Profile URL: https://hdl.handle.net/20.500.12514/8280
Job Title:Doç. Dr.
Main Affiliation:Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Status: Former Staff
Name Variants:
Baran, M. F. Baran, Mehmet Firat
88 results
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Book Part Effects of Essential Oil-Based Nanoparticles on the Plant Defense System(Elsevier, 2026) Yıldıztekin, Mahmut; Baran, Mehmet Fırat; Güneş, Zübeyir; Aktepe, Necmettin; Baran, AyşeArticle Citation - WoS: 25Citation - Scopus: 27Green synthesis and characterization of selenium nanoparticles (Se NPs) from the skin (testa) of Pistacia vera L. (Siirt pistachio) and investigation of antimicrobial and anticancer potentials(SpringerLink, 2023-05-30) Keskin, Cumali; Mehmet Fırat Baran, Cumali Keskin, Ayşe Baran, Kadri Kurt, Polat İpek, Aziz Eftekhari, Rovshan Khalilov, Ismayil Fridunbayov, William C. Cho; Baran, Mehmet Firat; Eftekhari, Aziz; Kurt, Kadri; Baran, Ayse; Ipek, Polat; Cho, William C.Metallic nanoparticles created by ecologically friendly synthesis processes are becoming increasingly useful in a variety of applications. Because of their strong bioactive component qualities, biocompatible architectures, high stability, and low toxicity, green-produced selenium nanoparticles are particularly signifcant materials for various medicinal applications. Plants include a wealth of essential phytochemicals with therapeutic and medical capabilities. Pistachio vera L. (Siirt pistachio) is a seasonal fruit that is frequently consumed for its nutritional worth and health advantages. However, the outer colored skin of the P. vera (Siirt pistachio) fruit, which is not consumed, contains many biologically active compounds. In this study, plant-mediated synthesis of selenium nanoparticles (SeNPs) was successfully accomplished after adding the sodium selenite solution to the aqueous extract of P. vera colored skin waste. The synthesized Se NPs were characterized with UV–Vis, transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta distribution, atomic force microscope (AFM), Fourier transform infrared spectrum (FTIR), thermogravimetric (TGA) and diferential thermal analysis, X-ray difraction (XRD), and energy-dispersive X-ray spectrum (EDX). Biogenic Pistacia vera (PV) PV-SeNPs were also tested for their ability to suppress the development of various pathogenic bacteria and cancerous cell lines. The UV-visible (UV–Vis) spectra revealed an absorption peak at 325 nm, which refected the surface plasmon band. The signifcant selenium signal on the EDX spectrum at 1.5 keV confrmed the creation of Se NPs. The presence of several peaks on the FTIR spectrum of the aqueous extract of Pv and the nanoparticles indicated the presence of some important functional groups such as amines, carbonyl compounds, and phenols, which are important in facilitating the process of capping and bioreduction, as well as conferring stability to nanoparticles. The TEM microphotographs revealed that the nanoparticles were highly distributed, had a spherical morphological form, and were monodisperse below 10 nm. Biogenic Pv-SeNPs exhibited similar antimicrobial activity as standard antibiotics. However, it was determined that the cytotoxic activity of Se-NPs against cancer cell lines was quite high depending on the dose and time. As a result, the Pv-SeNPs are likely to be extremely benefcial in the pharmaceutical and cosmetic sectors, as well as in the food and cosmetic industries, in producing antimicrobial and/or anticancer medications.Article Citation - WoS: 30Citation - Scopus: 32Green Synthesis, Characterization and Antimicrobial Activity of Silver Nanoparticles (AgNPs) from Maize (Zea Mays L.)(Aloki Applied Ecological Research and Forensic Inst Ltd, 2019) Eren, A.; Baran, M. F.In recent years, the biosynthesis (green synthesis) of metal nanoparticles such as silver nanoparticles (AgNPs) have become one of the safest, most cost-effective and environmentally friendly approaches. In this study, AgNPs were synthesized using maize (Zea mays L.) leaves. For the characterization of synthesized AgNPs different techniques were used, such as X-ray diffraction spectroscopy (XRD), Ultraviolet visible (UV-Vis) spectroscopy, transmission electron microscopy (TEM), Energy dispersive X-ray spectroscopy (EDX), Fourier-transformed infrared spectroscopy (FT-IR) and Thermal gravimetric and