Browsing by Author "Sagir, Suleyman"

Now showing 1 - 8 of 8

Citation - WoS: 0
Citation - Scopus: 0
Breaking Misconceptions: Assessing the Quality of Youtube Videos on Penile Fracture With Validated Scoring Tool
(Mre Press, 2025) Sağır, Süleyman; Ertek, Mehmet Sirin; Toktas, Izzettin; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
Background: The main objective of this research was to evaluate the effectiveness of YouTube videos related to penile fracture by applying established rating systems. Methods: A descriptive investigation was carried out by browsing YouTube for videos related to "Penile fracture". Out of a total of 108 videos that were found, 47 were deemed eligible for inclusion in the analysis. The features and substance of the videos were assessed utilizing the adjusted DISCERN tool, the criteria from the Journal of the American Medical Association (JAMA), and the Global Quality Scale (GQS). Statistical analysis was performed using SPSS 22.0 software, with a significance level of p < 0.05. Results: High-quality videos, as classified by GQS, had more views, likes, and comments than lower-quality videos; however, these differences were not statistically significant (p > 0.05). In contrast, videos with detailed and accurate content had significantly higher view counts (approximately tenfold) and more likes (approximately twofold) than poor-content videos (p < 0.05). A strong positive correlation was found between content analysis scores and DISCERN (r = 0.815, p < 0.001), JAMA (r = 0.781, p < 0.001), and GQS (r = 0.722, p < 0.001). Videos made by urologists and surgeons demonstrated superior quality across all measured criteria in comparison to those crafted by individuals without healthcare backgrounds (p <0.001). Conclusions: The quality of YouTube content addressing penile fracture exhibits a wide range, with content generated by healthcare experts standing out for its high quality. It is imperative for medical professionals to actively engage in disseminating accurate health information on these platforms.
Citation - WoS: 0
Citation - Scopus: 0
Comparison of Pde-5 Inhibitors Used in Erectile Dysfunction With Some Candidate Molecules: a Study Involving Molecular Docking, Admet, Dft, Biological Target, and Activity
(Bmc, 2025) Sağır, Süleyman; Unsal, Velid; Oner, Erkan; Yildiz, Resit; Mert, Basak Dogru; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
Erectile dysfunction (ED) is a urological condition defined as the inability of a man to achieve or maintain an erection. This condition negatively affects his sexual performance and the performance of his partner. Phosphodiesterase type 5 (PDE5) inhibitors are commonly used to treat ED. Arginase II plays an important role in regulating L-arginine to NO synthase in the smooth muscle of the human corpus cavernosum of the penis. NO is a molecule essential for regulating a variety of functions, including arterial blood pressure, penile erection, and energy balance. Substances such as vardenafil, alprostadil, papaverine, and resveratrol increase NO production, thereby supporting sexual function and vascular health. Additionally, NO donors such as L-arginine, L-citrulline, and alpha-lipoic acid provide effective alternatives when used in combination with PDE5 inhibitors. Medications used in the treatment of ED include vardenafil, alprostadil, and papaverine. In addition, although molecules such as L-arginine, citrulline, resveratrol, alpha-lipoic acid, and rutin are thought to play a role in ED, their pharmacological and molecular effects have not been sufficiently elucidated. The aim of this study was to investigate the effects of these molecules in the treatment of ED by computer-based calculations, to obtain new information about them and to inspire new treatment strategies for ED. The physicochemical, molecular and pharmacokinetic properties of the compounds were determined by SwissADME software, and ADMET (absorption, distribution, metabolism, excretion and toxicity) data were determined by ADMETlab 3.0 software. Biological target and activity data were obtained by MolPredictX and PASS Online software. While the Gaussian 09 program was used for DFT calculations, PyMOL, AutodockTools 4.2.6, AutoDock Vina, and Biovia Discovery programs were used for molecular docking studies. It was found that L-arginine, citrulline, resveratrol and alpha-lipoic acid were well absorbed from the intestine, while rutin showed limited absorption. When their metabolic risks were evaluated, L-arginine and citrulline were found to have lower toxicity. Molecular docking results of rutin and resveratrol were remarkable. The electronic properties of the compounds were explained by DFT calculations. L-arginine and citrulline were found to have low toxicity and positive therapeutic effects. L-arginine and citrulline stand out as promising candidates for future research. Although resveratrol data are promising, unfortunately their potential toxicity and metabolic interactions require further investigation. It is important to learn more about these compounds or conduct research to improve their therapeutic efficacy. Although computer-based calculations play an important role in toxicity predictions, drug interactions, pharmacokinetics and toxicity properties should be carefully evaluated.
