Browsing by Author "Kaya, Ahmet Ferhat"

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The Effectiveness of Halp Score in Predicting Mortality in Non-St Myocardial Infarction Patients
(Lippincott Williams & Wilkins, 2025) Kilic, Raif; Guzel, Tuncay; Aktan, Adem; Guzel, Hamdullah; Kaya, Ahmet Ferhat; Cankaya, Yusuf
Background:The HALP score, measured based on hemoglobin, albumin, lymphocyte, and platelet levels, is regarded as a novel scoring system that indicates the status of systemic inflammation and nutritional health. Our study aimed to evaluate the relationship between HALP score and prognosis in non-ST-elevation myocardial infarction (NSTEMI) patients. Methods Between 1 January 2020 and 1 January 2022, 568 consecutive patients diagnosed with NSTEMI from a single center were included in the study retrospectively. The patients were divided into two equal groups according to the median HALP cutoff value of 44.05. Patients were followed for at least 1 year from the date of admission. Results The average age of the patients was 62.3 +/- 10.6 years and 43.7% were female. In-hospital and 1-year mortality were found to be significantly higher in the group with low HALP scores (6.0 vs. 2.1%, P = 0.019 and 22.5 vs. 9.9%, P < 0.001, respectively). In receiver operating characteristic curve analysis, a cutoff level of 34.6 of the HALP score predicted 1-year mortality with 71% sensitivity and 65% specificity (area under the curve: 0.707, 95% confidence interval: 0.651-0.762, P < 0.001). In Kaplan-Meier analysis, higher mortality rates were observed over time in the group with lower HALP scores (log-rank test=16.767, P < 0.001). In Cox regression analysis, the HALP score was found to be an independent predictor of 1-year mortality (odds ratio: 0.969, 95% confidence interval: 0.958-0.981, P < 0.001). Conclusion We found that a low HALP score could predict in-hospital and 1-year mortality in patients admitted to the hospital with a diagnosis of NSTEMI.
A Novel Determinant of Prognosis in Acute Pulmonary Edema: Intermountain Risk Score
(Kare Publ, 2024) Kilic, Raif; Aktan, Adem; Guzel, Tuncay; Kaya, Ahmet Ferhat; Guzel, Hamdullah; Arslan, Bayram; Cankaya, Yusuf
Objective: The Intermountain Risk Score (IMRS), calculated using age, gender, complete blood count (CBC), and simple laboratory analyses, is an easy-to-use and cost-effective tool developed to predict mortality. In our study, we aimed to determine whether the IMRS could predict mortality in patients admitted to the hospital with a diagnosis of acute pulmonary edema. Methods: A total of 371 patients who were admitted with a diagnosis of pulmonary edema, were included in our study. The IMRS of the patients was determined using a calculation tool, and the patients were divided into three groups based on the determined value: low, moderate, and high IMRS. Results: The patients included in our study comprised 208 women and 163 men, with an average age of 68.7 years. There was a statistically significant difference between the patient groups concerning both 1-month and 1-year mortality rates. Additionally, there was a significant difference in IMRS between patients who developed in-hospital, 1-month, and 1-year mortality and those who survived. In the Receiver Operating Characteristic (ROC) analysis, a cutoff value of 15.5 for the IMRS predicted both 1-year and 1-month mortality. In the Kaplan-Meier analysis, the highest mortality risk was observed in the high IMRS group and the lowest mortality risk in the low IMRS group. Conclusion: Our research results show that the IMRS strongly predicts both short-term and long-term mortality in patients hospitalized with a diagnosis of acute pulmonary edema.
