Çetik Yıldız, Songül
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Songul Cetik
Cetik, Songul
Cetik Yildiz, Songul
Yıldız, Songül Çetik
Cetik, Songul
Cetik Yildiz, Songul
Yıldız, Songül Çetik
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Doktor Öğretim Üyesi
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songulcetik@gmail.com
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Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
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6.25
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| Scientific Reports | 2 |
| Journal of Trace Elements in Medicine and Biology | 2 |
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| Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi | 1 |
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Article Kefirin Sıçanlarda Oluşturulmuş Siklofosfamid Toksisitesi Üzerine Myeloprotektif ve Hematoprotektifetkileri(2021) Yıldız, Songül Çetik; Gözüoğlu, GülayAmaç: Kefir, bakteri ve maya karışımı içeren kefir taneleri ile sütten üretilen probiyotik ve prebiyotik bir \riçecektir. Siklofosfamid (CPx) gibi kanser kemoterapisi için kullanılan ilaçların kullanımı, genellikle, \ristenmeyen çoklu organ toksisitesi gibi yan etkiler nedeniyle sınırlıdır. Bu amaçla yapılan çalışmamızda \rantitümör ve antioksidan özellikleri iyi bilinen ve doğal bir probiyotik olan kefirin CPx nedenli hemotoksisite ve \rmyelotoksisite üzerine koruyucu etkileri araştırılmıştır.\rGereç ve Yöntem: Grup 1 (kontrol, 0,5 ml SF), grup 2; tek doz 150 mg/kg/b.w/i.p CPx, Grup 3; 5 mg /kg / b.w \rkefir, grup 4; 5 mg/kg/b.w+150 mg/kg/b.w/i.p CPx, grup 5; 10 mg/kg/b.w kefir, Grup 6; 10 mg /kg/b.w \rkefir+150 mg/kg/b.w/i.p CPx. Kefir, hayvanlara gavaj yöntemiyle 12 gün boyunca verildi. CPx ise 12. gün tek \rdoz olarak verildi. Deney sonunda tüm sıçanlardan kan ve kemikiliği örnekleri anestezi altında alındı. \rBulgular: DPPH sonuçları kefirin yüksek antioksidan aktiviteye sahip olduğunu göstermiştir. Sadece CPx \ruygulanan grupta lökosit, trombosit, eritrosit, hemoglobin, hematokrit ve kemik iliği çekirdekli hücre \rdüzeylerinin azaldığı, CPx+kefir verilen gruplarda ise göreceli olarak arttığı ve kontrole yaklaştığı gözlendi.\rSonuç: Sonuçlarımız antitümör, antioksidan ve sitoprotektif özellikleri olan kefirin kan ve kemik iliği \rhücrelerini CPx hasarına karşı koruduğunu göstermiştir.\rArticle The Protective and Antiapoptotic Effects of Hypericum Triquetrifolium Turra Against Cyclophosphamide-Induced Lung Injury in Rats: in Vitro Evaluation(2024) Yıldız, Songül Çetik; Şahintürk, Varol; Keskin, Cumali; Ayhancı, AdnanObjectives: Hypericum triquetrifolium Turra (HTT) has been traditionally used in medical treatments due to its sedative, antiseptic, antiinflammatory, and anthelmintic properties. The present study aims to investigate the lung-protective and antiapoptotic effects of HTT against cyclophosphamide (CP)-induced lung injury in rats. Methods: Thirty-five Sprague Dawley rats were categorized into 5 groups, each consisting of seven members. Phenolic acid and flavonoid contents of this plant were determined. The lung tissue samples cultivated from the rats were examined in histopathological and immunohistochemically for the apoptosis markers of Caspase-3, Bax, and Bcl-2. Results: Histopathological results indicated that structural defects, bleeding areas, and edema had occurred in the lungs of the CP-Alone Group. Besides, Caspase-3 and Bax positivity of the lung cells had also increased while Bcl-2 positivity had decreased. On the other hand, in the HTT+CP Group, HTT was shown to have reversed the aforementioned changes positively. Conclusion: Based on in vivo results, HTT could be a strong protective candidate for CP-induced lung injury and apoptosisArticle Hematoprotective Effect of N(G)-Nitro-L-Arginine Methyl Ester and Lycopene on Hematoxicity in Trinitrobenzene Sulfonic Acid–Induced Colitis in Rat(2015) Songul Cetik; Adnan Ayhanci; Yilmaz Altuner; Ahmet Musmul; Varol SahinturkAnemia is a neglected manifestation of inflammatory bowel disease (IBD) although it is commonly observed in IBD patients. Attempts to overcome anemia in IBD would help not only general well being of the patients but also minimize disease consequences. In this experimental study, the possible hematoprotective effects of lycopene and NG–nitro-Larginine methyl ester (L-NAME) on colitis induced by TNBS were analyzed. 