Differential thermal analysis (TGA-DTA). The XRD results showed that AgNPs had a mean diameter of 12.63 nm and a crystal-like appearance. In addition, antimicrobial activities of synthesized AgNPs were evaluated using 3 different antibiotics against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus bacteria and Candida albicans yeast. Antifungal activity of AgNPs with antibiotics has been observed to be better than the antibiotics against Gram-positive and Gram-negative bacteria. The minimum inhibitory concentrations were found to be 0.084, 0.337 and 0.021 mg mL(-1) for Escherichia coli, Staphylococcus aureus, and Candida albicans, respectively. The results revealed that AgNPs synthesized from maize leaf extract have antibacterial activity against Gram-negative Escherichia coli, Gram-positive Staphylococcus aureus and antifungal activity against Candida albicans yeast, and that the produced AgNPs could be used in the production of biomedical products and in the pharmaceutical industry.Article Citation - WoS: 120Citation - Scopus: 128Investigation of Antimicrobial and Cytotoxic Properties and Specification of Silver Nanoparticles (AgNPs) Derived From Cicer arietinum L. Green Leaf Extract(FRONTIERS, 2022-03-07) Baran, Ayşe; Baran, Mehmet Fırat; Keskin, Cumali; Hatipoğlu, Abdulkerim; Yavuz, Omer; Eftekhari, Aziz; İrtegün Kandemir, Sevgi; Fırat Baran, MehmetUsing biological materials to synthesize metallic nanoparticles has become a frequently preferred method by researchers. This synthesis method is both fast and inexpensive. In this study, an aqueous extract obtained from chickpea (Cicer arietinum L.) (CA) leaves was used in order to synthesize silver nanoparticles (AgNPs). For specification of the synthesized AgNPs, UV-vis spectrophotometer, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction analysis (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), electron dispersive X-ray (EDX), and zeta potential (ZP) analyses data were used. Biologically synthesized AgNPs demonstrated a maximum surface plasmon resonance of 417.47 nm after 3 h. With the powder XRD model, the mean crystallite dimension of nanoparticles was determined as 12.17 mm with a cubic structure. According to the TEM results, the dimensions of the obtained silver nanoparticles were found to be 6.11–9.66 nm. The ZP of the electric charge on the surface of AgNPs was measured as −19.6 mV. The inhibition effect of AgNPs on food pathogen strains and yeast was determined with the minimum inhibition concentration (MIC) method. AgNPs demonstrated highly effective inhibition at low concentrations especially against the growth of B. subtilis (0.0625) and S. aureus (0.125) strains. The cytotoxic effects of silver nanoparticles on cancerous cell lines (CaCo-2, U118, Sk-ov-3) and healthy cell lines (HDF) were revealed. Despite the increase of AgNPs used against cancerous and healthy cell lines, no significant decrease in the percentage of viability was detected. Copyright © 2022 Baran, Fırat Baran, Keskin, Hatipoğlu, Yavuz, İrtegün Kandemir, Adican, Khalilov, Mammadova, Ahmadian, Rosić, Selakovic and Eftekhari.Article Citation - Scopus: 2Investigation of Antimicrobial, Anticholinesterase Activities, and Phenolic Contents of Extracts Obtained from Prunus Cerasus (Sour Cherry) Fruit(Institute of Economic Development and Social Researches, 2025) Baran, Mehmet Fırat; Topgider, Özgür; Keskin, Cumali; Asyali, Şeyma; Baran, Ayşe; Aras, İbrahim Oğuz; Bilici, EsraArticle Citation - WoS: 89Citation - Scopus: 103Biosynthesis, characterization, and investigation of antimicrobial and cytotoxic activities of silver nanoparticles using Solanum tuberosum peel aqueous extract(Elsevier, 2023) Xu, Jiujun; Yıldıztekin, Mahmut; Han, Dayong; Keskin, Cumali; Baran, Ayşe; Baran, Mehmet Fırat; Eftekhari, Aziz; Aytuğ Ava, Canan; İrtegün Kandemir, Sevgi; Cebe, Deniz Barış; Dağ, Beşir; Beilerli, Aferin; Khalilov, RovshanMetallic nanoparticle biosynthesis is thought to offer opportunities for a wide range of biological uses. The green process of turning biological waste into utilizable products gaining attention due to its economical and eco-friendly approach in recent years. This study reported the ability of Solanum tuberosum (ST) peel extract to the green synthesis of non-toxic, stable, small-sized silver nanoparticles without any toxic reducing agent utilizing the phytochemical