Aktan, Adem
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Aktan, A.
Aktan, Adem
Aktan, Adem
Job Title
Doç. Dr.
Email Address
ademaktan@artuklu.edu.tr
Main Affiliation
Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü
Status
Current Staff
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ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals
3
GOOD HEALTH AND WELL-BEING
15
Research Products
5
GENDER EQUALITY
1
Research Products
14
LIFE BELOW WATER
1
Research Products
Documents
58
Citations
244
h-index
9
Documents
56
Citations
242
Scholarly Output
42
Articles
40
Views / Downloads
144/1792
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
74
Scopus Citation Count
77
WoS h-index
5
Scopus h-index
5
Patents
0
Projects
0
WoS Citations per Publication
1.76
Scopus Citations per Publication
1.83
Open Access Source
18
Supervised Theses
0
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| Journal | Count |
|---|---|
| International Journal of Cardiovascular Sciences | 3 |
| Aging Clinical and Experimental Research | 2 |
| Vascular | 2 |
| Annals of Vascular Surgery | 2 |
| BMC Cardiovascular Disorders | 2 |
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Scholarly Output Search Results
Now showing 1 - 10 of 42
Article Impact of Iron Deficiency Anemia on Electrocardiographic Markers in Pediatric Patients(Wiley, 2025) Orhan, Ozhan; Aktan, AdemBackground Iron deficiency anemia (IDA) is a condition in which healthy red blood cells are inadequately produced in children and, if left untreated, can lead to serious health problems. The impact of IDA on electrocardiographic (ECG) markers in children has not been sufficiently investigated, emphasizing the need for more comprehensive studies in this regard.Methods This study, conducted in our clinic, includes 75 children diagnosed with anemia and a control group of 77 healthy children. ECG analysis was employed to assess depolarization and repolarization parameters, including measurements such as QT interval, Tp-e interval (Tp-e), cardiac electrophysiological balance index (iCEB), and frontal QRS-T angle.Results The ECG parameters of children with IDA and ferritin levels below 15 ng/mL were contrasted with those of healthy children having ferritin levels exceeding 25 ng/mL. The anemic group exhibited significantly higher values for QT interval, corrected QT (QTc), Tp-e, P-wave dispersion (PWd), QT dispersion (QTd), corrected QTd, Tp-e dispersion, iCEB, and corrected iCEB compared to the control group. In the Pearson correlation analysis, a weak and negative correlation was found between ferritin levels and QT dispersion (p = 0.002) and QTc dispersion (p = 0.039). No significant relationship was detected between other parameters. These observations imply that IDA in children might induce alterations in depolarization and repolarization, potentially elevating the susceptibility to arrhythmias.Conclusions Our study demonstrated significant alterations in certain electrocardiographic parameters in children with IDA. These findings suggest that iron deficiency may influence cardiac repolarization and highlight the potential role of ECG monitoring in the early stages.Article Citation - WoS: 2Citation - Scopus: 2The Effect of Aortic Angulation on Clinical Outcomes of Patients Undergoing Transcatheter Aortic Valve Replacement(Soc Brasil Cirurgia Cardiovasc, 2024) Aktan, Adem; Demir, Muhammed; Aslan, Burhan; Guzel, Tuncay; Karahan, Mehmet Zulkuf; Kilic, Raif; Ertas, FarukIntroduction: The aim of this study was to assess the impact of aortic angulation (AA) on periprocedural and in -hospital complications as well as mortality of patients undergoing Evolut (TM) R valve implantation. Methods: A retrospective study was conducted on 264 patients who underwent transfemoral-approach transcatheter aortic valve replacement with self-expandable valve at our hospital between August 2015 and August 2022. These patients underwent multislice computer tomography scans to evaluate AA. Transcatheter aortic valve replacement endpoints, device success, and clinical events were assessed according to the definitions provided by the Valve Academic Research Consortium -3. Cumulative events included paravalvular leak, permanent pacemaker implantation, new-onset stroke, and in -hospital