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Fizyoloji Anabilim Dalı Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/4220

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    Effects of acute carbon monoxide posioning on liver damage and comparisons of related oxygen therapies in a rat model
    (Taylor & Francis Ltd, 2024) Gökdemir, Gül Şahika; Gokdemir, Gul Sahika; Seker, Ugur; Şeker, Uğur; Demirtas, Berjan; Taskin, Seyhan; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
    Acute carbon monoxide (CO) poisoning may cause liver damage and liver dysfunction. Therefore, in this study, we aimed to compare the efficiency of normobaric oxygen (NBO) and high-flow nasal cannula oxygen (HFNCO) treatments on liver injury. For that purpose, 28 male Wistar albino rats were divided into four groups (Control, CO, CO + NBO, and CO + HFNCO). The control group was allowed to breath room air for 30 min. Acute CO poisoning in CO, CO + NBO, CO + HFNCO was induced by CO exposure for 30 min. Thereafter, NBO group received 100% NBO with reservoir mask for 30 min. HFNCO group received high-flow oxygen through nasal cannula for 30 min. At the end of the experiment, all animals were sacrificed by cardiac puncture under anesthesia. Serum liver function tests were measured. Liver tissue total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI) levels, tissue histomorphology and immunoexpression levels of Bax, Caspase 3, TNF-alpha, IL-1 beta, and NF-kappa B were also examined. Our observations indicated that acute CO poisoning caused significant increases in blood COHb, serum aminotransferase (AST), alanine aminotransferase (ALT0, alkaline phosphatase (ALP), total protein, albumin, and globulin levels but a decrease in albumin to globulin ratio (all, p < 0.05). Furthermore, acute CO poisoning significantly increased the OSI value, and the immunoexpresssion of Bax, Caspase 3, TNF-alpha, IL-1 beta, and NF-kappa B in liver tissue (all, p < 0.05). These pathological changes in serum and liver tissue were alleviated through both of the treatment methods. In conclusion, both the NBO and HFNCO treatments were beneficial to alleviate the acute CO poisoning associated with liver injury and dysfunction. [GRAPHICS] .
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    Physiopathology of allergic diseases and their relation to circadian rhythm
    (Nova Science Publishers, Inc., 2024) Gökdemir, Gül Şahika; Department of Basic Medical Sciences / Temel Tıp Bilimleri Bölümü
    Allergic diseases have become a major health problem in modern society. These diseases are caused by an overreaction of the immune system and are often triggered by exposure to environmental allergens. Allergic diseases include asthma, allergicrhinitis, eczema, food allergies, and anaphylaxis. In recent years, research on the effectof circadian rhythm on the immune system has shown that there is an important relationship between the pathophysiology of allergic diseases and circadian rhythm. The pathophysiology of allergic diseases begins with responses to the immune system and the effect of allergens. The immune system is a complex network that regulates the response of immune cells. Immunoglobulin E (IgE) antibodies play an important role inreactions of hypersensitivity to allergens. Exposure to allergens triggers the activation of mast cells and basophils, resulting in the release of inflammatory mediators. The circadian rhythm is an internal clock system that regulates the 24-hour cycle of biological processes. The human body adapts various physiological and metabolic processes to this rhythm. The relationship of allergic diseases with the circadian rhythmis related to their effects on both the immune system and tissue and organ function. The circulation and activity of immune cells can change depending on the circadian rhythm. These changes can influence the immune system's response to exposure to allergens. In addition, the symptoms and severity of allergic diseases are also related to the circadian rhythm. Some studies have shown that allergic symptoms increase at night or in the morning. This suggests that the circadian rhythm may influence the severity of allergic reactions by affecting the release of immunoglobulins, the inflammatory response, and bronchial hyperreactivity. This chapter aims to provide researchers, clinicians, and healthcare professionals with an important resource on recent research findings that advance our understanding of the relationship between the pathophysiology of allergic diseases and the relationship between circadian rhythm.