Dündar, Abdurrahman
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Dundar, Abdurrahman
Dundar, A.
Dundar, A.
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anzdundar@gmail.com
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Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
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17
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2
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5
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6
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13
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10
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16
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8
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3
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4
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9
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1
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14
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11
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38
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655
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16
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40
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578
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36
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30
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154/3363
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WoS Citation Count
343
Scopus Citation Count
412
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11
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13
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2
WoS Citations per Publication
9.53
Scopus Citations per Publication
11.44
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12
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3
| Journal | Count |
|---|---|
| BIOREMEDIATION JOURNAL | 3 |
| Atomic Spectroscopy | 2 |
| ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE | 2 |
| Chemosphere | 1 |
| Cogent Food and Agriculture | 1 |
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Article Citation - WoS: 7Citation - Scopus: 6Several biological properties and synthesis of 2-(4-methylthiazol-5-yl) ethoxy substitute zinc phthalocyanine(John Wiley and Sons Ltd, 2023) Güngördü Solgun, Derya; Özdemir, Sadin; Dündar, Abdurrahman; Ağırtaş, Mehmet SalihIn this study, 4-(2-(4-methylthiazol-5-yl) ethoxy) phthalonitrile (3) and zinc phthalocyanine complex (4) were synthesized and characterized. UV–vis and fluorescence spectra, aggregation, and fluorescence parameters of the zinc phthalocyanine compound were investigated. As biological properties, DPPH radical capture, antidiabetic, DNA cutting, antimicrobial, photodynamic antimicrobial, anti-biofilm activities, and microbial cell viability parameters of the compounds were determined. The highest antioxidant activity was found as 62.80% at 100 mg/L concentration with compound 4, and compound 4 also showed the best antidiabetic activity as 65.17% at 400 mg/L concentration. In DNA cutting activity, it was determined that 3 and 4 cut DNA at all concentrations. For compounds 3–4, the minimum inhibitory concentration (MIC) values were found to be 32 and 16 mg/L for Enterococcus hirae and Enterococcus feacalis, respectively. The strongest MIC value of photodynamic antimicrobial activity was achieved as 4 mg/L for E. feacalis with 4. It was observed that both compounds inhibited the microbial viability activity of Escherichia coli by 100% at concentrations of 100 mg/L. Compound 4 inhibited biofilms of Pseudomonas aureginosa and Staphylococcus aureus as 92.48% and 98.56% at 50 mg/L concentration, respectively.Master Thesis COVID-19 tanısı konan hastaların cinsiyet ve yaş faktörlerinin bazı biyokimyasal değerlerle korelâsyonunun