Browsing by Author "Hatipoglu, Abdulkerim"

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Citation - WoS: 2
The Compositional and Biochemical Characteristics of Traditional Diyarbakir Orgu Cheese During the Ripening Period
(indian Dairy Assoc, 2020) Hatipoglu, Abdulkerim; Celik, Serafettin
This study was conducted to determine the changes in compositional and various biochemical parameters of traditional Diyarbakir Orgu cheese during storage period. For this purpose, cheese samples were collected from eight different small dairy plants. In this study, it was observed that the composition of the cheese samples during the storage period changed as follows: dry matter decreased from 55.87% to 52.29%, fat from 26.56% to 23.47%, fat in dry matter from 38.84% to 37.07%, protein from 26.56% to 23.47%; ash increased from 7.31% to 9.32%, salt from 6.31% to 8.16%, salt in dry matter from 11.40% to 15.48%, while the parameters investigated in relation to the biochemical properties of the cheese samples ranged as follows: 18.38-22.96 for SH, 5.47-5.64 for pH, 0.17-0.21% for soluble nitrogen in pH 4.6, 0.03-0.05% for soluble nitrogen in 12% TCA, 0.25-0.46% for lipolysis level and 4.19-5.61% for ripening index. In this study, the proteolysis level of the cheese during the ripening was determined electrophoretic analysis. According to the Turkish Food Codex Communique on Cheese (Notice No: 2015/6), DOC is a semi-fat (25. milk fat <45) and hard cheese with the desired moisture content (up to 50%) and salt (>7.5%).
Citation - WoS: 1
Citation - Scopus: 1
Effect of pleurotus Ostreatus Water Extract Consumption on Blood Parameters and Cytokine Values in Healthy Volunteers
(Routledge Journals, Taylor & Francis Ltd, 2024) Dundar, Abdurrahman; Yalcin, Pinar; Arslan, Nurgul; Acay, Hilal; Hatipoglu, Abdulkerim; Boga, Mehmet; Yaprak, Bulent
Objective: Our aim in this study is, does 29-day regular consumption of Pleurotus ostreatus water extract by volunteer individuals who meet the study criteria have an effect on blood and cytokine values? Method: In accordance with the purpose of the study, volunteers were asked to consume 100 ml of the extract every morning for 29 days. Three tubes of blood samples were taken from the volunteers on the 15th and 29th days of the study. Biochemical and hematological analysis of the blood samples were performed and immunomodulatory effects through cytokines were examined. The values obtained from 3 tubes of blood obtained from volunteers before the use of mushroom extract were used as control. The chemical composition and beta-glucan content of 100 ml of mushroom water extract were also analyzed. Result: IL-4, IL-6, IL-10 and IL-13 could not be detected because the values were below the lowest standard value. TNF-alpha, IFN-gamma and IL-1 beta 15th and 29th day values decreased compared to the 1st day (control) values (p < 0.05). However, there was no significant difference observed between the 15th and 29th day. No abnormalities were observed in biochemical and hematological values. Also, the beta-glucan content of extract was found 38.12 mg/100 ml. Conclusion: The frequency range of kidney and liver function test results confirmed that P. osreatus is a reliable food source. Considering the cytokine values these results indicate that P. ostreatus water extract has an anti-inflammatory effect. As no significant difference was observed in 29 days of use, it is thought that 15 days of daily consumption of the extract may be sufficient for the anti-inflammatory effect to occur. However, a large number of qualified clinical trials are needed to support the issue.
Citation - WoS: 56
Citation - Scopus: 62
Green synthesis and evaluation of antipathogenic, antioxidant, and anticholinesterase activities of gold nanoparticles (Au NPs) from Allium cepa L. peel aqueous extract
(SpringerLink, 2023) Baran, Ayşe; Polat İpek, Mehmet Fırat Baran, Ayşe Baran, Abdulkerim Hatipoğlu, Cumali Keskin, Mahmut Yildiztekin, Selçuk Küçükaydin, Hatice Becerekli, Kadri Kurt, Aziz Eftekhari, Irada Huseynova, Rovshan Khalilov, William C. Cho; Baran, Mehmet Firat; Yildiztekin, Mahmut; Keskin, Cumali; Hatipoglu, Abdulkerim; Ipek, Polat; Cho, William C.
