Savaş, Hasan Basri
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Savas, Hasan Basri
Savaş, H.B.
Savaş, H.B.
Job Title
Doç. Dr.
Email Address
hasansavas@artuklu.edu.tr
Main Affiliation
Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
Status
Current Staff
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
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WoS Researcher ID
Sustainable Development Goals
1NO POVERTY
0
Research Products
2ZERO HUNGER
0
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3GOOD HEALTH AND WELL-BEING
6
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4QUALITY EDUCATION
0
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5GENDER EQUALITY
0
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6CLEAN WATER AND SANITATION
0
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7AFFORDABLE AND CLEAN ENERGY
0
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8DECENT WORK AND ECONOMIC GROWTH
0
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9INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
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10REDUCED INEQUALITIES
0
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11SUSTAINABLE CITIES AND COMMUNITIES
0
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12RESPONSIBLE CONSUMPTION AND PRODUCTION
0
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13CLIMATE ACTION
0
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14LIFE BELOW WATER
0
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15LIFE ON LAND
0
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16PEACE, JUSTICE AND STRONG INSTITUTIONS
0
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17PARTNERSHIPS FOR THE GOALS
0
Research Products
Documents
44
Citations
385
h-index
12
Documents
46
Citations
377
Scholarly Output
33
Articles
31
Views / Downloads
65/108
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
48
Scopus Citation Count
45
Patents
0
Projects
1
WoS Citations per Publication
1.45
Scopus Citations per Publication
1.36
Open Access Source
28
Supervised Theses
0
| Journal | Count |
|---|---|
| The Pakistan Veterinary Journal | 2 |
| Cureus | 2 |
| Iranian Journal of Basic Medical Sciences | 2 |
| Beslenme Biyokimyası | 1 |
| Beyoglu Eye Journal | 1 |
Current Page: 1 / 6
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33 results
Scholarly Output Search Results
Now showing 1 - 10 of 33
Article Role of Oxidative Stress in Serous Otitis Media and Myringosclerosis(Springer Nature, 2025) Sari, Neslihan; Savas, Hasan Basri; Ugras, Seda; Durucu, CengizBackground Ventilation tube insertion (VTI) is the surgical treatment of serous otitis media (SOM). Myringosclerosis (MS) commonly appears after ventilation tube insertion (VTI). The exact etiology of both MS and SOM remains unclear. Objective The role of oxidative stress (OS) markers-total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON1), arylesterase (ARES), and zinc (Zn) levels-in the advancement of SOM and MS in patients following VTI was examined. Methods The study comprised 100 children aged six to thirteen, categorized into MS + SOM (n = 34), MS-SOM (n = 34), and control (n = 32) groups. Serum levels of TAS, TOS, OSI, PON1, ARES, and Zn were evaluated. ANOVA, independent t-test, and Receiver Operating Characteristic (ROC) analysis were used for statistical analysis (p < 0.05). Results For SOM, the means of TOS and OSI were greater than those of the control group, whereas ARES and Zn were found to be lower than those of the control group (p < 0.05). ANOVA results for MS revealed that TOS (p = 0.026), OSI (p = 0.009), PON1 (p = 0.047), ARES (p = 0.00), and Zn (p = 0.00) levels differed among the groups. In ROC analysis, TOS (AUC = 0.697, p = 0.0002), OSI (AUC = 0.701, p = 0.0002), ARES (AUC = 0.777, p = 0.0001), and Zn (AUC = 0.817, p = 0.0001) are predictive for SOM. No predictive parameters of OS for MS were identified (p > 0.05). Conclusion Serum TOS, OSI, ARES, and Zn can serve as diagnostic indicators in SOM. None of the serum OS markers is predictive of MS. More research is needed to support these conclusions.Article Mitigating High-Fat Diet-Induced