araştırılması(Mardin Artuklu Üniversitesi, 2022) Çömez, Mehmet; Dündar, Abdurrahman2019 yılının son döneminde Wuhan şehrinde ortaya çıkan Covid-19 hastalığı çok hızlı bir şekilde dünyaya yayılış göstermiş ve kısa bir süre sonra ülkemizde görülmeye başladı. Covid-19 ile ilgili önemli çalışmalar yapılmakta bu virüs ve benzeri virüs kökenli hastalıkların tespiti ve erken teşhisi ile tedavi amaçlı Crp, Lym, Ferritin, Kan Gazı ve D-dimer gibi bazı biyokimyasal değerlerin düzeylerinin hastalık şiddeti ve diğer biyokimyasal değerler ile ilişkisini değerlendirilmesi ve bu biyokimyasal değerlerin yaş, cinsiyet üzerindeki etkilerini değerlendirmeyi amaçladık. Yaptığımız çalışmada, hasta dosyalarının retrospektif incelenmesine dayalı kesitsel ve tanımlayıcı bir çalışmadır. 01 Haziran 2020 ile 30 Mayıs 2021 tarihleri arasında Kızıltepe devlet hastanesine başvuran ve hastalık tanısı konulan 12 aylık süreçte hastaların Crp, Lym, Ferritin, Kan Gazı ve D-dimer gibi bazı biyokimyasal değerleri ve aynı zamanda bu değerlerin diğer biyokimyasal değerler arasındaki ilişki ile bu değerlerin yaş ve cinsiyete olan etkileri incelendi ve analizleri yapıldı. Araştırma da elde edilen veriler SPSS for Windows 25.0 programı kullanılarak analiz edilmiştir. Verileri değerlendirilirken tanımlayıcı istatistiksel metotları (sayı, yüzde, ortalama, standart sapma) kullanılmıştır. Çalışmamız da inceleyeceğimiz tüm parametreleri eksiksiz olan 01 Haziran 2020 ile 30 Mayıs 2021 tarihleri arasında Kızıltepe devlet hastanesine başvuran ve COVID-19 tanısı koyulan 1812 hasta dahil edildi. Bu hastalardan %51,9'u (n: 941) kadın % 48,1 (n: 871) erkektir. Ve yaş ortalaması 56,58±19,89 olarak hesaplanmıştır. Yaptığımız çalışmaya göre Crp ve Ferritin değerleri erkeklerde daha yüksek, Lenfosit düzeyleri ise kadınlar daha yüksek olduğu saptandı. Ayrıca Crp, Ferritin ve D.Dimer değerleri ile yaş arasında pozitif yönde, Lenfosit ile yaş arasında ise negatif yönde anlamlı bir ilişki saptandı. Biyokimyasal değerlerin hastalığın klinik seyrinde önemli bir biyolojik belirteçler olduğu literatürde ki araştırmalar ile uyumludur. Covid-19 ile ilgili çok sayıda araştırma yapılmış ve literatüre kazandırılmıştır ve yeni çalışmalarda yapılmaktadır. Bizde biyokimyasal değerlerin Covid-19'un klinik seyrinde biyolojik belirteç olarak kullanılması ayrıca bu değerlerin yaş ve cinsiyet üzerindeki ilişkisinin tespitinin hastalığın seyrinde önemli olduğundan bu konu ile ilgili literatüre katkı sağlamayı amaçladık. Hastalığı daha ağır geçiren erkeklerde Crp ve Ferritin değerleri analiz sonuçlarına göre anlamlı yüksek olduğu görüldü. Lenfosit değerinin ise erkeklerde daha düşük olduğu saptandı. Yaşa bağlı olarak ise ileri yaşlarda Crp, Ferritin ve D.Dimer değerlerinin yüksek, Lenfosit değerinin düşük olması mortalite ile bağlantılı olduğunu gösterdi.Master Thesis Bazı makrofungusların fenolik içerikleri ile antioksidan ve antimikrobiyal potansiyellerinin araştırılması(Mardin Artuklu Üniversitesi, 2022) Çetin, Azad; Dündar, AbdurrahmanBu çalışmada 2012-2013 yılları ilkbahar ve sonbahar mevsimlerinde Siirt ve çevresinde toplanan Phallus impudicus, Coprinus silviaticus ile Morchella tomentosa, Amanita fulva adlı makro mantar türlerinin etanol ekstraktlarının bazı fenolik asit içerikleri ile antioksidan ve antimikrobiyal potansiyelleri çalışılmıştır. Söz konusu makro mantarların etanol ekstraktlarının antioksidan potansiyellerinin tespiti amacıyla; DPPH serbest radikal yakalama, metal iyonlarını şelatlama, indirgeme gücü ve süperoksit anyon radikal süpürme testleri uygulanmıştır. Antimikrobiyal aktivitenin belirlenmesi amacıyla da disk difüzyon yöntemi çalışılmıştır. Süperoksit anyon radikal aktivitesinde tespit edilen en yüksek değer % 83,24 ile Morchella tomentosa en düşük değer ise % 73,05 ile Coprinus silviaticus'a ait bulundu. DPPH serbest radikalini söndürme aktivite tekniğinde en fazla etkinliği gösteren Amanita fulva etanolik ekstraktının 1.0, 2.0, 5.0, 10.0, 15.0, 