Savaş, Hasan Basri
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Savas, Hasan Basri
Savaş, H.B.
Savaş, H.B.
Job Title
Doç. Dr.
Email Address
hasansavas@artuklu.edu.tr
Main Affiliation
Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
Status
Current Staff
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals
3
GOOD HEALTH AND WELL-BEING
6
Research Products
6
CLEAN WATER AND SANITATION
0
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
1
NO POVERTY
0
Research Products
5
GENDER EQUALITY
0
Research Products
10
REDUCED INEQUALITIES
0
Research Products
15
LIFE ON LAND
0
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
14
LIFE BELOW WATER
0
Research Products
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
4
QUALITY EDUCATION
0
Research Products
2
ZERO HUNGER
0
Research Products
13
CLIMATE ACTION
0
Research Products
Documents
44
Citations
385
h-index
12
Documents
46
Citations
377
Scholarly Output
31
Articles
29
Views / Downloads
58/10
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
48
Scopus Citation Count
45
WoS h-index
4
Scopus h-index
4
Patents
0
Projects
1
WoS Citations per Publication
1.55
Scopus Citations per Publication
1.45
Open Access Source
26
Supervised Theses
0
| Journal | Count |
|---|---|
| The Pakistan Veterinary Journal | 2 |
| Iranian Journal of Basic Medical Sciences | 2 |
| Cureus | 2 |
| Beslenme Biyokimyası | 1 |
| Beyoglu Eye Journal | 1 |
Current Page: 1 / 6
Scopus Quartile Distribution
Competency Cloud
31 results
Scholarly Output Search Results
Now showing 1 - 10 of 31
Article The Positive Effects of Wet Cupping Therapy on Thiol Disulfide Balance(Pakistan Medical Association, 2025) Savaş, H.B.; Sarikan, I.; Sufyan, AliObjective: To explore the oxidant and antioxidant effects of wet cupping therapy on thiol disulfide balance. Method: The cross-sectional study was conducted at Alanya Training and Research Hospital, Turkey, from March 15 to September 15, 2021, and comprised volunteers who received two sessions of wet cupping therapy with an interval of four weeks. Blood samples were taken before the session and then again after the session. Total thiol, native thiol and disulfide were measured in the blood samples using the colorimetric method. Data was analyzed using SPSS 26. Results: Of the 50 subjects with mean age 47.10±15.16 years, 25(50%) were males and 25(50%) were females. There was a statistically significant difference between baseline and post-intervention levels of total thiol, disulfide, reduced thiol ratio, oxidized thiol and thiol oxidation reduction (p<0.001). Conclusion: Wet cupping therapy could remove oxidants, reduce oxidative stress and produce antioxidant effects. © (c) 2025 Journal of the Pakistan Medical Association. This work is licensed under a Creative Commons Attribution 4.0 International License https://creativecommons.org/licenses/by-nc-nd/4.0/.Book Article Role of Oxidative Stress in Serous Otitis Media and Myringosclerosis(Springer Nature, 2025) Sari, Neslihan; Savas, Hasan Basri; Ugras, Seda; Durucu, CengizBackground Ventilation tube insertion (VTI) is the surgical treatment of serous otitis media (SOM). Myringosclerosis (MS) commonly appears after ventilation tube insertion (VTI). The exact etiology of both MS and SOM remains unclear. Objective The role of oxidative stress (OS) markers-total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase (PON1), arylesterase (ARES), and zinc (Zn) levels-in the advancement of SOM and MS in patients following VTI was examined. Methods The study comprised 100 children aged six to thirteen, categorized into MS + SOM (n = 34), MS-SOM (n = 34), and control (n = 32) groups. Serum levels of TAS, TOS, OSI, PON1, ARES, and Zn were evaluated. ANOVA, independent t-test, and Receiver Operating Characteristic (ROC) analysis were used for statistical analysis (p < 0.05). Results For SOM, the means of TOS and OSI were greater than those of the control group, whereas ARES and Zn were found to be lower than those of the control group (p < 0.05). ANOVA results for MS revealed that TOS (p = 0.026), OSI (p = 0.009), PON1 (p = 0.047), ARES (p = 0.00), and Zn (p = 0.00) levels differed among the groups. In ROC analysis, TOS (AUC = 