Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity
| dc.contributor.author | Alhilal, Mohammad | |
| dc.contributor.author | Alhilal, Suzan | |
| dc.contributor.author | Gomha, Sobhi | |
| dc.contributor.author | Ouf, Salama | |
| dc.contributor.author | Alhila, Suzan | |
| dc.date.accessioned | 2022-10-10T10:41:37Z | |
| dc.date.available | 2022-10-10T10:41:37Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Background: Adenocarpus complicatus L. is one of Adenocarpus genus, which has about 50 species, from Fabaceae (Papilionaceae) family. This plant is found in the Mediterranean basin as a southern west part of Europe and North Afric forestes. Objective: Isolation of Isocarpine From Adenocarpus Complicatus as Anticandidal Agent. Methods: A new piperidine alkaloid Isocarpine was isolated from the aerial parts of Adenocarpus complicatus L., which is gross in Syria. The structure of the new compound was determined by UV, IR, EI-Ms, 1H-NMR, 13C-NMR, DEPT-135, DQF-COSY and HMQC. Results: The anticandidal activity of isocarpine was screened against 38 Candida strains and showed remarkable inhibitory effect compared with fluconazole as an antifungal reference drug. Conclusion: Isocarpine is antifungal agent. | en_US |
| dc.description.sponsorship | The authors extend their appreciation to Al-Baath University, Homs, Syria, for funding this work (Approval Number 37-99). MA, SA and SAO designed research; MA, SA and SAO performed research and analysed the data; all authors wrote the paper and approved the final manuscript. | |
| dc.description.sponsorship | Al-Baath University, Homs, Syria [37-99] | |
| dc.identifier.citation | Alhilal, M., Alhilal, S., Gomha, S., & Ouf, S. (2022). Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity. The Natural Products Journal, 12(5), 79-92. | en_US |
| dc.identifier.doi | 10.2174/2210315511666211015085803 | |
| dc.identifier.issn | 2210-3155 | |
| dc.identifier.issn | 2210-3163 | |
| dc.identifier.scopus | 2-s2.0-85132846566 | |
| dc.identifier.uri | https://doi.org/10.2174/2210315511666211015085803 | |
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| dc.identifier.uri | https://hdl.handle.net/20.500.12514/3145 | |
| dc.identifier.uri | https://www.webofscience.com/wos/woscc/full-record/WOS:000830010900010?AlertId=d383397b-4355-449e-9419-70f9e0e77c15&SID=EUW1ED0C13jEGt7Yxd7bywdJHuz5d | |
| dc.language.iso | en | en_US |
| dc.publisher | Ingenta Connect | en_US |
| dc.relation.ispartof | Natural Products Journal | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Adenocarpus complicatus L; antifungal activity; fluconazole; isocarpines; piperidine alkaloids; structure elucidation | en_US |
| dc.subject | Isocarpines | |
| dc.subject | Piperidine Alkaloids | |
| dc.subject | Fluconazole | |
| dc.subject | Adenocarpus Complicatus L | |
| dc.subject | Structure Elucidation | |
| dc.subject | Antifungal Activity | |
| dc.title | Isocarpine as A New Peperidine Alkaloid from Adenocarpus Complicatus with Anticandidal Activity | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | 0000-0002-2832-8409 | |
| gdc.author.id | Ouf, Salama/0000-0001-6786-2703 | |
| gdc.author.id | Alhilal, Suzan/0000-0002-9372-9364 | |
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| gdc.author.wosid | Gomha, Sobhi/I-5312-2019 | |
| gdc.author.wosid | Alhilal, Suzan/AAN-3400-2020 | |
| gdc.author.wosid | Alhilal, Mohammad/AAK-7940-2021 | |
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| gdc.description.department | MAÜ, Fakülteler, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü | en_US |
| gdc.description.departmenttemp | [Alhilal, Mohammad] Mardin Artuklu Univ, Fac Hlth Sci, Dept Nursing, TR-47000 Mardin, Turkey; [Alhila, Suzan] Univ Albaath, Fac Sci, Dept Chem, TR-25080 Erzurum, Turkey; [Gomha, Sobhi] Cairo Univ, Fac Sci, Dept Chem, Giza 12613, Egypt; [Gomha, Sobhi] Islamic Univ Madinah, Fac Sci, Dept Chem, Al Madinah Al Munawwarah 42351, Saudi Arabia; [Ouf, Salama] Cairo Univ, Fac Sci, Bot & Microbiol Dept, Giza, Egypt | |
| gdc.description.endpage | 92 | en_US |
| gdc.description.issue | 5 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q4 | |
| gdc.description.startpage | 79 | en_US |
| gdc.description.volume | 12 | en_US |
| gdc.description.woscitationindex | Emerging Sources Citation Index | |
| gdc.description.wosquality | Q4 | |
| gdc.identifier.openalex | W3207960205 | |
| gdc.identifier.wos | WOS:000830010900010 | |
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| gdc.oaire.keywords | Adenocarpus complicatus L; antifungal activity; fluconazole; isocarpines; piperidine alkaloids; structure elucidation | |
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| gdc.virtual.author | Alhılal, Mohammad | |
| gdc.virtual.author | Alhılal, Suzan | |
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