Özgün, NezirOzgun, NezirAkdeniz, OsmanDepartment of Internal Medical Sciences / Dahili Tıp Bilimleri Bölümü10. Faculty of Medicine / Tıp Fakültesi01. Mardin Artuklu University / Mardin Artuklu Üniversitesi2023-12-312023-12-312024Özgün N, Akdeniz O. Effectiveness of Valproic Acid in the Treatment of Sydenham's Chorea and a Literature Review. Clin Pediatr (Phila). 2023 Aug 18:99228231194411. doi: 10.1177/00099228231194411. Epub ahead of print. PMID: 37594080.0009-92281938-2707https://doi.org/10.1177/00099228231194411There is still no evidence-based guideline and consensus on the treatment Sydenham's Chorea (SC). The first-line medication preference of specialists depends on personal experience and is variable. In this study, we evaluate the treatment results of pediatric patients who were treated with valproic acid (VPA). The medical records of 17 patients diagnosed with SC were reviewed retrospectively. The mean time to clinical improvement was found as approximately 5 days, the mean duration of remission as 13.60 & PLUSMN; 3.94 weeks and the mean duration of medication use was found as 17.96 & PLUSMN; 3.81 weeks. No side effects were observed in any of the patients and relapse occurred in 2 patients. A positive correlation was found between the initial C-reactive protein (CRP) level and the duration of medication use. Until evidence-based guidelines are established, VPA can be used as an effective, safe, and inexpensive first-line treatment option, especially in pediatric patients.en10.1177/00099228231194411info:eu-repo/semantics/closedAccessNeurologyGeneral PediatricsSydenham'S ChoreaValproic AcidAcute Rheumatic FeverReview2-s2.0-85170575402