Dündar, Abdurrahman

Dündar, Abdurrahman

Name Variants

Dundar, Abdurrahman
Dundar, A.

Job Title

Profesör

Email Address

anzdundar@gmail.com

Main Affiliation

Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü

Sustainable Development Goals Report Points

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Scholarly Output

34

Articles

29

Citation Count

600

Supervised Theses

3 Scholarly Output Search Results

Now showing 1 - 10 of 34

COVID-19 tanısı konan hastaların cinsiyet ve yaş faktörlerinin bazı biyokimyasal değerlerle korelâsyonunun araştırılması
(Mardin Artuklu Üniversitesi, 2022) Dündar, Abdurrahman; Dündar, Abdurrahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
2019 yılının son döneminde Wuhan şehrinde ortaya çıkan Covid-19 hastalığı çok hızlı bir şekilde dünyaya yayılış göstermiş ve kısa bir süre sonra ülkemizde görülmeye başladı. Covid-19 ile ilgili önemli çalışmalar yapılmakta bu virüs ve benzeri virüs kökenli hastalıkların tespiti ve erken teşhisi ile tedavi amaçlı Crp, Lym, Ferritin, Kan Gazı ve D-dimer gibi bazı biyokimyasal değerlerin düzeylerinin hastalık şiddeti ve diğer biyokimyasal değerler ile ilişkisini değerlendirilmesi ve bu biyokimyasal değerlerin yaş, cinsiyet üzerindeki etkilerini değerlendirmeyi amaçladık. Yaptığımız çalışmada, hasta dosyalarının retrospektif incelenmesine dayalı kesitsel ve tanımlayıcı bir çalışmadır. 01 Haziran 2020 ile 30 Mayıs 2021 tarihleri arasında Kızıltepe devlet hastanesine başvuran ve hastalık tanısı konulan 12 aylık süreçte hastaların Crp, Lym, Ferritin, Kan Gazı ve D-dimer gibi bazı biyokimyasal değerleri ve aynı zamanda bu değerlerin diğer biyokimyasal değerler arasındaki ilişki ile bu değerlerin yaş ve cinsiyete olan etkileri incelendi ve analizleri yapıldı. Araştırma da elde edilen veriler SPSS for Windows 25.0 programı kullanılarak analiz edilmiştir. Verileri değerlendirilirken tanımlayıcı istatistiksel metotları (sayı, yüzde, ortalama, standart sapma) kullanılmıştır. Çalışmamız da inceleyeceğimiz tüm parametreleri eksiksiz olan 01 Haziran 2020 ile 30 Mayıs 2021 tarihleri arasında Kızıltepe devlet hastanesine başvuran ve COVID-19 tanısı koyulan 1812 hasta dahil edildi. Bu hastalardan %51,9'u (n: 941) kadın % 48,1 (n: 871) erkektir. Ve yaş ortalaması 56,58±19,89 olarak hesaplanmıştır. Yaptığımız çalışmaya göre Crp ve Ferritin değerleri erkeklerde daha yüksek, Lenfosit düzeyleri ise kadınlar daha yüksek olduğu saptandı. Ayrıca Crp, Ferritin ve D.Dimer değerleri ile yaş arasında pozitif yönde, Lenfosit ile yaş arasında ise negatif yönde anlamlı bir ilişki saptandı. Biyokimyasal değerlerin hastalığın klinik seyrinde önemli bir biyolojik belirteçler olduğu literatürde ki araştırmalar ile uyumludur. Covid-19 ile ilgili çok sayıda araştırma yapılmış ve literatüre kazandırılmıştır ve yeni çalışmalarda yapılmaktadır. Bizde biyokimyasal değerlerin Covid-19'un klinik seyrinde biyolojik belirteç olarak kullanılması ayrıca bu değerlerin yaş ve cinsiyet üzerindeki ilişkisinin tespitinin hastalığın seyrinde önemli olduğundan bu konu ile ilgili literatüre katkı sağlamayı amaçladık. Hastalığı daha ağır geçiren erkeklerde Crp ve Ferritin değerleri analiz sonuçlarına göre anlamlı yüksek olduğu görüldü. Lenfosit değerinin ise erkeklerde daha düşük olduğu saptandı. Yaşa bağlı olarak ise ileri yaşlarda Crp, Ferritin ve D.Dimer değerlerinin yüksek, Lenfosit değerinin düşük olması mortalite ile bağlantılı olduğunu gösterdi.
Citation - WoS: 5
Citation - Scopus: 3
Several biological properties and synthesis of 2-(4-methylthiazol-5-yl) ethoxy substitute zinc phthalocyanine
(John Wiley and Sons Ltd, 2023) Dündar, Abdurrahman; Özdemir, Sadin; Dündar, Abdurrahman; Ağırtaş, Mehmet Salih; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
