Savas, Hasan BasriGunizi, Huseyin2023-01-162023-01-162022https://www.scopus.com/record/display.uri?eid=2-s2.0-85140843711&origin=SingleRecordEmailAlert&dgcid=raven_sc_affil_en_us_email&txGid=b9d074a18a636c2d694d00bc63370cfehttps://www.ajol.info/index.php/ahs/article/view/234924https://hdl.handle.net/20.500.12514/3318https://pubmed.ncbi.nlm.nih.gov/36910410/Abstract Background: The prevalence of allergic diseases is gradually increasing worldwide. The most common such allergic disease is allergic rhinitis (AR). Objective: The present study investigated the possible relationship between seasonal AR and the thiol-disulfide balance and zinc and copper levels in adult individuals. Study Design and Methods: 130 male and female adults were included in the study. The participants’ serum thiol-disulfide balance and zinc and copper levels were measured spectrophotometrically using commercial kits. Statistical significance was accepted as p < 0.05 between the groups. Results: The serum copper (p = 0.001), native thiol (p = 0.006), reduced thiol (p < 0.001), and thiol oxidation reduction ratio (p < 0.001) levels were significantly lower in the seasonal AR group than in the control group. Conclusion: In AR patients, the low level of copper, which is an important trace element, the deterioration of the thiol-disulfide balance, which represents a unique indicator of the oxidant-antioxidant balance, the increased disulfide level caused by oxidative stress, and the decreased native thiol level can all serve as important biochemical markers.en10.4314/ahs.v22i3.34info:eu-repo/semantics/openAccessSeasonal allergic rhinitis; native thiol; disulfide; oxidative stress; copper.Article223322328Q4WOS:0008796710000342-s2.0-8514084371136910410