Testicular Oxidative Stress and Fibrosis with Bromelain(2026) Gültekin, Burcu; Canbaz, Halıme Tuba; Savas, Hasan Basri; Koca, Raviye Özen; Görmüş, Z. Işık Solak; Başaran, Mustafa BerkObjectives: Obesity induced by a high-fat diet (HFD) is closely associated with impaired male fertility, primarily through oxidative stress, inflammation, and testicular dysfunction. Natural compounds with antioxidant and anti-inflammatory properties have gained increasing attention for their potential therapeutic effects. Bromelain, a proteolytic enzyme complex derived from Ananas comosus, exhibits antioxidant, anti-inflammatory, and antifibrotic activities, suggesting potential protective effects against obesity-related reproductive impairments. Methods: Male Wistar rats were randomly assigned to four groups (n=9 per group). Animals were fed an HFD for 12 weeks to induce obesity, followed by one month of bromelain supplementation. Testicular tissues were histologically assessed using hematoxylin & eosin (H&E) and Masson’s trichrome staining. Serum and testicular samples were analyzed for antioxidant and oxidative stress markers, including paraoxonase-1 (PON1), arylesterase (ARE), total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI). Results: The HFD group showed significant testicular alterations, including thickening of the tunica albuginea, perivascular collagen accumulation, germ cell loss, and disrupted seminiferous tubule architecture (P<0.0001). Biochemically, TAS (P<0.0001) and PON1 (P=0.0041) levels were significantly decreased, whereas TOS (P<0.0001) and OSI (P<0.0001) levels were elevated. Bromelain supplementation mitigated histopathological changes, reducing collagen deposition and tunica albuginea thickness. Moreover, Bromelain significantly restored TAS and PON1 levels while decreasing TOS and OSI. No significant differences were observed in ARE (P=0.0002) activity between the groups. Conclusions: Bromelain supplementation attenuated HFD-induced oxidative stress and fibrotic alterations in testicular tissue, improving both histological and biochemical parameters. These findings suggest that Br may be a potentially beneficial natural supplement for alleviating obesity-induced impairments in male reproductive functions and associated metabolic dysfunctions.Article The Positive Effects of Wet Cupping Therapy on Thiol Disulfide Balance(Pakistan Medical Association, 2025) Savaş, H.B.; Sarikan, I.; Sufyan, AliObjective: To explore the oxidant and antioxidant effects of wet cupping therapy on thiol disulfide balance. Method: The cross-sectional study was conducted at Alanya Training and Research Hospital, Turkey, from March 15 to September 15, 2021, and comprised volunteers who received two sessions of wet cupping therapy with an interval of four weeks. Blood samples were taken before the session and then again after the session. Total thiol, native thiol and disulfide were measured in the blood samples using the colorimetric method. Data was analyzed using SPSS 26. Results: Of the 50 subjects with mean age 47.10±15.16 years, 25(50%) were males and 25(50%) were females. There was a statistically significant difference between baseline and post-intervention levels of total thiol, disulfide, reduced thiol ratio, oxidized thiol and thiol oxidation reduction (p<0.001). Conclusion: Wet cupping therapy could remove oxidants, reduce oxidative stress and produce antioxidant effects. © (c) 2025 Journal of the Pakistan Medical Association. This work is licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by-nc-nd/4.0/.Book Article Is There a Relationship Between First-Trimester Aneuploidy Screening Serum Biomarker Values and Nuchal Translucency Measurements and the Development of Retinopathy of Prematurity (ROP) in Premature Infants?