Unsal, Velid
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Unsal, V.
Velid Unsal
Ünsal, Velid
Unsal V.
Velid Unsal
Ünsal, Velid
Unsal V.
Job Title
Doçent
Email Address
velidunsal@gmail.com
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Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü
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Sustainable Development Goals
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
2
ZERO HUNGER
0
Research Products
5
GENDER EQUALITY
0
Research Products
6
CLEAN WATER AND SANITATION
1
Research Products
13
CLIMATE ACTION
0
Research Products
10
REDUCED INEQUALITIES
0
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
0
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15
LIFE ON LAND
0
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3
GOOD HEALTH AND WELL-BEING
14
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
14
LIFE BELOW WATER
3
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4
QUALITY EDUCATION
0
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1
NO POVERTY
0
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
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11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
Documents
45
Citations
880
h-index
11
Documents
44
Citations
719
Scholarly Output
49
Articles
47
Views / Downloads
198/4996
Supervised MSc Theses
1
Supervised PhD Theses
0
WoS Citation Count
649
Scopus Citation Count
757
WoS h-index
8
Scopus h-index
9
Patents
0
Projects
3
WoS Citations per Publication
13.24
Scopus Citations per Publication
15.45
Open Access Source
37
Supervised Theses
1
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| Journal | Count |
|---|---|
| Folia Medica | 5 |
| Andrologia | 3 |
| BMC Chemistry | 2 |
| Turkish Journal of Biochemistry | 2 |
| Turkish Journal of Biochemistry-Turk Biyokimya Dergisi | 2 |
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49 results
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Now showing 1 - 10 of 49
Article Citation - Scopus: 1Evaluation of Oxidative Stress Biomarkers in Patients with Henoch-Schönlein Purpura(Folia Medica, 2021) Soylemez, Kadir; Temiz, Fatih; Dalkıran, Tahir; Kandur, Yasar; Kurutas, Ergul Belge; Unsal, Velid; Oner, ErkanIntroduction: Henoch-Schönlein Purpura (HSP) is a systemic vasculitic syndrome characterized by non-thrombocytopenic purpura, arthritis/arthralgia, abdominal pain, and glomerulonephritis. The pathogenesis of HSP has not been clearly identified. Oxidative damage has a role in the pathogenesis of most cases. Aim: This study aimed to evaluate changes of oxidative stress by studying parameters like superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA) in an attempt to identify the role of oxidative stress in HSP from another perspective. Materials and methods: This study enrolled 23 pediatric patients (ten girls and thirteen boys) diagnosed with HSP who were under follow-up at Sutcu Imam University School of Medicine Department of Pediatrics between 2014 and 2016 and twenty healthy children as the control group. The parents of all subjects gave informed consent to participate in the study. In the HSP group, the beginning season of the illness and the systemic involvement during follow-up were determined. Blood specimens were obtained at presentation before any treatment was started. SOD, CAT activities, and MDA values in erythrocyte and plasma samples were compared between the patient group and the healthy children. Results: Twenty-three patients with HSP (13 males, 10 females) and 20 healthy children participated in this study. The mean age of the HSP cases was 8.21±3.78 years (range 2-16 years) and of the controls was 8.6±4.2 (range 3-14 years). The mean MDA value was 2.95±0.71 nmol/ml in the patient group and 2.67±0.66 nmol/ml in the control group (p=0.787). The mean level of the CAT enzyme was 1.32±0.35 U/g Hb in the patient group and 7.8±1.74 U/g Hb in the control group (p=0.001). The mean levels of the SOD enzyme were 3.06±0.85 U/g Hb in the patient group