Ebelik Bölümü Koleksiyonu
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Article Citation - WoS: 8Citation - Scopus: 11The antioxidant and anti-apoptotic potential of Pleurotus eryngii extract and its chitosan-loaded nanoparticles against doxorubicin-induced testicular toxicity in male rats(Wiley, 2021) Erdem Güzel, Elif; Acay, Hilal; Yıldırım, Ayfer; Acay, Hilal; Yıldırım, Ayfer; Department of Midwifery/ Ebelik Bölümü; Department of Nutrition and Dietetics/ Beslenme ve Diyetetik Bölümü; Department of Medical Services and Techniques / Tıbbi Hizmetler ve Teknikleri BölümüThis study was conducted to evaluate the protective role of Pleurotus eryngii extract (PE) and Pleurotus eryngii extract-loaded chitosan nanoparticles (PE-CSNP) against doxorubicin (DOX)-induced testicular toxicity in rats. Male rats were divided into six groups: control (DMSO/ethanol), PE (200 mg/kg PE), PE-CSNP (30 mg/kg PECSNP), DOX (10 mg/kg DOX, a single dose, i.p), DOX+PE (10 mg/kg DOX+200 mg/ kg PE) and DOX+PE-CSNP (10 mg/kg DOX+30 mg/kg PE-CSNP). PE and PE-CSNP were administered by oral gavage every other day for 21 days. DOX-treated rats showed histopathological impairment compared with the control group. There was an increase in the apoptotic index, caspase 3 (CASP3), BCL2-associated X apoptosis regulator (BAX), dynamin-related protein 1 (DRP1) expression and total oxidative status (TOS) in the DOX group, while mitofusin-2 (MFN2), total antioxidative status (TAS) and serum testosterone levels of the DOX group reduced when compared with the other groups. PE and PE-CSNP treatments provided significant protection against DOX-induced oxidative stress by reducing TOS levels and increasing TAS levels. CASP3, BAX, apoptotic index and DRP1-MFN2 expressions were restored by PE and PE-CSNP. However, the PE-CSNP showed higher antioxidant and anti-apoptotic efficacy compared with PE. Thus, our results provide evidence that CSNP and PE could synergistically have a potent antioxidant and anti-apoptotic therapy against DOX-induced testicular damage in male rats.Article Citation - WoS: 8Citation - Scopus: 9Carbamazepine-induced renal toxicity may be associated with oxidative stress and apoptosis in male rat(Taylor & Francis Online, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Tektemur, Ahmet; Etem Önalan, Ebru; Department of Midwifery/ Ebelik BölümüCarbamazepine (CBZ) is the antiepileptic drug used in epilepsy and some psychiatric disorders. Besides its widely used, many adverse effects have been reported including hematotoxicity, hepatotoxicity, endocrine disorders, and testicular damages due to oxidative stress. However, the role of CBZ on renal toxicity is not fully known. In this study, we attempted to explain the connected mechanisms by focusing on the metabolism of CBZ-induced renal toxicity in rats. Twenty male Wistar-Albino rats were randomized into 2 groups (n = 10); control (1 mL/day distilled water, orally) and CBZ (25 mg/kg/day CBZ, orally) groups. After 60 days, TAS (total oxidant status) and TOS (total oxidant status) levels, histopathological features, some genes involved in apoptosis, 8-hydroxy-2-deoxyguanosine (8-OHdG) activity, and apoptotic cells were assessed of kidney tissue. The oxidative stress index (OSI) was measured from TAS and TOS levels. TOS levels and OSI significantly increased, while TAS levels decreased in the CBZ group relative to the control group. Histopathological observations, Caspase-3 (Casp3), Poly [ADP-ribose] polymerase-1 (PARP-1), 8-OHdG immunoreactivities, and apoptotic cells markedly raised in the CBZ group compared with the control group. Also, mRNA expression of Cytochrome c (Cytc) and CASP3 significantly increased in the CBZ group compared to the control group. In conclusion, long-term use of CBZ may promote renal damage in rats by inducing oxidative stress and apoptosis.Article Citation - WoS: 3Citation - Scopus: 3Chronic effects of maternal tobacco-smoke exposure and/or α-lipoic acid treatment on reproductive parameters in female rat offspring(Taylor & Francis Online, 2020) Erdem Güzel, Elif; Nalan Kaya, Ahmet Tektemur, Nazife Ulker, Ahmet Yardimci, Ramazan Fazil Akkoc, Sinan Canpolat & Ibrahim Enver; Department of Midwifery/ Ebelik BölümüPrenatal tobacco-smoke exposure negatively affects the reproductive functions of female