Acay, Hilal
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Acay, H.
Acay, Hilal
Acay, Hilal
Job Title
Doçent
Email Address
hilalacay@gmail.com
Main Affiliation
Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü
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Sustainable Development Goals
1
NO POVERTY
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
1
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
13
CLIMATE ACTION
0
Research Products
2
ZERO HUNGER
4
Research Products
4
QUALITY EDUCATION
0
Research Products
3
GOOD HEALTH AND WELL-BEING
7
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
1
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
5
GENDER EQUALITY
0
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
1
Research Products
10
REDUCED INEQUALITIES
0
Research Products
14
LIFE BELOW WATER
2
Research Products
11
SUSTAINABLE CITIES AND COMMUNITIES
1
Research Products
15
LIFE ON LAND
0
Research Products
6
CLEAN WATER AND SANITATION
3
Research Products
Documents
22
Citations
436
h-index
13
Documents
0
Citations
0
Scholarly Output
35
Articles
27
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0/0
Supervised MSc Theses
2
Supervised PhD Theses
0
WoS Citation Count
180
Scopus Citation Count
330
WoS h-index
8
Scopus h-index
12
Patents
0
Projects
3
WoS Citations per Publication
5.14
Scopus Citations per Publication
9.43
Open Access Source
21
Supervised Theses
2
| Journal | Count |
|---|---|
| Applied Ecology and Environmental Research | 3 |
| International Journal of Environmental Analytical Chemistry | 2 |
| Medicine Science | 2 |
| Journal of the Turkish Chemical Society, Section A: Chemistry | 2 |
| Preparative Biochemistry & Biotechnology | 2 |
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Now showing 1 - 10 of 35
Article Citation - WoS: 10Citation - Scopus: 14The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats(Wiley, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Tektemur, Ahmet; Acay, Hilal; Yıldırım, AyferThis study was conducted to evaluate the protective role of Pleurotus eryngii extract (PE) and Pleurotus eryngii extract-loaded chitosan nanoparticles (PE-CSNP) against doxorubicin (DOX)-induced testicular toxicity in rats. Male rats were divided into six groups: control (DMSO/ethanol), PE (200 mg/kg PE), PE-CSNP (30 mg/kg PECSNP), DOX (10 mg/kg DOX, a single dose, i.p), DOX+PE (10 mg/kg DOX+200 mg/ kg PE) and DOX+PE-CSNP (10 mg/kg DOX+30 mg/kg PE-CSNP). PE and PE-CSNP were administered by oral gavage every other day for 21 days. DOX-treated rats showed histopathological impairment compared with the control group. There was an increase in the apoptotic index, caspase 3 (CASP3), BCL2-associated X apoptosis regulator (BAX), dynamin-related protein 1 (DRP1) expression and total oxidative status (TOS) in the DOX group, while mitofusin-2 (MFN2), total antioxidative status (TAS) and serum testosterone levels of the DOX group reduced when compared with the other groups. PE and PE-CSNP treatments provided significant protection against DOX-induced oxidative stress by reducing TOS levels and increasing TAS levels. CASP3, BAX, apoptotic index and DRP1-MFN2 expressions were restored by PE and PE-CSNP. However, the PE-CSNP showed higher antioxidant and anti-apoptotic efficacy compared with PE. Thus, our results provide evidence that CSNP and PE could synergistically have a potent antioxidant and anti-apoptotic therapy against DOX-induced testicular damage in male rats.Article Citation - Scopus: 1Utilization of edible mushroom for nanomaterial-based bioactive material development(Iranian Journal of Materials Science and Engineering, 2021) Acay, Hilal; Yıldırım, Ayfer; Baran, AyşeGold nanoparticles (AuNP) were synthesized using edible mushroom Russula delica (RD) in this study. Possibilities to evaluate these synthesized nanoparticles (RD-AuNPs) as bioactive substances were investigated. Characterization of synthesized RD-AuNPs were characterized via UV-vis, XRD, FTIR, EDX. In a spherical view, RD-AuNPs with a crystal size of 34.76 nm were synthesized. As a