components present in its structure. UV-visible spectroscopy, X-ray diffraction analysis, Fourier transform infrared spectroscopy, flourier scanning electron microscopy, atomic force microscopy, transmission electron microscopy, and energy dispersive analysis X-ray confirmed the biosynthesis and char-acterization of silver nanoparticles. Also, dynamic light scattering and thermogravimetric ana-lyses showed stable synthesized nanoparticles. The antibacterial activity of the biosynthesized silver nanoparticles was evaluated against four different bacterial strains, Escherichia coli (E. coli), Pseudomonas aeruginosa (P. aeruginosa), Staphylococcus aureus (S. aureus) Bacillus subtilis (B. subtilis), and a yeast, Candida albicans (C. albicans) using the minimum inhibitory concen-tration technique. The cytotoxic activities were determined against Human dermal fibroblast (HDF), glioblastoma (U118), colorectal adenocarcinoma (CaCo-2), and human ovarian (Skov-3) cell lines cancer cells using MTT test. The nanoparticle capping agents that could be involved in the reduction of silver ions to Ag NPs and their stabilization was identified using FTIR. Nano -particles were spherical in shape and had a size ranging from 3.91 to 27.07 nm, showed crys-talline nature, good stability (-31.3 mV), and the presence of capping agents. ST-Ag NPs significantly decreased the growth of bacterial strains after treatment. The in vitro analysis showed that the ST-Ag NPs demonstrated dose-dependent cytotoxicity against cell lines. Based on the data, it is feasible to infer that biogenic Ag NPs were capped with functional groups and demonstrated considerable potential as antibacterial and anticancer agents for biomedical and industrial applications.Article Fatty acid compositions of total lipid, phospholipid and triacylglycerol fractions of the wild edible mushroom pleurotus ostreatus and russula delica with cytotoxic activities on prostate carcinoma cell lines(2019) Acay, Hilal; Baran, Mehmet FıratThe aim of the study to investigate fatty acids (FAs) of Pleurotus ostreatus and Russula delica in Total Lipid (TL), Triacylglycerol (TG) and Phospholipid (PL) fractions. The major FAs of TL, TG, PL in both species were palmitic acid (PA), oleic acid (OLA), and linoleic acid (LA). In both species, total PUFA amounts were found to be higher than total monounsaturated fatty acids (MUFA) and total saturated fatty acids (SFA) in TL, TG and PL fractions. Also, insufficiently studied cytotoxic activity (using prostate carcinoma (PC-3) cell lines) of these mushrooms were investigated by using various solvent systems. Ethyl acetate extract of Pleurotus ostreatus and Russula delica showed significant inhibitory value at the concentrations of 520-530 μg/ml (99.45-92.82%) against PC-3 cell lines with the half-maximal inhibitory concentration (IC50); 274.53-297.77 μg/mL respectively. The present study is a guide for biochemical and nutritional values of both species and can be useful for further investigation on pharmacological applications.Article Citation - WoS: 5Citation - Scopus: 6Nano-Enabled Biochar Modulate Arsenic Toxicity in Plants: a Step Towards Crop Safety and Health(Springer Int Publ Ag, 2025-06-30) Faizan, Mohammad; Sharma, Pooja; Eren, Abdullah; Afzal, Shadma; Alam, Pravej; Baran, Mehmet Firat; Hayat, ShamsulAs global agricultural demands continue to rise amidst increasing environmental stressors, enhancing plant resilience has become a critical necessity. Heavy metals (HMs), especially arsenic (As), severely impact crop productivity and quality, threatening global food security and human health. Arsenic toxicity disrupts normal physiological, biochemical and molecular processes in food crops due to its eco-toxicological effects. Nano-enabled biochar (Nano-BC) has emerged as a promising soil amendment capable of mitigating As-induced oxidative stress in horticultural crops by modulating stress responses, enhancing detoxification pathways and improving plant resilience. This review comprehensively examines the interactions of Nano-BC with soil matrices and microbial communities, highlighting its dual role in influencing soil health and plant growth. While Nano-BC improves soil structure, increases nutrient retention and supports beneficial microbial populations, its potential long-term ecological impacts and interactions with native microbial