In this study, 4-(2-(4-methylthiazol-5-yl) ethoxy) phthalonitrile (3) and zinc phthalocyanine complex (4) were synthesized and characterized. UV–vis and fluorescence spectra, aggregation, and fluorescence parameters of the zinc phthalocyanine compound were investigated. As biological properties, DPPH radical capture, antidiabetic, DNA cutting, antimicrobial, photodynamic antimicrobial, anti-biofilm activities, and microbial cell viability parameters of the compounds were determined. The highest antioxidant activity was found as 62.80% at 100 mg/L concentration with compound 4, and compound 4 also showed the best antidiabetic activity as 65.17% at 400 mg/L concentration. In DNA cutting activity, it was determined that 3 and 4 cut DNA at all concentrations. For compounds 3–4, the minimum inhibitory concentration (MIC) values were found to be 32 and 16 mg/L for Enterococcus hirae and Enterococcus feacalis, respectively. The strongest MIC value of photodynamic antimicrobial activity was achieved as 4 mg/L for E. feacalis with 4. It was observed that both compounds inhibited the microbial viability activity of Escherichia coli by 100% at concentrations of 100 mg/L. Compound 4 inhibited biofilms of Pseudomonas aureginosa and Staphylococcus aureus as 92.48% and 98.56% at 50 mg/L concentration, respectively.
Citation - WoS: 29
Citation - Scopus: 36
Mononuclear Complexes Based on Pyrimidine Ring Azo Schiff-Base Ligand: Synthesis, Characterization, Antioxidant, Antibacterial, and Thermal Investigations
(WILEY-V C H VERLAG GMBH, 2014) Dündar, Abdurrahman; Ozdemir, Sadin; Dundar, Abdurrahman; Ispir, Esin; Kurtoglu, Mukerrem; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Six transition metal(II) complexes with the heterocyclic ligand HL (1), [CuL2]center dot H2O (2), [NiL2]center dot 3H(2)O (3), [CoL2]center dot 3H(2)O (4), [MnL2]center dot 3H(2)O (5), [ZnL2]center dot 2H(2)O (6), [PdLOAc]center dot H2O (7) [HL = 5-benzoyl-1-((E)-(2-hydroxy-5-((E)-phenyldiazenyl)benzylidene)amino)-4-phenylpyrimidin-2(1H)-one] were synthesized. The features of the azo Schiff bases were assigned from microanalytical, spectroscopic (IR, UV/Vis., H-1- and C-13 NMR, API-ES mass), magnetic, and molar conductivity measurements at room temperature as well as thermal analysis. The electronic absorption spectroscopy and magnetic susceptibility measurements of the complexes indicate square pyramidal arrangement for Pd-II and octahedral environment for all the other complexes. The azo Schiff base HL acts as a monobasic tridentate ligand, which commonly coordinates through the oxygen atoms of the phenol OH and the pyrimidine one group, and the nitrogen atom of the azomethine group. The thermal behaviors of the ligand and its metal complexes were studied using thermogravimetric analysis (TGA) and differential thermal analysis (DTA). The metal complexes proved to be more thermally stable than the ligand; they decomposed at 10-30 degrees C higher temperatures. Antioxidant properties of the ligand and its metal complexes (DPPH free radical scavenging, ferrous chelating and reducing power activities) were tested. Antimicrobial activities were studied with gram-positive bacteria, which included Bacillus subtilis and Staphylococcus aureus, whereas Escherichia coli and Pseudomonas aeruginosa represented gram negative bacteria.
Citation - WoS: 0
Citation - Scopus: 1
Synthesis and biological properties of axially bis − (3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV)
(Elsevier Science Sa, 2024) Dündar, Abdurrahman; Ozdemir, Sadin; Dundar, Abdurrahman; Agirtas, Mehmet Salih; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
In this study, bis(3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) was obtained from the reaction of 3,4,5-trimethoxybenzyl alcohol with SiPcCl 2 . This phthalocyanine was characterized using 1 H NMR, FTIR, UV - vis and mass spectra. 