. The cytotoxic effects of Rrib AuNPs on cancer and healthy cell lines were investigated using the MTT method.Article Synthesis, Characterization, and Evaluation of the Antimicrobial Activities of Silver Nanoparticles From Cyclotrichium Origanifolium L.(2022) Keskin, Cumali; Aktepe, Necmettin; Baran, Ayşe; Aktepe, Necmettin; Baran, Ayşe; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; Department of Nursing / Hemşirelik BölümüCyclotricium origanifolium is a plant belonging to the Lamiaceae family and is a species that grows in the Western and Southern Anatolian regions of Turkey. In our study, the antimicrobial activities of silver nanoparticles (AgNP) were investigated through Cyclotricium origanifolium plant extract. Characterization processes of the obtained AgNPs, suitable spectral analysis methods; Uv-Vis was determined by FT-IR, SEM-EDX, XRD. According to the results of the analysis, it was determined that the AgNPs were spherical in shape and had an average diameter of 17.60 nm. The antimicrobial effect of AgNPs was determined by the minimum inhibition concentration (MIC) method. Gram positive as test microorganisms; Staphylococcus aureus, Bacillus subtilis and gram negative; Escherichia coli, Pseudomonas aeruginosa bacteria, and Candida albicans fungal pathogen species were used. The suppression of microorganism growth was investigated by comparing the efficacy of standard antibiotics used in our study with AgNPs produced by the green synthesis method. It has been observed that the obtained AgNPs have a very strong effect on gram-positive B. subtilis and gram-negative E. coli bacteria, and are more effective against C. albicans than the normal antifungal drug. It was determined that the antimicrobial activity of AgNPs produced from C. origanifolium L. plants showed a stronger effect than standard antibiotics.Article Citation - Scopus: 0Utilization of edible mushroom for nanomaterial-based bioactive material development(Iranian Journal of Materials Science and Engineering, 2021) Acay, Hilal; Yıldırım, Ayfer; Baran, Ayşe; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüGold nanoparticles (AuNP) were synthesized using edible mushroom Russula delica (RD) in this study. Possibilities to evaluate these synthesized nanoparticles (RD-AuNPs) as bioactive substances were investigated. Characterization of synthesized RD-AuNPs were characterized via UV-vis, XRD, FTIR, EDX. In a spherical view, RD-AuNPs with a crystal size of 34.76 nm were synthesized. As a result, fungal systems used for nanomaterial biosynthesis as an effective alternative to chemical synthesis can be used in different biotechnological and medical applications. RD-AuNPs produced by green synthesis can be evaluated in this context.Article Citation - WoS: 2Citation - Scopus: 3Activated Carbon-Coated Iron Oxide Magnetic Nanocomposite (ionps@ctac) Loaded With Morin Hydrate for Drug-Delivery Applications(Frontiers Media Sa, 2024) Dogan, Yusuf; Ozic, Cem; Ertas, Erdal; Baran, Ayse; Rosic, Gvozden; Selakovic, Dragica; Eftekhari, Aziz; Doğan, Yusuf; Baran, Ayşe; Department of Plant Protection / Bitki Koruma BölümüCancer is a major disease that affects millions of people around the world every year. It affects individuals of all ages, races, and backgrounds. Since drugs used to treat cancer cannot distinguish between cancerous and healthy cells, they cause systemic toxicity along with serious side effects. Recently, controlled drug-release systems have been developed to reduce the side effects caused by anticancer drugs used for treatment. Morin is an anticancer drug with a flavonol structure. It has been extensively researched for its antioxidant, anti-inflammatory, antitumoral, and antibacterial properties, especially found in Chinese herbs and fruits, and its multiple positive effects on different diseases. In this study, a nanocomposite with magnetic properties was synthesized by coating biocompatible activated carbon obtained using the fruits of the Celtis tournefortii plant on the surface of iron oxide magnetic nanoparticles. Characterization of the synthesized activated carbon-coated iron oxide magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction, dynamic light scattering, zeta potential, and vibrating sample magnetometry. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (colorectal), T98-G (glioblastoma) cancer cell lines, and human umbilical vein endothelial cell (HUVEC) healthy cell line. The morin loading and release behavior of the activated carbon-coated iron oxide magnetic nanocomposite were studied, and the results showed that up to 60% of the adsorbed morin was released within 4 h. In summary, activated carbon-coated iron oxide magnetic nanocomposite carriers have shown promising results for the delivery of the morin drug.Article Artemisia Absinthium Bitki Ekstraktından Altın Nanopartiküllerin Çevre Dostu Hızlı Sentezi ve Antimikrobiyal Aktivitelerin Uygulanması(2021) Keskin, Cumali; Baran, Mehmet Fırat; Baran, Ayşe; Baran, Ayşe; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüNanopartiküller, üstün özelliklerinden dolayı birçok alanda kullanılmaktadır. Son zamanlarda, bu parçacıkların çevre dostu sentez yöntemleri kullanılarak üretilmesi çok popüler hale gelmiştir. Bu bağlamda, bu çalışmada, altın nanopartiküller (AuNP'ler), Artemisia absinthium'un (pelin otu) yeşil yaprak özütü ile hızlı ve çevre dostu bir yöntem kullanılarak sentezlenmiştir. AuNP'lerin tane boyutu Debye-Scherrer denklemine göre 13.40 nm olarak belirlendi. AuNP'lerin test edilen mikroorganizmaların büyümesi üzerindeki inhibe edici etkileri, minimum inhibe edici konsantrasyon (MİC) yöntemi ile belirlenmiştir. MİC, bir mikroorganizmanın büyümesini engelleyen bir antimikrobiyal maddenin minimum konsantrasyonu olarak tanımlanmaktadır. Elde edilen AuNP'ler, sırasıyla 0.250, 0.125, 0.125, 0.033 ve 0.66 mg mL-1 konsantrasyonlarında S. aureus, S. pyogenes, E. coli, P. aeruginosa suşları ve C. albicans mayası üzerinde önleyici etkiler göstermiştir.