112 rats were assigned to 16 groups; control group, intrarectal 120 mg/kg TNBS group, intraperitoneal 40 mg/kg L-NAME group, 1 mg/kg olive oil group, 5 and 10 mg/kg lycopene groups. Each experimental group was divided into 3 subgroups according to duration of treatment. On the very first day of treatment number of erythrocytes decreased in all groups except TNBS treated group whereas leukocyte numbers increased in all groups except TNBS treated group pointing out an inflammation. The number of platelets decreased in all study groups with the exception of TNBS group. On the second day, while erythrocyte and platelet numbers increased in all but not in TNBS group, leukocytes decreased in all the groups. On the third day, erythrocyte and platelet numbers increased in all groups except for the 10 mg/kg lycopene group. While the number of leukocytes decreased in the 10 mg/kg lycopene group, it remained the same in the other groups as those observed on the second day. These results show that lycopene could have effects on hemopoiesis as well as in prevention of anemia in IBDMaster Thesis Sıçanlarda siklofosfamid ile oluşturulmuş hematoksisite ve myelotoksisite üzerine kefirin olası hücre koruyucu etkileri(Mardin Artuklu Üniversitesi, 2021) Gözüoğlu, Gülay; Yıldız, Songül ÇetikKefir, geleneksel olarak süt ve kefir mayasının fermentasyonu ile elde edilen ve egzotik tada sahip probiyotik/prebiyotik bir süt ürünüdür. Siklofosfamid (CPX) gibi kanser kemoterapisi için sıklıkla tercih edilen ilaçların gerekli ve etkin dozlarda kullanımı, genellikle, istenmeyen şiddetli akut toksik yan etkiler yüzünden sınırlıdır. Bu nedenle bu gibi ilaçların kemoterapötik etkinliklerini korurken yan etkilerini en aza indirecek yeni stratejilere ihtiyaç duyulmaktadır. Bu amaçla antitümör ve antioksidan özellikleri ile iyi bilinen, doğal bir probiyotik olan kefirin CPX nedenli hemotoksisite ve myelotoksisite üzerine hücre koruyucu etkileri araştırılmıştır. Bu deneysel çalışmada kullanılan 42 sıçan her grupta 7şer tane olmak üzere 6 gruba ayrıldı. Grup 1 (kontrol), Grup 2; 150 mg/kg CPX, Grup 3; 5 mg/kg kefir, Grup 4; 5 mg/kg kefir +150 mg/kg CPX, Grup 5; l0 mg/kg kefir, Grup 6; l0 mg/kg kefir + 150 mg/kg CPX olarak oluşturuldu. Kefir sıçanlara 12 gün boyunca gavaj yöntemi ile mg/kg/v.a olarak verilirken CPX ise tek doz ve ip./ v.a olarak deneyin son günü olan 12. gün verildi. Deney bitiminde yani 13. gün tüm sıçanlar disekte edilerek kan ve kemik iliği örnekleri alındı. Ayrıca kefirin antioksidan aktivitesi, asitlik ve pH'ı değerlendirildi. Elde edilen sonuç, kefirin güçlü antioksidan aktiviteye sahip olduğunu göstermiştir. Ayrıca lökosit, trombosit, eritrosit, hemoglobin, hematokrit ve kemik iliği çekirdekli hücre düzeylerinin sadece CPX verilen grupta düştüğünü, CPX+kefir verilen gruplarda ise sadece CPX verilen gruba kıyasla bu değerlerin yükseldiği ve kontrole yaklaştığı görülmüştür. Sonuç olarak çalışmamız kefirin antioksidan ve sitoprotektif özellik göstererek kan ve kemik iliği hücrelerini CPX hasarına karşı koruduğunu göstermiştir.Article Citation - WoS: 13Citation - Scopus: 13Protective properties of kefir on burn wounds of mice that were infected with S. aureus, P. auroginasa and E. coli(Cellular and Molecular Biology (CMB), 2019) Çetik Yıldız, Songül; Demir, Cemil; Cengiz, Mustafa; Ayhanci, AdnanBurns and burn wounds are very sensitive to infections and cause a large amount of death worldwide. Although burn wound is sterile at the beginning, because of the risk factors such as prolonged hospital stay, immune suppression and burn affecting large surface area, colonisation with Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli occur. For the burn therapy, one of the most important ways is to control bacterial infections. A probiotic fermented milk product kefir has antioxidant, antimicrobial, antiinflammatory, anticancer and various health promoting features. This study aims to examine possible protective properties of kefir which was used on the burn wounds that were infected with S. aureus, P. auroginasa and E. coli. Swiss albino / Balb-c mice were seperated into four groups: (1) used as control group, (2) second-degree burn model+ burn wounds were infected with P.aeruginosa + S.aureus + E.coli, (3) second-burn wounds were treated with sterile pads dressed with kefir and (4) second-degree burn+burn wounds were infected with P. aeruginosa + S.aureus +E.coli before being treated with sterile pads dressed with kefir. The serum biochemical results verified the histopathological results and our findings showed that kefir is an effective product with cell-protecting properties.Article Presence of biofilm and adhesin genes in