Kolukcu, VildanBala, Mehtap GurlerSahin, Ahmet TugrulGenc, AliUnsal, VelidFirat, FatihGurpinar, Ahmer Burak2026-01-152026-01-1520252667-6370https://doi.org/10.4274/TJAR.2025.251887https://hdl.handle.net/20.500.12514/10164Objective: We aimed to evaluate the effectiveness of sugammadex on renal tissue for against ischemia-reperfusion injury. Methods: Twenty-one Wistar albino strain female rats were divided into three groups. The first group functioned as the control cohort for comparison. In Groups 2 and 3, a renal ischemia-reperfusion model was established. Moreover, following the cessation of ischemia, the rats in Group 3 were intravenously administered sugammadex at a dose of 4 mg kg-1. Blood and tissue samples were subsequently collected for analysis. Results: Biochemical analyses revealed a notable increase in the enzymatic activities of glutathione peroxidase and superoxide dismutase in Group 3 relative to Group 2 (P < 0.001 and P=0.015, respectively). Additionally, the concentration of malondialdehyde was found to be significantly reduced in Group 3 relative to Group 2 (P=0.004). Group 3 exhibited a substantial decrease in tumor necrosis factor-alpha, interleukin 6, and interleukin 1 beta levels when compared to Group 2 (P=0.021, P=0.006, and P=0.016 respectively). Group 2 exhibited the highest concentrations of neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 (P < 0.001 and P=0.015, respectively). Similarly, the histopathologic tissue damage was the most prominent in Group 2 (P < 0.001). Conclusion: Sugammadex plays a protective role against ischaemia-reperfusion injury in renal tissue.en10.4274/TJAR.2025.251887info:eu-repo/semantics/openAccessIschaemia-Reperfusion InjuryRenalRatSugammadexArticle2-s2.0-105025572803