result, fungal systems used for nanomaterial biosynthesis as an effective alternative to chemical synthesis can be used in different biotechnological and medical applications. RD-AuNPs produced by green synthesis can be evaluated in this context.Article Citation - WoS: 22Citation - Scopus: 25Determination of Antimicrobial and Toxic Metal Removal Activities of Plant-Based Synthesized (capsicum Annuum L. Leaves), Ecofriendly, Gold Nanomaterials(Wiley-v C H verlag Gmbh, 2020) Baran, Mehmet Firat; Acay, Hilal; Keskin, CumaliNanoparticles are valuable materials with widespread use. The fact that these materials are obtained by biological resources with an environmentally friendly method contributes to the development of studies in this field. Gold nanoparticles (AuNPs) from waste vegetable sources (green leaves of Capsicum annum L.) are economically and easily synthesized. The obtained particles are characterized by UV-vis spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and scanning electron microscopy (SEM) analysis. The antimicrobial activity of the particles on the pathogenic microorganisms Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 29213, Bacillus subtilis bacteria, and Candida albicans yeast are found to have a significant suppressive effect. The removal activities of eight toxic metals (Pd, Cd, Fe, Ni, Co, Mn, Zn, Pb) in Diyarbakir drinking water and artificially prepared water within different pHs are investigated. Gold nanoparticles synthesized from Capsicum annuum L. leaves are found to be effective in toxic metal removal in water samples.Master Thesis Pleurotus Ostreatus Ekstratı Kullanarak Sentezlenen Nanopartiküllerin Antimikrobiyal Aktivitelerinin Araştırılması(2024) Polat, Elif; Acay, HilalGıda patojenlerinin azaltılmasına yönelik biyolojik kontrol stratejilerine yönelik küresel vurgu, geleneksel antimikrobiyal ajanların insan sağlığı üzerindeki etkilerine ilişkin endişeler ve mikrobiyal direncin artan zorluğu nedeniyle konuyla ilgili çalışmalar yoğunluk kazanmıştır. Bu zorluklara yanıt olarak nanoteknolojik müdahalelerde dikkate değer bir potansiyel bulunan, yeniden değerlendirilen yaklaşımlar ortaya çıkmaktadır. Bu çalışma, Pleurorus ostreatus ekstraktı (PO), Gümüş-(Ag) Kitosan (K) kullanılarak, etkili, düşük maliyetli, sürdürülebilir ve toksik olmayan, çevre dostu AgPOK nanomateryalinin sentezlenmesine odaklanmaktadır. Sentezlenen AgPOK nanomateryalinin karakterizasyonu Fourier Dönüşümü Kızılötesi Spektroskopisi (FTIR), Taramalı Elektron Mikroskobu (SEM), Termogravimetrik Analiz (TGA), X-ışını Kırınımı (XRD) ve zeta potansiyeli ölçümleri gibi analitik teknikler kullanılarak yapıldı. 237.4 nm buyutunda olan negatif yüklü AgPOK nanomateryalinin fitopatojenik türler, Penicillium expansum, Alternaria alternata, Aspergillus niger, ve Fusarium oxysporum karşı antifungal etkinliği, Escherichia coli ,Staphylococcus aureus'a karşı antibakteriyel etkinliği ayrıca Candida albicans'a karşı anticandidal etkinliği araştırıldı. Veriler, PO ve AgPOK 'nın çalışmada kullanılan patojenler üzerinde ciddi antimikrobiyal etkisi olduğunu ancak bu etkinin farklılıklar gösterdiğini göstermektedir.Patojenik türlerin çeşitliliğinden kaynaklandığı düşünülen bu farklılıklar nedeniyle PO ve AgPOK'nın birçok gıda patojeni üzerinde de etkili olabileceği düşünülmektedir.Article Citation - Scopus: 1The interaction methylene blue and glutathione-S-transferase purified from human erythrocytes(Journal of Planar Chromatography - Modern TLC, 2020) Acay, Hilal; Uzan, Serhat; Baran, Mehmet Fırat; Bilden, Alican; Aygün, HüsamettinIt is known that textile dyes have various risks on human health. Glutathione-S-transferase enzymes play a critical role in the detoxification of xenobiotics in living systems. This study aimed to examine the interaction of methylene blue with human erythrocyte glutathione-S-transferase purified in one step. Human erythrocyte glutathione-S-transferase was purified with approximately 750-fold purification and 30% efficiency by glutathione agarose affinity chromatography. The results showed that the