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Browsing by Author "Yilmaz, Mehmet"

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    Comparison of Orexigenic and Anorexigenic Neuropeptide Levels in Hyperemesis Gravidarum Patients With Normal Pregnant Women: a Prospective Cohort Study
    (Lippincott Williams & Wilkins, 2024) Balsak, Deniz; Aksin, Şerif; Balsak, Deniz; Batmaz, İbrahim; Batmaz, Ibrahim; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
    Background: The aim of this study was to determine whether orexigenic neuropeptides, orexin and galanin, and anorexigenic neuropeptides, alpha-melanocyte-stimulating hormone (alpha-MSH) and cocaine- and amphetamine-regulated transcript (CART), are implicated in hyperemesis gravidarum (HG). Methods: Fifty pregnant women who had been diagnosed with HG between April 2022 and February 2023 at the Siirt University Faculty of Medicine Training and Research Hospital (tertiary center) were recruited for this study. An equal number of pregnant women without an HG diagnosis were included in the study as the control group. Participants' age, pregnancy history, medical history, thyroid function test results, complete blood count results, and electrolyte levels were recorded, and their orexin, galanin, alpha-MSH, and CART serum levels were analyzed using an enzyme-linked immunosorbent assay. Results: No statistically significant differences in orexigenic neuropeptides (orexin and galanin) were observed between the HG and control groups. A statistical difference was found between an anorexigenic neuropeptide (alpha-MSH) and the control group (P = .012). Based on a receiver operating characteristic analysis, the alpha-MSH parameter was statistically significant for distinguishing between participants with an HG diagnosis and those without, with a sensitivity of 63.6%, specificity of 65.9%, and cutoff value of 11769.3 pg/mL (P = .012, area under curve: 0.655). Based on the severity classification of ketonuria (ketonuria levels of +1 or +2 were classified as mild, whereas levels of +3 or +4 were classified as moderate to severe), the anorexigenic CART neuropeptide was found to be a statistically significant diagnostic indicator of severe ketonuria (P = .020). Conclusion: alpha-MSH and CART levels were found to be related in HG patients and in HG patients with severe ketonuria.
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    Evaluation of Visceral Adipokines: Omentin, Vaspin, and Visfatin in Patients With Gestational Diabetes Mellitus
    (Imr Press, 2024) Balsak, Deniz; Aksin, Şerif; Bozbay, Nizamettin; Batmaz, İbrahim; Aboalhasan, Yasmin; Kurnuc, Fatma Zehra; Batmaz, Ibrahim; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
    Background: Gestational diabetes mellitus (GDM) is a common metabolic disorder characterized by glucose intolerance that develops during pregnancy. The underlying pathophysiological mechanisms of GDM involve complex interactions between genetic, environmental, and hormonal factors, including adipokines secreted by visceral adipose tissue. Omentin, vaspin, and visfatin are adipokines believed to influence insulin sensitivity and inflammation, though their precise relationship with GDM remains unclear. This study aimed to examine the association between these adipokines and GDM. Methods: This single-center, prospective controlled cohort study included 87 pregnant patients diagnosed with GDM via an oral glucose tolerance test (OGTT) between the 24th and 28th weeks of gestation, along with 87 control subjects without GDM. Serum levels of omentin, vaspin, and visfatin were measured using enzyme-linked immunosorbent assay (ELISA), and their association with GDM was analyzed. Results: Our results demonstrated that omentin levels were significantly higher in the GDM group compared to the control group (p = 0.012), while no significant differences were observed in vaspin and visfatin levels (p > 0.05). An omentin cut-off value of 29.0 ng/mL predicted GDM with 59.1% sensitivity and 59.1% specificity, suggesting its potential as a biomarker for GDM. Conclusions: This study underscores the unique role of omentin in GDM, in contrast to the non-significant changes observed in vaspin and visfatin levels. The elevated omentin levels in GDM patients suggest its potential as a biomarker for diagnosing and managing GDM. Further research is needed to elucidate the mechanisms through which omentin contributes to the pathophysiology of GDM.
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    Relationship Between First Trimester Placental Thickness and Perinatal Prognosis: a Prospective Cohort Study
    (Bayrakol Medical Publisher, 2025) Aksin, Şerif; Balsak, Deniz; Balsak, Deniz; Batmaz, İbrahim; Kurnuc, Fatma Zehra; Batmaz, Ibrahim; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
    Aim: This study aims to investigate the correlation between first-trimester placental thickness and perinatal prognosis. Material and Methods: A prospective cohort study was conducted at Siirt University Faculty of Medicine from March 2022 to March 2023 of 365 pregnant women in their first trimester (11-14 weeks of gestation). Placental volume was measured using two-dimensional (2D) ultrasound, and estimated placental volume (EPV) was calculated using Merwin's EPV Calculator app. The patients were followed until delivery, and outcomes such as gestational age at delivery, mode of delivery, fetal weight, APGAR score, fetal gender, perinatal outcomes, preeclampsia (PE), premature rupture of membranes (PROM), gestational hypertension (GHT), gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR), preterm birth, oligohydramnios, polyhydramnios, surmaturation, presentation anomaly, intrauterine death, fetal distress, and placental abruption were evaluated. Results: Data from 365 pregnant women were analyzed. The mean maternal age was 27.2 +/- 5.5 years. The distribution of placental location was 38.4% posterior, 43.0% anterior, 7.4% left sidewall and 11.2% right sidewall. No significant differences were found in placental volume measurements based on delivery mode, fetal gender, or conditions such as PE, GDM, IUGR, PROM, preterm birth, or other perinatal pathologies. Statistical analyses showed no significant association between first-trimester placental volume and adverse perinatal outcomes (p>0.05). Discussion: No relationship was found between first-trimester placental thickness and perinatal outcomes.
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    The Role of Thiol/Disulfide Homeostasis in Unexplained Primary Infertile Patients: a Prospective Cohort Study
    (Lippincott Williams & Wilkins, 2025) Aksin, Şerif; Yilmaz, Mehmet; Department of Surgical Medical Sciences / Cerrahi Tıp Bilimleri Bölümü
    Background:Our study aims to investigate whether there is a relationship by measuring the total oxidant/antioxidant load with the thiol/disulfide method in patients with unexplained infertility. Methods:A total of 82 participants were enrolled, consisting of 41 women with unexplained infertility and 41 fertile controls matched for age and body mass index (BMI). Hormonal profiles, including follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), thyroid-stimulating hormone (TSH), and prolactin, were assessed using the chemiluminescence immunoassay method. Thiol/disulfide homeostasis was evaluated using a validated automated spectrophotometric method, which measured native thiol (NT), total thiol (TT), and disulfide levels. Detailed quality control measures ensured the reliability of the results. Results:In the study, no significant difference was found between the infertile and fertile groups' demographic (age) and clinical variables in terms of height, weight, BMI, FSH, LH, E2, TSH, prolactin, antral follicle count, TT, NT, and disulfide values (P > .05). The rates were found to be greater in the infertile group in disulfide/NT ratio and disulfide/TT ratio compared to the fertile group, even though there was no statistically significant difference between the groups' disulfide/NT ratio, disulfide/TT ratio, and NT/TT ratio values. The fertile group, however, had a higher NT/TT ratio rate. Conclusion:Although the unexplained infertility and fertile groups in the study did not differ in serum thiol and disulfide levels, the infertile group was found to have a relatively high disulfide/thiol ratio. More prospective studies on thiol/disulfide balance related to unexplained infertility may help to understand the relationship.