Sağır, Süleyman
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Sagir, Suleyman
Sagir, Sueleyman
Sagir, Sueleyman
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Dr. Öğr. Üyesi
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Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
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Current Staff
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Scholarly Output
14
Articles
14
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0
13 results
Scholarly Output Search Results
Now showing 1 - 10 of 13
Article Mesane Tümörü Rezeksiyonunda Karl Storz ve Olympus Bipolar Rezeksiyon Sistemlerinin Karşılaştırılması(Harran Üniversitesi Tıp Fakültesi Dergisi, 2023) Sağır, Süleyman; Toktaş, İzzettin; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü; Department of Internal Medical Sciences / Dahili Tıp Bilimleri BölümüAmaç: Kasa invaze olmayan mesane kanserli hastalarda mesane tümörlerinin tedavisinde Olimpus ve Karl Storz bipolar transüretral mesane rezeksiyonunun perioperatif sonuçlarını ve komplikasyonlarını karşılaştırmayı amaçladık. Materyal ve metod: Etik Kurulu onayı (Karar No. 2023/5-17) takibinde, 01 Ocak 2019 ile 28 Şubat 2023 tarihleri arasında Olimpus ve Karl Storz bipolar sistemleri ile transüretral mesane tümörü rezeksiyonu yapılan tüm hastalar değerlendirilmeye alındı. Bulgular: Olimpus grubunda hemoglobin (hbg) değişimi 1,11±0,61 iken Karl Storz grubunda 1,35±0,82 olarak görüldü ve anlamlı istatistiksel fark görülmedi (p= 0,180). Tümör boyutu Olimpus grubunda 3,20±1,55 cm olup Karl Storz grubunda 4,20±2,79 cm olarak değerlendirildi. Benzer şekilde obturator reflex, mesane perforasyon varlığı, kan tranfuzyonu, postoperatif pıhtı retansiyonunda da istatistiksel olarak farklılıklar saptanmadı. Sonuç: Kasa invaze olmayan mesane kanserinin transüretral rezeksiyonunda bipolar teknolojinin kullanımı güvenli ve etkili bir yöntemdir. Her iki tekniktede mesane perforasyon oranı, postoperatif pıhtı retansiyonu, postoperatif hemoglobin düşüşü, obturator reflex oranı benzer bulunmuş olup, istatistiksel olarak fark görülmemiştir.Article Citation - WoS: 1Citation - Scopus: 1Prognostic and Predictive Value of Tertiary Lymphoid Structures in Turbt Materials: Should It Be Seated in the Routine Pathological Examination, and Can It Be Used in Deciding on the Treatment Method?(Elsevier Science inc, 2024) Sağır, Süleyman; Sagir, Suleyman; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri BölümüObjective: This study aims to reveal the importance of tertiary lymphoid structures (TLS) in transurethral resection of bladder tumor (TURBT) materials with a practical and applicable method in which the effect of a certain threshold value on survival and treatment response can be implicated. Methods: TURBT materials that had not previously received any treatment (chemotherapy, radiotherapy, or immunotherapy) and were diagnosed for the first time at Mardin Training and Research Hospital between 2014 and 2022 were included in the study. The maximum TLS per 4x magnification field (field diameter: 4.5 mm) was recorded. Grouping and statistical analysis of the TLS number were performed using threshold values of ">= 1", ">= 2", and ">= 3". Results: TLSs were more frequently found in high-grade tumors (P = 0.008) and showed a strong association with stage progression (P < 0.001). It was also significantly associated with many adverse histopathological parameters. Conversely, high TLS (>= 1, >= 2, and >= 3) appeared to be associated with fewer recurrences (P = 0.032, P = 0.001, and P = 0.018, respectively), and cases with higher TLS showed longer recurrence-free survival (P = 0.089, P = 0.023, P = 0.037, respectively). TLS >= 3 was found to be an independent parameter that was associated with favorable RFS (P = 0.019, HR = 0.401), and multifocality was found to be an independent risk factor for RFS (P = 0.023, HR = 2.302). Conclusion: This study is the first to demonstrate the relationship between the presence and specific thresholds of TLS in TURBT materials