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, antidiabetic, deoxyribonucleic acid (DNA) cutting, biofilm inhibition, anti -microbial and antimicrobial photodynamic therapy (aPDT) activities of newly synthesized bis(3,4,5-trimethoxybenzyloxy) phthalocyaninato silicon (IV) molecule were studied. The best activities were 41.58 % at 100 mg/L for antioxidant and 41.66 % for antidiabetic at 400 mg/L concentration. The molecule degraded the biofilm matrix formed by Pseudomonas aeruginosa and Staphylococcus aureus as 78.61 % and 89.26 %, at 50 mg/L concentration, respectively. It was observed that E. coli , which was used as a model microorganism, was inhibited at a level close to 100 % even at the lowest concentration of 50 mg/L. While double strand break was observed at 50 mg/L DNA cutting activity, it was determined that DNA was reduced to nucleotides at 100 and 200 mg/L. The Pc also displayed effective antimicrobial and aPDT abilities against pathogens. With the application of aPDT, the effectiveness of antimicrobial activity increased 2 to 4 times. These increase rates are very important. The main conclusion of the study was that the newly synthesized compound exhibited various effective biological activities such as effective antioxidant, antidiabetic, DNA cleavage, antimicrobial, aPDT, biofilm inhibition and microbial cell viability inhibition.
Citation - WoS: 26
Citation - Scopus: 33
Metallo and metal free phthalocyanines bearing (4-(1(4-phenoxyphenyl)-1-phenylethyl)phenol substituents: Synthesis, characterization, aggregation behavior, electronic, antioxidant and antibacterial properties
(ELSEVIER SCIENCE SA, 2014) Dündar, Abdurrahman; Guven, M. Emin; Gumus, Selcuk; Ozdemir, Sadin; Dundar, Abdurrahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
As starting material the phthalonitrile derivative bearing (4-(1(4-phenoxyphenyl)-1-phenylethyl)phenol substituents at peripheral position was prepared by a nucleophilic displacement reaction. Cyclotetramerization of 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalonitrile derivative in the presence of corresponding metal salts gave the new metallophthalocyanines. Metal free phthalocyanine was obtained from the reaction of 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalonitrile units. The novel compounds have been characterized by using various spectroscopic data. The aggregation investigations carried out in different concentrations indicate that 4-(4-(1-(4-hydroxyyphenyl)-1-phenylethyl)phenoxy)phthalocyanine compounds do not have any aggregation behavior for the concentration range of 10(-4)-10(-5) M in tetrahydrofuran. The antioxidant activities of novel compounds were analyzed through radical scavenging ability of 1,1-dipheny1-2-picrylhydrazyl, chelating ability to ferrous ions and reducing power. In addition to these, the antibacterial activities of compounds were investigated. Moreover, the ground-state geometries of the complexes were optimized using B3LYP/6-31G(d,p) level of density functional theory in order to predict the three-dimensional geometries and electronic structure. (C) 2014 Elsevier B.V. All rights reserved.
Bazı makrofungusların fenolik içerikleri ile antioksidan ve antimikrobiyal potansiyellerinin araştırılması
(Mardin Artuklu Üniversitesi, 2022) Dündar, Abdurrahman; Dündar, Abdurrahman; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Bu çalışmada 2012-2013 yılları ilkbahar ve sonbahar mevsimlerinde Siirt ve çevresinde toplanan Phallus impudicus, Coprinus silviaticus ile Morchella tomentosa, Amanita fulva adlı makro mantar türlerinin etanol ekstraktlarının bazı fenolik asit içerikleri ile antioksidan ve antimikrobiyal potansiyelleri çalışılmıştır. Söz konusu makro mantarların etanol ekstraktlarının antioksidan potansiyellerinin tespiti amacıyla; DPPH serbest radikal yakalama, metal iyonlarını şelatlama, indirgeme gücü ve süperoksit anyon radikal süpürme testleri uygulanmıştır. Antimikrobiyal aktivitenin belirlenmesi amacıyla da disk difüzyon yöntemi çalışılmıştır. Süperoksit anyon radikal aktivitesinde tespit edilen en yüksek değer % 83,24 ile Morchella tomentosa en düşük değer ise % 73,05 ile Coprinus silviaticus'a ait bulundu. DPPH serbest radikalini söndürme aktivite tekniğinde en fazla etkinliği gösteren Amanita fulva etanolik ekstraktının 1.0, 2.0, 5.0, 10.0, 15.0, 20.0 mg/mL konsantrasyonlardaki etkinlik verilerinin sırasıyla %19.33, %24.46, %58.74, %77.75, %87.89, %88.40 olduğu tespit edilmiştir. Metal şelatlama etkinliğinde kullanılan ekstraktların ve pozitif kontrol olarak çalışılan standartların etkinlik sıralaması EDTA> Amanita fulva> Morchella tomentosa> Phallus impudicus> Coprinus silviaticus> BHT> BHA> Trolox şeklinde tespit edilmiştir. Mantar indirgeme gücü aktivitesinde ise 10.0 mg/mL konsantrasyonda 2,89 aktivite ile en yüksek etkinliği gösteren mantar Morchella tomentosa olarak gözlenmiştir. Antimikrobiyal aktivite testinde ise Enterococcus hirae hariç diğer beş bakteriye karşı en yüksek inhibisyon zonlarını M. tomentosa'nın etanol ekstraktı sergilemiştir.