communities require further evaluation. Furthermore, we discuss the mechanisms by which Nano-BC modulates As bioavailability, phyto-toxicity and detoxification pathways in horticultural crops. Advances in Nano-BC applications have demonstrated its potential in producing "pollution-safe" crops, yet challenges remain regarding its environmental fate and persistence. Future research should focus on optimizing Nano-BC formulations to enhance its efficiency while minimizing unintended ecological consequences. By integrating Nano-BC into sustainable agricultural practices, we can move closer to achieving food security, mitigating HM stress in crops and aligning with global sustainable development goals (SDGs).Article Citation - WoS: 12Citation - Scopus: 13Green Synthesis of Silver Nanoparticles Derived from Papaver rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties(MDPI, 2023-09-04) İpek, Polat; Yıldız, Reşit; Baran, Mehmet Fırat; Hatipoğlu, Abdülkerim; Baran, Ayşe; Sufianov, Albert; Beylerli, OzalIn the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet-visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and atomic force microscope (AFM)), structural (X-ray diffractometer (XRD) and zetasizer), and analytic (thermogravimetric/differential thermal analyzer (TGA-DTA)) characterization of the silver nanoparticles (AgNPs) produced from Papaver rhoeas (PR) L. leaf extract are presented. PR-AgNPs are generally spherical and have a maximum surface plasmon resonance of 464.03 nm. The dimensions of the manufactured nanomaterial are in the range of 1.47-7.31 nm. PR-AgNPs have high thermal stability and a zeta potential of 36.1 mV. The minimum inhibitory concentration (MIC) values (mg L-1) of PR-AgNPs on Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans are 1.50, 0.75, 3.00, 6.00, and 0.37, respectively. In the study, the cytotoxic and proliferative effects of PR-AgNPs using the MTT (3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium bromide) method on various cancer cell lines (CACO-2 (human colon adenocarcinoma cell), MCF-7 (human breast cancer cell), T98-G (glioblastoma multiforme cell), and healthy HUVEC (human umbilical vein endothelial cell)) cell lines are presented. After 24 and 48 h of the application, the half-maximum inhibitory concentration (IC50) values (mu g mL(-1)) of PR-AgNPs on HUVEC, CACO-2, MCF-7, and T98-G lines are 2.365 and 2.380; 2.526 and 2.521; 3.274 and 3.318; 3.472 and 3.526, respectively. Comprehensive in vivo research of PR-AgNPs is proposed to reveal their potential for usage in sectors such as nanomedicine and nanochemistry.Article Citation - WoS: 30Citation - Scopus: 39Green Synthesis, Characterization of Gold Nanomaterials using Gundelia tournefortii Leaf Extract, and Determination of Their Nanomedicinal (Antibacterial, Antifungal, and Cytotoxic) Potential(Hindawi, 2022) Keskin, Cumali; Baran, Ayşe; Baran, Mehmet Fırat; Hatipoğlu, Abdulkerim; Adican, Mehmet Tevfik; Atalar, Mehmet Nuri; Huseynova, Irada; Khalilov, Rovshan; Ahmadian, Elham; Yavuz, Ömer; Kandemir, Sevgi İrtegün; Eftekhari, AzizIntroduction. Fighting against cancer and antibiotic resistance are important challenges of healthcare systems, and developing new treatment methods has become the most concentrated area of researchers. Method and Materials. Green synthesis, characterization, and some biological activities of gold nanomaterials (AuNPs) obtained with Gundelia tournefortii (kenger) leaf extract were investigated in this study. Fourier scanning electron microscope, UV-visible spectrophotometer, Fourier transform ınfrared spectroscopy, energy-dispersive X-ray spectrophotometer, X-ray diffraction diffractometer, transmission electron microscope, and Zetasizer instrument data were used to elucidate the structures of nanoparticles. Results. The maximum surface plasmon resonance was observed at 532.15 nm after 1 hour. With the powder XRD model, the mean cubic crystallite size was determined as 23.53 nm. It was observed that the shapes of the obtained AuNPs were spherical, and the dimensions were 5-40 nm and hexagonal. Surface charges (-27 mV) and average size (365.3 nm) of gold nanoparticles were measured with a zeta analyzer. Conclusion. The suppressive effects of AuNPs on the growth of pathogenic microorganisms and healthy and cancer cell lines were determined using the MIC and MTT methods, respectively.