Demir, Cemil
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Demir, C.
Demir Cemil
Demir Cemil
Job Title
Öğretim Görevlisi
Email Address
cemildemir@ymail.com
Main Affiliation
Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü
Status
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
2
ZERO HUNGER
0
Research Products
5
GENDER EQUALITY
0
Research Products
6
CLEAN WATER AND SANITATION
0
Research Products
13
CLIMATE ACTION
0
Research Products
10
REDUCED INEQUALITIES
0
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
15
LIFE ON LAND
2
Research Products
3
GOOD HEALTH AND WELL-BEING
5
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
14
LIFE BELOW WATER
1
Research Products
4
QUALITY EDUCATION
0
Research Products
1
NO POVERTY
0
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
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Scholarly Output
25
Articles
23
Views / Downloads
129/2029
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
223
Scopus Citation Count
243
WoS h-index
8
Scopus h-index
8
Patents
0
Projects
0
WoS Citations per Publication
8.92
Scopus Citations per Publication
9.72
Open Access Source
16
Supervised Theses
0
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| Journal | Count |
|---|---|
| Annals of Clinical and Analytical Medicine | 3 |
| Burns | 2 |
| Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi | 1 |
| CELL BIOCHEMISTRY AND BIOPHYSICS | 1 |
| Cellular and Molecular Biology (CMB) | 1 |
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25 results
Scholarly Output Search Results
Now showing 1 - 10 of 25
Article Citation - WoS: 1Citation - Scopus: 1Investigate Nasal Colonize Staphylococcus Species Biofilm Produced(Derman Medical Publ, 2015) Demir, Cemil; Inanc, Betul BattalogluAim: 127 S. aureus and 65 CoNS strains were isolated from patients noses'. To produce a biofilm ability was investigated using three different methods. Slime-positive and negative staphylococcies' resistance were evaluated against different antibiotics. Material and Method: Swap samples puted 7% blood agar. Staphylococcus aureus and coagulase-negative staphylococci (CoNS) isolates biofilm produced ability were investigated using Congo Red Agar (CRA), microplates (MP) and Standard Tube (ST) methods. In addition to that, presence of antibiotic resistance of the staphylococcal isolates are determined agar disc diffusion method. Results: The rate of biofilm producing Staphylococcus spp strains was found to be 72.4%, 67.7%, and 62.9%, respectively with CRA, MP, and ST tests. There was no significant relationship among the tests (p>0.05). In addition, antibiotic resistance of Staphylococcus spp. against various antibiotics was also determined by the agar disk diffusion method. Resistance rates of biofilm positive (BP) Staphylococcus spp for penicilin G, ampicilin, amocycilin/clavulanic acid, tetracyclin, eritromycin, gentamycin, and enrofloxacin 71.7%, 69.7%, 6.2%, 20.7%, 21.4%, 1.4%, and 0.7%, respectively. Resistance rates of biofilm negative (BN) spp for 42.6%, 23.4%, 4.3%, 14.9%, 19.1%, 0.0%, 0.0% respectively. All Staphylococcus isolates were found to be susceptible to vancomycin and teicaplonin. Although BP strains antibiotic resistance rates were observed higher than BN strains. But resistance rates were not found statistically significant (p>0.05). Discussion: CRA is the reliablity and specifity method to determine Staphylococcus spp. biofilm produce ability.Article Citation - WoS: 1Citation - Scopus: 2distribution of Oxa-Type Carbapenemase Genes in Carbapenem-resistant Acinetobacter Baumannii strains: an Investigation by Real-Time Polymerase Chain Reaction Method(Doc design informatics Co Ltd, 2019) Demirci, Mehmet; Yigin, Akin; Demir, CemilObjective: Carbapenems are the most important broad spectrum antimicrobials used in the treatment of Acinetobacter baumannii infections, but resistance to carbapenems is increasing worldwide. In this study, we aimed to investigate the distribution of OXA-type carbapenemase genes observed in carbapenem-resistant A. baumannii strains by real-time polymerase chain reaction (PCR) method and to provide epidemiological data. Methods: Between January 2016 and January 2018, 20 carbapenem-resistant A. baumannii strains from clinical specimens were included in the study. DNA isolations were performed, and distribution of OXA-type carbapenemase genes were examined using primers