Profile URL: https://hdl.handle.net/20.500.12514/7397
Job Title:Doç. Dr.
Email Address:ademaktan@artuklu.edu.tr
Main Affiliation:Dahili Tıp Bilimleri Bölümü
Status: Current Staff
ORCID:
0000-0003-0505-9784
0000-0003-0505-9784Scopus ID:
56783879500
56783879500YÖK Akademik: 131AF89001758E7A
Google Scholar:
m76i1JgAAAAJ
m76i1JgAAAAJWeb of Science ID:
GMX-2603-2022
GMX-2603-2022Name Variants:
Aktan, A. Aktan, Adem
82 results
Scholarly Output Search Results
Now showing 1 - 10 of 82
Article Citation - WoS: 2Citation - Scopus: 2The Effect of Aortic Angulation on Clinical Outcomes of Patients Undergoing Transcatheter Aortic Valve Replacement(Soc Brasil Cirurgia Cardiovasc, 2024) Aktan, Adem; Demir, Muhammed; Aslan, Burhan; Guzel, Tuncay; Karahan, Mehmet Zulkuf; Kilic, Raif; Ertas, FarukIntroduction: The aim of this study was to assess the impact of aortic angulation (AA) on periprocedural and in -hospital complications as well as mortality of patients undergoing Evolut (TM) R valve implantation. Methods: A retrospective study was conducted on 264 patients who underwent transfemoral-approach transcatheter aortic valve replacement with self-expandable valve at our hospital between August 2015 and August 2022. These patients underwent multislice computer tomography scans to evaluate AA. Transcatheter aortic valve replacement endpoints, device success, and clinical events were assessed according to the definitions provided by the Valve Academic Research Consortium -3. Cumulative events included paravalvular leak, permanent pacemaker implantation, new-onset stroke, and in -hospital mortality. Patients were divided into two groups, AA <= 48(degrees) and AA > 48(degrees), based on the mean AA measurement (48.3 +/- 8.8) on multislice computer tomography. Results: Multivariable logistic regression analysis was performed to identify predictors of cumulative events, utilizing variables with a P-value < 0.2 obtained from univariable logistic regression analysis, including AA, age, hypertension, chronic renal failure, and heart failure. AA (odds ratio [OR]: 1.73, 95% confidence interval [CI]: 0.89-3.38, P=0.104), age (OR: 1.04, 95% CI: 0.99-1.10, P=0.099), hypertension (OR: 1.66, 95% CI: 0.82-3.33, P=0.155), chronic renal failure (OR: 1.82, 95% CI: 0.92-3.61, P=0.084), and heart failure (OR: 0.57, 95% CI: 0.27-1.21, P=0.145) were not found to be significantly associated with cumulative events in the multivariable logistic regression analysis. Conclusion: This study demonstrated that increased AA does not have a significant impact on intraprocedural and periprocedural complications of patients with new generation self-expandable valves implanted.Article The Effect of Idiopathic Premature Ventricular Complexes on Left Ventricular Ejection Fraction(2019) Aktan, Adem; Özkalaycı, Flora; Çinier, Göksel; Altıntaş, Bernas; Tanboğa, İbrahi̇m Hali̇l; Kaya, İlyas; Küp, AyhanAIM: Current literature lacks a definitive threshold of idiopathic premature ventricular complex (PVC) burden for predicting cardiomyopathy (CMP). The main objective of the present study was to evaluate relationship between the PVC burden and left ventricular ejection fraction (LVEF). METHOD: This multicenter, cross-sectional study included 341 consecutive patients with more than 1,000 idiopathic PVC in 24 hr of Holter monitoring admitted to the cardiology clinics between January 2019 and May 2019 in the nineteen different centers. The primary outcome was the LVEF measured during the echocardiographic examination. RESULT: Overall, the median age was 50 (38-60) and 139 (49.4%) were female. Percentage of median PVC burden was 9% (IQR: 4%-17.4%). Median LVEF was found 60% (55-65). We used proportional odds logistic regression method to examine the relationship between continuous LVEF and candidate predictors. Increase in PVC burden (%) (regression coefficient (RE) -0.644 and 95% CI -1.063, -0.225, p < .001), PVC QRS duration (RE-0.191 and 95% CI -0.529, 0.148, p = .049), and age (RE-0.249 and 95% CI -0.442, -0.056, p = .018) were associated with decrease in LVEF. This inverse relationship between the PVC burden and LVEF become more prominent when PVC burden was above 5%. A nomogram developed to estimate the individual risk for decrease in LVEF. CONCLUSION: Our study showed that increase in PVC burden %, age, and PVC QRS duration were independently associated with decrease in LVEF in patients with idiopathic PVC. Also, inverse relationship between PVC burden and LVEF was observed in lower PVC burden than previously known.Article A Comparison of Postoperative Complications Following Cardiac