(Springer, 2023) Küçük, Mehmet Fatih; Savaş Hasan Basri; Süren, Elçin; Erol, Muhammet; Yaprak, Lütfiye; Sabancı, ŞenolPurpose The purpose of this study is the evaluation of serum biomarker and nuchal translucency (NT) values measured during first-trimester aneuploidy screening in terms of the development of retinopathy of prematurity (ROP) in premature infants and investigation of whether the development of ROP is associated with these parameters. Methods In this retrospective cohort study, 3,750 premature infants who underwent ROP screening from 2016 to 2021 were identified from the hospital medical record system. Among 2,130 premature babies screened for first-trimester aneuploidy, 166 babies whose mothers had single pregnancies were screened by the same method and showed the same clinical course in both eyes were included in the study. The infants were divided into two groups according to the presence of ROP, and those with ROP were further evaluated in two groups according to the presence of proliferation. The groups were compared in terms of the serum values of human chorionic gonadotropin and pregnancy-associated plasma protein A, among aneuploidy screening biomarkers, and NT measurements. Results There was no significant difference in the evaluated serum biomarker values and NT measurements between the ROP and non-ROP groups or between the proliferative ROP, non-proliferative ROP, and non-ROP groups. Conclusion Our results showed that first-trimester aneuploidy screening serum biomarker values and NT measurements were not associated with the development of ROP in premature infants.Article Effects of Carvacrol on Aortic Damage in a Streptozotocin-Induced Type 1 Diabetic Rat Model(MDPI, 2026) Gultekin, Burcu; Cetinkaya Karabekir, Seda; Savas, Hasan Basri; Cuce, Gokhan; Kalkan, SerpilDiabetes mellitus (DM) is associated with vascular complications that increase morbidity and mortality. Natural antioxidants play a vital role in reducing diabetes-related damage. This study investigated the protective effects of the phenolic monoterpene carvacrol (CAR) against diabetic complications. Thirty-two male Wistar Albino rats (4 months, 250-300 g) were divided into four groups: control, DM, DM + DMSO, and DM + CAR. Type 1 diabetes was induced via intraperitoneal injection of 50 mg/kg streptozotocin (STZ). The DM + CAR group received 20 mg/kg CAR daily for four weeks. Body weight and blood glucose levels were regularly monitored. At the end of the study, aortic tissues were examined using hematoxylin-eosin (H&E), Verhoeff-Van Gieson, and immunohistochemical staining, while cardiac tissues were analyzed with H&E and Masson's trichrome. Serum levels of ischemia-modified albumin (IMA), cholesterol (CHOL), triglycerides (TG), and high-density lipoprotein (HDL) were measured. In the DM group, IMA and CHOL levels were increased (p = 0.0208 and p = 0.0207, respectively), apoptosis was elevated (caspase-3 expression, p = 0.0001), and marked tissue damage was observed. In contrast, in the DM + CAR group, IMA levels (p = 0.0228) and caspase-3 expression (p = 0.0457) were reduced, and notable improvements were detected in vascular and cardiac tissues. These results suggest that CAR protects against diabetic complications by modulating oxidative stress, inhibiting apoptosis, and preventing tissue injury.Article Citation - WoS: 1Citation - Scopus: 1Effects of Ranolazine on Angiogenesis and Oxidant-Antioxidant Balance: an in Vivo Experimental Model Study(Nature Portfolio, 2025) Savas, Hasan Basri; Kayan, FethullahRanolazine is known for its antiarrhythmic, antianginal, anti-ischemic properties, as well as its favorable effects on glycemic control. This study aimed to evaluate the effects of ranolazine on oxidative-antioxidative balance and angiogenesis using an in vivo experimental model. A total of 40 Ross 308 chick embryos were used and randomly divided into four groups (n = 10 per group). On the eighth day of incubation, vascular density was assessed. Following vascular evaluation, 4-5 mL of albumen was aspirated using a syringe to measure oxidative stress markers. The groups were as follows: Control, Bevacizumab (BC), Ranolazine 10(-4), and Ranolazine 10(-5). Total antioxidant capacity (TAC) levels were significantly higher in the bevacizumab group compared to the control group (p < 0.05). Similarly, oxidative stress index (OSI) levels were also significantly elevated in the bevacizumab group (p < 0.05). Both Ranolazine 10(-4) and 10(-5) groups demonstrated significantly