and TaqMan probes specific to genes of OXA-23, OXA-24, OXA-51 and OXA-58 carbapenemases by real-time PCR method. Results: Tigecycline was the best choice for carbapenem-resistant A. baumannii strains, of which 16 (80%) were susceptible to this antimicrobial. bla(OXA-51) was detected in all strains, while bla(OXA-24) was detected in only 1 (5%) strain. Of 20 strains, 10 showed the presence of bla(OXA-23) and bla(OXA-51) simultaneously. Conclusions: Simultaneous occurence of bla(OXA-23) and bla(OXA-51 )is remarkable in terms of distribution of OXA-type carbapenemases in carbapenem-resistant A. baumannii strains. Valuable epidemiological data can be obtained by performing routine surveillance of such strains by means of techniques that can produce fast and reliable results such as real-time PCR.Article Citation - WoS: 9Citation - Scopus: 11Isolation and Molecular Characterization of Methicillin-Resistant Staphylococci from Horses, Personnel and Environmental Sites at an Equine Hospital in Turkey(JAPAN SOC VET SCI, 2012) Aslantas, Ozkan; Turkyilmaz, Suheyla; Yilmaz, Mehmet Ali; Erdem, Zeynep; Demir, CemilThe present study was carried out to assess the frequency of methicillin-resistant staphylococci (MRS) among racehorses (n=209) and veterinary personnel (n=13) as well as environmental surfaces (n=14) at an equine hospital in Adana, Turkey. In addition, species distribution, antimicrobial susceptibility, resistance genes, staphylococcal chromosomal cassette mec (SCCmec) type and clonality of these isolates were also investigated. MRS were identified by 16S rRNA sequencing, and typed by pulsed-field gel electrophoresis (PFGE). As a result, MRS was isolated in horses (48.3%), clinic staff (92.3%) and environmental samples (71.4%). Of the 123 MRS isolates, 118 isolates were identified as Staphylococcus lentus, and the remaining ones were found to be S. sciuri (n=3), S. intermedius (n=1) and S. fleuretti (n=1). All isolates were found to be susceptible against vancomycin, quinupristin-dalfopristin and rifampicin. Additionally, single or various combinations of resistance genes were detected among MRS isolates. SCCmec type II was identified in all isolates. Similar PFGE patterns were observed among MRS isolated from horses, humans, and environmental samples. Since MRS were concurrently isolated from horses and humans it is suggested that cross-transmission of MRS between horses and humans might occur. However, it cannot be ruled out that transmission is human to animal or animal to human.Conference Object Genotypic and phenotypic characterization of antimicrobial resistance in staphyloccoccus aureus strains isolated from wound infections in Mardin, Southeastern Turkey(ELSEVIER SCI LTD, 2016) Demir, C.; Demirci, M.; Yigin, A.; Tokman, H. Bahar…Article Kistik Ekinokokkoz Ön Tanısı ile Başvuran Hastaların Radyolojik, Hemogram ve Biyokimyasal Analizlerinin Değerlendirilmesi(2021) Demir, Cemil; Yıldız, Songül ÇetikGiriş ve Amaç: Hydatid cyst ya da echinococcosis, ülkemizde yaygın olarak görülen Echinococcus granulosus’un neden olduğu ve larval dönemin oluşturduğu zoonotik paraziter bir hastalıktır. Klinik semptomlarla bu hastalığın tanısını koymak oldukça zor olduğundan radyolojik ve serolojik yöntemlerin kullanılması gerekmektedir. Bu retrospektif çalışmada, kist hidatik ön tanısı konulan hastaların hemogram, biyokimya, radyolojik, patolojik bulguları ile epidemiyolojik verileri geriye dönük olarak incelenerek bölgemizdeki durumun belirlenip değerlendirilmesi amaçlanmıştır. Gereç ve Yöntemler: Çalışmaya, Kamu Hastaneler Birliği Mardin Devlet Hastanesine kist hidatik ön tanısı ile çeşitli kliniklere başvuran 279’u kadın 133’ü erkek olmak üzere toplam 412 hasta dahil edilmiştir. 412 hastadan 52’ine ultrasonografi, bilgisayarlı tomografi ve radyolojik bulgular ile kist hidatik tanısı konulmuş olup 12’sinde patolojik olarak doğrulanmış toplam 64 hastanın hepsinde karaciğerde tutulumunun olduğu saptanmıştır. Bulgular: Çalışmaya alınan 64 hastanın 38 (%59.3)’i kadın, 26 (%40.6)’sı erkek olup yaşları 0 ile 77 arasında değişmektedir. Hastalarda şiddetli karın ağrısı, karın şişliği, göğüs ağrısı, nefes darlığı, öksürük, ateş, bulantı, kusma en sık olarak saptanan semptomlardır. Hastaların sırasıyla; %83.4’ü genel cerrahi, %5.5’inin çocuk cerrahisi ve %10.1’inin ise diğer kliniklerine başvurduğu belirlenmiştir. Sonuç: Biyokimyasal olarak tanı anında en