Gökdemir, Gül Şahika
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Gokdemir, Gul Sahika
Gokdemir, G. S.
Gokdemir, G. S.
Job Title
Dr. Öğr. Üyesi
Email Address
gulsahikagokdemir@artuklu.edu.tr
Main Affiliation
Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
Status
Current Staff
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Sustainable Development Goals
3
GOOD HEALTH AND WELL-BEING
10
Research Products
6
CLEAN WATER AND SANITATION
0
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
1
NO POVERTY
0
Research Products
5
GENDER EQUALITY
0
Research Products
10
REDUCED INEQUALITIES
0
Research Products
15
LIFE ON LAND
0
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
14
LIFE BELOW WATER
1
Research Products
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
4
QUALITY EDUCATION
0
Research Products
2
ZERO HUNGER
0
Research Products
13
CLIMATE ACTION
0
Research Products
Documents
15
Citations
52
h-index
5
Documents
0
Citations
0
Scholarly Output
22
Articles
19
Views / Downloads
1/3
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0
Supervised PhD Theses
0
WoS Citation Count
16
Scopus Citation Count
15
WoS h-index
2
Scopus h-index
2
Patents
0
Projects
1
WoS Citations per Publication
0.73
Scopus Citations per Publication
0.68
Open Access Source
17
Supervised Theses
0
| Journal | Count |
|---|---|
| Acta Medica Alanya | 1 |
| EGE KLİNİKLERİ TIP DERGİSİ | 1 |
| Ege Klinikleri Tıp Dergisi | 1 |
| Endokrin Aciller | 1 |
| European Review for Medical and Pharmacological Sciences | 1 |
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22 results
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Now showing 1 - 10 of 22
Article EFFECT OF METFORMIN ON MUSCLE ATROPHY IN EXPERIMENTAL DIABETIC RATS(2023) Gökdemir.Gül Şahika; Keşim, Dilek Aygül; Gökdemir, Mehmet Tahir; Baylan,MukadderBackground: Although first-line biguanide metformin is frequently administered to T2DM patients, the effects of long-term use on muscle are unknown. This study aimed to examine the effect of metformin-treated diabetes on muscle atrophy in experimental diabetic rats. Materials and methods: Twenty-one Wistar albino male rats in 3 groups were included in our research. Insulin resistance HOMA-IR, mTOR, and Myostatin levels and gastrocnemius weight were measured. Results: Myostatin level was significantly higher in the non-medicated diabetes group than in the healthy control group (p<0.001). Moreover, myostatin level was significantly lower in the metformin group (p=0.001). The weight of gastrocnemius was significantly lower in both the metformin-treated and non-metformin-treated diabetic groups compared to the control group (p<0.001 for both groups). Moreover, the gastrocnemius weight was significantly higher in the metformin group than in the non-medicated group (p=0.004). The HOME-IR level had a significantly negative correlation with the mTOR level (R=-0.783; P<0.001) and a positive correlation with the myostatin level (R=0.622; P=0.003). Conclusion: Our evidence and data support that metformin may be effective in preventing muscle wasting. To conclude, this study showed that metformin has anti-atrophic effects on muscles in diabetes and that metformin can prevent muscle mass loss.Article Citation - WoS: 2Citation - Scopus: 2Assessment of Iron Metabolism and Inflammation in Children With Cerebral Palsy(Mdpi, 2025) Orhan, Ozhan; Gokdemir, Gul SahikaBackground/Objectives: Cerebral palsy (CP) is a motor disorder resulting from brain damage that is common in childhood. Iron is vital for the body's basic functions. Iron metabolism disorders and inflammation contribute to the neurological complications seen in CP. The purpose of this research was to ascertain the association and correlation between markers of inflammation and iron metabolism in children with CP. Methods: A total of 181 children diagnosed with CP and 111 typically developing children were retrospectively included in the study. Demographic data, blood parameters, C-reactive protein, iron, total iron binding capacity, and inflammation markers were evaluated. Results: C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and systemic immuno-inflammatory index (SII) levels of CP children were found to be statistically significantly higher than those of control group children (p < 0.05). Iron (Fe) and ferritin levels were lower in the CP group, while total iron binding capacity (TIBC) was higher. Spearman correlation analysis showed significant correlations between iron, ferritin and TIBC and SII. Conclusions: Iron deficiency and chronic inflammation are associated with the pathophysiology of CP in patients with CP, and therefore it is important