Baran, Ayşe
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Baran, Ayse
Baran, A.
Baran, Ayşe
Baran, A.
Baran, A.
Baran, Ayşe
Baran, A.
Job Title
Dr. Öğr. Üyesi
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BİTKİSEL VE HAYVANSAL ÜRETİM
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Current Staff
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Sustainable Development Goals
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
2
ZERO HUNGER
1
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5
GENDER EQUALITY
0
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6
CLEAN WATER AND SANITATION
3
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13
CLIMATE ACTION
0
Research Products
10
REDUCED INEQUALITIES
0
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16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
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8
DECENT WORK AND ECONOMIC GROWTH
0
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15
LIFE ON LAND
0
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3
GOOD HEALTH AND WELL-BEING
38
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9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
6
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14
LIFE BELOW WATER
4
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4
QUALITY EDUCATION
0
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1
NO POVERTY
0
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7
AFFORDABLE AND CLEAN ENERGY
4
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11
SUSTAINABLE CITIES AND COMMUNITIES
4
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12
RESPONSIBLE CONSUMPTION AND PRODUCTION
2
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This researcher does not have a Scopus ID.
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Scholarly Output
71
Articles
66
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359/3235
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0
Supervised PhD Theses
1
WoS Citation Count
716
Scopus Citation Count
902
WoS h-index
14
Scopus h-index
16
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0
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0
WoS Citations per Publication
10.08
Scopus Citations per Publication
12.70
Open Access Source
49
Supervised Theses
1
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| Journal | Count |
|---|---|
| International Journal of Agriculture, Environment and Food Sciences | 7 |
| ChemistrySelect | 4 |
| Frontiers in Pharmacology | 3 |
| Medicine Science | 3 |
| Advances in Biology and Earth Sciences | 3 |
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71 results
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Now showing 1 - 10 of 71
Article Citation - WoS: 27Citation - Scopus: 33Green Synthesis and Characterization of Silver Nanoparticles Using Anchusa Officinalis: Antimicrobial and Cytotoxic Potential(Dove Medical Press Ltd, 2025) Keskin, Cumali; Aslan, Seyhan; Baran, Mehmet Firat; Baran, Ayse; Eftekhari, Aziz; Adican, Mehmet Tevfik; Mohamed, Ali JimaleObjective: Anchusa officinalis L. (A. officinalis) is a herbaceous traditional medicinal plant used in the treatment of some diseases. The presence of its medicinal properties suggested that A. officinalis (AO) leaf extract could be used as a coating agent for the environmentally friendly production of silver nanoparticles (AgNPs). Methods: The synthesized biogenic silver nanoparticles (AO-AgNPs) were characterized using different techniques. The antimicrobial activity of AgNPs against common bacterial pathogenic strains was determined by the minimum inhibitory concentration (MIC) method. The presence of phytochemicals was determined by LSMS/MS. The MTT assay was used to investigate AO-AgNPs' cytotoxic activity in malignant (LnCap, Caco2, MDA-MB2, A549) and healthy (HEK-293) cell lines. Results: LC-MS/MS analysis detected the presence of rich phytochemicals that may be responsible for reduction reactions. Biogenic