and 0.97±0.36 U/g Hb in the control group (p=0.001). Conclusions: Although high MDA levels support the role of lipid peroxidation in the pathogenesis of HSP, statistical significance was not reached owing to a limited number of our patients. The reduced CAT enzyme activity is consistent with the findings of previous reports. This finding supports the notion that oxidative stress can play a role in the pathogenesis of HSP.Master Thesis Akut yüksek doz arsenik maruziyetinin insan göbek damarı endotel hücrelerinde(HUVEC) oluşturduğu sitotoksisite, oksidatif stres ve apoptozise karşı trans-chalcone uygulamasının koruyucu etkinliğinin araştırılması(Mardin Artuklu Üniversitesi, 2023) Gözüoğlu, Mustafa; Unsal, VelidBu çalışma, İnsan Umblikal Ven Endotel Hücreleri (HUVEC), arsenik maruziyeti sonucunda hücre hasarı uyarılacaktır. HUVEC hücrelerinde arsenik kaynaklı hücresel hasarı ve bu hasara karşı Trans-chalcone'nun olası koruyucu rolünü belirlemek amacıyla yapılacaktır. Trans-chalcone'nın hasara uğramış hücreler üzerindeki sitotoksisite, apoptotizis, oksidatif strese etkileri araştırılacaktır. Arsenik ile indükleniş hücreler Trans-chalcone ile tedavi edilerek, hücre canlılığı, sitotoksisite, Oksidatif stres parametreleri ve DNA hasarı in vitro olarak gösterilecektir. Arsenik büyük ölçüde çevreye yayılan ve yer kabuğunda metalloid olarak biriken toksik bir elementtir. Arsenik ve türevleri içme suyunda, besinlerde, toprak ve hava partiküllerinde bulunmaktadır. Özellikle içme suyu arsenik maruziyetinin en yaygın kaynağıdır. Arsenik Uluslararası Kanser Araştırmaları Ajansı tarafından grup I insan karsinojeni olarak sınıflandırılmıştır. Arseniğe maruziyet; akciğer, kan, cilt kanseri ve çeşitli cilt lezyonları ile ilişkilidir.Article Citation - WoS: 6Citation - Scopus: 6Etomidate Alleviates Ovarian Ischemia-Reperfusion Injury in Rats(Turkish Assoc Trauma Emergency Surgery, 2024) Katar, Muzaffer; Gevrek, Fikret; Unsal, Velid; Tapar, Hakan; Karaman, Tugba; Karaman, Serkan; Balta, MehtapBACKGROUND: This study investigates the protective effects of etomidate against oxidative damage in an experimental model of ovarian ischemia-reperfusion injury. METHODS: A total of 24 female rats were randomized into three groups. Group 1 served as the control. Group 2 underwent an ovarian torsion/detorsion procedure. Group 3 underwent similar procedures as Group 2; additionally, 4 mg/kg of etomidate was administered intraperitoneally 30 minutes before ovarian detorsion. Blood samples were analyzed for lipid peroxidation, pro-inflamma- tory cytokine levels, and antioxidant enzyme activity.Furthermore, histopathological scoring was performed to evaluate tissue damage in the ovaries. RESULTS: Biochemical analysis of blood samples revealed reductions in pro-inflammatory cytokines, including interleukin-1 Beta (IL- 1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α), in Group 3 compared to Group 2 (p=0.005, p=0.016, and p<0.001, respectively). Additionally, a decrease in malondialdehyde (MDA) levels was observed in Group 3 compared to Group 2 (p<0.001). In contrast, activities of antioxidant enzymes, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), were signifi- cantly increased in Group 3 compared to Group 2 (p=0.031 and p=0.001, respectively). Furthermore, Group 3 demonstrated notable reductions in histopathological scores for follicular degeneration, vascular occlusion, bleeding, and inflammation compared to Group 2 (p<0.001, p<0.001, p<0.001, and p=0.001, respectively). CONCLUSION: Etomidate alleviates ischemia-reperfusion injury in a rat ovarian torsion-detorsion model by improving both histo- pathological and biochemical outcomes.Article Citation - WoS: 7Citation - Scopus: 9Evaluation of Extra Virgin Olive Oil Compounds Using Computational Methods: in Vitro, Admet, Dft, Molecular Docking and Human Gene Network Analysis Study(Bmc, 2025) Unsal, Velid; Yildiz, Resit; Korkmaz, Aziz; Mert, Basak Dogru; Caliskan, Cemile Gunbegi; Oner, ErkanThis study investigates the phenolic compounds (PC), volatile compounds (VC), and fatty acids (FA) of extra virgin olive oil (EVOO) derived from the Turkish olive variety "Sar & imath; Ulak", along with ADMET, DFT, molecular docking, and gene network analyses of significant molecules identified within the EVOO. Chromatographic methods (GC-FID, HPLC) were employed to characterize FA, PC, and VC profiles, while quality parameters, antioxidant activities (TAC, ABTS, DPPH) were assessed via spectrophotometry. The analysis revealed a complex composition of 40 volatile compounds, with estragole, 7-hydroxyheptene-1, and 3-methoxycinnamaldehyde as the primary components. Hydroxytyrosol, tyrosol, oleuropein, apigenin, ferulic acid, and vanillic acid emerged as main phenolic constituents, with hydroxytyrosol and apigenin exhibiting high bioavailability. Molecular docking highlighted oleuropein and pinoresinol as compounds with strong binding affinities, though only hydroxytyrosol, apigenin, and pinoresinol fully met Lipinski and other drug-likeness criteria. DFT analysis showed that oleuropein and pinoresinol have notable dipole moments, reflecting polar and asymmetrical structures. KEGG enrichment analysis further linked key molecules like oleuropein and apigenin with pathways related to lipid metabolism and atherosclerosis, underscoring their potential bioactivity and relevance in health-related applications.Article Citation - WoS: 6Citation - Scopus: 3Protective effects of apocynin and melatonin on ovarian ischemia/reperfusion injury in rats(Clinical and Experimental Obstetrics and Gynecology, 2021) Unsal, Velid; İşgüder, Çiğdem Kunt; Can, Özlem Koşar; Pektaş, Mine Kanat; Arici, AkgülObjective: This study aims to determine the protective effects of apocynin, a NADPH oxidase inhibitor, and melatonin, an endogenous anti-oxidant, in an animal model of ovarian ischemia/reperfusion (I/R) injury. Materials/Methods: Thirty-five female rats were randomly divided into five groups, namely group I (sham), group II (I/R), group III (I/R + 10 mg/kg apocynin), group IV (I/R + 20 mg/kg apocynin), and group V (I/R + 10 mg/kg melatonin). Ovarian tissue and serum superoxide dismutase (SOD) and catalase (CAT) activities and malondialdehyde (MDA) and protein carbonyl (PC) levels were measured. Ovarian histopathology was examined and Bax, caspase 3, and iNOS immunoreactivities were evaluated. Results: Preoperative apocynin and melatonin significantly increased SOD and CAT activities (P < 0.05, P < 0.05, P < 0.01, P < 0.01, P < 0.01, P < 0.05, P < 0.05, and P<0.01, respectively, for both apocynin and melatonin). In addition, preoperative apocynin and melatonin significantly decreased the ovarian I/R injury score (P < 0.01 for both). Bax, caspase 3, and iNOS immunoreactivities were significantly lower in the I/R + 10 mg/kg apocynin and I/R + 10 mg/kg melatonin groups than in the I/R group (P<0.01, P<0.01, P<0.01, P<0.01, P<0.05, and P<0.01, respectively). Conclusions: Apocynin and melatonin are powerful antioxidant agents with considerable bioavailability and safety. Preoperative apocynin and melatonin administration might protect ovarian tissue from I/R injury after surgical adnexal detorsion.Article Citation - WoS: 34Citation - Scopus: 32Investigation of oxidant/antioxidant and anti-inflammatory effects of apigenin on apoptosis in sepsis-induced rat lung(Journal of Biochemical and Molecular Toxicology, 2021) Unsal, Velid; Çiçek, Mustafa; Doganer, Adem; Demir, MehmetWe suppose that apigenin may inhibit the cellular process of sepsis-induced lung injury, which is considered to be a major cause of morbidity and mortality, and may improve inflammation and oxidative stress. The aim of this study was to investigate the potential protective effect of apigenin in a rat model of polymicrobial sepsis. Eight groups consisting of a total of 64 female Wistar albino rats were used for this study. Pro-inflammatory (TNF-α, IL-1-β, IL-6) and anti-inflammatory (TGF-β, IL-10) cytokine levels were measured with the enzyme-linked immunosorbent assay