mortality. Patients were divided into two groups, AA <= 48(degrees) and AA > 48(degrees), based on the mean AA measurement (48.3 +/- 8.8) on multislice computer tomography. Results: Multivariable logistic regression analysis was performed to identify predictors of cumulative events, utilizing variables with a P-value < 0.2 obtained from univariable logistic regression analysis, including AA, age, hypertension, chronic renal failure, and heart failure. AA (odds ratio [OR]: 1.73, 95% confidence interval [CI]: 0.89-3.38, P=0.104), age (OR: 1.04, 95% CI: 0.99-1.10, P=0.099), hypertension (OR: 1.66, 95% CI: 0.82-3.33, P=0.155), chronic renal failure (OR: 1.82, 95% CI: 0.92-3.61, P=0.084), and heart failure (OR: 0.57, 95% CI: 0.27-1.21, P=0.145) were not found to be significantly associated with cumulative events in the multivariable logistic regression analysis. Conclusion: This study demonstrated that increased AA does not have a significant impact on intraprocedural and periprocedural complications of patients with new generation self-expandable valves implanted.Article Response to Comment Letter: The Effectiveness of HALP Score in Predicting Mortality in Non-ST Myocardial Infarction Patients(Lippincott Williams & Wilkins, 2025) Kiliç, R.; Aktan, A.; Guzel, T.Book Part KRONİK HASTALIĞI OLAN BİREY VE AİLE İLE İLETİŞİM(2023) Aktan, Adem; Karahan, Mehmet ZülkifKronik hastalık, uzun süreli tedavi gerektiren ve hayatı boyunca sürebilecek bir sağlık durumunu ifade eder. Bunlar, diyabet, hipertansiyon, kalp hastalığı, kanser, multipl skleroz gibi bir dizi farklı hastalığı içerebilir. Kronik hastalık tanısı alan bireylerin ve ailelerin yaşamlarında büyük bir etkiye sahip olabilir ve duygusal, sosyal ve fiziksel zorluklara neden olabilir. Bu nedenle, kronik hastalık tanısı almış bireylerle ve aileleriyle iletişim kurarken dikkatli ve duyarlı olmak önemlidir (1). İletişim, bireylerin duygularını ifade etmelerine, endişelerini paylaşmalarına ve birbirleriyle destek sağlamalarına yardımcı olabilir. Kronik hastalıkla ilgili iletişim becerileri, bireylerin sağlıklı bir şekilde başa çıkmalarına ve daha iyi sonuçlar elde etmelerine yardımcı olabilir. Kronik hastalık tanısı almış bireyler ve aileleri arasındaki iletişim, aşağıdaki bazı temel prensiplere dikkat ederek etkili bir şekilde gerçekleştirilebilir: Açık iletişim kurma: Kronik hastalık tanısı almış bir bireyin ve ailesinin duygularını ve deneyimlerini anlamak için empati kurmak önemlidir. Açık iletişim, dürüst, saygılı ve etkili bir iletişim tarzını içerir. Kronik hastalık tanısı almış bir birey ve ailesiyle iletişim kurarken açık ve net olmak önemlidir. VII. Sonuç Kronik hastalık tanısı almış bireyler ve aileleriyle etkili iletişim kurmak önemlidir. Etkili iletişim, hastaların sağlık sonuçlarını, yaşam kalitesini ve memnuniyetini artırabilir. Ailelerin de katılımıyla birlikte, uygun tıbbi bakım sağlanabilir ve sağlıklı bir iyileşme süreci desteklenebilir. Bu nedenle, sağlık profesyonellerive diğer ilgili paydaşlar, hastalarla etkili iletişim kurma becerilerini geliştirmek için yönlendirilmelidir. Kronik hastalık yönetiminde etkili iletişim, hastaların ve ailelerinin gereksinimlerini anlamak ve onları desteklemek için vazgeçilmez bir araçtır.Article Citation - WoS: 1Citation - Scopus: 1A Novel Determinant of Prognosis in Acute Pulmonary Edema: Intermountain Risk Score(Kare Publ, 2024) Kilic, Raif; Aktan, Adem; Guzel, Tuncay; Kaya, Ahmet Ferhat; Guzel, Hamdullah; Arslan, Bayram; Cankaya, YusufObjective: The Intermountain Risk Score (IMRS), calculated using age, gender, complete blood count (CBC), and simple laboratory analyses, is an easy-to-use and cost-effective tool developed to predict mortality. In our study, we aimed to determine whether the IMRS could predict mortality in patients admitted to the hospital with a diagnosis of acute pulmonary edema. Methods: A total of 371 patients who were admitted with a diagnosis of pulmonary edema, were included in our study. The IMRS of the patients was determined using a calculation tool, and the patients were divided into three groups based on the determined value: low, moderate, and high IMRS. Results: The patients included in our study comprised 208 women and 163 men, with an average age of 68.7 years. There was a statistically significant