Browsing by Author "Ertas, Erdal"

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Citation - WoS: 25
Citation - Scopus: 29
Activated Carbon-Coated Iron Oxide Magnetic Nanocomposite (ionps@ctac) Loaded With Morin Hydrate for Drug-Delivery Applications
(Frontiers Media Sa, 2024) Dogan, Yusuf; Ozic, Cem; Ertas, Erdal; Baran, Ayse; Rosic, Gvozden; Selakovic, Dragica; Eftekhari, Aziz
Cancer is a major disease that affects millions of people around the world every year. It affects individuals of all ages, races, and backgrounds. Since drugs used to treat cancer cannot distinguish between cancerous and healthy cells, they cause systemic toxicity along with serious side effects. Recently, controlled drug-release systems have been developed to reduce the side effects caused by anticancer drugs used for treatment. Morin is an anticancer drug with a flavonol structure. It has been extensively researched for its antioxidant, anti-inflammatory, antitumoral, and antibacterial properties, especially found in Chinese herbs and fruits, and its multiple positive effects on different diseases. In this study, a nanocomposite with magnetic properties was synthesized by coating biocompatible activated carbon obtained using the fruits of the Celtis tournefortii plant on the surface of iron oxide magnetic nanoparticles. Characterization of the synthesized activated carbon-coated iron oxide magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction, dynamic light scattering, zeta potential, and vibrating sample magnetometry. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (colorectal), T98-G (glioblastoma) cancer cell lines, and human umbilical vein endothelial cell (HUVEC) healthy cell line. The morin loading and release behavior of the activated carbon-coated iron oxide magnetic nanocomposite were studied, and the results showed that up to 60% of the adsorbed morin was released within 4 h. In summary, activated carbon-coated iron oxide magnetic nanocomposite carriers have shown promising results for the delivery of the morin drug.
Citation - WoS: 16
Citation - Scopus: 22
Green-Synthesized Characterization, Antioxidant and Antibacterial Applications of Ctac/Mnps-ag Nanocomposites
(Mdpi, 2024) Baran, Ayse; Ertas, Erdal; Baran, Mehmet Firat; Eftekhari, Aziz; Gunes, Zubeyir; Keskin, Cumali; Khalilov, Rovshan
The emergence of antibiotic resistance, caused by the improper use of antibiotics, is a significant challenge in combating infectious diseases, leading to millions of annual fatalities. The occurrence of antimicrobial side effects catalyzes the investigation of novel antimicrobial compounds and sources of drugs. Consequently, the research on biological activity that is conducted on plants, plant extracts, and compounds that are produced from plant components is of utmost significance. In this study, CtAC/MNPs were obtained by the reaction of activated carbon (AC) obtained from the fruits of the Celtis tournefortii (Ct) plant and magnetic nanoparticles (MNPs), and a CtAC/MNPs-Ag nanocomposite was synthesized by the reduction in silver ions added to the reaction. The synthesized CtAC/MNPs and CtAC/MNPs-Ag nanocomposites were analyzed spectroscopically (FTIR, XRD), microscopically (SEM, EDX), optically (DLS), electrochemically (zeta potential) and magnetically (VSM). The antibacterial activities of CtAC/MNPs and CtAC/MNPs-Ag nanocomposites against S. aureus and E. coli were investigated by microdilution method using minimal inhibitory concentration (MIC) and disk diffusion methods. Antioxidant activity study, including total phenolic content and DPPH and cuprac assays, revealed the remarkable effect of the CtAC/MNPs-Ag nanocomposite. This study has the advantages of obtaining CtAC/MNPs and CtAC/MNPs-Ag nanocomposites in a short time without requiring energy, and most importantly, the reaction takes place without using any toxic substances. In addition, according to the data obtained in the study, the CtAC/MNPs-Ag nanocomposite is thought to shed light on biomedical research.
