Kangin, MuratAkar, AsumanTalay, Mehmet NurGul, OzlemTas, MuhammedSemdinoglu, AytenYakut, Nurhayat2025-02-152025-02-1520241110-66382090-9942https://doi.org/10.1186/s43054-024-00309-8https://hdl.handle.net/20.500.12514/6069KANGIN, MURAT/0000-0003-0042-0569; talay, mehmet nur/0000-0002-7361-3823; AKAR, ASUMAN/0000-0001-5265-3271; Gul, Ozlem/0000-0002-4415-4437; Semdinoglu, Ayten/0000-0002-0934-2790BackgroundMultisystem inflammatory syndrome in children (MIS-C) is one of the complications of SARS-CoV-2 infection. This study aims to evaluate the clinical and laboratory characteristics, as well as treatment results, of MIS-C patients who received intravenous immunoglobulin (IVIG) monotherapy.MethodsThis retrospective study included patients diagnosed with MIS-C. Demographic data, organ involvements at the admission, laboratory evaluations for diagnosis, treatment, and follow-up were recorded. We evaluated outcomes by the length of the intensive care unit stay, the total hospitalization period, complications, and mortality.ResultsA total of 95 patients diagnosed with MIS-C were evaluated. The mean age was 118.8 (+/- 52.5) months. 76.8% of the patients had four or more organ systems involved. Seventy-nine patients (83%) were hospitalized in the pediatric intensive care unit (PICU) for a mean of 4.59 days. Seventy-seven (81%) patients received IVIG. A second dose of IVIG was administered to 66.3% of patients. All patients received vitamin D and C supplementation. Six patients who had cardiac involvement or cerebral infarction were treated with plasmapheresis. No patients received steroids. There was no mortality at the end of the follow-up.ConclusionsFavorable outcomes may be obtained with IVIG monotherapy in MIS-C patients. More clinical trials are needed to establish the role of supportive treatments like vitamin D and C in MIS-C management.en10.1186/s43054-024-00309-8info:eu-repo/semantics/openAccessIntravenous ImmunoglobulinMultisystem Inflammatory Syndrome In Children (Mis-C)Covid-19Pediatric Intensive Care UnitChildrenArticle721N/AWOS:0013126215000010