AO-AgNPs exhibited effective inhibition of the growth of pathogenic microorganisms at low concentrations. The most effective antimicrobial activity was measured as 0.5 mu g/mL MIC against S. aureus, E. coli, and C. albicans. Moreover, AO-AgNPs showed significant inhibition on the growth of cancerous cell lines, especially at a concentration of 25 mu g/mL. On the contrary, it was determined that the inhibition rate decreased in the growth of healthy cell lines due to the increase in concentration. The lowest EC50 values were determined as 15.15 mu g/mL in A549 cells. Conclusion: The obtained results showed that AO could be an important source for the synthesis of AgNPs. Especially their ability to inhibit the growth of antibiotic-resistant pathogenic bacteria at low concentrations compared to common antibiotics indicates that AOAgNPs can be used as biomedical agents in various areas. Moreover, their suppressive effect on cancerous cell lines showed that they have the potential to be used as an anticancer agent, but due to their proliferative effect on healthy cell lines, care should be taken in determining the appropriate dose.Article Citation - WoS: 8Citation - Scopus: 10Determination of Chemical Components of the Endemic Species allium Turcicum L. Plant Extract by Lc-ms/Ms and Evaluation of Medicinal Potentials(Cell Press, 2024) Ipek, Polat; Atalar, Mehmet Nuri; Baran, Ayse; Baran, Mehmet Firat; Ommati, Mohammad Mehdi; Karadag, Musa; Khalilov, RovshanThe Allium turcicum L. (Zuzubak) plant as a cultivated vegetable have various health benefits and consumed as a food. Due to the shortcoming evidence in literature and the importance of this plant in folk medicine, in the present study, for the first time, we evaluated the bioactive profile of components (using LC-MS/MS), cytotoxicity, anticancer, antioxidant, and antibacterial prospectives of Zuzubak methanol extract. Reported results show that the extract is rich in bioactive compounds and has anticancer activity with breast cancer cells (MCF-7), human prostate cancer cells (DU -145), and Human osteosarcoma cancer Cell lines of (IC50) in dose dependent manner in the concentration range of 31.25 mu g/mL and 2000 mu g/mL for 24 and 48 h. Western blotting results determined that the extract significantly suppressed the growth of U2OS, MCF-7, and DU -145 cancer cells by down expression of Ang-1 (angiogenic protein) and Beclin-1 (autophagy protein) and overexpression of Bax (a proapoptotic protein). The oxidative stress indices showed a reduction in RPE-1 and MCF-7 cells and an upsurge in U2OS and DU -145 cells. Additionally, the antimicrobial assay showed suppression of the growth of various pathogenic microorganisms in 4.00 - 8.00 mu g/concentrations of Zuzubak extract using the microdilution method. The phytochemicals identified showed promising anticancer, antioxidant effects, and antimicrobial properties, representing a valuable herbal source for drug development studies.Article Citation - Scopus: 4Inhibitory effects of gold nanoparticles biosynthesized by redox reaction using Rheum ribes lam fruit peels on pathogen strains and cancer cells(Particulate Science and Technology, 2023) Baran, AyşeGold nanoparticles (AuNPs) are very valuable materials used in many fields, especially in biomedical applications. In this study Rheum ribes Lam-derived AuNPs (Rrib AuNPs) were synthesized in an environmentally friendly, easy and low-cost method using the extract obtained from the waste skin of the fruit known as Rheum ribes Lam (Kurdish banana). Functional groups of phytochemicals responsible for redox reactions were determined by FTIR data. Properties of synthesized Rrib AuNPs UV-vis, TEM, FE-SEM, Zeta potential, XRD, AFM, TGA-DTA), EDX), Zetasizer devices. In the characterization data, it was determined that Rrib AuNPs had an average size distribution of 58.27 nm, a spherical appearance morphology, a maximum absorbance of 543.96 nm, a surface charge of 23.0 mV, a monodisperse and stable structure. It was