technique, oxidant/antioxidants parameters were measured using the spectrophotometric method and Bax and Caspase-3 immunohistochemical methods. TNF-α, TGF-β, IL-1β, and IL-6 levels significantly increased in the sepsis-induced group than in the control groups, while IL-10 levels decreased. Lipid peroxidase (LPO), an oxidative stress marker, increased, while the antioxidant defense parameters of superoxide dismutase (SOD), catalase (CAT) activities, glutathione (GSH) levels decreased. Although Bax and Caspase-3 immunoreactivity and H score levels significantly increased in the sepsis group, significant decreases were found in the groups treated with apigenin. In conclusion, we are of the opinion that apigenin treatment improves lung injury by inhibiting oxidative stress and inflammatory cell damage.Article An Animal Model of Reperfusion in Ischemic Corporal Tissue and the Effect of Sugammadex on Oxidative Injury Parameters(MRE Press, 2025) Kolukcu, Vildan; Yalcin, Kenan; Eroglu, Askin; Gevrek, Fikret; Gurpinar, Ahmet Burak; Unsal, VelidBackground: The aim of this study was to analyze the effect of sugammadex on ischemia-reperfusion injury in corporal tissue. Methods: Eighteen male Wistar Albino strain rats were divided into three groups. Group 1 served as the control group. A priapism model was induced in rats in Group 2 and 3. Rats in Group 3 were additionally administered 4 mg/kg sugammadex intravenously immediately after reperfusion. All rats underwent penectomy for histopathological and biochemical evaluations, and blood samples were collected. Results: In Group 2, total oxidant status (TOS) and malondialdehyde (MDA) levels were significantly higher compared to other groups (p < 0.001 and p = 0.009, respectively). A substantial reduction in both TOS and MDA levels was found in Group 3 (p <0.001 and p = 0.043, respectively). Group 2 exhibited significantly lower activities of a glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) compared to Group 1 (p = 0.043 and p = 0.024, respectively). In contrast, Group 3 showed significant increases in both antioxidant enzyme activities (p = 0.036 and p = 0.034, respectively). Similarly, the total antioxidant status (TAS) was dramatically higher in Group 3 compared to Group 2 (p < 0.001). Microscopic examinations revealed improvements in vasocongestion, edema, desquamation and inflammation scores in Group 3 compared to Group 2 (p < 0.001). Conclusions: Biochemical and histopathological findings suggest that, sugammadex significantly mitigates oxidative damage parameters in corporal tissue affected by ischemia-reperfusion injury.Article Citation - WoS: 5Protective Effects of Syringic Acid on Ischemia-Reperfusion Injury in Testicular Torsion: An Experimental Study in a Rat Model(CUREUS INC, 2023) Sarıkaya, Kubilay; Kölükçü, Engin; Unsal, VelidAim: The purpose of this study was to assess the effectiveness of syringic acid in preventing ischemia-reperfusion injury following detorsion in a rat model of induced testicular torsion.Material and methods: In our study, a total of 24 rats, eight in each group, were used. Group 1 served as the control group. Group 2 underwent testicular torsion and detorsion. Group 3 underwent the same procedures as Group 2, but also received 100 mg/kg syringic acid immediately following ischemia. Spectrophotometric analysis was performed on blood samples, and the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), as well as the values of malondialdehyde (MDA), were evaluated under direct microscopic examination of the testis to determine tissue injury. The architecture of the seminiferous tubules and spermatogenesis processes were graded using the Johnsen and Cosentino scoring systems.Results: The mean value of MDA was higher in Group 2 compared to the other groups (p < 0.001). Group 3 demonstrated a decline in the concentrations of proinflammatory cytokines, such as tumor necrosis factor -alpha, interleukin-6, and interleukin-1 beta, as indicated by biochemical analysis of blood samples, when