Cicek, MustafaUnsal, VelidTumer, Mehmet Kemal2021-09-152025-09-172021-09-152025-09-1720200250-46851303-829Xhttps://doi.org/10.1515/tjb-2019-0174Unsal, Velid/0000-0003-1415-0563Objective: In this study, we aimed to investigate the changes in the levels of oxidative stress and antioxidant enzymes on the mandibular bone caused by the expression of aquaporin-1 and aquaporin-3 proteins. Material and method: 14 Balb/C white mice were divided into two groups of seven, based on whether they are young or old. Mandibular tissue samples were taken for biochemical and histological analysis. Results: Findings of our study has shown that, AQP-1 and AQP-3 immunoreactivity significantly decreased in mandibular bone tissues of aged mice in comparison to younger mice (p < 0.05). MDA and AOPP levels, which are the indicators of oxidative stress, increased in elderly mice and antioxidant defense system SOD enzyme activity was decreased (p < 0.05). The TNF-alpha cytokine level, which is the indicator for inflammations, was found to be higher in older mice than in young mice (p < 0.05). Conclusion: As a result, it was observed that cellular damage, disruption in water - electrolyte balance and increased inflammation that occur during the natural process of aging had caused serious and irreversible disturbances.en10.1515/tjb-2019-0174info:eu-repo/semantics/openAccessAquaporin-1Aquaporin-3Oxidative StressTNF-AlphaArticle2-s2.0-85096934920