Ozic, CemErtas, ErdalBaran, Mehmet FiratBaran, AyseAhmadian, ElhamEftekhari, AzizYildiztekin, Mahmut2025-02-152025-02-1520241663-9812https://doi.org/10.3389/fphar.2024.1482130https://hdl.handle.net/20.500.12514/6037Aliyev, Elvin/0000-0003-3755-5846Introduction The method of encapsulating the drug molecule in a carrier, such as a magnetic nanoparticle, is a promising development that has the potential to deliver the medicine to the site where it is intended to be administered. Morin is a pentahydroxyflavone obtained from the leaves, stems, and fruits of various plantsmainly from the Moraceae family exhibiting diverse pharmacological activities such as anti-inflammatory, anti-oxidant, and free radical scavenging and helps treat diseases such as diabetes, myocardial infarction and cancer.Methods In this study, we conducted the synthesis of a nanocomposite with magnetic properties by coating biocompatible activated carbon obtained from okra plant leaves with magnetic nanoparticles.Results Characterization of the synthesized activated carbon-coated magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and zeta potential. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (Colorectal), MCF-7 (breast), U373 (brain), T98-G (Glioblastoma) cancer cell lines, and human umbilical vein endothelial cells healthy cell line.Discussion We studied the loading and release behavior of morin hydrate in the activated carbon-coated magnetic nanocomposite. Activated carbon-coated magnetic nanocomposite carriers can show promising results for the delivery of Morin hydrate drugs to the targeted site.en10.3389/fphar.2024.1482130info:eu-repo/semantics/openAccessMorin HydrateMcf-7Anticancer ActivityMagnetic NanocompositeDrug DeliveryArticle15Q1Q1WOS:0013383628000012-s2.0-85207435158394446080