Browsing by Author "Baran, A."

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Analysis of Bioactive Compounds Using Lc-esi-ms/Ms, Cytotoxic, Antimicrobial Effects, and Enzyme Activities From Cyclotrichium Origanifolium (Vol 101, Pg 740, 2023)
(Wiley, 2024) Aktepe, Necmettin; Keskin, Cumali; Atalar, M. N.; Baran, F.; Baran, Ayşe; Taskin, A.; Jahan, I; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 09.01. Department of Nursing / Hemşirelik Bölümü; 9. Faculty of Health Sciences / Sağlık Bilimleri Fakültesi; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Composition and Characterization of Phytochemicals in Aromatic Species
(Elsevier, 2025) Baran, Ayşe; Güneş, Zübeyir; 16.03. Department of Medical and Aromatic Plants / Tıbbi ve Aromatik Bitkiler Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Plants have a crucial role in sustaining all living organisms. Plants possess unique systems that they have evolved to counteract different biotic and abiotic stressors, ensuring the continuation of their essential functions. Specifically, the organisms generate secondary metabolites that bear significant bioactivity. Aromatic plants, rich in bioactive compounds, produce these phytochemicals as a defense mechanism and for preventive purposes, exerting substantial impacts on human health. The effects encompass antibacterial, anticancer, antioxidant, antidiabetic, and antiinflammatory actions. Incorporating plants with these effects into the human diet enhances the significance of plants in terms of their defensive and beneficial characteristics. The characterization of bioactive compounds in aromatic plants can be determined utilizing a variety of equipment and methodologies. By analyzing the chemical composition of the plant, we can establish the specific type and quantity of bioactive compounds it contains. These characterization techniques play a crucial role in determining the direction of many activities involving bioactive compounds. This study aimed to investigate the secondary metabolites, bioactivities, and characteristics of aromatic plants. © 2025 Elsevier Inc. All rights reserved.
Destructive Effect of Heavy Metals on the Oxidative Defense Mechanism of Some Aromatic Plants
(Elsevier, 2025) Baran, Ayşe; Yildiztekin, M.; Baran, A.
Aromatic plants are used in the production of natural medicines, treatment of various diseases, production of essential oils, and as a food source. Many plants are cultivated for their aromatic compounds. The essential oils they produce are used as antibacterial, antifungal, antiviral, and insecticidal agents, and as appetite suppressants against herbivores. Heavy metal pollution, which has become a significant environmental issue, can be highly reactive and toxic to living cells. Aromatic plants may be exposed to heavy metals in both natural and cultivated environments, leading to stress and oxidative damage in the plants. Some heavy metals cannot undergo biological degradation reactions, while others, due to their immobile nature, cannot be removed from the environment, resulting in accumulation. Those that are mobile can enter cells through various transport pathways and negatively affect physiological processes in the plant. The formation of reactive oxygen species (ROS) occurs as a result of these physiological processes. ROS types, such as O2 •-, 1O2, H2O2, and •OH, can be hazardous to cells, cause structural damage, and lead to cell death. The imbalance between the accumulation and removal of these oxidative molecules in the cell causes oxidative stress. The effects of oxidative stress can be observed in enzyme inactivation, disruption of membrane integrity, and inhibition of growth in plants. To mitigate the effects of oxidative stress and defend themselves, plants have antioxidant defense mechanisms. These mechanisms include enzymatic antioxidants such as superoxide dismutase, peroxidase, ascorbate peroxidase, and nonenzymatic antioxidants such as lipid-soluble and water-soluble reducing agents. The type, dose, and duration of heavy metal exposure, as well as the species and developmental stages of the plant, trigger various antioxidant defense mechanisms and responses. In this process, the role of ROS detoxifying enzymes is particularly significant. Due to their various properties, such as metal exclusion, aromatic plants are able to cope with oxidative stress. In conclusion, understanding the factors that affect the antioxidant defense mechanisms and enzyme inhibition in plants under heavy metal stress, and developing strategies to address them, is important for enhancing plant productivity and ensuring adaptation to environmental stress. © 2025 Elsevier Inc. All rights reserved.