Staphylococcus aureus strains taken from chronic wound infections and their genotypic and phenotypic antimicrobial sensitivity patterns(2020) Demir, Cemil; Demirci, Mehmet; Yigin, Akin; Tokman, Hrisi Bahar; Cetik Yildiz, SongulThe purpose of this research was to examine biofilm (icaA, icaD and bap) and adhesin (clfA, fnbA, cna) genes, and also assess the genotypic and phenotypic antimicrobial resistance patterns of Staphylococcus aureus strains taken from wound specimens in Mardin, Turkey. A total of 220 wound specimens were investigated. The biofilm forming ability and resistance pattern for eleven antimicrobial agents were investigated by conventional and multiplex PCR methods. S. aureus were taken from 112 (50.9%) of 220 wound specimens. Moreover, biofilm production was found in 79 (70.5%) of the 112 S. aureus isolates. 97 (86.6%) strains of all isolates were positive for icaA and icaD, and 15 (13.4%) for bap. The adhesin genes, cna, fnbA and clfA were detected in 98 (87.5%), 87 (77.7%), and 75 (66.9%) strains, respectively. The numbers of MSSA and MRSA bearing antimicrobial resistance genes were 19 (16.96%) and 32 (28.57%) for blaZ, 9 (8.04%) and 17 (15.18%) for tetK, 6 (5.36%) and 14 (12.5%) for ermC, 2 (1.79%) and 7 (6.25%) for tetM, 0 (0%) and 5 (4.46%) for mecA, 2 (1.79%) and 4 (3.57%) for ermA, 1 (0.89%) and 2 (1.79%) for both tetK and tetM, respectively. Our findings indicate that multiplex PCR is a suitable way for identifying biofilm and adhesin producing S. aureus. Our data also provided a country-wide oversight of the S. aureus antimicrobial resistance gene profiles for the properly therapy of patients and to control the spreading of the resistance genes.Article Myeloprotective and hematoprotective role of kefir on cyclophosphamide toxicity in rats(2021) Gözüoğlu, Gülay; Cetik Yildiz, SongulAbstract Aim: Kefir is a probiotic and prebiotic beverage produced from milk and kefir grains containing a mixture of bacteria and yeast. Drugs like cyclophosphamide (CPx) that are used for cancer chemotherapy are generally limited due to numerous unwanted side-effects such as multiple organ toxicity. For this purpose, the cell-protective effects of kefir, a natural probiotic known for its antitumor and antioxidant properties, on CPx-induced hemotoxicity and myelotoxicity were investigated in this study. Methods: Group 1 (control, 0.5 ml SF). Group 2 were administered a single dose of 150mg/kg CPx. Group 3 and 5 were given 5 and 10mg/kg kefir. Group 4 and 6 were given 5 and 10mg/kg kefir+150mg/kg CPx. While kefir was administered to the rats by gavage method for 12 days, CPx was administered as single-dose on the 12th day. Results: The DPPH results showed that kefir possesses high antioxidant activity. It was observed that the leukocytes, thrombocytes, erythrocytes, hemoglobin, hematocrit and bone marrow nucleated cell levels decreased in the group that was administered only CPx, and increased relatively in the groups that were administered CPx+kefir, drawing close to the control. Conclusion: The results of the present study showed that kefir had antioxidant and cytoprotective activity, protecting blood and bone marrow cells against CPx-induced damage.Article Citation - WoS: 4Citation - Scopus: 5The Protection Afforded by Kefir Against Cyclophosphamide Induced Testicular Toxicity in Rats by Oxidant Antioxidant and Histopathological Evaluations(Nature Portfolio, 2024) Yildiz, Songul Cetik; Demir, Cemil; Cengiz, Mustafa; Irmak, Halit; Cengiz, Betul Peker; Ayhanci, AdnanCyclophosphamide (CTX) is the most commonly used effective alkylating drug in cancer treatment, but its use is restricted because its toxic side effect causes testicular toxicity. CTX disrupts the tissue redox and antioxidant balance and the resulting tissue damage causes oxidative stress. In our study based on this problem, kefir against CTX-induced oxidative stress and testicular toxicity were investigated. Rats were divided into 6 groups: control, 150 mg/kg CTX, 5 and 10 mg/kg kefir, 5 and 10 mg/kg kefir + 150 CTX. While the fermented kefirs were mixed and given to the rats for 12 days, CTX was given as a single dose on the 12th day of the experiment. Testis was scored according to spermatid density, giant cell formation, cells shed into tubules, maturation disorder, and atrophy. According to our biochemical findings, the high levels of total oxidant status (TOS), and the low levels of total antioxidant status (TAS) in the CTX group, which are oxidative stress markers, indicate the toxic effect of CTX, while the decrease