Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity
| dc.contributor.author | Alhilal, Mohammad | |
| dc.contributor.author | Alhilal, Suzan | |
| dc.contributor.author | Gomha, Sobhi | |
| dc.date.accessioned | 2022-10-10T10:41:37Z | |
| dc.date.available | 2022-10-10T10:41:37Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Background: Adenocarpus complicatus L. is one of Adenocarpus genus, which has about 50 species, from Fabaceae (Papilionaceae) family. This plant is found in the Mediterranean basin as a southern west part of Europe and North Afric forestes. Objective: Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent. Methods: A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Adenocarpus complicatus L., which is gross in Syria. The structure of the new compound was determined by UV, IR, EI-Ms, 1H-NMR, 13C-NMR, DEPT-135, DQF-COSY and HMQC. Results: The anticandidal activity of isocarpine was screened against 38 Candida strains and showed remarkable inhibitory effect compared with fluconazole as an antifungal reference drug. Conclusion: Isocarpine is antifungal agent. | en_US |
| dc.identifier.citation | Alhilal, M., Alhilal, S., Gomha, S., & Ouf, S. (2022). Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity. The Natural Products Journal, 12(5), 79-92. | en_US |
| dc.identifier.doi | 10.2174/2210315511666211015085803 | |
| dc.identifier.issn | 2210-3155 | |
| dc.identifier.scopus | 2-s2.0-85132846566 | |
| dc.identifier.uri | https://doi.org/10.2174/2210315511666211015085803 | |
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| dc.identifier.uri | https://hdl.handle.net/20.500.12514/3145 | |
| dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:000830010900010?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=EUW1ED0C13jEGt7Yxd7bywdJHuz5d | |
| dc.language.iso | en | en_US |
| dc.publisher | Ingenta Connect | en_US |
| dc.relation.ispartof | Natural Products Journal | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Adenocarpus complicatus L; antifungal activity; fluconazole; isocarpines; piperidine alkaloids; structure elucidation | en_US |
| dc.title | Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | 0000-0002-2832-8409 | |
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| gdc.description.department | MAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü | en_US |
| gdc.description.endpage | 92 | en_US |
| gdc.description.issue | 5 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q4 | |
| gdc.description.startpage | 79 | en_US |
| gdc.description.volume | 12 | en_US |
| gdc.description.wosquality | Q4 | |
| gdc.identifier.openalex | W3207960205 | |
| gdc.identifier.wos | WOS:000830010900010 | |
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| gdc.oaire.keywords | Adenocarpus complicatus L; antifungal activity; fluconazole; isocarpines; piperidine alkaloids; structure elucidation | |
| gdc.oaire.popularity | 1.7808596E-9 | |
| gdc.oaire.publicfunded | false | |
| gdc.oaire.sciencefields | 01 natural sciences | |
| gdc.oaire.sciencefields | 0104 chemical sciences | |
| gdc.openalex.collaboration | International | |
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| gdc.virtual.author | Alhılal, Mohammad | |
| gdc.virtual.author | Alhılal, Suzan | |
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