offspring and oxidative stress plays a major role at this point. Alpha-lipoic acid (ALA), well known as a biological antioxidant, has been used as a nutritional supplement and as a therapeutic agent in the treatment of certain complications during pregnancy. We aimed to investigate the effects of maternal tobacco-smoke exposure and/or ALA administration on puberty onset, sexual behavior, gonadotrophin levels, apoptosis-related genes, apoptotic cell numbers and oxidative stress markers in the adult female rat offspring. Sprague-Dawley rats were divided into four groups; control, tobacco smoke (TS), TS+ALA and ALA groups. Animals were exposed to TS and/or ALA for 8 weeks before pregnancy and throughout pregnancy. All treatments ended with birth and later newborn female rats were selected for each experimental group. The experiment ended at postnatal day 74-77. Maternal tobacco smoke advanced the onset of puberty in the female offspring of the TS group (p < 0.05). In all treatment groups; the mean number of anogenital investigations and lordosis quality scores showed a decline, serum luteinizing hormone levels significantly increased (p < 0.05) and several histopathological changes in ovaries were observed compared to the control group. In addition, an increase in apoptotic marker levels and apoptotic cell numbers was detected in the ovaries of all treatment groups. Decreased TAS and increased TOS levels were detected in all treatment groups compared to control. These findings suggested that maternal tobacco smoke and/or ALA administration may be leading to the impaired reproductive health of female offspring. Abbreviations: ALA: alpha-lipoic acid; LH: luteinizing hormone; FSH: follicle-stimulating hormone; TAS: total antioxidant status; TOS: total oxidant status; Apaf1: apoptotic protease-activating factor 1; Casp3: caspase 3; Casp9: caspase 9; CF: cyst follicles; 4-HNE: 4-Hidroxynonenal; 8-OHdG: 8-hydroxydeoxyguanosine; TUNEL: terminal deoxynucleotidyl transferase-mediated deoxyuridine-biotin nick end labeling; ROS: reactive oxygen species; GnRHR: gonadotropin-releasing hormone receptor; HPG: hypothalamic-pituitary-gonadal; AMPK: AMP-activated protein kinase; ELISA: enzyme-linked immunosorbent assay; cDNA: complementary DNA; qPCR: quantitative real-time PCR; FC: follicular cysts; PF: primary follicle; SF: secondary follicle; GF: graafian follicle; CL: corpus luteum; DF: degenerated follicle; AF: atretic follicle.Article Citation - WoS: 1Citation - Scopus: 1Effect of Auricular Acupressure in Management of Constipation in Palliative Care Patients(Sage Journals Home, 2023) Bıçak Ayık, Derya; Can, Gülbeyaz; Department of Midwifery/ Ebelik BölümüObjectives: This experimental randomized-controlled study was performed to define the efficacy of auricular acupressure (AA) in the management of constipation developing in palliative care patients. Methods: According to the pre-prepared randomization list, 44 patients were included in the experimental group and 46 patients were included in the control group. Routine clinical treatment and care implementation were maintained in the patients in both groups. AA was performed for 4 weeks in patients in the experimental group. During the study, to determine the complaints of the patients regarding constipation, the information in the daily patient chart was examined at least 5 times by interviewing with the patient/patient's relative in the clinic and/or via phone call, and the results were recorded in the patient chart and data collection forms. The independent variable of the study is AA application, and the dependent variables are constipation and quality of life. Results: It was determined that there was no statistically significant difference between the daily defecation frequency of the 2 groups during the first 11 days. However, after the 12th day, the daily stool frequency of the experimental group was higher compared to the control group and this difference obtained between the 2 groups was statistically significantly different. AA was effective in decreasing laxative use. Conclusion: This intervention increased stool frequency, reduced physical and psychosocial symptoms, anxieties, and improved stool satisfaction and it was an effective approach to improving the quality of life. It is recommended that the daily