enzyme was inhibited by methylene blue with an IC50 value of 1.40 mmol/L. The Ki constant of methylene blue was 1.17 mmol/L. The Lineweaver–Burk graph of the methylene blue showed that the type of inhibition was compatible with mixed type inhibition. A new third spot was also detected by thin-layer chromatography. Furthermore, the cytotoxicity of methylene blue on human erythrocytes was evaluated and it was found that the haemolysis per cent of methylene blue on erythrocytes was approximately 14%.Article Citation - Scopus: 23Methylene Blue and Malachite Green Dyes Adsorption Onto Russula Delica/Bentonite(Elsevier Ltd, 2025) Yildirim, A.; Acay, H.In the current research Russula delica mushroom/bentonite clay (RDBNC) as a low-cost bionanosorbent was investigated for adsorption of methylene blue (MB) and malachite green (MG) dye from contaminated water. The bionanosorbent was characterized by Fourier transform infrared (FTIR), X-ray diffraction (XRD), Scanning electron microscopy (FESEM), Thermal Gravimetric Analysis (TGA), and Zeta-potential techniques. Adsorption experiments of RDBNC for MB, MG dyes following Freundlich isotherm and pseudo second order kinetic models. To determine their effects on the adsorption efficiency, the adsorption parameters were investigated including dye concentration, contact time, temperature, and dosage of the bionanosorbent. The adsorption process can operate through three primary mechanisms: the π–π interaction, the hydrogen bonding, and electrostatic interactions between the surface of RDBNC and MB, MG dyes. Desorption results revealed that MB and MG dyes were effectively desorbed during the fourth cycle without a notable loss in adsorption capacity. The thermodynamics parameters including ΔH, ΔS, and ΔG, were determined, and the adsorption process was favorable, spontaneous, and exothermic for MB and MG. The results showed that RDBNC, which showed effective inhibition at low concentrations, especially against E. coli, can be used as a low-cost bionanosorbent synthesised for the first time to remove industrial dyes. © 2024 The AuthorsArticle Citation - WoS: 20Citation - Scopus: 24Kinetic and isotherm investigation into the removal of heavy metals using a fungal-extract-based bio-nanosorbent(Environmental Technology and Innovation, 2020) Yıldırım, Ayfer; Baran, Mehmet Fırat; Acay, HilalAdsorption is very economical and environmentally friendly method that is commonly accepted as a promising technique for the removal of heavy metals. In this study a fungal-extract-based (FE-CB) bio-nanosorbent was prepared and used as an efficient biosorbent for the removal of heavy metals, namely Cu(II) and Ni(II), from aqueous solutions. FE-CB was characterized by scanning electron microscope, Brunauer–Emmett–Teller surface area and porosity analyzer, Fourier transform infrared, x-ray diffraction, differential scanning calorimeter, thermalgravimetric analysis and zeta potential. The Brunauer–Emmett–Teller surface area, pore volume and average pore diameter of FE-CB were 7.43 m2/g, 0.060 cm3/g, and 2.82 nm, respectively. The adsorbtion properties of FE-CB onto both Cu(II) and Ni(II) were investigated in terms of biosorbent dosage, temperature, initial concentration of Cu(II) and Ni(II) ions, pH and contact time in the batch experiments. The dependence of the biosorption mechanism on pH was revealed and the optimum pH was determined as 6 for Ni(II) and 5 for Cu(II). The Langmuir and Freundlich isothermal models and the kinetic Pseudo-first-order and Pseudo-second-order kinetic models were used to describe the adsorption performance of FE-CB. The activation energy was calculated by pseudo-second-order rate constants. In addition, thermodynamic parameters, standard Gibbs free energy, standard enthalpy and standard entropy were analyzed using the (Van't Hoff equation). The biosorption process was found to be spontaneous, favorable and endothermic.Article Fatty acid compositions of total lipid, phospholipid and triacylglycerol fractions of the wild edible mushroom pleurotus ostreatus and russula delica