Implantable Electronic Device Procedures in Patients Treated with Antithrombotic Drugs(2022) Özbek, Mehmet; Aktan, Adem; Argun, Lokman; Toprak, Nizamettin; Polat, Nihat; Demir, Muhammed; Yıldırım, BünyaminBACKGROUND: The incidence of postoperative complications following cardiac implantable electronic device (CIED) procedures in patients treated with antithrombotic drugs has not been studied sufficiently. Here we present a comparison of complications after CIED implantations. METHODS: Using an observational study design, the study included 1807 patients with a taking antiplatelet drugs (n: 1601), nonvitamin K anticoagulants (NOAC) (n: 136), and warfarin (n: 70) undergoing CIED surgery. Primary endpoint was accepted as cumulative events including composite of clinically significant hematoma (CSH), pericardial effusion or tamponade, pneumothorax, and infection related to device system. Secondary outcomes included each compenent of cumulative events. Multivariable analysis was performed to identify predictors of cumulative events. RESULTS: The overall cumulative event rate was 3.7% (67 of 1807). Cumulative events occured 3.1% (50 of 1601) in the antiplatelet, 5.1% (7 of 136) NOAC, and 14.3% (10 of 70) warfarin groups (p < 0.001). CSH occurred in 2 of 70 patients (2.9%) in the warfarin group, as compared with 5 of 1601 (0.3%) in the antiplatelet group (p: 0.032). However, no significant differences were found between NOAC and warfarin groups in terms of CSH (0.7% vs. 2.9% respectively, p: 0.267). Warfarin treatment was an independent predictor of cumulative events and increased 2.9-fold the risk of cumulative events. Major surgical complications were rare and did not differ significantly between the study groups. CONCLUSIONS: The incidence and severity of complications may be lower in patients treated with periprocedurally antiplatelet or NOAC therapy when compared with warfarin therapy. Further randomized control studies are required to confirm our findings.Other Prognostic Value of Hemoglobin, Albumin, Lymphocyte, Platelet (HALP) Scores in Patients with Non-Valvular Atrial Fibrillation: Insights From the AFTER-2 Study(2025) Aktan, Adem; Kılıç, Raif; Demir, Muhammed; Söner, Serdar; Ertaş, Faruk; Güzel, Tuncay; Söner, Hülya TosunArticle Effect of the Prognostic Nutrition Index on Long-Term Outcomes in Unprotected Left Main Coronary Artery Revascularization(2023) Arık, Baran; İldırımlı, Kamran; Kırış, Tuncay; Arslan, Bayram; Ertaş, Faruk; Güzel, Tuncay; Avcı, EyüpObjective The prognostic nutritional index (PNI) is a practical, applicable, prognostic scoring system. However, its clinical significance in unprotected left main coronary artery (ULMCA) patients undergoing percutaneous coronary intervention (PCI) has not yet been clarified. This study aimed to examine the relationship between malnutrition as assessed by PNI and major adverse cardiac events (MACE) in ULMCA patients undergoing PCI.Material and methods 185 patients who were hospitalized in our clinic underwent coronary angiography, had a critical LMCA lesion, and underwent angiography-guided PCI were included. The study population was divided into tertiles based on the PNI values. A high PNI (n=142) was defined as a value in the third tertile (≥ 34.0), and a low PNI (n=43) was defined as a value in the lower 2 tertiles (< 34.0). The primary endpoint was MACE.Results MACE and mortality rates in the low PNI group were significantly higher compared to the high PNI group (51 % vs. 30 %, p=0.009; 44 % vs. 20 %, p=0.002, respectively). High PNI (HR:1.902; 95 % CI:1.112-3.254; p=0.019), previous stroke (HR:3.025; 95 % CI:1.038-8.810; p=0.042) and SYNTAX score (HR:1.028; 95 % CI:1.004-1.057, p=0.023) were independent predictors of MACE in the multivariable cox regression analyzes.Conclusions In patients undergoing ULMCA PCI, nutritional status can be considered an indicator of MACE rates by evaluating the PNI score. This index can be used for risk classification.Article Prognostic Value of the Naples Prognostic Score for Predicting Major Adverse Cardiac Events and Long-Term Outcomes in Patients with NSTEMI(2026-01-14) Özbek, Mehmet; Aktan, Adem; Karahan, Mehmet Zülkif; Kılıç, Raif; İldırımlı, Kamran; Evsen, Ali; Güzel, TuncayObjectives: The Naples prognostic score (NPS) is determined using four parameters: Serum albumin, total cholesterol, the neutrophil-to-lymphocyte ratio, and the lymphocyte-to-monocyte ratio. Since both inflammation and nutritional status have a critical impact on the onset and advancement of cardiovascular diseases, this score has been suggested as a beneficial prognostic