in TOS levels and the increase in TAS levels in the kefir groups indicate the protective effect of kefir. In the CTX-administered group, tubules with impaired maturation and no spermatids were observed in the transverse section of the testicle, while in the kefir groups, the presence of near-normal tubule structures and tubule lumens despite CTX showed the protective effect of kefir. In our study, it was observed that kefir had a protective and curative effect on CTX-induced toxicity and oxidative stress and could be a strong protector.Article Hematoprotective Effect of N(G)-Nitro-L-Arginine Methyl Ester and Lycopene on Hematoxicity in Trinitrobenzene Sulfonic Acid–Induced Colitis in Rat(2015) Cetik, Songul; Ayhanci, Adnan; Altuner, Yilmaz; Musmul, Ahmet; Sahinturk, VarolAnemia is a neglected manifestation of inflammatory bowel disease (IBD) although it is commonly observed in IBD patients. Attempts to overcome anemia in IBD would help not only general well being of the patients but also minimize disease consequences. In this experimental study, the possible hematoprotective effects of lycopene and NG–nitro-L-arginine methyl ester (L-NAME) on colitis induced by TNBS were analyzed. 112 rats were assigned to 16 groups; control group, intrarectal 120 mg/kg TNBS group, intraperitoneal 40 mg/kg L-NAME group, 1 mg/kg olive oil group, 5 and 10 mg/kg lycopene groups. Each experimental group was divided into 3 subgroups according to duration of treatment. On the very first day of treatment number of erythrocytes decreased in all groups except TNBS treated group whereas leukocyte numbers increased in all groups except TNBS treated group pointing out an inflammation. The number of platelets decreased in all study groups with the exception of TNBS group. On the second day, while erythrocyte and platelet numbers increased in all but not in TNBS group, leukocytes decreased in all the groups. On the third day, erythrocyte and platelet numbers increased in all groups except for the 10 mg/kg lycopene group. While the number of leukocytes decreased in the 10 mg/kg lycopene group, it remained the same in the other groups as those observed on the second day. These results show that lycopene could have effects on hemopoiesis as well as in prevention of anemia in IBD.Article Kynurenine Pathway Metabolites as Potential Biomarkers in Age-Related Macular Degeneration: An ELISA-Based Prospective Study(BMC, 2025) Dundar, Ahmet; Cetik Yildiz, SongulObjectivesAge-related macular degeneration (AMD), in which oxidative stress, inflammation and metabolic imbalances play a role in its pathogenesis, is one of the leading causes of irreversible vision loss. The kynurenine (KYN) pathway, one of the principal routes of tryptophan (TRP) metabolism, constitutes an important mechanism in retinal neurodegeneration. Based on this information, our study aimed to compare the serum TRP, KYN, kynurenic acid (KYNA), 3-hydroxykynurenine (3HK), 3-hydroxyanthranilic acid (3HAA) and, quinolinic acid (QA) levels of AMD patients and to investigate the diagnostic values of these biomarkers.MethodsSerum samples were collected from AMD patients and control groups. TRP, KYN, KYNA, 3HK, 3HAA, and QA levels were measured using a commercial ELISA method. KYN pathway activity, KYN/TRP and, KYNA/3HK ratios were also assessed. Mann-Whitney U test, ROC analysis, Spearman correlation were applied for statistical comparisons.ResultsAccording to our results, 3HK was significantly higher in the AMD group, while TRP, KYN, QA, and KYNA/3HK ratio were higher in the control. ROC analysis revealed 3HK to be the strongest discriminatory marker. The KYNA/3HK ratio also provided significant diagnostic value. Correlation analysis revealed strong negative correlations between 3HK and KYN, QA, and especially KYNA/3HK. Conversely, strong positive correlations were found between KYN and KYNA/3HK, and between TRP, KYN, QA, and KYNA.ConclusionKYN pathway metabolites exhibit significant alterations in patients with AMD. 3HK levels and the reduction of the KYNA/3HK ratio suggest a disruption of the neurotoxic-neuroprotective balance and imply that KYN pathway dysfunction may play a role in the pathogenesis of AMD. Among the biomarkers examined, 3HK displayed the highest diagnostic performance, while the KYNA/3HK ratio emerged as an additional biological indicator. These findings indicate that 3HK and the KYNA/3HK ratio may serve as potential biomarker candidates for the early diagnosis and monitoring of AMD.
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