difference between the patient groups concerning both 1-month and 1-year mortality rates. Additionally, there was a significant difference in IMRS between patients who developed in-hospital, 1-month, and 1-year mortality and those who survived. In the Receiver Operating Characteristic (ROC) analysis, a cutoff value of 15.5 for the IMRS predicted both 1-year and 1-month mortality. In the Kaplan-Meier analysis, the highest mortality risk was observed in the high IMRS group and the lowest mortality risk in the low IMRS group. Conclusion: Our research results show that the IMRS strongly predicts both short-term and long-term mortality in patients hospitalized with a diagnosis of acute pulmonary edema.Article Citation - WoS: 7Citation - Scopus: 7The Performance of the Naples Prognostic Score in Predicting One-Year Mortality and Major Adverse Cardiovascular Events After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis(Polish Cardiac Soc, 2025) Gitmez, Mesut; Guzel, Tuncay; Kis, Mehmet; Coskun, Ferhat; Isik, Mehmet Ali; Aktan, Adem; Ertas, FarukBackground: Existing risk scores for transcatheter aortic valve implantation (TAVI) may not fully capture patient complexity. Combining nutritional and inflammatory markers, the NPS (the NAPLES prognostic score) might improve outcome prediction. Aims: This study investigated the associations of the NPS with one-year mortality and major adverse cardiovascular events (MACEs) in TAVI patients. Material and methods:This retrospective analysis included 222 patients with severe aortic stenosis who underwent TAVI. The NPS was calculated based on the serum alb & uuml;min concentration, cholesterol concentration, lymphocyte/monocyte ratio, and neutrophil/lymphocyte ratio. The patients were subsequently categorized into two groups: the low-NPS group (NPS 0-2) and the high-NPS group (NPS 3-4). Results: A high NPS was significantly associated with increased one-year mortality (4.8% vs. 23.7%; P <0.001) and MACE rates (7.2% vs. 35.9%; P <0.001). Cox regression analysis demonstrated that a high NPS was an independent predictor of both mortality (HR, 5.94; 95% CI, 2.03-17.37; P = 0.001) and MACEs (HR, 5.09; 95% CI, 2.15-12.02; P <0.001). Conclusions: The NPS emerged as a potential predictor of long-term mortality and MACEs in TAVI patients. Further validation through larger, multicenter, studies is warranted.This research contributes valuable data on the role of the NPS in TAVI risk stratification.Article Citation - WoS: 3Citation - Scopus: 3The prognostic value of ORBIT risk score in predicting major bleeding in patients with acute coronary syndrome(ScienceDirect, 2023) Günlü, Serhat; Arpa, Abdulkadir; Kayan, Fethullah; Güzel, Tuncay; Kılıç, Raif; Aktan, Adem; Altintaş, Bernas; Karahan, Mehmet ZülkifBackground: The most significant adverse effect of antithrombotic medication in acute coronary syndrome (ACS) is major bleeding, which is related to increased mortality. Studies on ORBIT risk score in predicting major bleeding in ACS patients are limited. Objective: This research aimed to examine whether the ORBIT score calculated at the bedside can identify major bleeding risk in patients with ACS. Methods: This research was retrospective, observational, and conducted at a single center. Analyses of receiver operating characteristics (ROC) were utilized to define the diagnostic value of CRUSADE and ORBIT scores. The predictive performances of the two scores were compared using DeLong's method. Discrimination and reclassification performances were evaluated by the integrated discrimination improvement (IDI), and net reclassification improvement (NRI). Results: The study included 771 patients with ACS. The mean age was 68.7 ± 8.6 years, with 35.3 % females. 