Citation - WoS: 0
Citation - Scopus: 0
Evolving Approach in Nephron-Sparing Surgery: Has Anything Changed From Open Surgery To Laparoscopy
(Iniestares, S.a., 2024) Sağır, Süleyman; Sagir, Suleyman; Akyuz, Osman; Akman, Ramazan Yavuz; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
Objective: This study aimed to provide valuable insights into the comparative efficacy of different surgical approaches fornephron-sparing surgery (NSS) and contribute to the existing literature in this field. Materials and Methods: This study included patients who underwent NSS for small renal masses between January 2016 andMarch 2024. A total of 97 patients (41 in the open approach group, 56 in the laparoscopic approach group) with demographic,radiological, intraoperative, renal functional, and oncological follow-up data were included. Three different anatomical scoringsystems (R.E.N.A.L. nephrometry score, PADUA score and C-index) were utilised to assess tumour location and estimate prox-imity to the hilum and collecting system. Results: In the open nephron-sparing surgery (ONSS) and laparoscopic nephron-sparing surgery (LNSS) groups, the mean kid-ney tumour diameters (SD) were 5.20 +/- 2.30 and 4.90 +/- 2.10, which were similar in both surgical method groups (p= 0.061).However, tumours treated with ONSS had significantly more adverse morphometric features (p<0.05). For ONSS and LNSSgroups, the mean R.E.N.A.L. nephrometry scores (SD) were 6.15 +/- 2.04 and 5.2 +/- 1.4 (p= 0.032), respectively; The mean PADUAscores (SD) were 7.46 +/- 1.14 and 6.8 +/- 1.0 (p= 0.049), respectively; And the mean C-index (SD) scores were 1.39 +/- 0.4 and 1.37 +/- 0.5 (p= 0.062), respectively. No significant differences were found in the mean tumour diameter (cm) (Inter Quantile Range(IQR)) distribution of both groups (p= 0.058). Despite the slight increase in transfusion rate in the LNSS group, estimated bloodloss (EBL), transfusion rates, and length of hospital stay were similar in both groups. Conclusions: Although LNSS does not appear superior in terms of intraoperative blood loss, length of hospital stay and transfu-sion rate, it provides comparable long-term outcomes to ONSS. Our study suggests that when matched with nephrometry scores,LNSS can achieve similar outcomes to ONSS
Citation - WoS: 0
Citation - Scopus: 0
Factors Affect Progressive Sperm Motility
(Mexican Acad Surgery, 2025) Sağır, Süleyman; Tuncekin, Adem; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
Objective: In this study, it was aimed to investigate the effects of age, body mass index, and diet factors on sperm parameters and developing a novel index (Artuklu Sperm Quality Index [ASQI]). Method: The study incorporated a total of 115 patients who sought medical attention due to infertility and underwent semen analysis (spermiogram). The ASQI score was developed. Results: About 73% reported eating three meals daily, while 62% consume fruits a few times a week. When considering grain consumption, 30% rarely do, mirroring the 25% who never do. Carbonated drinks are consumed a few times in 15 days by 39% of respondents. Salt consumption showed 47% taking very little, whereas 42% consume caffeine very minimally. Sausage/ salami is minimally consumed by 44%, and 32% of participants reported never being exposed to air pollution. ASQI score ranges from 6 to 61 point. A lower score indicates good nutrition and quality of life, while a higher score suggests deteriorating nutrition and increasing unhealthy habits. Cronbach alfa value was noted as 0.72. A negative correlation was found between ASQI and sperm progressive motility (p < 0.001, r = -0.405). Conclusions: This study revealed a clear negative correlation between the ASQI score, which signifies deteriorating nutrition and escalating unhealthy habits, and sperm progressive motility.
Citation - WoS: 0
Citation - Scopus: 0
Low-Intensity Extracorporeal Shock Wave Therapy and Platelet-Rich Plasma: Effective Combination Treatment of Chronic-Phase Peyronie's Disease
(Iniestares, S.a., 2025) Sağır, Süleyman; Sagir, Suleyman; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
Objective: This study aimed to investigate the effectiveness, safety and outcomes of the combination therapy of low-intensity extracorporeal shockwave therapy (Li-ESWT) and platelet-rich plasma (PRP) for the treatment of chronic-phase Peyronie's Methods: The clinical outcomes of patients diagnosed with Peyronie's disease and treated with Li-ESWT combined with PRP at our clinic between January 2018 and January 2024 were retrospectively reviewed and analysed. Twenty-three patients were excluded based on inclusion criteria, leaving 26 patients for the retrospective analysis. Each patient received three sessions of PRP and six sessions of Li-ESWT. The treatment regimen involved sessions administered twice weekly over a period of 3 weeks, followed by 1-week post-treatment follow-up. The patients were then monitored for 24 weeks. Result: After treatment, no significant reduction in average plaque size was observed. However, a statistically significant average improvement of 10 degrees was noted for penile curvature. Among the patients, 14 (53.8%) reported satisfaction with the treatment outcome, and 12 (46.2%) expressed dissatisfaction. No significant adverse effects were observed at the injection sites or in the areas subjected to Li-ESWT post-procedure. Conclusions: The combination of Li-ESWT and PRP is effective and safe for the treatment of chronic-phase Peyronie's disease.