use of AA should be evaluated. The healthcare providers including nurses, patients, and patient relatives should be trained regarding AA.Article Citation - WoS: 0Citation - Scopus: 0Effect of Delivery Method on Breastfeeding Status in Primiparous Mothers Within the First 24 Hours(Springer Publishing Co, 2024) Yeşil, Yeşim; Bay, Habibe; Celik, Gulbiye Dinc; Bay, Habibe; Eksioglu, Aysun; Turfan, Esin Ceber; Department of Midwifery/ Ebelik Bölümü; Department of Nursing / Hemşirelik BölümüObjective: This study aims to evaluate the effect of the delivery method on breastfeeding status of primiparous mothers during the first 24 hours. Methods: In this descriptive and analytical study, the sample consisted of 126 primiparous mothers with vaginal (n = 54) and cesarean (n = 72) deliveries. The research data were collected in a hospital through a personal information form and LATCH. Breastfeeding was assessed at the 6th, 12th, and 24th hours within the first 24 -hour period after the delivery. Results: A total of 83.3% of mothers with vaginal delivery started out breastfeeding in the first hour, while the rate was 43.1% for mothers with cesarean delivery. A total of 94.4% of mothers who had vaginal birth gave their babies colostrum, whereas the rate was 80.6% for mothers who had a cesarean birth. While there were no statistically significant differences in Applications 1 and 3 between the LATCH scores of mothers with vaginal and cesarean deliveries, Application 2 produced a significant difference (p < .05). Conclusions: Delivery method influenced the breastfeeding behavior and had an impact particularly on initiation of breastfeeding in the first hour.Article Citation - WoS: 26Citation - Scopus: 37The effect of ethnocentrism and moral sensitivity on intercultural sensitivity in nursing students, descriptive cross-sectional research study(Nurse Education Today, 2021) Yaşar, Beril Nisa; Kaya, Yunus; Arslan, Sevda; Erbaş, Atiye; Küçükkelepçe, Gürhan Erkuş; Department of Midwifery/ Ebelik BölümüBackground: Factors affecting intercultural sensitivity and care are becoming an increasingly important issue due to ethnic diversity. Nurses play a crucial role in care and therefore should keep up with this trend and improve their intercultural sensitivity. Objective and design: This descriptive cross-sectional study investigated the effects of ethnocentrism and moral sensitivity on intercultural sensitivity in nursing students. Methods and participants: Data were collected using a demographic characteristics questionnaire and the Intercultural Sensitivity Scale, Generalized Ethnocentrism Scale, and Moral Sensitivity Scale. The sample consisted of 1343 nursing students. The Pearson correlation coefficient was used to determine correlations between scale scores. Multiple linear regression was used to determine the effects of ethnocentrism, moral sensitivity, and demographic characteristics on intercultural sensitivity. Results: Intercultural sensitivity was found to be negatively correlated with ethnocentrism and positively correlated with moral sensitivity. Ethnocentrism predicted intercultural sensitivity more than moral sensitivity. Ethnocentrism and moral sensitivity explained 16.8% of the total variance of intercultural sensitivity. However, ethnocentrism affected intercultural sensitivity more than moral sensitivity did (beta = −0.406). Conclusion: Nursing education should adopt strategies to reduce ethnocentrism by helping students develop cultural competence and intercultural sensitivity. Such education can equip nurses to provide higher quality care to patients of different cultural backgrounds.Article Citation - Scopus: 5The effect of hospital-based breastfeeding group education given early perinatal period on breastfeeding self-efficacy and breastfeeding status(ScienceDirect, 2022) Yeşil, Yeşim; Ekşioğlu, Aysun; Ceber Turfan, Esin; Department of Midwifery/ Ebelik BölümüAim: This study was conducted to examine the effect of hospital-based group breastfeeding education provided to mothers before discharge from the hospital on mothers’ self-efficacy and on the increase of breastfeeding rates. Methods: This randomized controlled educational research was conducted in the hospital is located in the West of Turkey. Ninety mothers who had healthy and term babies, and an