to monitor markers of iron metabolism and inflammation in these patients.Article The Effect of Gliclazide use on BDNF and NGF Levels in Rats with Diabetes Mellitus(2023) Gökdemir.Gül Şahika; Baylan,MukadderObjective: In this study, the effects of gliclazides, a second generation sulfonylurea group, on BDNF and NGF plasma levels, which are considered neurodegeneration biomarkers, will be examined. When designing our study, we assumed that gliazides might have positive neuronal effects. Thus, the possible positive effects of gliclazide will be emphasized in our study. Methods: In the experiment, 21 adult male Wistar-Albino rats were used. Serum BDNF and NGF levels were determined by analyzing with enzyme-linked immunosorbent assay kit in accordance with the recommendations. Results: BDNF levels were significantly lower in gliclazide-treated diabetic rats and nonmedicated diabetic rats compared to the healthy control group (p=0.017, p<0.001, respectively). Although the BDNF level of rats with diabetes given gliclazide was increased compared to rats with and without diabetes, this difference was not significant (p=0.107). Similarly, NGF levels were significantly lower in rats given gliclazide (p=0.009) and diabetic rats not given gliclazide (p=0.001) compared to the healthy control group. When the diabetic groups were compared among themselves, although the NGF level was increased in the gliclazide group, this difference was not statistically significant (p=0.638). The differences between the groups were significant in cyclic AMP regulatory element binding (p<0.001), c-FOS (p<0.001), amyloid precursor protein (p<0.001), B-SECRETASE1 (p=0.004), and doublecortin (p<0.001) levels. Conclusion: As a result, serum BDNF and NGF levels were significantly higher in non-diabetic healthy control group rats than in diabetic rats. While low serum levels of BDNF and NGF neurotrophins, which increase in neurodegeneration, were observed in diabetic rats, this level was observed to be higher in diabetic rats given gliclazide.Book Part Endokrin Sistem Fizyolojisi(Akademisyen Kitapevi, 2023) Gökdemir, Gül ŞahikaEndokrin Sistem FizyolojisiArticle Importance of Curcumin Effect and Asprosin Level on Glucose Metabolism in Diabetic Rats(2023) Gökdemir, Mehmet Tahir; Taşdemir, Ezel; Yokus, Beran; Atmaca, Mukadder; Gokdemir, Gul SahikaAsprosin is a new hormone secreted mainly from white adipose tissue. It may be associated with the pathogenesis of obesity, diabetes and some metabolic diseases. The changes in plasma asprosin levels of experimental diabetic rats and the relation of these changes with liver glucose metabolism and some diabetes parameters were investigated, and the effects of metformin, gliclazide or curcumin treatment on plasma asprosin levels were tried. The study was designed as an animal model in diabetic rats The albino rats were divided into five groups. To induce diabetes, a single dose of STZ was injected intraperitoneally. Diabetics rats were treated intragastrically with metformin (D+Metformin group), gliclazide (D+Giliclazide group) or 20 curcumin (D+Curcumin group) for eight weeks. Fasting blood glucose, insulin levels and other parameters were measured. Plasma asporsin levels of untreated diabetic rats increased significantly (P<.001). Although the plasma asprosin levels of diabetic rats treated with the rugs were significantly lower (P<.001). Fasting blood glucose levels of diabetic rats treated with the drugs were found to be remarkably lower than the diabetic control values (P<.001, respectively). There was no significant difference in the insulin levels and HOMA- IR between these three groups. Curcumin treatment provides significant improvements in plasma asprosin level and diabetes parameters. The increase in plasma asprosin level in diabetic rats may be one of the main reasons that facilitate the development of the disease or is responsible for its pathogenesis. Our findings support the idea that curcumin may be an important treatment option for diabetes.Book Part Physiopathology of allergic diseases and their relation to circadian rhythm(Nova Science Publishers, Inc., 2024) Gökdemir, Gül ŞahikaAllergic diseases have become a major health problem in modern society. These diseases are caused by an overreaction of the immune system and are often triggered by exposure to environmental allergens. Allergic diseases include asthma, allergicrhinitis, eczema, food allergies, and anaphylaxis. In recent years, research on the effectof circadian rhythm on the immune system has shown that there is an important relationship between the pathophysiology of allergic diseases and circadian rhythm. The