Citation - WoS: 0
The Performance of the Inflammatory Indexes in Predicting Double J Catheter Insertion Necessity Among Children and Adult Patients With Ureteral Stone
(Reial Acad Medicina Illes Balears, 2023) Sağır, Süleyman; Sagir, Suleyman; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
Objective: The present study was designed to examine the differences in NLR, PLR, and PNLR between two distinct patient groups, further examining their utility as diagnostic markers.Materials and methods: Patients were then separated into two categories: Group 1 (those not require DJ catheter insertion) and Group 2 (those needed DJ catheter insertion). Factors such as patient age, gender, symptoms, diagnosis, hematological parameters, and some indexes (NLR, PLR, and PNLR) were thoroughly assessed.Results: The research study featured 150 participants, split into two groups of 80 (Group 1) and 70 (Group 2) individuals. Despite average age differences, the distribution of ages was statistically significant. Group 1 had more children, while Group 2 contained more adults. Gender distribution between groups was not significantly different. Group 2 had larger mean stone sizes than Group 1. Stone location showed no significant variation between the groups. WBC and NEU were higher in Group 2, while LYM was higher in Group 1. There was no significant difference in MONO, PLT, and urea levels, but CRE level was higher in Group 2. NLR, PLR, and PNLR were also significantly higher in Group 2. Cut-off values for NLR, PLR, and PNLR had moderate to good predictive abilities. There was a positive correlation between stone size and PNLR index.Conclusions: Our study demonstrates the predictive utility of hematological parameters (NLR, PLR, PNLR) in determining the need for DJ catheter placement in ureteral stone patients.
Citation - WoS: 1
Citation - Scopus: 1
Prognostic and Predictive Value of Tertiary Lymphoid Structures in Turbt Materials: Should It Be Seated in the Routine Pathological Examination, and Can It Be Used in Deciding on the Treatment Method?
(Elsevier Science inc, 2024) Sağır, Süleyman; Sagir, Suleyman; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
Objective: This study aims to reveal the importance of tertiary lymphoid structures (TLS) in transurethral resection of bladder tumor (TURBT) materials with a practical and applicable method in which the effect of a certain threshold value on survival and treatment response can be implicated. Methods: TURBT materials that had not previously received any treatment (chemotherapy, radiotherapy, or immunotherapy) and were diagnosed for the first time at Mardin Training and Research Hospital between 2014 and 2022 were included in the study. The maximum TLS per 4x magnification field (field diameter: 4.5 mm) was recorded. Grouping and statistical analysis of the TLS number were performed using threshold values of ">= 1", ">= 2", and ">= 3". Results: TLSs were more frequently found in high-grade tumors (P = 0.008) and showed a strong association with stage progression (P < 0.001). It was also significantly associated with many adverse histopathological parameters. Conversely, high TLS (>= 1, >= 2, and >= 3) appeared to be associated with fewer recurrences (P = 0.032, P = 0.001, and P = 0.018, respectively), and cases with higher TLS showed longer recurrence-free survival (P = 0.089, P = 0.023, P = 0.037, respectively). TLS >= 3 was found to be an independent parameter that was associated with favorable RFS (P = 0.019, HR = 0.401), and multifocality was found to be an independent risk factor for RFS (P = 0.023, HR = 2.302). Conclusion: This study is the first to demonstrate the relationship between the presence and specific thresholds of TLS in TURBT materials with prognostic parameters. Including this information in the routine pathological examination of TURBT materials will allow a more accurate approach to treatment and follow-up, especially in patients with non-muscle invasive bladder cancer (NMIBC).
Citation - WoS: 1
Subcutaneous Ring Block and Dorsal Penile Nerve Block Effectiveness in Male Circumcision: a Cross-Sectional Study
(Reial Acad Medicina Illes Balears, 2024) Sağır, Süleyman; Kose, Elif Ozge Cinar; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
Background: Our aim was to compare the effectiveness and postoperative implications of two regional anesthesia techniques, namely the subcutaneous ring block (SRB) and the dorsal penile nerve block (DPNB), when applied during routine circumcision in children. Patients and methods: This comparative retrospective study was conducted between the years 2021 and 2022. The subjects were patients who underwent circumcision during this period. The techniques compared were the subcutaneous ring block (SRB) (group 1) and the deep dorsal penile nerve block (DPNB) (group 2). Results: We observed that neither group had any instances of comorbidity or infection, rendering these factors statistically identical between the two groups (p=1.000 in both cases). Group 1 showed edema in 4 patients (21.2%) while it was reported in 12 patients (63.2%) in Group 2 (p =0.009). Similarly, bleeding was observed in 4 patients (21.2%) in group 1, but there were no instances of bleeding in group 2 (p =0.034). In terms of postoperative pain, group 1 had a higher average pain score (6.02 +/- 1.33) compared to Group: 2 (4.68 +/- 3.12) (p =0.040). In Group 1, 18 patients (94.7%) required postoperative analgesia, whereas in Group 2, only 3 patients (15.8%) needed it (p <0.001). Conclusions: Our comparative analysis demonstrates that the deep dorsal penile nerve block (DPNB) was associated with fewer postoperative complications, lower pain scores, and less need for postoperative analgesia than the subcutaneous ring block (SRB) in pediatric circumcision