increased TAC levels compared to the control group (p < 0.05). In terms of angiogenesis scores, bevacizumab exhibited a marked anti-angiogenic effect compared to control. However, no statistically significant difference was observed between the ranolazine groups and the control group regarding angiogenesis scores (p > 0.05). This study provides the first in vivo evidence that Ranolazine enhances total antioxidant capacity but does not influence angiogenesis in the CAM model. Future research should explore the molecular mechanisms underlying this effect.Article Evaluation of Thiol/Disulfide Homeostasis and Ischemia Modified Albumin as Potential Markers for Periodontitis(BMC, 2025) Karci, Bilge; Savas, Hasan BasriBackground The current study aimed to assess the impact of periodontitis on oxidative stress parameters by examining serum total antioxidant capacity (TAS), total oxidant status (TOS), oxidative stress index (OSI), thiol/ disulfide homeostasis and ischemia modified albumin (IMA). Methods The study had 90 participants, categorized into 3 groups: Group 1: Periodontally healthy; Group 2: Stage II Grade B periodontitis; Group 3: Stage III and IV Grade B periodontitis. Demographic and periodontal variables were assessed. The levels of serum TAS, TOS, OSI, IMA, and thiol/disulfide were assessed. Results No significant differences in sex and age were detected among the groups (p > 0.05). When compared to Group 1, all clinical measurements were statistically significantly greater in Group 3 (p < 0.05). Statistical analysis revealed no significant differences in serum TAS, TOS, and OSI levels among the groups (p > 0.05). The highest serum IMA value was observed in Group 3 (p = 0.037), whereas native thiol (p = 0.00), total thiol (p = 0.00) and disulfide values (p = 0.023) were highest in Group 1. Conclusions These findings indicate that thiol/disulfide homeostasis and IMA could hold promise as a potential biomarker of inflammation in periodontitis.Article Citation - WoS: 3Citation - Scopus: 3Effect of Carvacrol on Diabetes-Induced Oxidative Stress, Fibrosis and Apoptosis in Testicular Tissues of Adult Rats(Acad Sciences Czech Republic, Inst Physiology, 2025) Gultekin, Burcu; Cetinkaya Karabekir, Seda; Cinar Ayan, Ilknur; Savas, Hasan Basri; Cuce, Gokhan; Kalkan, Sabiha SerpilDiabetes mellitus (DM) is a chronic and widespread disease that negatively affects the male reproductive system. Carvacrol (CAR), a naturally occurring flavonoid in plants, exhibits various biological and pharmacological activities, including antiinflammatory, antioxidant, and anticancer properties. This study aimed to investigate the potential effects of CAR on testicular tissue damage induced by diabetes, which was modeled by Streptozotocin (STZ) administration. Thirty-two male Wistar albino rats were divided into four groups: Group 1: Control (n=8), Group 2: DM (n=8), Group 3: DM+DMSO (0.1 % dimethyl sulfoxide) (n=8), and Group 4: DM+CAR (20 mg/kg) (n=8). Diabetes was induced by a single intraperitoneal STZ injection (50 mg/kg). Histological changes were assessed using Hematoxylin-Eosin (H&E) staining and the Johnsen scoring system. Apoptosis was evaluated through immunohistochemical staining for the mitochondrial apoptosis markers Bax and Bcl-2, as well as RT-qPCR analysis of their gene expression levels. Fibrosis assessment involved Masson-Trichrome staining and RT-qPCR analysis of mRNA levels for the COL1A1 and COL3A1 genes. Additionally, Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Oxidative Stress Index (OSI), and C-Reactive Protein (CRP) levels were measured in testicular tissue. CAR treatment significantly improved histological alterations associated with diabetes-induced testicular damage. DM was found to increase Bax levels while reducing Bcl-2 levels, whereas CAR reduced Bax levels and increased Bcl-2 gene and protein expression. TOS and OSI levels were elevated in the DM group, whereas TAS levels increased in the DM+CAR group. No significant differences in CRP levels were observed between the groups. These findings suggest that CAR may be effective in mitigating diabetes-induced testicular damage.Book