with prognostic parameters. Including this information in the routine pathological examination of TURBT materials will allow a more accurate approach to treatment and follow-up, especially in patients with non-muscle invasive bladder cancer (NMIBC).Article Prematür Ejakülasyon Tanılı Hastalarda Depresyon ve Kaygı Düzeylerinin Değerlendirilmesi(2024) Sağır, Süleyman; Allahverdi, Şule; Ergün, Müslüm; Katar, Kübra Sezer; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri BölümüAMAÇ: Prematür ejakülasyon şikayeti olan hastalar sıklıkla kötü psikolojik durumla hastaneye başvururlar. Bu çalışmada amacımız prematür ejakülasyon şikayetiyle başvuran hastalarda depresyon ve kaygı düzeylerinin değerlendirilmektir. GEREÇ ve YÖNTEMLER: Çalışmaya sadece yaşam boyu prematür ejakülasyon (PE) ve sonradan kazanılmış olan PE hastaları dahil edildi. Bu çalışmaya toplam 80 hasta dahil edildi. Dahil edilme kriterlerini karşılayan hastaların yaş, boy, kilo, vücut kitle indeksi (BMI), meslek gibi demografik verileri kaydedildikten sonra depresyon ve anksiyete şiddetini değerlendirmede kullanılan Beck Depresyon Ölçeği (BDÖ) ve Hastane Anksiyete ve Depresyon Ölçeği (HADÖ) anketleri doldurtuldu. BULGULAR: Araştırmaya katılanların prematür ejakülasyon süresi 30 saniyesinin altında olanlarda 30 saniyenin üstünde olanlara göre; PE değerlendirme anketi puanı, Beck Depresyon Ölçeği ve HAD Ölçeği puanları anlamlı olarak yüksek bulunmuştur (p<0,05). Ayrıca yaılan korelasyon analizleri Prematür ejakülasyon anketi puanı arttıkça; BDÖ puanı (r=0,775) ve HAD Ölçeği puanının da (r=0,882) arttığını göstermektedir. SONUÇ: Erkek hastalarda prematür ejakülasyon şiddeti arttıkça depresyon ve anksiyete düzeylerinde artış gözlenmekte bu nedenle hasta değerlendirilmesinde ve tedavisinde multidisipliner bir yaklaşım sergilenmelidir.Article Citation - WoS: 0Citation - Scopus: 0Comparison of Pde-5 Inhibitors Used in Erectile Dysfunction With Some Candidate Molecules: a Study Involving Molecular Docking, Admet, Dft, Biological Target, and Activity(Bmc, 2025) Sağır, Süleyman; Unsal, Velid; Oner, Erkan; Yildiz, Resit; Mert, Basak Dogru; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri BölümüErectile dysfunction (ED) is a urological condition defined as the inability of a man to achieve or maintain an erection. This condition negatively affects his sexual performance and the performance of his partner. Phosphodiesterase type 5 (PDE5) inhibitors are commonly used to treat ED. Arginase II plays an important role in regulating L-arginine to NO synthase in the smooth muscle of the human corpus cavernosum of the penis. NO is a molecule essential for regulating a variety of functions, including arterial blood pressure, penile erection, and energy balance. Substances such as vardenafil, alprostadil, papaverine, and resveratrol increase NO production, thereby supporting sexual function and vascular health. Additionally, NO donors such as L-arginine, L-citrulline, and alpha-lipoic acid provide effective alternatives when used in combination with PDE5 inhibitors. Medications used in the treatment of ED include vardenafil, alprostadil, and papaverine. In addition, although molecules such as L-arginine, citrulline, resveratrol, alpha-lipoic acid, and rutin are thought to play a role in ED, their pharmacological and molecular effects have not been sufficiently elucidated. The aim of this study was to investigate the effects of these molecules in the treatment of ED by computer-based calculations, to obtain new information about them and to inspire new treatment strategies for ED. The physicochemical, molecular and pharmacokinetic properties of the compounds were determined by SwissADME software, and ADMET (absorption, distribution, metabolism, excretion and toxicity) data were determined by ADMETlab 3.0 software. Biological target and activity data were obtained by MolPredictX and PASS Online software. While the Gaussian 09 program was used for DFT calculations, PyMOL, AutodockTools 4.2.6, AutoDock Vina, and Biovia Discovery programs were used for