Çetik Yıldız, Songül

Çetik Yıldız, Songül

Name Variants

Songul Cetik
Cetik, Songul
Cetik Yildiz, Songul
Yıldız, Songül Çetik

Job Title

Doktor Öğretim Üyesi

Email Address

songulcetik@gmail.com

Main Affiliation

Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü

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Scholarly Output

25

Articles

23

Citation Count

0

Supervised Theses

2 Scholarly Output Search Results

Now showing 1 - 10 of 25

Kefirin Sıçanlarda Oluşturulmuş Siklofosfamid Toksisitesi Üzerine Myeloprotektif ve Hematoprotektifetkileri
(2021) Çetik Yıldız, Songül; Gözüoğlu, Gülay; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Amaç: Kefir, bakteri ve maya karışımı içeren kefir taneleri ile sütten üretilen probiyotik ve prebiyotik bir \riçecektir. Siklofosfamid (CPx) gibi kanser kemoterapisi için kullanılan ilaçların kullanımı, genellikle, \ristenmeyen çoklu organ toksisitesi gibi yan etkiler nedeniyle sınırlıdır. Bu amaçla yapılan çalışmamızda \rantitümör ve antioksidan özellikleri iyi bilinen ve doğal bir probiyotik olan kefirin CPx nedenli hemotoksisite ve \rmyelotoksisite üzerine koruyucu etkileri araştırılmıştır.\rGereç ve Yöntem: Grup 1 (kontrol, 0,5 ml SF), grup 2; tek doz 150 mg/kg/b.w/i.p CPx, Grup 3; 5 mg /kg / b.w \rkefir, grup 4; 5 mg/kg/b.w+150 mg/kg/b.w/i.p CPx, grup 5; 10 mg/kg/b.w kefir, Grup 6; 10 mg /kg/b.w \rkefir+150 mg/kg/b.w/i.p CPx. Kefir, hayvanlara gavaj yöntemiyle 12 gün boyunca verildi. CPx ise 12. gün tek \rdoz olarak verildi. Deney sonunda tüm sıçanlardan kan ve kemikiliği örnekleri anestezi altında alındı. \rBulgular: DPPH sonuçları kefirin yüksek antioksidan aktiviteye sahip olduğunu göstermiştir. Sadece CPx \ruygulanan grupta lökosit, trombosit, eritrosit, hemoglobin, hematokrit ve kemik iliği çekirdekli hücre \rdüzeylerinin azaldığı, CPx+kefir verilen gruplarda ise göreceli olarak arttığı ve kontrole yaklaştığı gözlendi.\rSonuç: Sonuçlarımız antitümör, antioksidan ve sitoprotektif özellikleri olan kefirin kan ve kemik iliği \rhücrelerini CPx hasarına karşı koruduğunu göstermiştir.\r
The Protective and Antiapoptotic Effects of Hypericum Triquetrifolium Turra Against Cyclophosphamide-Induced Lung Injury in Rats: in Vitro Evaluation
(2024) Keskin, Cumali; Şahintürk, Varol; Çetik Yıldız, Songül; Ayhancı, Adnan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Objectives: Hypericum triquetrifolium Turra (HTT) has been traditionally used in medical treatments due to its sedative, antiseptic, antiinflammatory, and anthelmintic properties. The present study aims to investigate the lung-protective and antiapoptotic effects of HTT against cyclophosphamide (CP)-induced lung injury in rats. Methods: Thirty-five Sprague Dawley rats were categorized into 5 groups, each consisting of seven members. Phenolic acid and flavonoid contents of this plant were determined. The lung tissue samples cultivated from the rats were examined in histopathological and immunohistochemically for the apoptosis markers of Caspase-3, Bax, and Bcl-2. Results: Histopathological results indicated that structural defects, bleeding areas, and edema had occurred in the lungs of the CP-Alone Group. Besides, Caspase-3 and Bax positivity of the lung cells had also increased while Bcl-2 positivity had decreased. On the other hand, in the HTT+CP Group, HTT was shown to have reversed the aforementioned changes positively. Conclusion: Based on in vivo results, HTT could be a strong protective candidate for CP-induced lung injury and apoptosis
Evaluation of the Serological, Biochemical and Hemogram Parameters of Patients Prediagnosed with Hydatid Cyst