Prevalence of Sarcopenia in Heart Failure With Mildly Reduced Ejection Fraction and Its Impact on Clinical Outcomes
(Taylor & Francis Ltd, 2024) Kilic, Raif; Guzel, Tuncay; Aktan, Adem; Guzel, Hamdullah; Kaya, Ahmet Ferhat; Arslan, Bayram; Karahan, Mehmet Zuelkuef
Background: Sarcopenia is a progressive age-related skeletal muscle disease associated with adverse outcomes in those with cardiovascular disease. In this study, the prevalence of sarcopenia and its effect on clinical outcomes in heart failure with mildly reduced ejection fraction (HFmrEF) patients were examined. Methods: A total of 722 patients from three centres who applied to the outpatient clinic with the diagnosis of HFmrEF between 01 January 2020 and 01 June 2021 were included in the study retrospectively. Sarcopenia was diagnosed with a screening test using age, grip srength and calf circumference. At least two-year follow-up results were reviewed from the date the patients were included in the study. Results: Of the 722 HFmrEF patients, 169 (23.4%) were sarcopenic. During the follow-up of sarcopenic patients, a higher rate of hospitalisation and two-year mortality was detected compared to the non-sarcopenic group (49.7% vs 33.3%, p < .001 and 23.7% vs 13.2%, p = .001, respectively). Additionally, atrial fibrillation (AF), chronic obstructive pulmonary disease (COPD), chronic renal failure (CRF) and smoking were detected at higher rates in sarcopenic patients. In subgroup analysis, AF was found to be significantly higher in overweight/obese sarcopenia patients compared to other groups. According to Receiver operating characteristic (ROC) analysis, the sarcopenia score cut-off of 73.61 predicted mortality with 65% sensitivity and 63% specificity, and the cut-off level of 71.10 predicted hospitalisation with 68% sensitivity and 69% specificity. Conclusion: In HFmrEF patients, sarcopenia is associated with adverse events and is an important prognostic marker.
Sistemik İmmün İnflamasyon İndeksi Koroner Arter Hastalığının Yükünü Tahmin Edebilir
(2024) Kaya, Ahmet Ferhat; Kılıç, Raif; Aktan, Adem
Arkaplan: Koroner arter hastalığının patofizyolojisinde ateroskleroz önemli bir yer almaktadır. Aterosklerozun çok yönlü etkileri göz önüne alındığında tam kan sayımıyla kolayca hesaplanabilen sistemik immün inflamatuar indeks (SII) inflamasyon dengesini tanımlamak için kullanılabilmektedir. Amaç: Biz çalışmamızda 166 hastada değerlendirilen bu biyobelirteç ile inflamasyon şiddetinin,koroner anjiografi ile değerlendirilen koroner arter hastalığı şiddeti ile ilişkisini incelemeyi amaçladık. Yöntem: Çalışmamıza Akut koroner sendrom nedeni ile koroner anjiografisi yapılan 166 hasta dahil edildi. Hastaların SYNTAX skoru web sitesindeki uygulama üzerinden hesaplandı. (http://www.SYNTAXcore.com.) SYNTAX puanı 3 gruba ayrılmaktadır: 0-22, düşük; 23-32, orta; 33 ve üzeri, yüksek. Biz çalışmamızda SYNTAX puanını iki gruba ayırarak inceledik: 0-22 düşük, 23 ve üzeri orta -yüksek olarak tanımladık. SII ile düşük ve orta-yüksek grup arasındaki ilişkiyi inceledik. Bulgular: Akut koroner sendrom ile başvuran hastalarda sistemik immun inflamatuar indeks (SII) ile SYNTAX (Synergy Between PCI With TAXUS and Cardiac Surgery) skoru ile değerlendirilen koroner arter hastalığı yaygınlığı arasında istatiksel olarak anlamlı sonuç tespit edildi.(p=0,022) Sonuç: SII klinik olarak pratik bir yöntem olup akut koroner sendrom yaygınlığı ile ilgili biz klinisyenlere tedavi yaklaşımı açısından önemli ipuçları verebilir, ve bulduğumuz sonucun hasta tedavi yaklaşımına katkı sağlayacağı inancındayız. Yine de SII için daha derinlemesine ve iyi düzenlenmiş araştırmalara gereksinme duyulmaktadır.