tool. In this research, we sought to assess the predictive value of NPS, measured at the time of hospital admission, for major adverse cardiac events (MACE) and long-term outcomes in patients with non-ST-segment elevation myocardial infarction (NSTEMI). Patients and methods: A cohort of 125 individuals with NSTEMI, identified between January 1 and June 1, 2019, was retrospectively evaluated. According to their NPS values, the cohort was stratified into two groups: Low NPS (0-2 points; n=73) and high NPS (3,4 points; n=52). Over an average follow-up period of 60 months, the manifestation of MACE and overall mortality was systematically documented. Results: MACE was observed in 31 patients, with a markedly greater frequency in the high-NPS group (n=22; p<0.001). Long-term mortality occurred in 18 individuals, of whom 15 belonged to the high-NPS category (p<0.001). ROC curve analysis determined an optimal NPS threshold of 2.5 for predicting both MACE and overall mortality. Survival analysis using the Kaplan-Meier method revealed a considerable decrease in survival among patients with elevated NPS (p<0.001). Conclusion: The NPS, which incorporates inflammatory and nutritional components, functions as a prognostic determinant of MACE and long-term mortality in NSTEMI cases.Article Citation - WoS: 4Citation - Scopus: 4Aging and cardiac implantable electronic device complications: is the procedure safe in older patients?(ELSEVIER, 2023-08-21) Güzel, Tuncay; Aktan, Adem; Kılıç, Raif; Günlü, Serhat; Arslan, Bayram; Arpa, Abdulkadir; Güzel, Hamdullah; Tatlı, İsmail; Aydın, Saadet; Suzan, Veysel; Demir, MuhammedBackground In this study, we investigated whether there is a higher incidence of cardiac implantable electronic devices (CIED) procedures related complications in older (≥75 years) than in younger (<75 years) patients. Methods This retrospective cohort study enrolled patients who had undergone CIED procedures (de novo implantation, system upgrade, generator substitution, pocket revision or lead replacement) at two heart centers in Turkey between January 2011 and May 2023. The primary composite endpoint included clinically signifcant hematoma (CSH), pericardial efusion or tamponade, pneumothorax, and infection related to the device system. Secondary outcomes included each component of the composite end point. Results The overall sample included 1923 patients (1419<75 years and 504 aged≥75 years). There was no diference between the groups in terms of cumulative events defned as primary outcome (3.5% vs. 4.4%, p=0.393). Infection related to device system was signifcantly higher in the≥75 age group (1.8% vs. 3.4%, p=0.034). There was no signifcant diference between the groups in terms of clinically signifcant hematoma and pneumothorax (0.7% vs. 0.4%, p=0.451, 1.4% vs. 1.0%, p=0.477, respectively). In multivariate model analysis, no association was found between age≥75 years and infection related to the device system. Conclusion Infection rates were relatively higher in the patient group aged≥75 years. This patient group should be evaluated more carefully in terms of infection development before and after the procedure.Article Citation - WoS: 4Citation - Scopus: 4Aging and cardiac implantable electronic device complications: is the procedure safe in older patients?(Springer, 2023-08-21) Güzel, Tuncay; Aktan, Adem; Kılıç, Raif; Günlü, Serhat; Arslan, Bayram; Arpa, Abdulkadir; Güzel, Hamdullah; Tatlı, İsmail; Aydın, Saadet; Suzan, Veysel; Demir, MuhammedBackground: In this study, we investigated whether there is a higher incidence of cardiac implantable electronic devices (CIED) procedures related complications in older (≥ 75 years) than in younger (< 75 years) patients. Methods: This retrospective cohort study enrolled patients who had undergone CIED procedures (de novo implantation, system upgrade, generator substitution, pocket revision or lead replacement) at two heart centers in Turkey between January 2011 and May 2023. The primary composite endpoint included clinically significant hematoma (CSH), pericardial effusion or tamponade, pneumothorax, and infection related to the device system. Secondary outcomes included each component of the composite end point. Results: The overall sample included 1923 patients (1419 < 75 years and 504 aged ≥ 75 years). There was no difference between the groups in terms of cumulative events defined as primary outcome (3.5% vs. 4.4%, p = 0.393). Infection related to device system was significantly higher in the ≥ 75 age group (1.8% vs. 3.4%, p = 0.034). There was no significant difference between the