0.697, p = 0.0002), OSI (AUC = 0.701, p = 0.0002), ARES (AUC = 0.777, p = 0.0001), and Zn (AUC = 0.817, p = 0.0001) are predictive for SOM. No predictive parameters of OS for MS were identified (p > 0.05). Conclusion Serum TOS, OSI, ARES, and Zn can serve as diagnostic indicators in SOM. None of the serum OS markers is predictive of MS. More research is needed to support these conclusions.Article Citation - WoS: 1Citation - Scopus: 1Effects of Ranolazine on Angiogenesis and Oxidant-Antioxidant Balance: an in Vivo Experimental Model Study(Nature Portfolio, 2025) Savas, Hasan Basri; Kayan, FethullahRanolazine is known for its antiarrhythmic, antianginal, anti-ischemic properties, as well as its favorable effects on glycemic control. This study aimed to evaluate the effects of ranolazine on oxidative-antioxidative balance and angiogenesis using an in vivo experimental model. A total of 40 Ross 308 chick embryos were used and randomly divided into four groups (n = 10 per group). On the eighth day of incubation, vascular density was assessed. Following vascular evaluation, 4-5 mL of albumen was aspirated using a syringe to measure oxidative stress markers. The groups were as follows: Control, Bevacizumab (BC), Ranolazine 10(-4), and Ranolazine 10(-5). Total antioxidant capacity (TAC) levels were significantly higher in the bevacizumab group compared to the control group (p < 0.05). Similarly, oxidative stress index (OSI) levels were also significantly elevated in the bevacizumab group (p < 0.05). Both Ranolazine 10(-4) and 10(-5) groups demonstrated significantly increased TAC levels compared to the control group (p < 0.05). In terms of angiogenesis scores, bevacizumab exhibited a marked anti-angiogenic effect compared to control. However, no statistically significant difference was observed between the ranolazine groups and the control group regarding angiogenesis scores (p > 0.05). This study provides the first in vivo evidence that Ranolazine enhances total antioxidant capacity but does not influence angiogenesis in the CAM model. Future research should explore the molecular mechanisms underlying this effect.Article Evaluation of Thiol/Disulfide Homeostasis and Ischemia Modified Albumin as Potential Markers for Periodontitis(BMC, 2025) Karci, Bilge; Savas, Hasan BasriBackground The current study aimed to assess the impact of periodontitis on oxidative stress parameters by examining serum total antioxidant capacity (TAS), total oxidant status (TOS), oxidative stress index (OSI), thiol/ disulfide homeostasis and ischemia modified albumin (IMA). Methods The study had 90 participants, categorized into 3 groups: Group 1: Periodontally healthy; Group 2: Stage II Grade B periodontitis; Group 3: Stage III and IV Grade B periodontitis. Demographic and periodontal variables were assessed. The levels of serum TAS, TOS, OSI, IMA, and thiol/disulfide were assessed. Results No significant differences in sex and age were detected among the groups (p > 0.05). When compared to Group 1, all clinical measurements were statistically significantly greater in Group 3 (p < 0.05). Statistical analysis revealed no significant differences in serum TAS, TOS, and OSI levels among the groups (p > 0.05). The highest serum IMA value was observed in Group 3 (p = 0.037), whereas native thiol (p = 0.00), total thiol (p = 0.00) and disulfide values (p = 0.023) were highest in Group 1. Conclusions These findings indicate that thiol/disulfide homeostasis and IMA could hold promise as a potential biomarker of inflammation in periodontitis.Article Is There a Relationship Between First-Trimester Aneuploidy Screening Serum Biomarker Values and Nuchal Translucency Measurements and the Development of Retinopathy of Prematurity (ROP) in Premature Infants?