Unsal, VelidKolukcu, VildanBalta, Mehtap GurlerTapar, HakanKaraman, TugbaKaraman, SerkanUnsal, VelidFirat, Fatih2024-05-162024-05-1620241306-696X1307-7945https://doi.org/10.14744/tjtes.2024.33262Gevrek, Fikret/0000-0002-3722-2542BACKGROUND: This study aimed to evaluate the histopathological and biochemical effects of ketamine on penile tissues following ischemia-reper fusion injury induced by priapism. METHODS: Twenty-four male rats were randomized into three groups. Group 1 served as the control group. Group 2 underwent the priapism model to induce ischemia-reperfusion injury. Group 3, the treatment group, experienced a similar ischemia-reper fusion model as Group 2; additionally, 50 mg/kg of ketamine was administered intraperitoneally just before reperfusion. Blood biochemical analyses and penile histopathological evaluations were performed. RESULTS: In Group 3, significant improvements were observed in all histopathological scores, including desquamation, edema, inflammation, and vasocongestion compared to Group 2 (p<0.001). Blood biochemical analyses showed that the malondialdehyde (MDA) levels were recorded as 10 in Group 2, with a significant decrease in Group 3 (p=0.013). Similarly, proinflammatory cytokine levels, including interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha), were found to be suppressed in Group 3 compared to Group 2 (p=0.003, p=0.022, and p=0.028, respectively). Antioxidant enzyme activities, such as glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), were higher in Group 3 compared to Group 2 (p=0.016 and p=0.024, respectively). CONCLUSION: Ketamine is an effective anesthetic agent in alleviating the effects of penile ischemia-reper fusion injury.en10.14744/tjtes.2024.33262info:eu-repo/semantics/openAccessAnesthesiaIschemia-ReperfusionKetaminePenisArticle305309315Q4Q3WOS:0012273013000042-s2.0-8519287192638738674