molecular docking studies. It was found that L-arginine, citrulline, resveratrol and alpha-lipoic acid were well absorbed from the intestine, while rutin showed limited absorption. When their metabolic risks were evaluated, L-arginine and citrulline were found to have lower toxicity. Molecular docking results of rutin and resveratrol were remarkable. The electronic properties of the compounds were explained by DFT calculations. L-arginine and citrulline were found to have low toxicity and positive therapeutic effects. L-arginine and citrulline stand out as promising candidates for future research. Although resveratrol data are promising, unfortunately their potential toxicity and metabolic interactions require further investigation. It is important to learn more about these compounds or conduct research to improve their therapeutic efficacy. Although computer-based calculations play an important role in toxicity predictions, drug interactions, pharmacokinetics and toxicity properties should be carefully evaluated.Article Citation - WoS: 0Citation - Scopus: 0Breaking Misconceptions: Assessing the Quality of Youtube Videos on Penile Fracture With Validated Scoring Tool(Mre Press, 2025) Sağır, Süleyman; Ertek, Mehmet Sirin; Toktas, Izzettin; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri BölümüBackground: The main objective of this research was to evaluate the effectiveness of YouTube videos related to penile fracture by applying established rating systems. Methods: A descriptive investigation was carried out by browsing YouTube for videos related to "Penile fracture". Out of a total of 108 videos that were found, 47 were deemed eligible for inclusion in the analysis. The features and substance of the videos were assessed utilizing the adjusted DISCERN tool, the criteria from the Journal of the American Medical Association (JAMA), and the Global Quality Scale (GQS). Statistical analysis was performed using SPSS 22.0 software, with a significance level of p < 0.05. Results: High-quality videos, as classified by GQS, had more views, likes, and comments than lower-quality videos; however, these differences were not statistically significant (p > 0.05). In contrast, videos with detailed and accurate content had significantly higher view counts (approximately tenfold) and more likes (approximately twofold) than poor-content videos (p < 0.05). A strong positive correlation was found between content analysis scores and DISCERN (r = 0.815, p < 0.001), JAMA (r = 0.781, p < 0.001), and GQS (r = 0.722, p < 0.001). Videos made by urologists and surgeons demonstrated superior quality across all measured criteria in comparison to those crafted by individuals without healthcare backgrounds (p <0.001). Conclusions: The quality of YouTube content addressing penile fracture exhibits a wide range, with content generated by healthcare experts standing out for its high quality. It is imperative for medical professionals to actively engage in disseminating accurate health information on these platforms.Article Citation - WoS: 0Combining Multiparametric Mri and Psa Density for Improved Diagnostic Accuracy in Prostate Cancer(Galenos Publ House, 2024) Sağır, Süleyman; Ozden, Cuneyt; Bulut, Suleyman; Gokkaya, Cevdet Serkan; Aktas, Binhan Kagan; Kizilkan, Yalcin; Sagir, Sueleyman; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri BölümüObjective: The objective of this research was to investigate the combined use of multiparametric magnetic resonance imaging (Mp-MRI) and prostate-specific antigen density (PSAD) to increase diagnostic accuracy in detecting prostate cancer (PCa) and to reduce unnecessary biopsies. Materials and Methods: This retrospective analysis included 399 patients who underwent prostate biopsy at Ankara City Hospital between 2021 and 2022, primarily due to clinical indications suggestive of PCa. The patient cohort was categorized into distinct groups according to their PSAD, with a defined threshold of 0.15 ng/mL/cc, and their respective prostate imaging reporting and data system (PI-RADS) scores; subsequently, the diagnostic performance metrics, including sensitivity, specificity, and predictive values for determining Pca, were meticulously evaluated across different combinations of PI-RADS classifications and PSAD levels. Results: Among the 399 patients, 37.6% had PCa and 16.8% had clinically significant PCa (csPca). Patients who exhibited PI-RADS scores of 3 or higher combined with a PSAD score of at least 0.15 ng/mL/cc exhibited the greatest positive predictive value, achieving 74.1% for overall PCa and 39.3% for csPca. The integration of PI-RADS assessment with PSAD thresholds notably enhanced diagnostic accuracy, leading to improved detection rates of clinically significant cases while concurrently minimizing the frequency of unnecessary biopsy procedures. Conclusion: The simultaneous application of Mp-MRI and PSAD enhances the precision of Pca diagnosis and serves as a valuable tool for reducing the need for unnecessary biopsies, especially in patients with PI-RADS scores of 3 or above accompanied by elevated PSAD levels.Article Citation - WoS: 6Citation - Scopus: 7Oxidative stress, apoptosis, inflammation, and proliferation modulator function of visnagin provide gonadoprotective activity in testicular ischemia-reperfusion injury(Verduci Editore srl, 2023) Sağır, Süleyman; Şeker, Uğur; Pekince Özener, Merve; Yüksel, Meral; Demir, Mehmet; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü; Department of Basic Medical Sciences / Temel Tıp Bilimleri BölümüOBJECTIVE: Visnagin (Vis) is a compound found in the flowers and seeds of the Ammi visnaga plant with promising antioxidant and anti-inflammatory properties. We aimed to investigate the dose-dependent gonadoprotective effects of visnagin in rats while considering oxidative stress, apoptosis, and inflammation-related protein expression levels. MATERIALS AND METHODS: Twenty-eight adult rats were divided into four groups of seven animals each; control, ischemia/reperfusion (I/R), I/R+30Vis, and I/R+60Vis. Animals in control received no surgical application and were sacrificed at the end of the experiment. The rats in I/R, I/R + Vis30, and I/R + Vis60 were exposed to testicular ischemia and the animals in I/R + Vis30, and I/R + Vis60 groups received either 30 or 60 mg/kg visnagin intraperitoneal. At the end of the experiment, testis tissues were used for the measurement of oxidative stress, apoptosis, and inflammation. RESULTS: Our microscopic examinations indicated that I/R resulted in testicular degenerations and morphological alterations, which were improved in visnagin-treated animals. The biochemical analyses demonstrated that oxidative stress in the I/R group increased significantly (p<0.05) compared to the control group. The immunohistochemical examinations showed that pro-apoptotic Bax and Caspase 3 expressions, and pro-inflammatory tumor necrosis factor-alpha (TNF-α) levels were significantly up-regulated (p<0.05) but proliferating nuclear antigen (PCNA) levels in I/R group was significantly (p<0.001) down-regulated compared to the control group. CONCLUSIONS: Ischemia leading to testicular torsion is a reproductive health-affecting problem, and current surgical treatment methods might be insufficient to recover the testis due to the accumulation of reactive oxygen species (ROS). Our observations indicate that visnagin is a potential co-modality along with the surgical interventions for the recovery of ischemia encountered testis, but we believe the requirement of more detailed studies to explore the underlying signaling pathways and the strength of visnagin against testicular ischemia-reperfusion injury.Article Citation - WoS: 0Citation - Scopus: 0Factors Affect Progressive Sperm Motility(Mexican Acad Surgery, 2025) Sağır, Süleyman; Tuncekin, Adem; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri BölümüObjective: In this study, it was aimed to investigate the effects of age, body mass index, and diet factors on sperm parameters and developing a novel index (Artuklu Sperm Quality Index [ASQI]). Method: The study