Relationship between Serum Vaspin Levels and the Severity of Coronary Disease in Non-Diabetic Patients with Non-ST Elevation Myocardial Infarction

Abstract

Objectives: Vaspin is an adipocytokine, serine protease inhibitor, correlated to obesity, insülin sensitivity, diabetes mellitus, and coronary artery disease. The association between vaspin and coronary artery disease was shown in several studies. Whether this value is independent of diabetes in coronary artery disease patients is not known. Also, a study that shows the importance of vaspin in patients with Non-ST elevation myocardial infarction (NONSTEMI) is not conducted. This study aimed to investigate the relationship between serum vaspin levels and the severity of coronary artery disease, which is determined by the SYNTAX score, in nondiabetic patients with NONSTEMI Materials and Methods: A total of 165 nondiabetic patients with NONSTEMI were included in this cross-sectional study. Serum vaspin levels were measured by the ELISA method.SYNTAX scores were evaluated by two expert operators blinded to the angiography results. Patients were divided into three groups according to the SYNTAX score by the interquartile range method (group 1 with SS 22). Results: Serum vaspin levels were found significantly different between three groups (p = 0,03) and significantly higher in group 1 than group 3 (p = 0,01).No significant difference was found between group 1 and 2 also group 2 and 3 (p = 0, 52, p = 0.06 ).It was found to be a significant but weak negative correlation between the SYNTAX score and serum vaspin levels (r = -0,207, p = 0.008). Conclusion: Vaspin negatively correlates to SYNTAX score and maybe a useful marker to show the severity of coronary disease in nondiabetic patients with NONSTEMI