(2021) Demir, Cemil; Çetik Yıldız, Songül; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Objective: Hydatid cyst or echinococcosis is a zoonotic parasitic disease caused by the larval stages of Echinococcus granulosus, which is common in our country. It is necessary to use radiological and serological methods as diagnosing this disease based on clinical symptoms is very difficult. In this retrospective study, it was aimed to determine the condition in our region by retrospectively analyzing the hemogram, biochemistry, radiological and pathological findings and the epidemiological data of the patients prediagnosed with hydatid cyst. Materials and Methods: A total of 412 patients, 279 female and 133 male, who applied to various clinics of the Mardin State Hospital with hydatid cyst prediagnosis. 52 patients were diagnosed with hydatid cyst based on ultrasonography, computerized tomography and radiological findings, and liver involvement was detected in all 64 patients, 12 of which were pathologically verified. Results: 38 (59.3%) of 64 patients included in the study were female, 26 (40.6%) were male and their ages ranged from 0-77. The most common symptoms were severe abdominal pain, distention, chest pain, shortness of breath, 415 cough, fever, nausea and vomiting. 83.4% of the patients applied to the general surgery, 5.5% applied to the pediatric surgery and 10.1% applied to other clinics. Conclusion: The parameter with the highest increase was GGT, followed by ALT, AST and ALP. Elevated RDW (29%) was the most common finding in the hemogram parameters, followed by decreased MCV, hematocrit and hemoglobin.
Citation - WoS: 3
Citation - Scopus: 1
Examination of the effects of kefir on healing factors in a mice burn model infected with E.coli, S.aureus and P.aeruginosa using qRT-PCR
(Elsevier, 2023) Çetik Yıldız, Songül; Demir, Cemil; Ayhancı, Adnan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Burn areas are susceptible to bacterial growth and infections, particularly in cases with lengthy periods of hospital stay. Burn wound healing, which involves various molecular and cellular mechanisms, continues to be a significant problem. Growth factors and cytokines play an active and vital role in wound healing. In the present study, the effects of kefir on wound healing in a 2nd-degree mouse burn model infected with e.coli, s.aureus and p.aeruginosa were investigated in vitro. In order to clarify the effects of kefir in the wound healing process, the macroscopic changes in kefir-applied scar tissue as well as wound depth and width were examined and IL-1α, IL-1β, IL-6, IL-8, IL-10 and TNF-α, VEGF, TGF-β protein levels were determined using the qRT-PCR method. The findings of the present study show that kefir has a positive impact on the factors playing a role in wound healing and accelerates the healing process.
Protective Effect of Carvacrol Against Oxidative Stress and Heart Injury in Cyclophosphamide–Induced Cardiotoxicity in Rat
(2016) Çetik Yıldız, Songül; Ayhanci, Adnan; Sahinturk, Varol; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Possible protective effects of carvacrol (Car) against cyclophosphamide (CP)-induced cardiotoxicity was examined in this study. Experimental groups of the rats were randomly divided into 13 groups,each including seven animals: Group 1 (control) treated with saline; groups 2, 3, and 4 treated with 50, 100, or 150 mg/kg of CP, respectively; group 5 treated with 0.5 mL olive oil; groups 6 and 7 treated with 5.0 and 10 mg/kg of Car, respectively; groups 8, 9, or 10 treated with respective CP plus 5.0 mg/kg of Car; and groups 11, 12, or 13 treated with respective CP plus 10 mg/kg of Car. Serum alanine transaminase (ALT),aspartat transaminase (AST), lactate dehydrogenase (LDH), malondialdehyde (MDA),creatine kinase-MB (CK-MB), total oxidant state (TOS), oxidative stress index (OSI), and levels were high only in the CP groups. There was a dose-dependence on the CP-induced cardiotoxicity. Hemorrhage, inflammatory cell infiltration and the separation of the muscle fibers in the heart tissue supported the biochemical data. With 5.0 and 10 mg/kg Car, there was an important decrease in the CP toxicity and this was related to the oxidative and nitrosative stress in the CP-induced cardiotoxicity. Reduced inflammation and lipid peroxidation in the heart tissue and increase of serum glutathione (GSH) and total antioxidant capacity (TAS) levels were found when carvacrol was applied. Based on these findings, it could be proposed that Car was a strong candidate in preventing the CP-induced cardiotoxicity but further clinical studies should be done in order to verify its application on humans.
Hematoprotective Effect of N(G)-Nitro-L-Arginine Methyl Ester and Lycopene on Hematoxicity in Trinitrobenzene Sulfonic Acid–Induced Colitis in Rat