incorporated a total of 115 patients who sought medical attention due to infertility and underwent semen analysis (spermiogram). The ASQI score was developed. Results: About 73% reported eating three meals daily, while 62% consume fruits a few times a week. When considering grain consumption, 30% rarely do, mirroring the 25% who never do. Carbonated drinks are consumed a few times in 15 days by 39% of respondents. Salt consumption showed 47% taking very little, whereas 42% consume caffeine very minimally. Sausage/ salami is minimally consumed by 44%, and 32% of participants reported never being exposed to air pollution. ASQI score ranges from 6 to 61 point. A lower score indicates good nutrition and quality of life, while a higher score suggests deteriorating nutrition and increasing unhealthy habits. Cronbach alfa value was noted as 0.72. A negative correlation was found between ASQI and sperm progressive motility (p < 0.001, r = -0.405). Conclusions: This study revealed a clear negative correlation between the ASQI score, which signifies deteriorating nutrition and escalating unhealthy habits, and sperm progressive motility.Article Penis Kırıklarının Acil Cerrahi Tedavisinin Sonuçları: Dikiş Malzemeleri, Gecikmiş Onarım ve Ameliyat Sonrası Sonuçlar Üzerine Bir Çalışma(2024) Toktaş, İzzettin; Sağır, Süleyman; Toktaş, İzzettin; Sağır, Süleyman; Çelikkaleli, Ferhat; Ergün, Müslüm; Department of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri BölümüAmaç: Bu çalışma, penis kırığı (PK) hastalarında cerrahi zamanlama ve dikiş malzemelerinin ameliyat sonrası sonuçlar üzerindeki etkisini, özellikle penil kurvatür (PK) gelişimine odaklanarak incelemektedir. Gereç ve Yöntemler: 2015-2024 yılları arasında penis kırıkları nedeniyle tedavi edilen 63 hasta üzerinde retrospektif bir analiz yapıldı. Ameliyat süresi, dikiş malzemeleri ve PK gibi ameliyat sonrası komplikasyonlar hakkındaki veriler toplandı. Bulgular: Hastaların %27’sinde PK gelişti ve bu hastalarda cerrahi müdahale süresi, PK gelişmeyenlere kıyasla anlamlı derecede daha uzun bulundu. Dikiş malzemesi türü (2-0 Prolene ve 3-0 Vicryl) PK veya nodül oluşumu üzerinde anlamlı bir etkiye sahip değildi. Sonuç: Gecikmiş cerrahi müdahale, PK riskinin artmasıyla ilişkilidir. Komplikasyonları azaltmak için erken cerrahi önerilmektedir, ancak dikiş malzemesi sonuçları etkilememektedir.Article Citation - WoS: 0Citation - Scopus: 0Low-Intensity Extracorporeal Shock Wave Therapy and Platelet-Rich Plasma: Effective Combination Treatment of Chronic-Phase Peyronie's Disease(Iniestares, S.a., 2025) Sağır, Süleyman; Sagir, Suleyman; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri BölümüObjective: This study aimed to investigate the effectiveness, safety and outcomes of the combination therapy of low-intensity extracorporeal shockwave therapy (Li-ESWT) and platelet-rich plasma (PRP) for the treatment of chronic-phase Peyronie's Methods: The clinical outcomes of patients diagnosed with Peyronie's disease and treated with Li-ESWT combined with PRP at our clinic between January 2018 and January 2024 were retrospectively reviewed and analysed. Twenty-three patients were excluded based on inclusion criteria, leaving 26 patients for the retrospective analysis. Each patient received three sessions of PRP and six sessions of Li-ESWT. The treatment regimen involved sessions administered twice weekly over a period of 3 weeks, followed by 1-week post-treatment follow-up. The patients were then monitored for 24 weeks. Result: After treatment, no significant reduction in average plaque size was observed. However, a statistically significant average improvement of 10 degrees was noted for penile curvature. Among the patients, 14 (53.8%) reported satisfaction with the treatment outcome, and 12 (46.2%) expressed dissatisfaction. No significant adverse effects were observed at the injection sites or in the areas subjected to Li-ESWT post-procedure. Conclusions: The combination of Li-ESWT and PRP is effective and safe for the treatment of chronic-phase Peyronie's disease.