Integrated RSM-ANN Modelling and Mechanistic Evaluation of Arsenate Adsorption onto Click-Functionalized Magnetic NanoSorbent (M-TACA)
(Springer Heidelberg, 2026) Tarhan, Tuba; Tural, Servet; Tural, Bilsen; Ertas, Erdal
A click-functionalized magnetic nano-adsorbent (M-TACA) incorporating N-methyl-D-glucamine (NMDG) ligands was systematically evaluated for arsenate [As(V)] removal using a newly generated multivariate experimental dataset. The adsorption behaviour was modelled using an integrated response surface methodology (RSM) and artificial neural network (ANN) framework to assess the combined effects of initial As(V) concentration, solution pH, contact time, and adsorbent dose. Both modelling approaches demonstrated excellent predictive performance, with coefficients of determination exceeding 0.99 (R-2 > 0.99). Under the RSM-derived optimal conditions (pH 8.0, initial As(V) concentration of 200 mg L-1, contact time of 150 min, and adsorbent dose of 1.5 g L-1), adsorption capacities of 97.3 mg g(-1) (experimental) and 99.8 mg g(-1) (ANN-predicted) were obtained. Mechanistic interpretation based on pH-dependent zeta potential measurements and aqueous arsenate speciation indicated that electrostatic attraction governs As(V) uptake below the point of zero charge (pH(p)zc approximate to 7.7), whereas surface complexation and hydrogen-bonding interactions become increasingly relevant under near-neutral conditions. The presence of NMDG moieties introduces multiple hydroxyl and amine functional groups, enhancing arsenate affinity across a broad pH range and supporting the formation of inner-sphere surface interactions. In comparison with other Fe3O4-based sorbents, M-TACA exhibits a higher adsorption capacity together with a wider operational pH tolerance. This study presents the first multivariate, AI-assisted optimization of a click-functionalized magnetic sorbent for As(V) removal and demonstrates that the hybrid RSM-ANN framework provides improved predictive capability and mechanistic insight for sustainable water treatment applications.
Preparation and Characterization of Silver-Loaded Magnetic Activated Carbon Produced From Crataegus Monogyna for Antimicrobial and Antioxidant Applications
(Wiley-v C H verlag Gmbh, 2025) Ertas, Erdal; Dogan, Serap; Baran, Ayse; Baran, Mehmet Firat; Evcil, Murat; Kurt, Baris; Aslan, Kadir Sinan
Secondary metabolites from several plant species have been used to cure various illnesses. Current advances allowed green synthesis nanoparticle manufacturing of metal salts from plant sources. This study involves binding activated carbon obtained from the Crataegus monogyna plant to magnetic nanoparticles and coating the resulting magnetic activated carbon nanocomposite with Ag ions (CMAC/MNPs-Ag) to produce a biomedical nanobiological material. Various techniques such as SEM, EDX, XRD, FTIR, UV-Vis, VSM, DLS, and zeta potential were used to characterize synthesized nanocomposites. CMAC/MNPs-Ag nanocomposite demonstrated activity in several processes of antioxidant activity tests. DPPH and CUPRAC activities of CMAC/MNPs-Ag nanocomposite were measured as 90.21 +/- 0.42 and 46.73 +/- 0.108 mg TE/g, respectively, while total phenolic content was measured as 27.15 +/- 0.381 mg GAE/g. Finally, the antibacterial activity of CMAC/MNPs-Ag nanocomposite was evaluated against Escherichia coli and Staphylococcus aureus by microdilution and disk diffusion techniques. The antimicrobial activity of CMAC/MNPs-Ag nanocomposite was determined using microdilution and disk diffusion techniques. For Escherichia coli, microdilution and disk diffusion were measured as 1.17 mu g mL-1 and 12 mm, respectively, while for Staphylococcus aureus, microdilution and disk diffusion were measured as 2.34 mu g mL-1 and 10 mm, respectively.
Citation - WoS: 14
Citation - Scopus: 19
Synthesis and Characterization of Activated Carbon-Supported Magnetic Nanocomposite (mnps-Olac) Obtained From Okra Leaves as a Nanocarrier for Targeted Delivery of Morin Hydrate
(Frontiers Media Sa, 2024) Ozic, Cem; Ertas, Erdal; Baran, Mehmet Firat; Baran, Ayse; Ahmadian, Elham; Eftekhari, Aziz; Yildiztekin, Mahmut
Introduction The method of encapsulating the drug molecule in a carrier, such as a magnetic nanoparticle, is a promising development that has the potential to deliver the medicine to the site where it is intended to be administered. Morin is a pentahydroxyflavone obtained from the leaves, stems, and fruits of various plantsmainly from the Moraceae family exhibiting diverse pharmacological activities such as anti-inflammatory, anti-oxidant, and free radical scavenging and helps treat diseases such as diabetes, myocardial infarction and cancer.Methods In this study, we conducted the synthesis of a nanocomposite with magnetic properties by coating biocompatible activated carbon obtained from okra plant leaves with magnetic nanoparticles.Results Characterization of the synthesized activated carbon-coated magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, dynamic light scattering, and zeta potential. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (Colorectal), MCF-7 (breast), U373 (brain), T98-G (Glioblastoma) cancer cell lines, and human umbilical vein endothelial cells healthy cell line.Discussion We studied the loading and release behavior of morin hydrate in the activated carbon-coated magnetic nanocomposite. Activated carbon-coated magnetic nanocomposite carriers can show promising results for the delivery of Morin hydrate drugs to the targeted site.