Gold nanoparticles (Au NPs) have potentially therapeutic properties as they are synthesized via biomolecules as reducing and stabilizing agent(s). The aim of this study is to develop an easy and eco-friendly method for the synthesis of Au NPs using extracts from the Allium cepa (AC) red peel (skin) extract and investigate the antibacterial and antioxidant activity and also inhibitory efects on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. UV–Vis peak at~564 nm confrmed the Au NPs absorbance. TEM images revealed the formation of Au NPs with mostly spherical shapes and sizes between 6.08 and 54.20 nm. FTIR analysis confrmed the important biological compounds responsible for the reduction of gold. The strong absorption property of Au NPs was studied by EDX. The produced Au NPs demonstrated signifcant antibacterial and antifungal activity against the bacterial and fungal strains tested, as well as efcient inhibitory activity against both AChE and BChE enzymes. The highest antimicrobial activities were found against Staphylococcus aureus (0.06° mg/ ml) and Candida albicans (0.06° mg/ml). The antioxidant test fndings revealed that AC-Au NPs had lesser activity when compared to normal antioxidants. The Au NPs showed excellent inhibitory efcacy against AChE and BChE. The proposed green technique could encourage the innocuous generation of Au NPs, implying therapeutic possibilities.
Green Synthesis of Silver Nanoparticles Derived from Papaver Rhoeas L. Leaf Extract: Cytotoxic and Antimicrobial Properties
(MDPI, 2023) Baran, Mehmet Firat; Beylerli, Ozal; Baran, Ayse; Sufianov, Albert; Yildiz, Resit; Hatipoglu, Abdulkerim; Ipek, Polat
In the last few decades, the search for metal nanoparticles as an alternative to cancer treatments and antibiotics has increased. In this article, the spectroscopic (ultraviolet-visible (UV-vis), electron-dispersing X-ray (EDX), and Fourier transform infrared (FT-IR)), microscopic (field emission scanning electron microscope (FE-SEM), transmission electron microscope (TEM), and atomic force microscope (AFM)), structural (X-ray diffractometer (XRD) and zetasizer), and analytic (thermogravimetric/differential thermal analyzer (TGA-DTA)) characterization of the silver nanoparticles (AgNPs) produced from Papaver rhoeas (PR) L. leaf extract are presented. PR-AgNPs are generally spherical and have a maximum surface plasmon resonance of 464.03 nm. The dimensions of the manufactured nanomaterial are in the range of 1.47-7.31 nm. PR-AgNPs have high thermal stability and a zeta potential of 36.1 mV. The minimum inhibitory concentration (MIC) values (mg L-1) of PR-AgNPs on Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans are 1.50, 0.75, 3.00, 6.00, and 0.37, respectively. In the study, the cytotoxic and proliferative effects of PR-AgNPs using the MTT (3-(4,5-dimethylthiazol-2-yl)-diphenyltetrazolium bromide) method on various cancer cell lines (CACO-2 (human colon adenocarcinoma cell), MCF-7 (human breast cancer cell), T98-G (glioblastoma multiforme cell), and healthy HUVEC (human umbilical vein endothelial cell)) cell lines are presented. After 24 and 48 h of the application, the half-maximum inhibitory concentration (IC50) values (mu g mL(-1)) of PR-AgNPs on HUVEC, CACO-2, MCF-7, and T98-G lines are 2.365 and 2.380; 2.526 and 2.521; 3.274 and 3.318; 3.472 and 3.526, respectively. Comprehensive in vivo research of PR-AgNPs is proposed to reveal their potential for usage in sectors such as nanomedicine and nanochemistry.
Citation - WoS: 103
Citation - Scopus: 125
Green Synthesis of Silver Nanoparticles from Allium cepa L. Peel Extract, Their Antioxidant, Antipathogenic, and Anticholinesterase Activity
(Molecules, 2023) Keskin, Cumali; Mehmet Fırat Baran, Ayşe Baran, Abdulkerim Hatipoğlu, Mahmut Yildiztekin, Selçuk Küçükaydin, Kadri Kurt, Hülya Hoşgören. Moklesur Rahman Sarker, Albert Sufianov, Ozal Beylerli, Rovshan Khalilov, Aziz Eftekhari; Baran, Mehmet Firat; Yildiztekin, Mahmut; Kucukaydin, Selcuk; Eftekhari, Aziz; Hatipoglu, Abdulkerim; Baran, Ayse
The present work deals with the green synthesis and characterization of silver nanoparticles (AgNPs) using Allium cepa (yellowish peel) and the evaluation of its antimicrobial, antioxidant, and anticholinesterase activities. For the synthesis of AgNPs, peel aqueous extract (200 mL) was treated with a 40 mM AgNO3 solution (200 mL) at room temperature, and a color change was observed. In UV-Visible spectroscopy, an absorption peak formation at ~439 nm was the sign that AgNPs were present in the reaction solution. UV-vis, FE-SEM, TEM, EDX, AFM, XRD, TG/DT analyses, and Zetasizer techniques were used to characterize the biosynthesized nanoparticles. The crystal average size and zeta potential of AC-AgNPs with predominantly spherical shapes were measured as 19.47 ± 1.12 nm and −13.1 mV, respectively. Pathogenic microorganisms Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans were used for the Minimum Inhibition Concentration (MIC) test. When compared to tested standard antibiotics, AC-AgNPs demonstrated good growth inhibitory activities on P. aeuruginosa, B. subtilis, and S. aureus strains. In vitro, the antioxidant properties of AC-AgNPs were measured using different spectrophotometric techniques. In the β-Carotene linoleic acid lipid peroxidation assay, AC-AgNPs showed the strongest antioxidant activity with an IC50 value of 116.9 µg/mL, followed by metal-chelating capacity and ABTS cation radical scavenging activity with IC50 values of 120.4 µg/mL and 128.5 µg/mL, respectively. The inhibitory effects of produced AgNPs on the acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes were determined using spectrophotometric techniques. This study provides an eco-friendly, inexpensive, and easy method for the synthesis of AgNPs that can be used for biomedical activities and also has other possible industrial applications.