20.0 mg/mL konsantrasyonlardaki etkinlik verilerinin sırasıyla %19.33, %24.46, %58.74, %77.75, %87.89, %88.40 olduğu tespit edilmiştir. Metal şelatlama etkinliğinde kullanılan ekstraktların ve pozitif kontrol olarak çalışılan standartların etkinlik sıralaması EDTA> Amanita fulva> Morchella tomentosa> Phallus impudicus> Coprinus silviaticus> BHT> BHA> Trolox şeklinde tespit edilmiştir. Mantar indirgeme gücü aktivitesinde ise 10.0 mg/mL konsantrasyonda 2,89 aktivite ile en yüksek etkinliği gösteren mantar Morchella tomentosa olarak gözlenmiştir. Antimikrobiyal aktivite testinde ise Enterococcus hirae hariç diğer beş bakteriye karşı en yüksek inhibisyon zonlarını M. tomentosa'nın etanol ekstraktı sergilemiştir.Article Citation - WoS: 2Citation - Scopus: 1Biological Effect of Thiazole-Containing Zinc(II) Phthalocyanine on Different Sizes of Gold Nanoparticles(Amer Chemical Soc, 2025) Ozturk, Nazli Farajzadeh; Uzunmehmetoglu, Hilal Zengin; Yenilmez, Hacer Yasemin; Ozdemir, Sadin; Dundar, Abdurrahman; Bayir, Zehra AltuntasThis study aims to design multidisciplinary bioagents for a wide range of biological applications. The synthesis and characterization of 4,5-bis((4-phenylthiazol-2-yl)thio)phthalonitrile (a) and its octa-substituted zinc(II) phthalocyanine derivative (b) were described in this study. Additionally, gold nanoparticles were synthesized in three different sizes, including 10 nm (1), 45 nm (2), and 80 nm (3). Macromolecule (b) was used for surficial functionalization of gold nanoparticles (1-3) to prepare nanoconjugates (1-3b). Antioxidant, antimicrobial, antibacterial, antibiofilm, antidiabetic, and deoxyribonucleic acid (DNA) cleavage activities of biocandidates (b, 1-3, and 1-3b) were examined to determine the optimum size of gold nanoparticles and the effect of modifying groups on their bioactivity in this study for the first time. The highest antioxidant activities were obtained for biocandidates (b and 1b) at 100 mg/L. The best minimum inhibitory concentration (MIC) values were obtained at 32 mg/L for bioagents (b, 1, and 3b) against E. faecalis whereas the MIC value was obtained at 32 mg/L for 1b against E. hirae and E. faecalis. Bioagents (b and 1-3b) exhibited high APDT activities (16 mg/L) against the studied microorganisms. The highest biofilm inhibition activities were obtained 94.57 and 89.28% for 50 mg/L nanoconjugate (1b) against S. aureus and P. aeruginosa, respectively. All the studied biocandidates inhibited 100% E. coli viability at 50 mg/L. The antidiabetic activities of biocandidates (b, 1-3, and 1-3b) were obtained between 7.52 and 100 mg/L. Bioagents (2, 3, 1b, and 2b) destroyed the DNA integrity, as well. The significant improvement in the biological activities of gold nanoparticles confirmed that new nanoconjugates especially 1b can be considered promising medical nanomaterials after further clinical investigation.Article Citation - WoS: 27Citation - Scopus: 29Preparation, spectral studies, theoretical, electrochemical and antibacterial investigation of a new Schiff base and its some metal complexes(ELSEVIER SCIENCE BV, 2014) Ilhan, S.; Baykara, H.; Seyitoglu, M. S.; Levent, A.; Ozdemir, S.; Dundar, A.; Oztomsuk, A.; Cornejo, M. H.A new Schiff base ligand, 1,6-Bis(2-(5-bromo-2-hydroxybenzylideneamino)-4-chlorophenoxy)hexane was synthesized. Some Schiff metal complexes of the new Schiff base were prepared by the reaction of some metal salts and the Schiff base. The complexes are non-electrolytes as shown by their molar conductivities (Lambda M). The structures of metal complexes are proposed from elemental analysis, FT-IR, UV-vis, magnetic susceptibility measurements, molar conductivity measurements, mass spectra and thermal gravimetric analysis. In addition theoretical H-1 NMR, HOMO-LUMO studies of the ligand; antimicrobial and cyclic voltammetric studies of the compounds were also carried out. In this study antioxidant and antibacterial activities of