(2015) Çetik Yıldız, Songül; Ayhanci, Adnan; Altuner, Yilmaz; Musmul, Ahmet; Sahinturk, Varol; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Anemia is a neglected manifestation of inflammatory bowel disease (IBD) although it is commonly observed in IBD patients. Attempts to overcome anemia in IBD would help not only general well being of the patients but also minimize disease consequences. In this experimental study, the possible hematoprotective effects of lycopene and NG–nitro-L-arginine methyl ester (L-NAME) on colitis induced by TNBS were analyzed. 112 rats were assigned to 16 groups; control group, intrarectal 120 mg/kg TNBS group, intraperitoneal 40 mg/kg L-NAME group, 1 mg/kg olive oil group, 5 and 10 mg/kg lycopene groups. Each experimental group was divided into 3 subgroups according to duration of treatment. On the very first day of treatment number of erythrocytes decreased in all groups except TNBS treated group whereas leukocyte numbers increased in all groups except TNBS treated group pointing out an inflammation. The number of platelets decreased in all study groups with the exception of TNBS group. On the second day, while erythrocyte and platelet numbers increased in all but not in TNBS group, leukocytes decreased in all the groups. On the third day, erythrocyte and platelet numbers increased in all groups except for the 10 mg/kg lycopene group. While the number of leukocytes decreased in the 10 mg/kg lycopene group, it remained the same in the other groups as those observed on the second day. These results show that lycopene could have effects on hemopoiesis as well as in prevention of anemia in IBD.
Citation - WoS: 3
Investigation of Uroprotective Effects of Seed Methanol Extracts of Hypericum Triquetrifolium Turra. on Cyclophosphamide-Induced Bladder Hemorrhagic Cystitis and Nephrotoxicity in Wistar Albino Rats
(Cukurova Univ, Fac Medicine, 2020) Keskin, Cumali; Çetik Yıldız, Songül; Sahinturk, Varol; Ayhanci, Adnan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Purpose: This study investigated the possible uroprotective effects of Hypericum triquetrifolium Turra. (HT) seed methanol extracts (25,50,100 mg/kg, i.p., for 6 days) against cyclophosphamide (CYP)-induced (150 mg/kg, single dose, i.p.) acute bladder hemorrhagic cystitis (HC) and nephrotoxicity in rats. Materials and Methods: Wistar albino rats used in this study were divided into nine groups, each including seven rats. Group 1 (control) was treated with 0.5ml saline (SF) and Group 2 was treated with CYP (150 mg/kg). Groups 3, 4, 5 were treated with 25, 50, 100 mg/kg HT, respectively while groups 6, 7, 8 were treated with 25, 50, 100 mg/kg CYP + HT, respectively. Finally, Group 9 (control-2) was treated with 0.5ml-%0.2 dimethyl sulfoxide (DMSO). The serum creatinine, blood urea nitrogen (BUN), superoxide dismutase (SOD) and catalase (CAT) levels were measured in blood serum. Results: The CYP-treated rats histopathologically had mild-moderate bladder and renal injuries. The serum creatinine and BUN levels, which are the biochemical markers of renal injury, significantly increased compared to the control group. Conclusion: HT showed a protective effect on CYPrelated bladder HC and nephrotoxicity in rats by inhibiting inflammation and apoptosis.
Cardioprotective effects of Hypericum triquetrifolium Turra. against cyclophosphamide related cardiotoxicity in rats
(2018) Çetik Yıldız, Songül; KESKİN, Cumali; Sahinturk, Varol; Ayhanci, Adnan; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
ABSTRACT: Cyclophosphamide (CYP) is commonly used as anticancer agent but its usage is limited by cardiotoxic side effects such as dose-dependent cardiac damage, morphologically defined necrosis and bleeding. Hypericum triquetrifolium Turra. (HT) shows anti-oxidative and anticarciogenic properties with its rich phenolic contents. The current study was designed to investigate the possible protective effect of HT on CYP-induced cardiotoxicity. Albino rats were randomly divided into 9 groups, each included 7 animals. Serum creatine kinase-MB (CK-MB), malondialdehyde (MDA), aspartate transaminase (AST), glutathione (GSH), total antioxidant (TAC) and total oxidant capacity (TOC) levels were investigated. Furthermore, the cardiac tissue samples were investigated histopatologically. While the levels of serum CK-MB, MDA, AST and TOC were high, the levels of serum GSH and TAC levels were low in the CYP groups. It was also observed that CYP-induced cardiotoxicity was dose dependent. In the treatment with CYP plus HT doses there was observed an essential decrease in the CYP cardiotoxicity; decreased cell damage and oxidative stress parameters and also increased GSH and TAC levels. Based on our findings, it can be proposed that HT seed methanol extract was a strong candidate in preventing the CYP-induced cardiotoxicity.
