Yavas, M. C.Kilitci, A.Celik, E.Yegin, K.Sirav, B.Varol, S.2025-02-152025-02-1520242322-3243https://doi.org/10.61186/ijrr.22.3.529https://hdl.handle.net/20.500.12514/6147Varol, Salih/0000-0002-9954-6657Background: : The Background: We evaluate the effects of radiofrequency electromagnetic field (RF-EMF) on rat brain and testicular tissue using histopathology, comet assay, and real-time quantitative PCR techniques. Materials and Methods: Two equal groups of fourteen rats one for sham-control and the other for exposure (n = seven) were created. For a duration of 14 days, the exposure group (2100 MHz, testicular tissue SAR values of 163 mW/kg for 10 g, brain tissue SAR values of 292 mW/ kg on average) was subjected to five hours of exposure per day. Evaluations were conducted on tissue gene expression levels, histopathology, and DNA damage to brain tissue. Results: The histological examination of brain tissue from the exposed group revealed vascular alterations and significant edema (p < 0.05). It was determined that RF radiation-induced much more cellular damage in the exposed group (18.26% tail DNA) than in the control group (4.06% tail DNA). Signs of deterioration in spermatogenic cells in the testicular tissue of the exposed group also changed significantly (p < 0.05). The Bax and bcl-2 genes showed a significant difference (p < 0.05) in the mRNA level data, whereas the p53 genes showed no significant change (p > 0.05). Conclusion: These findings suggest that it may cause some histopathological and cellular damage in brain and testis tissue.en10.61186/ijrr.22.3.529info:eu-repo/semantics/closedAccess2100 MhzBrainRadiationHistopathologicalQrt-PcrRadiofrequencyTesticularArticle223529536Q4Q4WOS:0013307649000022-s2.0-852059913750