determined by microdilution that the synthesized Rrib AuNPs had antibacterial and anti-fungal effects with 0.03–0.50 mg ml1 Minimum Inhibition Concentration amounts. The cytotoxic effects of Rrib AuNPs on cancer and healthy cell lines were investigated using the MTT method.Article Citation - Scopus: 39Development, Characterization and Application of Chitosan-Based Formulation Incorporating Crataegus Orientalis Extract for Food Conservation(Jomard Publishing, 2025) Evcil, Murat; Kurt, Barış; Baran, Ayse; Mouhoub, Anouar; Karakaplan, MehmetIn this investigation, chitosan-based films loaded with plant extracts from Crataegus orientalis (CR) were elaborated and evaluated in terms of structural, physicochemical and antimicrobial properties. Firstly, the CR extract was characterized by LC-MS/MS showing an abundance of Protocatechuic acid (56.82 μg/g) and Chlorogenic acid (67.13 μg/g). Then, the extract was incorporated into chitosan-based films at different concentrations (CHCR1-3). Findings revealed modifications in FTIR and XRD graphs as well as SEM micrographs following the incorporation of CR extract confirming the changes in the matrix structure and texture. Moreover, the addition of the extract reduced the transparency, swelling ratio, water solubility and moisture content potencies while increasing considerably the material thickness reaching 2.5-fold as regards CHCR3. Furthermore, Thermogravimetric findings showed three stages of degradation for CH control and CHCR2, with mass loss due to water evaporation and glycerol breakdown. Ultimately, CHCR bioformulations showed significant antimicrobial activity against Escherichia coli, Staphylococcus aureus and Candida albicans, especially in the case of the CHCR3, which was verified by the application as a preservative coating for lemon fruit. These encouraging results highlight the potential utilization of CHCR bioformulation as coating/packaging for perishable food products. © 2025 Elsevier B.V., All rights reserved.Article Synthesis, Characterization and Evaluation of Antimicrobial Activities of Silver Nanoparticles Obtained From Rumex Acetosella L. (sorrel) Plant(2022) Aktepe, Necmettin; Bütüner, Hafize; Baran, Ayşe; Keskin, Cumali; Baran, Mehmet FıratRumex acetosella L. (sorrel) is a plant belonging to the Polygonaceous family and is a species that grows naturally across Turkey. In this study, the characterization of silver nanoparticles (AgNPs) obtained from the Rumex acetocella L. (RA) plant using the green synthesis method was performed and their antimicrobial activities were investigated. AgNPs were successfully synthesized in the first stage of the study using plant extract taken from plant samples collected from the natural growing environment. Characterization of synthesized AgNPs was performed using appropriate analytical methods (UV-vis, FT-IR, XRD, SEM-EDX, TEM, Zeta Potential and Zeta Sizer). According to the analysis results, it was determined that AgNPs had a maximum absorbance at 476 nm wavelength, a pentagonal, hexagonal, and spherical appearance, a size of 29.16 nm, and a zeta potential of -9.88 mV. The antimicrobial activities of AgNPs were tested using the microdilution technique, in which Minimum Inhibition Concentration (MIC) values were determined on gram-positive Staphylococcus aureus, Bacillus subtilis and gram-negative Pseudomonas aeruginosa, Escherichia coli bacteria and Candida albicans fungus. It showed a very strong antimicrobial effect on C. albicans, S. aureus and P. aeruginosa. Consequently, AgNPs had stronger antimicrobial activity at low concentrations and when compared to commercial antibiotics.Article Citation - WoS: 6Citation - Scopus: 7Green Synthesis Study: Adsorption of Congo Red Dye With Selenium Nanoparticles Obtained From prunus Armeniaca L. Leaf Waste(Wiley-v C H verlag Gmbh, 2024) Turna, Talip; Solmaz, Alper; Baran, AyseIn this study, it was aimed to remove Congo Red (CR) dye in aqueous solution by biosynthesized Selenium Nanoparticles from Prunus armeniaca L. (PAL-SeNPs) leaf wastes by green synthesis method. The characteristic structure of PAL-SeNPs was determined by UV-vis spectroscopy, X-ray diffraction (XRD), Brunauer-Emmett-Teller (BET), scanning electron microscope (SEM), energy dispersive X-ray (EDX), fourier transform infrared spectroscopy (FTIR), thermogravimetry-differential thermal analysis (TGA-DTA), dynamic light scattering (DLS), zetasizer, and point of zero charge (pHpzc). The effects of pH, adsorbent amount, time, initial concentration, and temperature were investigated by batch adsorption studies. 