Investigation of nasal Staphylococcus aureus carriage by real-time PCR in patients receiving hemodialysis treatment
(2023) Demir, Cemil; Çetik Yıldız, Songül; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
ABSTRACT Objectives: Staphylococcus aureus, coagulase-negative staphylococci (CoNS), and methicillin-resistant S. aureus (MRSA), which are significant nosocomial pathogens, have become a growing global problem because their carriage and diseases have become resistant to many antibiotics. This study aimed to investigate and determine the rate of MRSA carriage among patients receiving hemodialysis treatment using molecular methods. Methods: In the 254 hemodialysis patients, the nasal carriage rates, susceptibility and resistance to S. aureus, CoNS and MRSA were examined using culture and real-time PCR methods. Nasal samples from hemodialysis patients were examined using real-time PCR. Microscopic examination was performed using the Gram staining method, and S. aureus was identified using catalase and coagulase. The strains were then tested for antibiotic susceptibility. Staphylococci was isolated from 231 of the 254 patients. Results: S. aureus carriage was detected in 50 patients, MRSA in 16, methicillin-susceptible S. aureus (MSSA) in 33, CoNS in 66, methicillin-resistant CoNS (MR-CoNS) in 38, and methicillin-susceptible CoNS (MSCoNS) in 28. S. aureus and MRSA strains exhibited 100% susceptibility to nitrofurantoin, and vancomycin. MSSA strains showed the highest susceptibility to chloramphenicol, clindamycin (84.8%), and co-trimoxazole (36.4%). CoNS showed 100% susceptibility to vancomycin, and 16.7% susceptibility to ampicillin. Vancomycin was found to be the most effective antibiotic against S. aureus, CoNS, and MRSA pathogens identified in patients undergoing hemodialysis, whereas penicillin resistance was found. Conclusions: It can be concluded that one of the most effective ways to prevent the formation of antibiotic resistant strains is the hygiene of the hospital and hospital staff. Real-time PCR is very important for analyzing with high sensitivity.
Citation - WoS: 8
Citation - Scopus: 3
Cardioprotectiveeffectsof Hypericumtriquetrifoliumturra. Against Cyclophosphamide Related Cardiotoxicity in Rats
(2018) Çetik Yıldız, Songül; Keskin, Cumali; Ayhanci, Adnan; Şahintürk, Varol; Yıldız, Songul Cetık; Keskin, Cumali; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Cyclophosphamide (CYP) is commonly used as anticancer agent but its usage is limited by cardiotoxic side effects such as dose-dependent cardiac damage, morphologically defined necrosis and bleeding. Hypericum triquetrifoliumTurra. (HT) shows anti-oxidative and anticarciogenic properties with its rich phenolic contents. The current study was designed to investigate the possible protective effect of HT on CYP-induced cardiotoxicity. Albino ratswererandomlydividedinto9groups,eachincluded7animals.Serumcreatinekinase-MB(CK-MB), malondialdehyde (MDA), aspartate transaminase (AST), glutathione (GSH), total antioxidant (TAC) and total oxidant capacity (TOC) levels were investigated. Furthermore, the cardiac tissue samples were investigated histopatologically. While the levels of serum CK-MB, MDA, AST and TOC were high, the levels of serum GSH and TAC levels were low in the CYP groups. It was also observed that CYP-induced cardiotoxicity was dose dependent. In the treatment with CYP plus HT doses there was observed an essential decrease in the CYP cardiotoxicity; decreased cell damage and oxidative stress parameters and also increased GSH and TAC levels. Based on our findings, it can be proposed that HT seed methanol extract was a strong candidate in preventing the CYP-induced cardiotoxicity.