(Springer, 2023) Küçük, Mehmet Fatih; Savaş Hasan Basri; Süren, Elçin; Erol, Muhammet; Yaprak, Lütfiye; Sabancı, ŞenolPurpose The purpose of this study is the evaluation of serum biomarker and nuchal translucency (NT) values measured during first-trimester aneuploidy screening in terms of the development of retinopathy of prematurity (ROP) in premature infants and investigation of whether the development of ROP is associated with these parameters. Methods In this retrospective cohort study, 3,750 premature infants who underwent ROP screening from 2016 to 2021 were identified from the hospital medical record system. Among 2,130 premature babies screened for first-trimester aneuploidy, 166 babies whose mothers had single pregnancies were screened by the same method and showed the same clinical course in both eyes were included in the study. The infants were divided into two groups according to the presence of ROP, and those with ROP were further evaluated in two groups according to the presence of proliferation. The groups were compared in terms of the serum values of human chorionic gonadotropin and pregnancy-associated plasma protein A, among aneuploidy screening biomarkers, and NT measurements. Results There was no significant difference in the evaluated serum biomarker values and NT measurements between the ROP and non-ROP groups or between the proliferative ROP, non-proliferative ROP, and non-ROP groups. Conclusion Our results showed that first-trimester aneuploidy screening serum biomarker values and NT measurements were not associated with the development of ROP in premature infants.Article Examining the Angiogenic and Antioxidant Effects of Various Paracetamol Dosages Using a Chorioallantoic Membrane Model(Yuzuncu Yil University Tip Fakultesi, 2025) Savaş, H.B.; Batur, T.Introduction: Paracetamol is one of the most popular and frequently used analgesic and antipyretic medications in the world. It was aimed at investigating the effects of paracetamol on angiogenesis and oxidative stress markers in the in vivo chorioallant oic membrane model (CAM). Materials and Methods: The 40 fertilized chick eggs were used in the experiment. The four groups were as; the control group (n = 10), 10-6 M bevacizumab group (n = 10), 10-4 M paracetamol group (n = 10) and 10-5 M paracetamol group (n = 10). Stereoscopic microscopy was used to assess angiogenesis on the window that was opened on the eggshell. Total oxidant capacity (TOS), total antioxidan t capacity (TAS), and oxidative stress index (OSI) were analyzed in albumen specimens. The scoring methodology described in earlier research publications was used to determine and compare the average score values. One-way analysis of variance and the post hoc Tukey test were performed to assess oxidative stress markers between the groups. Results: The bevacizumab group demonstrated a strong anti-angiogenic effect, but the control group and both paracetamol groups showed no anti-angiogenic effect. Paracetamol increased TAS values at a 10-4 M concentration. The bevacizumab group's TOS and OSI values were significantly higher compared to the control group. Conclusion: Paracetamol is used by a lot of people; healthy blood vessel growth and the balance between oxidants and antioxidants are important. The important result of this study is that paracetamol has strong antioxidant effects and no anti-angiogenic effects. © 2025, Van Medical Journal. All rights reserved.Article Anti-Angiogenic and Oxidant Effects of Monosodium Glutamate at Different Concentrations in Chorioallantoic Membrane Model(Muğla Sıtkı Koçman Üniversitesi, 2023)Monosodium glutamate (MSG) is a flavor-enhancing food additive. MSG exposure is rising day by day because of the high commercial food consumption. MSG exposure causes damage to various tissues and organs. The aim of this study is to investigate the effects of MSG on angiogenesis and oxidant-antioxidant balance. Three different concentrations of MSG (10-4 M, 10-5 M, and 10-6 M), control, and the bevacizumab (10-6 M) were prepared and placed on the chorioallantoic membrane (CAM) of the embryos. Albumen was taken from the embryos before and after the experiment. Angiogenesis was investigated through the window that was opened on the eggshell. Angiogenesis was found to be normal in the control and 10-6 M MSG group (average score: 0.3). Anti-angiogenic effects were moderate in the 10-5 M MSG group (average score: 0.5) and in the 10-4 M MSG group (average score: 0.7), and strong in the bevacizumab group (average score: 1.1). According to our results, MSG shows anti-angiogenic properties in higher doses. MSG increased