intent to breastfeed their babies participated in the study. The questionnaire forms were collected by the researcher using face to face interview technique. Chi-square, dependent and independent groups t-test and ANOVA analysis were used along with descriptive statistics in analyzing the data. Results: Compared to the control group, the scores obtained from the Breastfeeding Self-Efficacy Scale were higher in the education group in all the follow-ups. Similarly, status of exclusive breastfeeding was higher in the education group compared to the control group. In the twelfth week, the rate of exclusive breastfeeding was 80.0% in the education group, while it was 47.5% in the control group. Conclusion: These results show that breastfeeding group education and follow-up counseling given before discharge from the hospital were effective. This is evidence in favor of increasing the use of group education. This RCT was registered NCT04515862 with www.clinicaltrials.gov on 2020.Conference Object Citation - WoS: 0Effects of Maternal Tobacco Smoke or Alpha Lipoic Acid on Puberty Onset, Estrous Cycle and Gonadotropin Levels in Female Rats(KARGER, 2018) Erdem Güzel, Elif; Yardimcı, Ahmet; Kaya, Nihat; Tektemur, Ahmet; Akkoç, Ramazan Fazıl; Erdem Güzel, Elif; Canpolat, Sinan; Ozan, Enver; Department of Midwifery/ Ebelik BölümüVarious environmental factors are known to affect puberty onset. However, there are few studies in literature about how maternal tobacco smoke (ts) or alpha lipoic acid (ala) affect the hypothalamus-pituitary-gonadal axis at peripheral or central levels in rats. This study aimed to investigate effects of maternal tobacco smoke or alpha lipoic acid on puberty onset, estrous cycle and serum gonadotropin levels in female rats. Adult female spraque-dawley rats were used. All animals were randomly divided into 4 groups (control, ts, ts+ala and ala) and each group consisted of 7 rats. All ts rats were exposed to ts (20 gram\day, for one hour twice a day) and all ala rats received daily oral ala (20 mg/kg) during 8 week. Afterwards all rats were impregnated, ts or ala treatments continued during pregnancy. All treatments ended with birth and later newborn female rats were selected for each group (n=7). Puberty onset was monitored by examination of vaginal opening in female rat pups. Subsequently, estrous cycle was conducted daily for 15 days and determined by examination of the vaginal smear cytology. Also, serum fsh and lh levels were measured using elisa method at the end of the experiment. There was significantly advanced on puberty onset day for ts group (p<0.05). There was a significantly increase in pubertal weight in ala group compared to control group (p<0.001). The mean total number of estrous cycles and average duration of metestrus, diestrus, proestrus or estrus phases were not significantly different in all treatments groups compared to control group. There was no any significant change in serum fsh levels, but serum lh levels were significantly increased in all treatment groups compared to control group (p<0.05). Present study showed that maternal tobacco smoke or alpha lipoic acid may affect hypothalamus-pituitary-gonadal axis differently in rats.Article Citation - WoS: 0Citation - Scopus: 0Evaluation of Nurses' and Midwives' Knowledge and Attitudes Towards Recognizing Violence Against Women(Womens Health & Action Research Centre, 2024) Yeşil, Yeşim; Yesil, Yesim; Department of Midwifery/ Ebelik BölümüThe study was cross-sectional research that surveyed 410 nurses and midwives from March 2020 to March 2021 in Turkey. The aim of this study was to evaluate the knowledge and attitudes of nurses and midwives towards recognizing violence against women. The "Scale for Nurses' and Midwives' Recognition of the Symptoms of Violence against Women" were used. The average total scale score was 20.3 +/- 3.2. The score of participants who are receiving postgraduate education, working in the field of gynaecology and obstetrics, and considering intervention as a professional responsibility when encountering a woman who has experienced violence was found to be significantly higher than the other groups (p<.05). It is important for midwives and nurses to be aware of signs of violence to identify violence against women. Providing education to midwives