Gomha, Sobhi M.Abd El-Ghany, Nahed A.Ebaid, Manal S.Abolibda, Tariq Z.E. A. Zaki, MagdiAlhilal, MohammadMohamed, Nadia A.2025-02-152025-02-1520242073-4344https://doi.org/10.3390/catal14120840https://hdl.handle.net/20.500.12514/6102Ebaid, MANAL S./0000-0003-1222-5816; Abolibda, Tariq/0000-0002-0121-2553; E. A. Zaki, Magdi/0000-0002-5643-9202; Alhilal, Suzan/0000-0002-9372-9364; M.Gomha, Sobhi/0000-0002-7739-2837; Mohamed, Nadia A./0000-0002-7837-5131; ALHILAL, MOHAMMAD/0000-0002-2832-8409In the current study, pyromellitimide benzoyl thiourea cross-linked chitosan (PIBTU-CS) hydrogel, was evaluated as a green biocatalyst for the efficient synthesis of novel thiazole derivatives. The PIBTU-CS hydrogel showcased key advantages, such as an expanded surface area and superior thermal stability, establishing it as a potent eco-friendly catalyst. By employing PIBTU-CS alongside ultrasonic irradiation, we successfully synthesized a series of novel thiazoles through the reaction of 2-(4-((2-carbamothioylhydrazineylidene)methyl)phenoxy)-N-(4-chlorophenyl)acetamide with a variety of hydrazonoyl halides (6a-f) and alpha-haloketones (8a-c or 10a,b). A comparative analysis with TEA revealed that PIBTU-CS hydrogel consistently delivered significantly higher yields. This synthetic strategy provided several benefits, including mild reaction conditions, reduced reaction times, and consistently high yields. The robustness of PIBTU-CS was further underscored by its ability to be reused multiple times without a substantial reduction in catalytic efficiency. The structures of the synthesized thiazole derivatives were meticulously characterized using a range of analytical techniques, including IR, 1H-NMR, 13C-NMR, and mass spectrometry (MS), confirming their successful formation. These results underscore the potential of PIBTU-CS hydrogel as a sustainable and recyclable catalyst for the synthesis of heterocyclic compounds. Additionally, all synthesized products were tested for their anticancer activity against HepG2-1 cells, with several new compounds exhibiting good anticancer effects.en10.3390/catal14120840info:eu-repo/semantics/openAccessChitosanHeterogeneous CatalysisHydrazonoyl HalidesThiazolesSynthesisAnticancerArticle1412Q2Q2WOS:0013837429000012-s2.0-852112169411