2 different kinetic and 4 isotherm models were tested and error analysis functions were determined for the most suitable model. Accordingly, the particle size, crystallinity, pHpzc value and average surface charge of PAL-SeNPs were determined as 9.969 nm, 48.50 %, 3.47, and -23.6 mV, respectively. Also, the most suitable kinetic and isotherm models for the removal of CR dye with PAL-SeNPs were found as Pseudo-second-order and Freundlich, with R2 values of 0.996, respectively. Also, where the optimum pH was 7.00, the maximum adsorption capacity was calculated as 96.59 mgCR/gPAL-SeNPs. The results obtained show that environmentally friendly and low-cost PAL-SeNPs produced by the green synthesis method are a suitable alternative for the removal of CR dye.Article Gümüş Nano Malzemelerin Çevre Dostu, Hızlı Sentezi ve Biomedikal Uygulamaları(2021) Baran, AyşeBu çalışmada, ceviz yaprakları kullanılarak hazırlanan özüt ile gümüş nano malzemeler çevre dostu hızlı ve basit bir şekilde sentezlendi. Elde edilen bu malzemelerin karakterizasyonu UV-visiblespektrofotometre (UV-Vis.), Fourier dönüşümü kızılötesi spektroskopisi (FTIR), X- Işınımı Kırınımı Difraktrometresi(XRD), Taramalı Elektron Mikroskobu (SEM), zeta potansiyeli analiz verileri ile belirlendi. Gümüş nano malzemelerin 454.01 nm dalga boyunda maksimum absorbans, 23.66 nm kristal nano boyut, küresel görünüm ve -11.53 mV zeta potansiyeline sahip oldukları belirlendi. Biomedikal ugulamalar için anti-mikrobiyal etkileri patojen türler üzerinde incelendi. Bu türler üzerinde Minumum İnhibisyon Konsantrasyonları (MİK) 0.25-1.0 mg/L olarak mikrodilusyon yöntemi ile belirlendi.Article Farklı Biyosorbentler Kullanarak Su Ortamında Ağır Metallerin Biyosorbsiyon Metodu ile Giderilmesi(2022) Düz, M.zahir; Keskin, Cumali; Aktepe, Necmettin; Baran, Mehmet Fırat; Baran, AyşeSu canlılar için ekosistemin önemli parçasıdır. Endüstrileşme ile birlikte su kaynaklarındaki kirlenme endişe edilir boyutlara ulaşmıştır. Ağır metallere bağlı su kirliliği ve artan konsantrasyonları su ekosistemlerine verdiği zarar nedeniyle araştırmacıların konuya olan ilgisinin artmasına sebep olmuştur. Ağır metallerin sularda oluşturduğu kirliliği gidermek ciddi maliyet ve zaman gerektirmektedir. Son yıllarda suda bulunan ağır metallerin uzaklaştırılması için bakteriler kullanılarak biyosorbsiyon yönteminin kullanılması yaygınlaşmıştır. Bu yöntemin tercih edilmesinin temel sebebi gram pozitif bakterilerin hücre duvarında kalın bir peptidoglikan tabakasına sahip olması ile adsorbsiyon kapasitesini artırmasıdır. Bu çalışmada içme, atık, nehir suları ve suni olarak hazırlanan numunelerde çalkalamalı metod kullanarak ağır metal biyosorbsiyonu ile birlikte çoklu hazırlanmış ağır metal çözeltilerinde biyosorbsiyon rekabeti incelenmiştir. Bu işlemler için Dicle nehri bölgesine ait topraklardan izole edilen Bacillus licheniformis sp. Bacillus subtilis sp. ve Bacillus subtilis (ATCC 6051) suşları ile sulu çözeltiden Cd (II), Cu (II), Pb (II), Fe (II), Ni (II) ve Zn (II) metallerinin biyosorbsiyonu değerlendirildi. B. subtilis suşları ve B.licheniformis sp. organizmalarının yüzey morfoljik yapıları SEM görüntüleri, element kompozisyonları EDAX verileri ile incelendi. ICP-OES kullanılarak element içeriği tespit edildi. Sulu çözeltideki Cd (II), Cu (II), Pb (II), Fe (II), Ni (II) ve Zn (II) metal iyonları farklı pH’larda 25 °C de 0,25 mg L-1 biomass ile biyosorbsiyon gerçekleştirildi. pH 