Hatipoğlu, Abdulkerimİpek, PolatBaran, Mehmet FıratBaran, Ayşe2025-02-152025-02-1520242146-05742536-4618https://doi.org/10.21597/jist.1357481https://search.trdizin.gov.tr/en/yayin/detay/1226881/anticancer-activities-of-zinc-oxide-nanoparticles-znonps-synthesized-from-mentha-longifolia-l-leaf-extracthttps://hdl.handle.net/20.500.12514/6631Recently, there has been a remarkable increase in cancer and cancer-related deaths. In this study, the impacts of zinc oxide nanoparticles (ZnONPs) produced from the aqueous leaf extract of Mentha longifolia L. (ML) on ovary adenocarcinoma (OVCAR-3), colorectal carcinoma (HCT-116), and healthy retinal pigment epithelial cell (RPE-1) lines were investigated. The MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test was performed to discover its antiproliferative properties. As a result of the application of ML-ZnONPs on RPE-1, OVCAR-3, and HCT-116 cell lines at doses (µg/mL) of 250, 500, and 1000 for 24 hours, the viability rates (%) in the cell lines were 18.73-30.56, 21.98-28.76, and 27.27-40.93, respectively. In the 48-hour application, the viability rates (%) of the same cells were between 29.51-46.83, 32.49-40.81, and 46.82-44.37, respectively. The MTT test revealed that ML-ZnONPs strongly suppressed the growth of RPE-1, OVCAR-3, and HCT-116 cell lines. The test showed that the effect of dose increase and time on the viability of both cancer cell lines was negative.en10.21597/jist.1357481info:eu-repo/semantics/openAccessTıbbi Araştırmalar DeneyselMikrobiyolojiBiyoteknoloji Ve Uygulamalı MikrobiyolojiOnkolojiArticle141107114N/AN/A12268810