Assessment Of The Antimicrobial, Antioxidant And Cytotoxic Activities Of The Wild Edible Mushroom Pleurotus Eryngii From Hakkari, Turkey
(2017) Acay, Hilal; Dündar, Abdurrahman; Keskin, Cumali; Kaçar, Semra; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Abstract: Mushroom is an important source of natural compounds with acknowledged bioactivity. Pleurotus eryngii, in particular, is widely recognized for its organoleptic quality and favorable healthy effects, being commercially produced in great extent. The present study is just for evaluating the antioxidant capacity (scavenging DPPH radicals, reducing power, Total antioxidant activity by β-carotene-linoleic acid metod, Chelating effect on ferrous ions, superoxide anion radical scavenging activity ), antimicrobial effects (by using the disc diffusion method) and insufficiently studied cytotoxic activity (using PC-3 cell lines) of Pleurotus eryngii by using various solvent systems. For this reason; obtained extracts of the mushroom applying hexane, ethylacetate and methanol respectively were tested with in its biologic activities. As a result, The highest total antioxidant activity by β -carotene-linoleic acid metod was identified in methanol extract (63.62 mg /ml). The highest DPPH scavenging activity was obtained from ethyl acetate extract with 88.81 mg/ml. EDTA is used as standard in methal chelating activity. The highest metal chelating activity of Pleurotus eryngii identified in hexane (88,1 mg /ml) and ethylacetate (88.84 mg /ml) extracts. Additionally, in most of studied tests antioxidant activity of the mushroom increased with increasing concentration. On the other hand, the highest antimicrobial activity was obtained against Pseudomonas aeruginosa ATCC 27853 (11 mm) in ethyl acetate extract. However, the best antimicrobial activities were observed in hexane and methanol extracts for other tested microorganism. It was not determined any antimicrobial activity against Escherichia coli ATCC 25922. It has been found that the potential of cytotoxic activity is depended on concentration and solvent type of extracts. Ethyl acetate extract showed significant inhibitory value at the concentrations of 530 µg/ml (86.20 %) against PC-3 cell lines. Using methanol extract, the maximun inhibition was observed at concentration of 680 µg/ml with value of 51.86 %. Overall, the mushroom used as a daily nutrient could be a source for new drug developments and a kind of treatment in cancer therapies, and also, organic extracts of Pleurotus eryngii may contain substances that stimulate bioactivity
Citation - WoS: 12
Citation - Scopus: 14
Preconcentration with Bacillus subtilis-Immobilized Amberlite XAD-16: Determination of Cu2+ and Ni2+ in River, Soil, and Vegetable Samples
(TAYLOR & FRANCIS INC, 2015) Dündar, Abdurrahman; Ozdemir, Sadin; Kılınç, Ersin; Dundar, Abdurrahman; Yuksel, Uyan; Baysal, Zubeyde; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Solid-phase extraction (SPE) method was developed for the preconcentration of Cu2+ and Ni2+ before their determination by inductively coupled plasma optical emission spectrometry (ICP-OES). Bacillus subtilis-immobilized Amberlite XAD-16 was used as biosorbent. Effects of critical parameters such as pH, flow rate of samples, amount of Amberlite XAD-16 and biosorbent, sample volume, eluent type, and volume and concentration of eluent on column preconcentration of Cu2+ and Ni2+ were optimized. Applicability of the method was validated through the analysis of the certified reference tea sample (NCS