compared to Group 2 (p-values: 0.045, 0.001, and <0.001, respectively). In addition, the improvement in Johnsen and Cosentino scores was significantly higher in Group 3 compared to Group 2 (p = 0.028 and p = 0.001, respectively).Conclusion: These findings suggest that syringic acid has a protective effect against testicular oxidative damage.Article Citation - WoS: 1Renoprotective effect of diacerein in rats with partial unilateral ureteral obstruction model(Walter de Gruyter, 2024) Katar, Muzaffer; Gevrek, Fikret; Fırat, Fatih; Kölükçü, Engin; Unsal, VelıdObjectives: We aimed to analyze the effects of diacerein in a rat model of partial unilateral ureteral obstruction (PUUO). Methods: We randomly divided 24 female rats into three groups. Control group, PUUO group and PUUO + diacerein group. The PUUO group was subjected to the PUUO model for seven days. The PUUO + diacerein group received oral diacerein (80 mg/kg) for seven days. Spectrophotometric methods were employed to measure oxidative stress parameters, including malondialdehyde (MDA), protein carbonyl (PC) and antioxidant enzyme levels, including glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD), while indicators of renal function, such as kidney injury molecule-1 (KIM-1) and neutrophil gelatinous- associated lipocalin (NGAL), along with inflammatory parameters interleukin-1 beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6), were assessed using the ELISA method. Inflammatory parameters were measured in blood samples, and other parameters were analyzed in kidney tissue. Hematoxylin-eosin method examinations were used for histological analyses. Results: IL-1beta, TNF-alpha, and IL-6 levels were found to be significantly decreased in the PUUO + diacerein group compared to the PUUO group (p=0.006, p=0.002 and p=0.001, respectively). In the PUUO + diacerein group, GSH-Px and SOD activities increased compared with the PUUO group (p=0.031 and p=0.037, respectively). We also observed a significant improvement in renal function parameters, such as KIM-1 and NGAL levels in the PUUO + diacerein group compared to PUUO (p=0.002 and p=0.012, respectively). The PC and MDA levels were highest in the PUUO group (p<0.001). Similarly, the histopathologic tissue damage was the most prominent PUUO group (p<0.001). Conclusions: Our study found that diacerein is a highly effective pharmacologic agent in alleviating oxidative dam- age in PUUO model rats.Article Dapsone Can Be a New Treatment Option for Reducing the Detrimental Effect of Priapism(2021) Uluocak, Nihat; Kolukcu, Engin; Parlaktaş, Bekir Süha; Deresoy, Faik Alev; Katar, Muzaffer; Unsal, VelidAim: This study aims to analyze the effect of dapsone against ischaemia-reperfusion injury on corporal tissue in a model of induced-priapism in rats. Material and Method: A total of 24 rats were randomized into three groups. Group 1 was defined as the control group. Ischaemia-reperfusion injury was evaluated following the priapism model in Group 2. Group 3 had similar procedures to the rats in Group 2. Group 3 additionally had 12.5 mg/kg dapsone administered intraperitoneally 30 minutes after priapism. Results: Biochemical analysis of blood indicated a significant increase in Group 3 in terms of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) activity and total antioxidant status (TAS) values compared with Group 2 (p:0.002, p:0.029 and p:0.009, respectively). The highest values of malondialdehyde (MDA), protein carbonyl (PC) and total oxidant status (TOS) were recorded in Group 2 (p<0.001). Interleukin 1beta (IL-1beta), Interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF alpha) levels were found to be significantly decreased in Group 3 compared with Group 2 (p:0.022, p:0.049 and p<0.001, respectively). Direct microscopic evaluation determined an improvement in inflammation, edema, desquamation and vasocongestion scores in Group 3 compared to Group 2 (p<0.05). Conclusion: Dapsone has a protective effect on ischaemia-reperfusion injury in corporal tissue.