with cytotoxic activities on prostate carcinoma cell lines(2019) Acay, Hilal; Baran, Mehmet FıratThe aim of the study to investigate fatty acids (FAs) of Pleurotus ostreatus and Russula delica in Total Lipid (TL), Triacylglycerol (TG) and Phospholipid (PL) fractions. The major FAs of TL, TG, PL in both species were palmitic acid (PA), oleic acid (OLA), and linoleic acid (LA). In both species, total PUFA amounts were found to be higher than total monounsaturated fatty acids (MUFA) and total saturated fatty acids (SFA) in TL, TG and PL fractions. Also, insufficiently studied cytotoxic activity (using prostate carcinoma (PC-3) cell lines) of these mushrooms were investigated by using various solvent systems. Ethyl acetate extract of Pleurotus ostreatus and Russula delica showed significant inhibitory value at the concentrations of 520-530 μg/ml (99.45-92.82%) against PC-3 cell lines with the half-maximal inhibitory concentration (IC50); 274.53-297.77 μg/mL respectively. The present study is a guide for biochemical and nutritional values of both species and can be useful for further investigation on pharmacological applications.Article Citation - Scopus: 5Synthesis and Characterization of Molecularly Imprinted Composite as a Novel Adsorbent and Competition With Non-Imprinting Composite for Removal of Dye(2021) Yildirim, Ayfer; Baran, Ayşe; Acay, HilalDue to its high visibility, high resistance, and toxic effects, colored substances in the textile and other dyeing industries waste-water cause great damage to biological organisms and ecology. Therefore, current research efforts to develop high selectivity, specificity, and efficient water treatment technologies are very intense, and molecularly imprinting methods (MIM) constitute a category of functional materials to meet these criteria. Polymethylmethacrylate-chitosan molecularly imprinted composite (PMMAC-MIC) and non-imprinted composite (PMMAC-NIC) were successfully prepared by MIM. Dye adsorption performance of MIC and NIC composites was investigated by comparison. The obtained adsorbents were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), and zeta potential techniques. The kinetics of adsorption followed a pseudo-first-order model while the Langmuir adsorption isotherm provided the best fit. The maximum adsorption capacity of dye was found as 93.78 mg/g for PMMAC-MIC and 17.70 mg/g for PMMAC-NIC at 298 K temperature, the initial dye concentration was 100 mg/L. Thermodynamic parameters indicated that the removal of dye from PMMAC-MIC was endothermic and spontaneous. Besides, the regeneration of composite was recycled four times.Other Verticillium dahliae Fungal Patojeni ile Mücadelede Mikonanoteknolojinin Kullanım Olanakları(2022) Yildirim, Ayfer; Acay, HilalVerticillium dahliae toprak kökenli bir bitki patojenidir ve mücadelesi kimyasal fungusitler ile sınırlıdır. Tüm dünyada önemli ekonomik tarımsal kayıplara neden olan hastalık etmeni fungusun çok geniş bir konukçu dizisine sahiptir. Hastalığın kontrolünde başarılı yöntemlerin azlığı, hastalığın önemini daha da arttırmaktadır. Ayrıca alternatif mücadele yöntemleri geliştirilme çabası çevre dostu fungusitlerin yetersizliği, patojenlerde fungisit dayanıklılığının ortaya çıkışı ve patojen popülasyonlarının konukçu dayanıklılığını kırması nedenlerine dayanmaktadır. Günümüzde ise hastalıklarının kontrolünde daha iyi etkinlik sağlayan nanoparçacık uygulamalarının popülerliği her geçen gün artmaktadır. Mevcut araştırma, yabani mantar olan Russula delica metanol ekstresi (RDE) ile herhangi bir tehlikeli madde kullanmadan yeni, basit, uygun maliyetli ve çevre dostu bir yöntem ile biyonanomateryal (RDEK) sentezlemek ve ilk defa sentezlenen bu materyalinantifungal madde olarak tarımsal uygulamlarda kullanımına işaret etmeyi amaçlamaktadır. Çalışmada, farklı konsnatrasyonlarda uygulanan RDE ve RDEK’nın Verticillium dahlia’ye karşı antifungal aktivite gösterdiği tespit edilmiştir. 0.02 mg/ml konsanrtasyonda en iyi aktivite gösteren RDEK biyonanomateryali tarımsal uygulamlarda fungusit olarak değerlendirilebilir.