6.0 da maksimum biyosorbsiyon ile metal iyonlarının % 98 varan oranda giderildiği belirlendi.Article Citation - WoS: 7Citation - Scopus: 9Silver Nanoparticles for Anticancer and Antibacterial Therapy: a Biogenic and Easy Production Strategy(Wiley-v C H verlag Gmbh, 2025) Dogan, Serap; Baran, Ayse; Baran, Mehmet Firat; Eftekhari, Aziz; Khalilov, Rovshan; Aliyev, Elvin; Smutok, OlehMetal nanoparticles are very valuable products due to their wide range of uses. Among these silver nanoparticles are beneficial products used in many fields, especially in medicine, due to their antibacterial properties. This research aimed to produce silver nanoparticles (Ag NPs) that are both affordable and environmentally friendly. For this purpose, Ag NPs were quickly obtained from domestic waste components of the carrot plant (Daucus carota L.). The UV-vis spectrophotometric, TEM, AFM, FE-SEM, STEM, EDX, XRD, and DLS analyses were performed to determine the properties of the obtained Ag NPs. It has been found that their surface charge is -21.8 mV, with a maximum absorbance at a wavelength of 421.37 nm, spherical appearance, and an average size distribution of 85.41 nm. The anticancer and antibacterial activities of the produced Ag NPs were investigated by MTT and microdilution. The synthesized Ag NPs showed the most significant antimicrobial effect on Pseudomonas aeruginosa ATCC 27833 with microdilution and low concentration. However, they were also determined to be effective on Bacillus subtilis ATCC 11774 and on Candida albicans ATCC 10231 pathogenic strains. In fact, the effective concentrations of Ag NPs on these strains were significantly lower than the antibiotics used. Furthermore, aside from exhibiting a superior anticancer impact on CaCO-2 cancer cells, it was established that Ag NPs also had remarkable efficacy in inhibiting U118 and Skov-3 cancer cells.Article Citation - WoS: 2Citation - Scopus: 2Deciphering the Effect Of Potentilla Fulgens Root Extract Against Healthy Huvec Cell Line and Cancer Cell Lines (a549 and Skov-3)(Elsevier, 2024) Ipek, Polat; Baran, Ayse; Baran, Mehmet Firat; Eftekhari, Aziz; Khusro, Ameer; Ommati, Mohammad Mehdi; Almutairi, Saeedah MusaedBackground: Potentilla fulgens, , a highly valued indigenous medicinal herb grown in high altitudes of the Himalayan region with anticancer, hypoglycaemic, antibacterial, anti-inflammatory, and antiulcerogenic properties, are used in traditional systems of medicine. This study was aimed to investigate the effect of P. fulgens root extract, as one of the natural alternatives to chemotherapeutic drugs used in cancer treatment, on proliferation, apoptosis, and autophagy of human non-small cell lung cancer cell line (A549), human ovarian cancer cell line (SKOV-3), and healthy human umbilical vein endothelial cell line (HUVEC). Methods: Anti-proliferative effect was assessed by MTT assay. The expression of autophagy and apoptosis-related proteins was evaluated by western blotting. Total oxidant status (TOS) and total antioxidant capacity (TAC) test were determined using standard kit methods. Results: Our results showed that the extract inhibited proliferation of HUVEC, A549, and SKOV-3 cells in a dose- dependent manner. MTT assay analysis revealed that the extract significantly (P<0.05) P <0.05) induced mortality in HUVEC, A549, and SKOV-3 cells. Western blot results revealed increased expression of NF-kappa B after the extract treatment but led to the down-regulation in Beclin-1, Bax, extracellular-signal-related kinase 1 and 2, Sequestosome-1, and cleaved Casp-3 levels. Treatment groups showed an increase in TOS and TAC values in A549 and SKOV-3 cell lines, while HUVEC cell line showed an increase in TAC and a decrease in TOS values, compared to the control group. Conclusions: Our findings indicated that P. fulgens root extract inhibited the proliferation of healthy cells and cancer cells through cell cycle arrest, representing its limited application as therapeutic agent in cancer treatment.