oxidative stress. According to the results of our research, it is seen that MSG inhibits angiogenesis in a dose-dependent manner in the CAM model and may cause an increase in oxidative damage by disrupting the oxidant-antioxidant balance. Since no previous study has been found in the literature regarding the effects of MSG on angiogenesis and oxidant-antioxidant balance in the CAM model, we think our results will fill an important gap in the literature.Article Is There a Relationship Between First-Trimester Aneuploidy Screening Serum Biomarker Values and Nuchal Translucency Measurements and the Development of Retinopathy of Prematurity (ROP) in Premature Infants?(Nature, 2023) Erol, Muhammet; Sabanci, Senol; Kucuk, Mehmet Fatih; Savas, Hasan Basri; Yaprak, Lutfiye; Suren, ElcinAbstract Purpose The purpose of this study is the evaluation of serum biomarker and nuchal translucency (NT) values measured during first-trimester aneuploidy screening in terms of the development of retinopathy of prematurity (ROP) in premature infants and investigation of whether the development of ROP is associated with these parameters. Methods In this retrospective cohort study, 3,750 premature infants who underwent ROP screening from 2016 to 2021 were identified from the hospital medical record system. Among 2,130 premature babies screened for firsttrimester aneuploidy, 166 babies whose mothers had single pregnancies were screened by the same method and showed the same clinical course in both eyes were included in the study. The infants were divided into two groups according to the presence of ROP, and those with ROP were further evaluated in two groups according to the presence of proliferation. The groups were compared in terms of the serum values of human chorionic gonadotropin and pregnancy-associated plasma protein A, among aneuploidy screening biomarkers, and NT measurements. Results There was no significant difference in the evaluated serum biomarker values and NT measurements between the ROP and non-ROP groups or between the proliferative ROP, non-proliferative ROP, and non-ROP groups. Conclusion Our results showed that first-trimester aneuploidy screening serum biomarker values and NT measurements were not associated with the development of ROP in premature infants.Article Citation - WoS: 1Citation - Scopus: 1The Ameliorative Effects of Hesperidin in Rats Developed Hepatotoxicity With Deltamethrin(Mashhad Univ Med Sciences, 2025) Karabekir, Seda Cetinkaya; Sozen, Mehmet Enes; Ayan, Ilknur Cinar; Savas, Hasan Basri; Cuce, Gokhan; Kalkan, SerpilObjective(s): Deltamethrin (DLM) is a widely used insecticide in agriculture; however, exposure to it can lead to serious health problems. This study aimed to evaluate the protective effects of hesperidin (HSP), a natural antioxidant, against DLM-induced liver toxicity. Materials and Methods: Thirty-two male Wistar Albino rats (250-300 g, 4 months old) were divided into four groups. The control group received 1 ml of corn oil via oral gavage for 30 days. The DLM group received 1.28 mg/kg DLM in corn oil for 30 days. The DLM+HSP 100 mg/kg and DLM+HSP 300 mg/kg groups received 1.28 mg/kg DLM followed by 100 mg/kg or 300 mg/kg HSP in distilled water, respectively, 30 min after DLM administration for 30 days. Liver tissues were examined histopathologically. Masson's trichrome staining and PCR assessed fibrosis. Caspase 3 and 9 expressions in liver tissues were determined by immunohistochemistry and PCR. Biochemical analyses were conducted on serum samples. Results: HSP supplementation led to a dose-dependent decrease in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. DLM exposure decreased antioxidant capacity, while HSP supplementation increased it dose-dependently. Histopathological evaluations showed increased liver damage in the DLM group, while HSP administration reduced liver toxicity. Masson's trichrome staining and analysis of collagen I (COL1A1) and collagen III (COL3A1) gene expression revealed increased fibrosis in the DLM group, which was attenuated with HSP treatment. Conclusion: The potential prevention of DLM-induced liver toxicity and apoptosis by HSP may be an alternative protective strategy.