sık yükselen test GGT olup, bunu ALT, AST, ALP artışı izlemiştir. Hemogram parametrelerinde RDW yüksekliği (%29) en sık rastlanılan bulgu olup, bunu hematokrit, hemoglobin ve MCV düşüklüğü sırayla takip etmiştir.Article Investigation of Nasal Staphylococcus Aureus Carriage by Real-Time PCR in Patients Receiving Hemodialysis Treatment(2023) Yıldız, Songul Cetık; Demir, CemilObjectives: Staphylococcus aureus, coagulase-negative staphylococci (CoNS), and methicillin-resistant S. aureus (MRSA), which are significant nosocomial pathogens, have become a growing global problem because their carriage and diseases have become resistant to many antibiotics. This study aimed to investigate and determine the rate of MRSA carriage among patients receiving hemodialysis treatment using molecular methods. Methods: In the 254 hemodialysis patients, the nasal carriage rates, susceptibility and resistance to S. aureus, CoNS and MRSA were examined using culture and real-time PCR methods. Nasal samples from hemodialysis patients were examined using real-time PCR. Microscopic examination was performed using the Gram staining method, and S. aureus was identified using catalase and coagulase. The strains were then tested for antibiotic susceptibility. Staphylococci was isolated from 231 of the 254 patients. Results: S. aureus carriage was detected in 50 patients, MRSA in 16, methicillin-susceptible S. aureus (MSSA) in 33, CoNS in 66, methicillin-resistant CoNS (MR-CoNS) in 38, and methicillin-susceptible CoNS (MS-CoNS) in 28. S. aureus and MRSA strains exhibited 100% susceptibility to nitrofurantoin, and vancomycin. MSSA strains showed the highest susceptibility to chloramphenicol, clindamycin (84.8%), and co-trimoxazole (36.4%). CoNS showed 100% susceptibility to vancomycin, and 16.7% susceptibility to ampicillin. Vancomycin was found to be the most effective antibiotic against S. aureus, CoNS, and MRSA pathogens identified in patients undergoing hemodialysis, whereas penicillin resistance was found. Conclusions: It can be concluded that one of the most effective ways to prevent the formation of antibiotic resistant strains is the hygiene of the hospital and hospital staff. Real-time PCR is very important for analyzing with high sensitivity.Article Citation - WoS: 42Citation - Scopus: 40Association with Leptin Gene c.-2548 G > A Polymorphism, Serum Leptin Levels, and Body Mass Index in Turkish Obese Patients(HUMANA PRESS INC, 2013) Say Şahin, Deniz; Tümer, Cemil; Demir, Cemil; Çelik, M. Murat; Çelik, Mustafa; Uçar, Edip; Güneşaçar, RamazanLeptin is a protein hormone which plays a critical role in the regulation of both body-weight through reducing food intake and stimulating energy expenditure. Several polymorphisms in leptin gene (LEP), which encodes for leptin, have been described. However, its association with obesity is still controversial. Therefore, in the present study, we aimed to investigate whether LEP c.-2548 G > A polymorphism was associated with serum leptin levels, lipid parameters, and body mass index in Turkish obese patients. Forty-seven obese patients and 48 healthy individuals were included in the study. Blood samples were collected for DNA extraction. LEP c.-2548 G > A polymorphism were detected using polymerase chain reaction-restriction fragment length polymorphism technique. Serum leptin levels and lipid parameters were measured by ELISA and enzyme colorimetric assay techniques, respectively. GA or AA genotypes and A allele carrier frequencies of the c.-2548 G > A polymorphism in the LEP were higher in obese (38.3, 34.0 and 72.3 %) when compared with controls (14.6, 12.5, and 27.1 %; p = 0.011, 0.016, and 0.002, respectively). On the other hand, AA or AG genotypes were also related to increased serum leptin levels (p < 0.001) and body mass index (p < 0.0001). All these consequences showed that LEP -2548 AA or AG genotypes are important predictors for increased levels of leptin and BMI in Turkish obese patients and it may be a useful marker for obesity risk in our population.Article Citation - WoS: 16Citation - Scopus: 22Presence of Biofilm and Adhesin Genes in Staphylococcus aureus Strains Taken from Chronic Wound Infections and their Genotypic and Phenotypic Antimicrobial Sensitivity Patterns(Photodiagnosis and Photodynamic Therapy, 2020) Demir, Cemil; Demirci, Mehmet; Yigin, Akin; Bahar Tokman, Hrisi; Çetik Yıldız, SongulThe aim of this study was to investigate some biofilm (icaA, icaD and bap) and some adhesion (clfA, fnbA, cna) genes, and also evaluate the phenotypic and genotypic antimicrobial resistance patterns of Staphylococcus aureus strains isolated from wound samples in Mardin, Turkey. A total of 220 wound samples were studied. The biofilm forming ability and resistance pattern for eleven antimicrobial agents were investigated by conventional and multiplex PCR methods. S. aureus was isolated from 112 (50.9%) of 220 wound samples. Moreover, biofilm production was found in 79 (70.5%) of the 112 S. aureus isolates. 