the compounds were examined via in vitro methods. (C) 2014 Elsevier B.V. All rights reserved.Article Citation - WoS: 1Investigation of Nutritional Content, Antioxidant Anticancer and Antimicrobial Activities of Pleurotus eryngii (DC. Ex Fr.) Quel, Extract Obtained by Different Solvents(KSÜ Tarım ve Doğa Dergisi, 2021) Acay, Hilal; Dündar, Abdurrahman; Kaçar, Semra; Baran, Mehmet Fırat; Keskin, CumaliThe present study related the nutritional contents, fatty acidcompositions, in vitro antioxidant, anticancer and antimicrobialactivities of different solvents extracts of Pleurotus eryngii. Thenutritional contents of the P. eryngii were investigated in detail.Crude protein (g 100 kg-1), carbohydrate (g 100 kg-1), lipid (g 100 kg1), ash (g 100 kg-1), dietary fiber (g 100 kg-1) and energy value (cal100 g-1) of fruiting bodies were analysed. Fatty acid compositions oftotal lipid, phospholipid and triacylglycerol fractions of Pleurotuseryngii were investigated by Gas chromatography. Totally 13 differentfatty acids constituents were identified. Antioxidant propertiesincluding total antioxidant activity, free radical scavenging activity,reducing power activity, metal chelating activity, and superoxideanion radical scavenging activity were evaluated using different tests.The highest total antioxidant, DPPH scavenging, metal chelating, andsuperoxide anion radical scavenging activities were determined inethyl acetate extracts. The potential of cytotoxic activity on PC-3(prostate cancer) cell lines was found to depend on the concentrationand the type of the tested extracts fractions. It was determined thathexane, ethyl acetate, and methanol extracts of Pleurotus eryngii haveinhibition effect on the growth of tested microorganisms. The presentresults suggested that used as a daily nutrient, the Pleurotus eryngiicould be a novel source for new drug developments and promising insome cancer treatment.Article Citation - WoS: 27Citation - Scopus: 34Metallo and metal free phthalocyanines bearing (4-(1(4-phenoxyphenyl)-1-phenylethyl)phenol substituents: Synthesis, characterization, aggregation behavior, electronic, antioxidant and antibacterial properties(ELSEVIER SCIENCE SA, 2014) Agirtas, M. Salih; Guven, M. Emin; Gumus, Selcuk; Ozdemir, Sadin; Dundar, AbdurrahmanAs starting material the phthalonitrile derivative bearing (4-(1(4-phenoxyphenyl)-1-phenylethyl)phenol substituents at peripheral position was prepared by a nucleophilic displacement reaction. Cyclotetramerization of 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalonitrile derivative in the presence of corresponding metal salts gave the new metallophthalocyanines. Metal free phthalocyanine was obtained from the reaction of 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalonitrile units. The novel compounds have been characterized by using various spectroscopic data. The aggregation investigations carried out in different concentrations indicate that 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10(-4)-10(-5) M in tetrahydrofuran. The antioxidant activities of novel compounds were analyzed through radical scavenging ability of 1,1-dipheny1-2-picrylhydrazyl, chelating ability to ferrous ions and reducing power. In addition to these, the antibacterial activities of compounds were investigated. Moreover, the ground-state geometries of the complexes were optimized using B3LYP/6-31G(d,p) level of density functional theory in order to predict the three-dimensional geometries and electronic structure. (C) 2014 Elsevier B.V. All rights reserved.Article Citation - WoS: 30Citation - Scopus: 37Mononuclear Complexes Based on Pyrimidine Ring Azo Schiff-Base Ligand: Synthesis, Characterization, Antioxidant, Antibacterial, and Thermal Investigations(WILEY-V C H VERLAG GMBH, 2014) Gulcan, Mehmet; Ozdemir, Sadin; Dundar, Abdurrahman; Ispir, Esin; Kurtoglu, MukerremSix transition metal(II) complexes with the heterocyclic ligand HL (1), [CuL2]center