groups in terms of clinically significant hematoma and pneumothorax (0.7% vs. 0.4%, p = 0.451, 1.4% vs. 1.0%, p = 0.477, respectively). In multivariate model analysis, no association was found between age ≥ 75 years and infection related to the device system. Conclusion: Infection rates were relatively higher in the patient group aged ≥ 75 years. This patient group should be evaluated more carefully in terms of infection development before and after the procedure.Article Assessment of Left Atrial Volumes and Functions in Patients with Coronary Slow Flow(2021) Özbek, Mehmet; Aktan, Adem; Çil, Habib; Tenekecioğlu, Erhan; Aslan, Burhan; Karadeniz, Muhammed; Peker, TezcanObjectives: Coronary slow flow phenomenon (CSFP) is the slow or late progression of the opaque material to the distal vascular structures during angiography in patients with normal or near-normal coronary arteries. This study aims to evaluate left atrial volumes and functions using conventional transthoracic and tissue Doppler echocardiographic parameters in patients with CSFP.Article Local Against General Anesthesia For Transcatheter Aortic Valve Replacement(Bandırma Onyedi Eylül Üniversitesi Tıp Fakültesi, 2023-07-24) Günlü, Serhat; Kayan, Fethullah; Güzel, Tuncay; Aktan, Adem; Tanırcan, Muhammed Raşid; Karahan, Mehmet ZülkifBackground/Aims: Transcatheter aortic valve replacement (TAVR) poses significant challenges concerning anesthesia management. There is no consensus on the type of safer anesthesia for TAVR procedures. We aimed to evaluate the effectiveness and safety of TAVR performed with trans-femoral approach under local anesthesia with sedation (LAS) against general anesthesia (GA). Methods: This observational and retrospective analysis included individuals who were admitted on a planned basis from 2016 to 2022 and underwent Transfemoral TAVR. Effectiveness and safety outcomes were evaluated at 30 days. İndividuals were separated into two groups: GA and LAS. Demographic characteristics and procedural data were recorded during hospitalization. Results: 115 patients were included, of whom 62 (53.9%) received LAS and 53 received GA (46.1%). 59 female (48.8%) patients with a mean age of 83.2±5.7 participated in the study. Successful TAVR procedure was performed in 100 (86.9%) of 115 patients with the transfemoral approach. The mean procedure time was 136.7±46.7 minutes, and the procedure time was shorter in patients who underwent LAS against GA (p=0.001). There were no differences among the groups including fluoroscopy time, contrast, and radiation dose (p>0.05). In 2 patients (3.2%), significant vascular complications necessitated immediate surgical intervention, necessitating a change in the anesthesia technique. Overall 30-day mortality was 5.2%, with no significant differences among the groups (GA 7.5% vs. LAS 3.2%, p =0.28). GA had substantially longer ICU and total hospitalization stays than LAS (p=0.009 and p =0.004, respectively). Conclusions: In our study, TAVR via the transfemoral route using LAS was an alternative for GA.
Research Topics
Domains
Health Sciences
Fields
Medicine
Subfields
Cardiology and Cardiovascular MedicineSurgery
Specific Research Areas
Atrial Fibrillation Management and Outcomes
Cardiac Valve Diseases and Treatments
Cardiovascular Function and Risk Factors
Acute Myocardial Infarction Research
Cardiac Arrhythmias and Treatments
Coronary Interventions and Diagnostics
Sustainable Development Goals
3GOOD HEALTH AND WELL-BEING
20
Research Products
14LIFE BELOW WATER
2
Research Products
5GENDER EQUALITY
1
Research Products
Documents
61
Citations
299
h-index
10
Documents
59
Citations
292
Publication Collaboration
| Affiliation Name | Count |
|---|---|
| Mardin Artuklu University | 67 |
| Dicle University | 46 |
| Diyarbakır Gazi Yaşargil Eğitim ve Araştırma Hastanesi | 43 |
| Sağlık Bilimleri Üniversitesi | 36 |
| State Hospital | 21 |
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Data obtained from OpenAlex
| Journal | Count |
|---|---|
| Aging Clinical and Experimental Research | 4 |
| Revista Da Associação Médica Brasileira | 4 |
| International Journal of the Cardiovascular Academy | 4 |
| Dicle Medical Journal / Dicle Tip Dergisi | 3 |
| International Journal of Cardiovascular Sciences | 3 |
Current Page: 1 / 11
Scholarly Output
82
Articles
76
Views / Downloads
83/324
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
124
Scopus Citation Count
149
Patents
0
Projects
0
WoS Citations per Publication
1.51
Scopus Citations per Publication
1.82
Open Access Source
52
Supervised Theses
0
Scopus Quartile Distribution
Competency Cloud