pathophysiology of allergic diseases begins with responses to the immune system and the effect of allergens. The immune system is a complex network that regulates the response of immune cells. Immunoglobulin E (IgE) antibodies play an important role inreactions of hypersensitivity to allergens. Exposure to allergens triggers the activation of mast cells and basophils, resulting in the release of inflammatory mediators. The circadian rhythm is an internal clock system that regulates the 24-hour cycle of biological processes. The human body adapts various physiological and metabolic processes to this rhythm. The relationship of allergic diseases with the circadian rhythmis related to their effects on both the immune system and tissue and organ function. The circulation and activity of immune cells can change depending on the circadian rhythm. These changes can influence the immune system's response to exposure to allergens. In addition, the symptoms and severity of allergic diseases are also related to the circadian rhythm. Some studies have shown that allergic symptoms increase at night or in the morning. This suggests that the circadian rhythm may influence the severity of allergic reactions by affecting the release of immunoglobulins, the inflammatory response, and bronchial hyperreactivity. This chapter aims to provide researchers, clinicians, and healthcare professionals with an important resource on recent research findings that advance our understanding of the relationship between the pathophysiology of allergic diseases and the relationship between circadian rhythm.Article Hastaneye İskemik İnme ile Başvuran Geriatrik Hastalarda Ortalama Trombosit Hacmi/trombosit, Nötrofil/lökosit Oranı ve Troponin Değerlerinin Araştırılması(2024) Gökdemir, Gül ŞahikaAmaç: Bu çalışmanın amacı, iskemik inme ile hastaneye başvuran geriatrik hastalarda ortalama MPV/PLT oranı, NLR ve troponin I düzeylerini araştırmak ve bu parametrelerin prognostik değerlerini değerlendirmektir. Bu şekilde, iskemik inme hastalarının değerlendirme ve tedavi süreçlerinde daha iyi bir klinik karar verme sağlanabilir. Yöntem: Geriye dönük bir tasarım kullanılarak, iskemik inme tanısıyla hastaneye başvuran geriatrik hastaların verileri retrospektif olarak incelendi. Hastaların demografik özellikleri, klinik bulguları, laboratuvar sonuçları ve radyolojik bulguları elektronik tıbbi kayıtlardan elde edildi. Trombosit hacmi, platelet sayısı, nötrofil sayısı, lökosit sayısı ve troponin I düzeyleri primer veriler, diğer demografik, klinik ve laboratuvar parametreleri de ikincil veriler olarak kaydedildi. Bulgular: MPV/PLT oranı, iskemik inme hastalarında (0,04±0,02) iskemik inme olmayan hastalara (0,03±0,02) göre anlamlı oranda daha yüksek olarak gözlemlendi (p<0,001). Benzer olarak iskemik inme hastalarında NLR (5,29±5,09), diğer gruba oranla (1,93±0,87) anlamlı oranda daha yüksek idi (p<0,001). Buna ek olarak Troponin I düzeyi, iskemik inme hastalarında (10,48±7,88 ng/mL) diğer gruptan (2,18±1,11 ng/mL) bariz olarak yüksek idi (p<0,001). Sonuç: Bu çalışma, iskemik inme ile hastaneye başvuran geriatrik hastalarda ortalama MPV/PLT oranı, NLR ve troponin I düzeylerinin prognostik değerlerini ortaya koymaktadır. Bu parametrelerin klinik değerlendirmelerde kullanılması, iskemik inme hastalarının takibinde ve tedavi stratejilerinin belirlenmesinde yardımcı olabilir.Article Citation - WoS: 6Citation - Scopus: 5Effects of Acute Carbon Monoxide Poisoning on Liver Damage and Comparisons of Related Oxygen Therapies in a Rat Model(Taylor & Francis Ltd, 2024) Demirtas, Berjan; Taskin, Seyhan; Gokdemir, Gul Sahika; Seker, UgurAcute carbon monoxide (CO) poisoning may cause liver damage and liver dysfunction. Therefore, in this study, we aimed to compare the efficiency of normobaric oxygen (NBO) and high-flow nasal cannula oxygen (HFNCO) treatments on liver injury. For that purpose, 28 male Wistar albino rats were divided into four groups (Control, CO, CO + NBO, and CO + HFNCO). The control group was allowed to breath room air for 30 min. Acute CO poisoning in CO, CO + NBO, CO + HFNCO was induced by CO exposure for 30 min. Thereafter, NBO group received 100% NBO with reservoir mask for 30 min. HFNCO group received high-flow oxygen through nasal cannula for 30 min. At the end of the experiment, all animals were sacrificed by cardiac puncture under anesthesia. Serum liver function tests were measured. Liver tissue total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels, tissue histomorphology and immunoexpression levels of Bax, Caspase 3, TNF-alpha, IL-1 beta, and NF-kappa B were also examined. Our observations indicated that acute CO poisoning caused