Green-Synthesized Nanoparticles for Biomedical Sensor Technology
(Elsevier, 2024) Keskin, Cumali; Baran, M.F.; Baran, Ayşe; Baran, Mehmet Fırat; Keskin, C.; Atalar, M.N.; Alma, M.H.; 21.02. Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri Bölümü; 21. Vocational School of Health Services / Sağlık Hizmetleri Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Sensor technology is an integral part of the many cost-effective and efficient factors possible in modern medical devices. Biosensors have good potential as they are easy, scalable, and effective in manufacturing processes. Nanotechnology has become one of the promising technologies applied in all fields of science. Biotechnologically produced metallic nanoparticles (NP) attract attention in scientific applications and technology platforms due to their extensive applications in biomedical and physiochemical fields. In recent years, the side effects caused by the use of synthetic drugs and the medical and economic problems caused by them have made the use of plants popular again. Ecofriendly, nontoxic metal-based NPs (such as gold, silver, palladium, manganese, and zinc) smaller than 100nm in size can be synthesized with extracts obtained from plants by different methods. As the sizes and shapes of NPs change, the physical, chemical, bioactive, optical, electrical, catalytic, and toxicity properties of the particles also change. Biological synthesis, also known as green synthesis, is a practical method to obtain NPs easily and ecologically without the need for high pressure, high-temperature values, and toxic chemicals. Green synthesis of NPs is carried out using different biomaterials such as bacteria, fungi, yeast, viruses, microalgae, and plant biomass/essence. Plant-mediated biosynthesis of metallic NPs occurs through biomolecules containing organic functional groups in the plant. Nanobiosensors, analytical devices combining a biologically sensitive element with a nanostructured transducer, are widely used for the molecular detection of biomarkers associated with the diagnosis of diseases and the detection of infectious organisms. Nanobiosensors show certain advantages over laboratory and many field methods due to their inherent specificity, simplicity, and rapid response. In this study, advancements in the development of nanobiosensors are illuminated. Considering all these aspects, it can be said that nanobiosensors enable diagnostic tools with increased sensitivity, specificity, and reliability for medical applications. © 2025 Elsevier Inc. All rights reserved.
Citation - Scopus: 2
Production of Value-Added Cosmetic Products From Cold-Pressed Helianthus Annuus L. Oil and Pulp
(Jomard Publishing, 2024) Karadağ, Murat; Baran, Ayşe; Güneş, Zübeyir; 16.03. Department of Medical and Aromatic Plants / Tıbbi ve Aromatik Bitkiler Bölümü; 02.12. Department of Sociology / Sosyoloji Bölümü; 02. Faculty of Letters / Edebiyat Fakültesi; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Recycling, in its literal sense, is the recycling of obsolete recyclable waste materials into manufacturing processes as raw materials through various recycling methods. We can say that a lot of waste is generated in environmental and industrial terms. Sunflower (Helianthus annus L.) is one of the major oil crops grown in the world for the production of edible and biodiesel oil. A large number of plant and raw material wastes, especially those used in food products, are recycled into cleaning, health, cosmetic and industrial products. In this study, the cold-pressed oil and pulp obtained from the seeds of the sunflower plant were evaluated and transformed into an added-value cosmetic product. Especially the fact that it contains other valuable compounds such as phenolic compounds, fatty acids, fibers, vitamins, minerals and polyphenols increases the popularity of the value-added product. Within the scope of our work, we produced two value-added products. These products are creams containing sunflower oil, which has nourishing, moisturizing and protective properties and the other product is a skin mask containing sunflower pulp. As our university specializes in added-value agricultural products, our product production is increasing day by day. © 2024, Jomard Publishing. All rights reserved.
Rapid Adsorption of Methylene Blue by Synthesizing Zinc Oxide Nanoparticles From Ocimum Basilicum L. Waste
(Springer, 2025) Baran, Ayşe; Solmaz, A.; Baran, A.
In this study, zinc oxide nanoparticles (ZnONp) were synthesized from Ocimum basilicum L. (ObL-ZnONp) plant wastes by green synthesis method to remove methylene blue (MB) dye, which has toxic effects on the environment. In batch adsorption studies, the effects of pH (3-11), ObL-ZnONp amount (0.0312-1.25 g/L), time (0-30 min), initial MB concentration (2-64 mg/L) and temperature (25-45 degrees C) were tested to determine the adsorption mechanism. The obtained results were tested with Pseudo first order (PFO), Pseudo second order (PSO), Elovich and Intraparticle diffusion kinetic models and evaluated in Freundlich, Langmuir, Temkin and Dubinin-Radushkevich isotherm models. Also 6 different error functions were used to interpret the results. Additionally, the morphological properties of the synthesized ObL-ZnONp were characterized by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) analysis. In addition, desorption tests were also performed. According to the obtained results, the most suitable kinetic and isotherm models were determined as PSO (R2: 0.999) and Freundlich (0.991), respectively. In addition, while more than 90% removal efficiency was achieved in 4 min, the maximum adsorption amount was determined as 21.41 mgMB/gObL-ZnONp. This study determined that Np synthesized at low cost was quite effective in MB removal.