Aslan, ErcanCetik Yildiz, Songul2025-12-152025-12-1520252045-2322https://doi.org/10.1038/s41598-025-23652-1https://hdl.handle.net/20.500.12514/10056Carriers and diseases caused by Staphylococci, one of the important hospital pathogens, are an important problem in the emergence of antibiotic resistance and finding effective treatments. Our study aimed to investigate the relationship between changes in hematological and biochemical parameters and the development of antibiotic-resistant Staphylococcus infections in patients hospitalized in the intensive care unit (ICU). The study included the 1st and 5th day data of 100 patients who had been hospitalized in the adult ICU for at least 5 days. Demographic data, blood and biochemical parameters and culture samples of the patients were evaluated. The higher NLR, CRP, LAC, and WBC values and lower HGB values observed on the 5th day compared to the 1st day suggest that patients in the ICU were likely exposed to hospital-acquired Staphylococcus infections, which adversely affected their prognosis. Indeed, the 31 Staphylococcus strains identified were isolated from blood (18), sputum (6), wound (4), urine (0), stool (0) and, catheter (3) cultures. It was determined that the most isolated strains, S. aureus, were resistant to levofloxacin, erythomycin, tetracycline, nitroforantoin, trimethoprim/sulfamethoxazole, oxacillin MIC, clindamycin, fusidic acid and oxsf. Based on our results, the observed increase in hematological and biochemical values on day 5 relative to day 1 reinforces the probability of hospital-acquired infection. Since this situation will put the life of the patient and the individuals related to the patient at risk, monitoring these values, early diagnosis and initiation of treatment are vital.en10.1038/s41598-025-23652-1info:eu-repo/semantics/openAccessStaphylococciAntibiotic ResistanceIntensive Care UnitArticle2-s2.0-105021828212