31 patients had major bleeding. Twenty-three of these patients were BARC 3 A, five were BARC 3 B, and three were BARC 3 C. Bleeding history [OR (95 % CI), 2.46 (1.02-5.94), p = 0.021], hemoglobin levels [OR (95 % CI), 0.54 (0.45-0.63), p < 0.001], and age > 74 years [OR (95 % CI), 1.03 (1.01-1.06), p = 0.039] were independent predictors of major bleeding. The ORBIT score was an independent predictor of major bleeding in the multivariate analysis: continuous variables [OR (95 % CI), 2.53 (2.61-3.95), p < 0.001] and risk categories [OR (95 % CI), 3.06 (1.69-5.52), p < 0.001]. Comparison of c-indexes for major bleeding events revealed a non-significant difference for the discriminative ability of the two tested scores (p = 0.07) with a continuous NRI of 6.6 % (p = 0.026) and an IDI of 4.2 % (p < 0.001). Conclusion: In ACS patients, the ORBIT score independently predicted major bleeding.Letter The Naples Prognostic Score in TAVI Patients: a Promising Tool Requiring Further Validation. Authors' Reply(Polish Cardiac Soc, 2025) Gitmez, Mesut; Guzel, Tuncay; Kis, Mehmet; Coskun, Ferhat; Isik, Mehmet Ali; Aktan, Adem; Ertas, FarukArticle Effect of cardio-gastric interaction on atrial fibrillation in GERD patients(2023) Günlü, Serhat; Araç, Eşref; Aktan, Adem; Kayan, Fethullah; Bernas, Altıntaş; Karahan, Mehmet ZülkifObjective: Atrial fibrillation (AF) and gastroesophageal reflux disease (GERD) are very common in daily clinical practice. Post-prandial AF episodes have been reported in GERD patients. Although it was reported in previous studies that it was caused by sympathovagal imbalance, there are no studies on cardiac conduction system involvement. In this study, we aimed to evaluate whether the risk of developing AF increases in untreated GERD patients with non-invasive electrophysiological tests. Methods: The research was prospectively performed. Endoscopy was performed on the individuals due to reflux complaints. ECG was recorded at 25mm/s and 10 mm/mV amplitude, and 24-hour Holter ECG (three-channel; V1, V2, and V5) was performed. ECG parameters were measured and Holter ECG results were analyzed. Results: A total of 120 individuals, 60 patients and 60 controls, were included. No significant statistically differences existed between groups for hypertension, diabetes, smoking, or dyslipidemia (p>0.05). In terms of heart rate, Pmax, Pmin, QTd, and QTcd, there were no significant differences across the two groups (p>0.05). P-wave dispersion (Pd) was substantially higher in the study group (p=0.014). Comparing the heart rate variabilities of 24-hour Holter ECG recordings across the groups, the standard deviation of R-R intervals (SDNN) was substantially higher in the study group (p<0.001). Low Frequency (LF) and LF/HF were significantly higher in the control group (p<0.001 and p=0.003, respectively). AF was detected in nine individuals on Holter ECG. Conclusion: Pd duration and risk of developing AF were higher in GERD patients.Article Citation - WoS: 2Citation - Scopus: 2Assessing the Prognostic Value of Halp Score in Peripheral Artery Disease: Correlation With Lesion Severity and Long-Term Mortality(Sage Publications Ltd, 2025) Evsen, Ali; Aktan, Adem; Kilic, Raif; Yalcin, Abdulaziz; Ozbek, MehmetIntroduction Peripheral artery disease (PAD) poses a growing clinical challenge due to an aging population, despite advances in treatment methods. Various scoring systems have emerged to predict high-risk patients, including the HALP (hemoglobin, albumin, lymphocyte, and platelet) score, known for predicting prognosis in cancers and stroke. This study assesses the HALP score's relation to lesion severity and long-term mortality in PAD patients. Methods We retrospectively analyzed 305 symptomatic PAD patients undergoing endovascular intervention. The following formula was used to calculate the HALP score: hemoglobin (g/L) x albumin (g/L) x lymphocyte count (/L) / platelet count (/L). Lesion severity was classified by TASC-II: TASC AB and TASC CD. Mortality data were obtained from hospital and social security records. Results The study involved 305 patients (mean age 64.4 +/- 11.8 years; 72.1% male), divided into survivors (208) and non-survivors (97). ROC analysis identified HALP score as the strongest predictor of long-term mortality (AUC: 0.736; 95% CI: 0.679-0.793; p < .001). HALP score (HR, 0.087; 95% CI, 0.025-1.300; p < .001), age (p < .001), DM (p = .007), and CRP (p = .013) independently predicted mortality. Kaplan-Meier analysis showed higher HALP scores linked to lower long-term mortality (Log-rank: 20.102, p < .001), with an average follow-up of 48 +/- 18 months. Conclusion The HALP score emerged as a robust predictor of PAD prognosis, surpassing individual components and other parameters. Lower HALP scores correlated with more severe lesions and reduced life expectancy.