and nurses regarding signs of violence against women will contribute to the recognition, prevention, and awareness of violence. (Afr J Reprod Health 2024; 28 [2]: 116-124)Article Citation - Scopus: 0Factors Affecting the Burden and Quality of Life of Caregivers for Gynecological Cancer Patients(Archives of Health Science and Research, 2022) Yaşar, Beril Nisa; Terzioğlu, Füsun; Department of Midwifery/ Ebelik BölümüObjective: The aim of this study is to evaluate the care burden and quality of life of caregivers of patients with gynecologic cancer. Material and Methods: This descriptive study was conducted with 251 individuals who provided care to patients with gynecologic cancer in gynecologic oncology services of a university hospital and a state oncology hospital. The data were collected by a semi-structured questionnaire form, Caregiver Burden Inventory (CBI), and Quality of Life Family Version. Results: The mean age of the participants was 39.76 ± 14.20; 79.3% of them were female, 65.3% were married, 28.7% were high school graduates, 57.4% were employed and 56.2% were unemployed before starting care, 91.2% had health insurance, 58.6% perceived their income as moderate, and 57% had relatives of the patient receiving care. Care burden was statistically significant in terms of gender, marital status, educational level, and degree of affinity with the patient (P < .005). The correlation between caregivers’ quality of life, gender, health insurance, income status, and the degree of affinity with the patient was statistically significant (P < .005). Conclusion: As a result of this study, it was determined that some socio-demographic characteristics of the caregivers of patients with gynecologic cancer affected the care burden and quality of life.Article Citation - WoS: 12Citation - Scopus: 12Hesperetin may alleviate the development of doxorubicin-induced pulmonary toxicity by decreasing oxidative stress and apoptosis in male rats(Elsevier, 2021) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Department of Midwifery/ Ebelik BölümüDoxorubicin (DOX) is one of the most widely used chemotherapeutic agents. However, it causes pulmonary toxicity which decreases its clinical use in human cancer therapy. The present study was undertaken to obtain an insight into the potential protective effect of hesperetin (HES) against doxorubicin-induced pulmonary toxicity in rats. The animals were divided into 4 groups with 7 rats per group. The experimental treatments were as follows: Control, DOX, DOX + HES, and HES groups. DOX was administered at the dosage of 15 mg/kg i.p for a single dose. HES was administered at the dosage of 50 mg/kg by oral gavage every other day. After 28 days, biochemical parameters, oxidative stress status, histopathological changes, apoptosis-related genes and apoptotic index (AI) were examined of lung tissue. Histopathological changes, Poly [ADP-ribose] polymerase 1 (PARP-1), Caspase-3 (Casp3), Cytochrome c (Cytc), apoptosis-related genes, and AI significantly increased in the DOX group relative to the control group. Malondialdehyde (MDA) significantly increased, while superoxide dismutase (SOD) and glutathione peroxidase (GPx) decreased in the DOX group relative to the control group. However, histopathological findings, MDA, AI, and PAPR1, Casp3 protein expression, mRNA expression of Cytc significantly decreased, while SOD, GPx increased in the DOX + HES group relative to the DOX group. These results attested HES might be a potential agent for the treatment of DOX-induced pulmonary toxicity.Article Citation - WoS: 5Citation - Scopus: 5King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes), Extract Can Attenuate Doxorubicin-Induced Lung Damage by Inhibiting Oxidative Stress in Rats(International Journal of Medicinal Mushrooms, 2023) Erdem Güzel, Elif; Tektemur, Ahmet; Güzel, Elif Erdem; Department of Midwifery/ Ebelik BölümüDoxorubicin (DOX), a broad spectrum chemotherapeutic, has toxic effects on healthy tissues. Mitochondrial processes and oxidative stress act in the DOX-induced toxicity, therefore antioxidant therapies are widely used. The study was aimed to evaluate the therapeutic potential of Pleurotus eryngii extract (PEE), an extract of a fungus with antioxidant properties, against DOX-induced lung damage. Rats were divided