97 (86.6%) strains of all isolates were positive for icaA and icaD, and 15 (13.4%) for bap. The adhesin genes, cna, fnbA and clfA were detected in 98 (87.5%), 87 (77.7%), and 75 (66.9%) strains, respectively. The numbers of MSSA and MRSA carrying antimicrobial resistance genes were 19 (16.96%) and 32 (28.57%) for blaZ, 9 (8.04%) and 17 (15.18%) for tetK, 6 (5.36%) and 14 (12.5%) for ermC, 2 (1.79%) and 7 (6.25%) for tetM, 0 (0%) and 5 (4.46%) for mecA, 2 (1.79%) and 4 (3.57%) for ermA, 1 (0.89%) and 2 (1.79 %) for both tetK and tetM, respectively. Our findings indicate that multiplex PCR is a reliable method for identifying biofilm and adhesin producing S. aureus. Our data also provided a nationwide surveillance of the antimicrobial resistance gene profiles of S. aureus for the accurate treatment of patients and to control the dissemination of the resistance genes.Article Evaluation of the Serological, Biochemical and Hemogram Parameters of Patients Prediagnosed with Hydatid Cyst(2021) Demir, Cemil; Cetik Yildiz, SongulObjective: Hydatid cyst or echinococcosis is a zoonotic parasitic disease caused by the larval stages of Echinococcus granulosus, which is common in our country. It is necessary to use radiological and serological methods as diagnosing this disease based on clinical symptoms is very difficult. In this retrospective study, it was aimed to determine the condition in our region by retrospectively analyzing the hemogram, biochemistry, radiological and pathological findings and the epidemiological data of the patients prediagnosed with hydatid cyst. Materials and Methods: A total of 412 patients, 279 female and 133 male, who applied to various clinics of the Mardin State Hospital with hydatid cyst prediagnosis. 52 patients were diagnosed with hydatid cyst based on ultrasonography, computerized tomography and radiological findings, and liver involvement was detected in all 64 patients, 12 of which were pathologically verified. Results: 38 (59.3%) of 64 patients included in the study were female, 26 (40.6%) were male and their ages ranged from 0-77. The most common symptoms were severe abdominal pain, distention, chest pain, shortness of breath, 415 cough, fever, nausea and vomiting. 83.4% of the patients applied to the general surgery, 5.5% applied to the pediatric surgery and 10.1% applied to other clinics. Conclusion: The parameter with the highest increase was GGT, followed by ALT, AST and ALP. Elevated RDW (29%) was the most common finding in the hemogram parameters, followed by decreased MCV, hematocrit and hemoglobin.Article Citation - WoS: 3Citation - Scopus: 2Examination of the effects of kefir on healing factors in a mice burn model infected with E.coli, S.aureus and P.aeruginosa using qRT-PCR(Elsevier, 2023) Çetik Yıldız, Songül; Demir, Cemil; Ayhancı, AdnanBurn areas are susceptible to bacterial growth and infections, particularly in cases with lengthy periods of hospital stay. Burn wound healing, which involves various molecular and cellular mechanisms, continues to be a significant problem. Growth factors and cytokines play an active and vital role in wound healing. In the present study, the effects of kefir on wound healing in a 2nd-degree mouse burn model infected with e.coli, s.aureus and p.aeruginosa were investigated in vitro. In order to clarify the effects of kefir in the wound healing process, the macroscopic changes in kefir-applied scar tissue as well as wound depth and width were examined and IL-1α, IL-1β, IL-6, IL-8, IL-10 and TNF-α, VEGF, TGF-β protein levels were determined using the qRT-PCR method. The findings of the present study show that kefir has a positive impact on the factors playing a role in wound healing and accelerates the healing process.
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