significant increases in blood COHb, serum aminotransferase (AST), alanine aminotransferase (ALT0, alkaline phosphatase (ALP), total protein, albumin, and globulin levels but a decrease in albumin to globulin ratio (all, p < 0.05). Furthermore, acute CO poisoning significantly increased the OSI value, and the immunoexpresssion of Bax, Caspase 3, TNF-alpha, IL-1 beta, and NF-kappa B in liver tissue (all, p < 0.05). These pathological changes in serum and liver tissue were alleviated through both of the treatment methods. In conclusion, both the NBO and HFNCO treatments were beneficial to alleviate the acute CO poisoning associated with liver injury and dysfunction. [GRAPHICS] .Article Citation - WoS: 1Citation - Scopus: 1Evaluation of the pleth variability index, perfusion index, and other physiological parameters after COVID-19(Verduci Editore srl, 2023) Gökdemir, Gül ŞahikaObjective: The aim of this study was to observe the changes in pleth variability index (PVI), perfusion index (PI) and other hemodynamic parameters in adult individuals who had had Coronavirus disease 2019 (COVID-19) and were currently living a normal life. A further aim was to draw attention to the fact that some hemodynamic changes after COVID-19 may cause long-term health problems. Patients and methods: A total of 174 adult individuals who had had COVID-19 and were currently living a normal life and 56 healthy individuals with similar demographic characteristics who had not had COVID-19 were included in the study. The PI, PVI, oxygen saturation (SpO2), pulse rate (PR), total hemoglobin (Hgb), oxygen reserve index (ORI), and blood pressure values were measured by Masimo Radical 7. The data of individuals who had and did not have COVID-19 before were compared. Results: The mean PVI (p = 0.008) and PI (p < 0.001) were significantly lower in people who had been exposed to COVID-19. Likewise, the mean of ORI, SpO2, and SpOC values was observed to be significantly lower in participants exposed to COVID-19 disease (p < 0.001, p < 0.001, and p = 0.006, respectively). The PVI had a positive correlation with body mass index (BMI) (r = 0.263, p < 0.001) and a negative correlation with SpO2 (r = -0.194, p = 0.003) and PR (r = 0.190, p = 0.004). Conclusions: The PVI, PI, and other physiological parameters could potentially be useful for monitoring COVID-19 patients and evaluating their response to therapy. We believe that people who have been exposed to COVID-19 may be more susceptible to other diseases; therefore, they should be subjected to regular clinical checks.Article Dose-Dependent Hepatotoxicity of Diethyl Phthalate in Female Wistar Rats(MDPI, 2026) Tan, Fazile Canturk; Gokdemir, Gul Sahika; Kalkan, Kubra Tugce; Varol, Salih; Yavas, Mehmet Cihan; Cantürk Tan, FazilePhthalates are a class of compounds commonly used as plasticizers in various industrial and consumer products. In line with the increasing environmental and biological exposure concerns regarding these compounds, this study investigated the dose-dependent effects of diethyl phthalate (DEP) on the liver in a subacute rat model. Diethyl phthalate (DEP) was given orally by gavage to female Wistar albino rats at doses of 100, 300, and 600 mg/kg body weight per day for 21 days in order to assess liver tissue and associated function test levels. Liver function was evaluated by analyzing serum biochemical data. Liver tissues were evaluated using histopathological staining (H&E and Masson's trichrome staining), immunohistochemical analysis of IL-1 beta and TGF-beta, tissue ELISA for IL-6 and TNF-alpha, and comet assay to determine DNA damage. DEP exposure was found to cause significant, dose-dependent histopathological changes in liver tissue, including hepatocyte necrosis, cytoplasmic vacuolization, sinusoidal dilation, and vascular congestion. AST levels were significantly increased compared to the control group, while no significant changes were observed in other serum biochemical parameters. Compared to the control group, the expression of pro-inflammatory cytokines (IL-6 and TNF-alpha), IL-1 beta, and TGF-beta was found to be elevated in the DEP-treated groups, and their levels increased with increasing exposure dose. DEP exposure also caused significant DNA damage in liver tissue. These findings indicate that despite an increase in AST levels observed in subacute DEP exposure, there were limited changes in serum biochemical parameters; serum liver enzymes alone may not fully reflect the extent of hepatic damage, and DEP can cause significant inflammatory, histopathological, and genotoxic effects in liver tissue.
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