Yildiz, Songul CetikKeskin, CumaliSahinturk, VarolAyhanci, Adnan2025-03-152025-03-1520202602-30322602-3040https://doi.org/10.17826/cumj.730817https://search.trdizin.gov.tr/en/yayin/detay/1112418/investigation-of-uroprotective-effects-of-seed-methanol-extracts-of-hypericum-triquetrifolium-turra-on-cyclophosphamide-induced-bladder-hemorrhagic-cystitis-and-nephrotoxicity-in-wistar-albino-ratsCetik Yildiz, Songul/0000-0002-7855-5343; Keskin, Cumali/0000-0003-3758-0654;Purpose: This study investigated the possible uroprotective effects of Hypericum triquetrifolium Turra. (HT) seed methanol extracts (25,50,100 mg/kg, i.p., for 6 days) against cyclophosphamide (CYP)-induced (150 mg/kg, single dose, i.p.) acute bladder hemorrhagic cystitis (HC) and nephrotoxicity in rats. Materials and Methods: Wistar albino rats used in this study were divided into nine groups, each including seven rats. Group 1 (control) was treated with 0.5ml saline (SF) and Group 2 was treated with CYP (150 mg/kg). Groups 3, 4, 5 were treated with 25, 50, 100 mg/kg HT, respectively while groups 6, 7, 8 were treated with 25, 50, 100 mg/kg CYP + HT, respectively. Finally, Group 9 (control-2) was treated with 0.5ml-%0.2 dimethyl sulfoxide (DMSO). The serum creatinine, blood urea nitrogen (BUN), superoxide dismutase (SOD) and catalase (CAT) levels were measured in blood serum. Results: The CYP-treated rats histopathologically had mild-moderate bladder and renal injuries. The serum creatinine and BUN levels, which are the biochemical markers of renal injury, significantly increased compared to the control group. Conclusion: HT showed a protective effect on CYPrelated bladder HC and nephrotoxicity in rats by inhibiting inflammation and apoptosis.en10.17826/cumj.730817info:eu-repo/semantics/openAccessCyclophosphamideHypericum TriquetrifoliumNephrotoxicityHemorrhagic CystitisArticle