dot H2O (2), [NiL2]center dot 3H(2)O (3), [CoL2]center dot 3H(2)O (4), [MnL2]center dot 3H(2)O (5), [ZnL2]center dot 2H(2)O (6), [PdLOAc]center dot H2O (7) [HL = 5-benzoyl-1-((E)-(2-hydroxy-5-((E)-phenyldiazenyl)benzylidene)amino)-4-phenylpyrimidin-2(1H)-one] were synthesized. The features of the azo Schiff bases were assigned from microanalytical, spectroscopic (IR, UV/Vis., H-1- and C-13 NMR, API-ES mass), magnetic, and molar conductivity measurements at room temperature as well as thermal analysis. The electronic absorption spectroscopy and magnetic susceptibility measurements of the complexes indicate square pyramidal arrangement for Pd-II and octahedral environment for all the other complexes. The azo Schiff base HL acts as a monobasic tridentate ligand, which commonly coordinates through the oxygen atoms of the phenol OH and the pyrimidine one group, and the nitrogen atom of the azomethine group. The thermal behaviors of the ligand and its metal complexes were studied using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The metal complexes proved to be more thermally stable than the ligand; they decomposed at 10-30 degrees C higher temperatures. Antioxidant properties of the ligand and its metal complexes (DPPH free radical scavenging, ferrous chelating and reducing power activities) were tested. Antimicrobial activities were studied with gram-positive bacteria, which included Bacillus subtilis and Staphylococcus aureus, whereas Escherichia coli and Pseudomonas aeruginosa represented gram negative bacteria.Article Citation - WoS: 3Citation - Scopus: 4Synthesis, Characterization, Aggregation Behavior, Antioxidant Activity, and Antibacterial Activity of Metallophthalocyanines Carrying Four Phthalonitriles Group(Editura Acad Romane, 2016) Guven, M. Emin; Dündar, Abdurrahman; Agirtas, M. Salih; Ozdemir, Sadin; Dundar, Abdurrahman; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu ÜniversitesiA novel phthalonitrile derivative and zinc (II), cobalt (II), and cupper (II) phthalocyanines complexes were synthesis and characterized. The novel compounds have been characterized by using various spectroscopic data FTIR, UV/vis, NMR, elemental analysis etc. The aggregation investigations carried out in different concentrations indicate that 4- (4-(1-(4-phenoxypheny1)-1-phenylethyl)phenoxy)phthalonitrile substituted phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10(-4)-10(-5) M in tetrahydrofuran. The antioxidant properties of the phthalonitrile and its phthalocyanine compounds were evaluated in three series of in vitro tests: DPPH free radical scavenging, ferrous ion chelating activity and reducing power. Antimicrobial activities of compounds were investigated.Article Citation - WoS: 4Citation - Scopus: 3Different peripheral substituted phthalocyanines: Synthesis, characterization, aggregation behavior, antioxidant and antibacterial activity(PLEIADES PUBLISHING INC, 2015) Celebi, M.; Agirtas, M. S.; Dundar, A.In this study, a novel phthalonitrile, 4-chloro-5-(2-((2-hydroxyethyl)(p-tolyl)amino)ethoxy)phthalonitrile (3), and its metallophthalocyanine derivatives (4-6) are prepared by cyclotetramerization with appropriate metal salts in dimethylformamide. The newly prepared compounds have been characterized by several spectroscopic techniques. All compounds are evaluated for their antioxidant and antibacterial potential. For the antioxidant studies, three tests are applied; DPPH (2,2-diphenyl-1-picrylhydrazylradical) scavenging, metal chelating and reducing power activity. Compound 4 exhibits the best DPPH scavenging activity as 35.2% at 100 mg/L concentration. The metal chelating activities of compounds 3 and 4 are 69.7% and 56.4%, respectively. Reducing power activities of compounds 3 and 4 are higher than alpha-tocopherol which is used as positive control. All compounds show moderate antibacterial activity when compared to the standard antibiotics, amikacin and tetracycline.
