Çiçek, M.Unsal, V.Tümer, M.K.2021-09-152021-09-1520200250-4685https://doi.org/10.1515/TJB-2019-0174Objective: In this study, we aimed to investigate the changes in the levels of oxidative stress and antioxidant enzymes on the mandibular bone caused by the expression of aquaporin-1 and aquaporin-3 proteins. Material and method: 14 Balb/C white mice were divided into two groups of seven, based on whether they are young or old. Mandibular tissue samples were taken for biochemical and histological analysis. Results: Findings of our study has shown that, AQP-1 and AQP-3 immunoreactivity significantly decreased in mandibular bone tissues of aged mice in comparison to younger mice (p < 0.05). MDA and AOPP levels, which are the indicators of oxidative stress, increased in elderly mice and antioxidant defense system SOD enzyme activity was decreased (p < 0.05). The TNF-α cytokine level, which is the indicator for inflammations, was found to be higher in older mice than in young mice (p < 0.05). Conclusion: As a result, it was observed that cellular damage, disruption in water – electrolyte balance and increased inflammation that occur during the natural process of aging had caused serious and irreversible disturbances. © 2020 De Gruyter. All rights reserved.en10.1515/TJB-2019-0174info:eu-repo/semantics/openAccessAquaporin-1Aquaporin-3Oxidative StressTnf-AlphaArticle455621629Q4Q4WOS:0005825680000202-s2.0-85096934920