Browsing by Author "Yildiz, G."

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Histological Evaluation of Algan Hemostatic Agent's Effect in a Rat Experimental Spleen Injury Model
(Ondokuz Mayis Universitesi, 2024) Şener Akçora, D.; Mavuş, D.; Şeker, U.; Yildiz, G.; Gökçe, K.
Uncontrolled hemorrhage may result from injuries to the parenchym and splenic capsule. Hemostatic material applications are among the methods used to prevent spleen parenchymal hemorrhage. Algan Hemostatic Agent (AHA) is a standardized mixture of six distinct herbs that are capable of hemostasis, either individually or in combination. Aim of this study was to investigate efficiency of AHA in bleeding control in experimental spleen injury model, and to evaluate its histopathological effects and IL-1β, TNF-α, and Bax expressions in tissue. Twenty-four Wistar albino female rats, aged 10-12 weeks, were randomly separated into three groups (n=8); control, AHA-liquid, and AHA-powder. After surgery physiological saline, liquid and powder were applied to the injured area for twenty seconds. On the tenth postoperative day all rats’ spleens were removed for histopathological and immunohistochemical analysis. The AHA-liquid group demonstrated more efficacy in controlling hemorrhage than the AHA powder group after both the initial and subsequent applications. Parenchyma of the spleen was intact, and a thin capsule was detected in the liquid group. In the powder group, thick granulation tissue was observed along with acute lymphocyte and neutrophil infiltration. Expressions of IL-1 β and TNF-α were mild in control and AHA-liquid groups and intense in AHA-powder groups. Similar Bax protein expression was detected in all groups. Current study demonstrated that liquid form of AHA was more effective in reducing local bleeding and inflammation in spleen tissue. Therefore, liquid form could be preferred in animal experiments and clinics as a rapid, safe, and effective agent for organ injury. © 2024 Ondokuz Mayis Universitesi. All rights reserved.
Investigation of the Relationship Between the Viscoelastic Properties and Muscle Strength of Accessory Respiratory Muscles in Obstructive Sleep Apnea
(WB Saunders Co Ltd, 2026) Ramazanoglu, E.; Yildiz, G.; Sahin, G.E.; Kara, E.; Yaprak, F.; Bağcı, B.; Gündoǧdu, N.
BACKGROUND: The link between respiratory muscle strength and viscoelastic properties of accessory muscles offers a perspective for individualized treatment in Obstructive Sleep Apnea Syndrome (OSAS). PURPOSE: This study investigated associations between respiratory muscle strength and viscoelastic properties of the sternocleidomastoid (SCM) and rectus abdominis (RA) in OSAS. METHODS: Patients with moderate (n = 33) and severe OSAS (n = 45) diagnosed by polysomnography were included. Muscle viscoelasticity was assessed using Myoton®PRO, and respiratory strength (maximal inspiratory (MIP), maximal expiratory pressure (MEP)) was measured by spirometer at rest and during maximal efforts. RESULTS: In moderate OSAS, MEP-best correlated negatively with left SCM elasticity at rest (r = -0.622, p < 0.001), elasticity during inspiration (r = -0.401, p = 0.021), and stiffness (r = -0.357, p = 0.041). In severe OSAS, MEP-best correlated negatively with left SCM stiffness (r = -0.380), right SCM elasticity at rest (r = -0.393) and inspiration (r = -0.495), and left SCM elasticity during expiration (r = -0.323). MIP-best correlated negatively with right SCM elasticity during inspiration (r = -0.301) and left SCM elasticity during expiration (r = -0.323). Age correlated positively with SCM and RA parameters, while AHI correlated negatively with SCM and RA stiffness/elasticity, especially left RA elasticity during expiration (r = -0.544, p < 0.001). Side-specific differences were noted. CONCLUSION: Both inspiratory (SCM) and expiratory (RA) muscles are important in OSAS. With greater severity, viscoelastic properties shift from active support to passive adaptation, with RA contributing alongside SCM to functional changes. © © 2025. Published by Elsevier Ltd.