ZC73014). Sensitivity of ICP-OES was improved by 36.4-fold for Cu2+ and 38.0-fold for Ni2+ by SPE-ICP-OES method. Limit of quantitation (LOQ) was found to be 0.7 and 1.1ng/ml for Cu2+ and Ni2+, respectively. Concentrations of Cu2+ and Ni2+ were determined by ICP-OES after application of developed method. Relative standard deviations (RSDs) were lower than 4.9% for Cu2+ and 7.9% for Ni2+. The Tigris River that irrigates a large agricultural part of Southeast Turkey is polluted by domestic and industrial wastes. Concentrations of Cu2+ and Ni2+ were determined in water, soil, and some edible vegetables as a biomonitor for heavy metal pollution.
Citation - WoS: 22
Citation - Scopus: 22
Antioxidant Properties of Cultured Mycelia from Four Pleurotus Species Produced in Submerged Medium
(TAYLOR & FRANCIS INC, 2013) Dündar, Abdurrahman; Okumus, Veysi; Ozdemir, Sadin; Yildiz, Abdunnasir; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
The ethanolic extracts of dried cultured mycelia of Pleurotus ostreatus, Pleurotus eryngii, Pleurotus florida, and Pleurotus sajor-caju were analyzed for antioxidant activity in different systems. Tests used are as follows: reducing power, free radical scavenging, superoxide anion radical scavenging, total antioxidant activity, metal chelating activitiy, etc.; total phenolic content was determined. The percentage inhibition of P. ostreatus, P. eryngii, P. florida, and P. sajor-caju at 20 mg/mL concentration on peroxidation in a -carotenelinoleic acid system was 57.19, 60.68, 62.12, and 58.81%, respectively. The reducing power of P. eryngii was higher than the other samples, and its value was 0.86 at 10 mg/mL concentration. P. ostreatus and P. sajor-caju proved to be better at scavenging superoxide anion radicals than the P. eryngii and P. florida. In the scavenging effect of DPPH radical test, P. ostreatus showed the highest activity potential and P. sajor-caju showed the strongest metal chelating capacity.
Citation - WoS: 24
Citation - Scopus: 24
Solid Phase Extraction Based on the Use of Agaricus arvensis as a Fungal Biomass for the Peconcentrations of Pb and Al Prior to Their Determination in Vegetables by ICP-OES
(ATOMIC SPECTROSCOPY, 2013) Dündar, Abdurrahman; Dündar, Abdurrahman; Özdemir, Sadin; Okumuş, Veysi; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
A solid phase extraction (SPE) method based on the use of a fungal biomass as sorbent was developed for the preconcentrations of Pb and Al. Agaricus arvensis was immobilized on Amberlite XAD-4 and loaded onto a column. Important parameters such as pH and flow rate of the solution, amount of biosorbent and resin, volume of sample solution, which affect the efficiency of the preconcentration procedure for Pb and Al, were optimized. The effect of possible interfering ions, i.e., Cd2+, Cu2+, Ni2+, Zn2+, Co2+, Na+, K+, Ca2+, Mg2+, and Fe2+, was investigated. Experiments on the repeatability of the solid phase column showed that the same column could be used at least 30 cycles without loss of the biosorption efficiency for the recovery of Pb and Al. The limit of detection (LOD) of Pb and Al was found to be 0.10 ng m(L-1) and 0.03 ng mL(-1), respectively. The sensitivity of ICP-OES improved 39.8-fold for Pb and 39.5-fold for Al. Linearity was obtained in the concentration range of 1.25-50.0 ng mL(-1) for Pb and 0.5-50.0 ng mL(-1) for Al. The relative standard deviation (RSD) of the method under optimum conditions was lower than 8.4% (n=5) for Pb and Al, which was validated through the analysis of certified reference tea and poplar leaves samples. The biosorption capacity of immobilized Agaricus arvensis for Pb and Al was found to be 31.2 mg g(-1) and 45.7 mg g(-1), respectively. The developed method was applied to determine the concentrations of Pb and Al in various edible vegetable samples (cucumber, okra, tomato, beans, aubergine, watermelon, zucchini, pepper, melon, lettuce, roka, purslane, scallion, cress, parsley, cabbage, sugar cane, and basil) grown along the cultivated banks of the Tigris River in Diyarbakir, Turkey.