Phenolic Profile, Antioxidant Capacity, Enzyme Inhibitory Potential and Physicochemical Properties of Almond Milk and Date Enriched Plant-Based Ice Cream
(Springer, 2026) Kizmaz, Veysi; Cavusoglu, Mehmet; Hatipoglu, Abdulkerim
The aim of this study was to evaluate the effects of almond milk and date fruit on the functional and physicochemi-cal properties of ice cream formulations. For this purpose, four ice cream formulations with a fixed fat content of 5% were produced: IC1 (control, condensed cow's milk and refined sugar); IC2 (milk-based using dates instead of refined sugar); IC3 (plant-based containing almond milk and dates); and IC4 (plant-based containing almond milk and refined sugar). The pH, viscosity, overrun, and melting behavior of the samples were investigated, along with total phenolic and flavonoid contents and antioxidant capacities determined by DPPH, ABTS, and CUPRAC assays. In addition, inhibitory activities against alpha-amylase, alpha-glucosidase, urease, tyrosinase, elastase, collagenase, AChE, and BChE enzymes were evaluated. The results indicated that formulations containing almond milk and dates exhibited significantly higher total phenolic and flavonoid contents, as well as enhanced antioxidant capacities, particularly as measured by the CUPRAC assay (P < 0.05). These formulations also demonstrated greater inhibitory activity against alpha-amylase and alpha-glucosidase enzymes. Physicochemical evaluation revealed that IC3 exhibited superior viscosity and melting resistance, as reflected by the longest first drip time, whereas IC4 achieved the highest overrun. The highest melting speed and melting rates were observed in IC2 (P < 0.05). Overall, the findings suggest that the combined use of almond milk and dates represents an effective strategy for developing plant-based ice cream formulations with enhanced functional properties and favor-able physicochemical characteristics.
Self-Control as a Key Mediator and Moderator of the Relationship Between Psychological Distress and Food Addiction in a Large Community Sample of Adults
(Academic Press Ltd- Elsevier Science Ltd, 2026) Ceylan, Jiyan Aslan; Korkmaz, Aziz; Hatipoglu, Abdulkerim; Akcali, Caglar; Coskunsu, Sedat
Objective: This study investigated the extent to which psychological distress (depression, anxiety, and stress) predicts food addiction (FA) symptoms and examined whether self-control operates as both a mediator and a moderator in these associations. Method: A total of 4234 adults (40.7 % male) participated in a large-scale, community-based, cross-sectional survey conducted in T & uuml;rkiye. FA symptoms were measured via the Yale Food Addiction Scale (YFAS), self-control was assessed via the Brief Self-Control Scale (BSCS), and psychological distress was evaluated via the Depression Anxiety Stress Scales (DASS-21). Statistical analyses were conducted in SPSS, with significance defined at p < 0.05. Results: Overall, 35.1 % of the participants met the criteria for FA, with no significant sex difference (p = 0.19). Logistic regression analyses revealed that greater anxiety (OR = 1.078, p < 0.01) and stress (OR = 1.109, p < 0.01) were significant predictors of increased risk for FA, whereas greater self-control emerged as a protective factor (OR = 0.952, p < 0.01). Mediation analyses confirmed that self-control partially accounted for the effects of psychological distress on FA symptoms, with significant indirect effects observed for stress (beta = 0.025), anxiety (beta = 0.029), and depression (beta = 0.032). Moderation analysis revealed that self-control attenuated the effect of depression on FA symptoms (interaction term: B = 0.002, p < 0.01), although no moderating effects were found for anxiety or stress. Conclusions: This study highlights self-control as both a mechanism through which psychological distress contributes to food addiction and a protective factor that reduces its impact. Enhancing self-control may help mitigate addiction-related eating behaviors.