into Control, DOX, DOX + PEE, and PEE groups (n = 6). DOX was administered intraperitoneally in a single dose (10 mg/kg BW) and PE (200 mg/kg BW) was administered by oral gavage every other day for 21 days. Histopathological evaluations, immunohistochemical analyses, total oxidant status (TOS)/total antioxidant status (TAS) method, and quantitative real-time polymerase chain reaction (qRT-PCR) analysis were performed. DOX led to severe histopathological disruptions in rat lungs. Also, DOX remarkably increased the expression of dynamin 1 like (DRP1) and decreased the expression of mitofusin 1 (MFN1) and mitofusin 2 (MFN2) genes, which are related to mitochondrial dynamics. Moreover, DOX caused an increase in TOS/ TAS and 8-hydroxy-2-deoxyguanosine (8-OHdG) levels. On the other hand, PEE treatment remarkably normalized the histopathological findings, mitochondrial dynamics-related gene expressions, markers of oxidative stress, and DNA damage. The present study signs out that PEE can ameliorate the DOX-mediated lung toxicity and the antioxidant mechanism associated with mitochondrial dynamics can have a role in this potent therapeutic effect.Book Part PERİMENOPOZAL UTERİN KANAMALAR(Akademisyen Yayınevi, 2022) Gündüz, Ülkin; Kurt, Nuray; Department of Midwifery/ Ebelik BölümüKadın hayatının önemli evrelerinden biri olan menopoz, yaşamın doğal ve sağlıklı bir sürecidir. Menopoz, overlerin aktivitesinin durması ile 12 aylık amenoreyi takiben tespit edilen, hormonal ya da patolojik sebeplerle açıklanamayan menstrüasyonun tamamen sonlanmasıdır. Overdeki morfolojik ve fonksiyonel değişmelere bağlı hormonal dengenin bozulması, özellikle östrojen eksikliği sonucu fizyolojik bir olayın, yaşamı ve yaşam kalitesini bozan patolojik bir döngüye girmesine sebep olmaktadır.Book Part PRETERM EYLEM(AKADEMİSYEN YAYINEVİ, 2023) Gündüz, Ülkin; Kurt, Nuray; Department of Midwifery/ Ebelik BölümüGebelik, yaşamın normal bir evresi olarak kabul edilir. Gebelikte oluşabilecek komplikasyonların annenin ve yenidoğanın sağlığını tehdit etmeden kontrol altına alınabilmesi, ana-çocuk sağlığı hizmetlerinin başarı göstergesidir. Bu hizmetlerde sağlık profesyonellerinin rolü, risk durumlarının gebeliğe getireceği zararları önlemek için riski en erken evrede tanılamak ve alınabilecek tedbirlerle maternal-fetal sağlığı korumak olmalıdır. Sağlık profesyonelleri antenatal dönemde bakım sunarken, risklere ilişkin bilgileri tanımlayabilmeli, değerlendirebilmeli ve uygun yöntemleri planlayabilmelidirArticle Citation - WoS: 6Citation - Scopus: 7The relationship between unemployment anxiety, job satisfaction and migration attitude among the next generation of Turkish nurses: A cross-sectional study(Elsevier, 2023) Çiftçioğlu Yalçın, Gülcan; Köksoy Vayısoğlu, Sümbüle; Karadağ, Gülendam; Şahin Orak, Nuray; Selçuk Tosun, Alime; Doğan Yüksekol, Özlem; Çatıker, Aslıhan; Çiftçioğlu Yalçın, Gülcan; Department of Midwifery/ Ebelik BölümüBackground: The global nursing shortage is complex and multifaceted. Despite the policy of increasing the number of nurses, concerns about the sustainability of the nursing workforce in Turkey continue. Aim: To evaluate the relationship between unemployment anxiety, job satisfaction, and migration attitudes among Turkish nursing candidates. Methods: A cross-sectional study was conducted with 1100 nursing candidates between April and June 2022. The data gathered from the "Personal Form, Job Satisfaction, and Brain Drain Attitudes Scale" were analyzed using logistic regression and decision tree analysis. Results: Of the participants, 67.1% were female, and the mean age was 22.6 ± 1.7 years. Being male (OR = 1.317, 95% Cl 0.994-1.743) having a low income (OR = 1.754, 95% Cl 1.334-2.306), feeling insecure about the future (OR = 2.340, 95% Cl 1.312-4.175), expecting a lower wage than desired (OR = 2.015, 95% Cl 1.132-3.586), and employment precariousness (OR = 1.786, 95% Cl 1.355-2.353) increase the possibility of experiencing high unemployment anxiety. On the other hand, family support for living abroad (OR = 0.579, 95% CI 0.408-0.821) and job satisfaction (OR = 0.799, 95% CI 0.692-0.921) decrease unemployment anxiety (p < 0.05). According to the results of the decision tree analysis, the host country's pull factors are the best predictors of the nursing candidates' intention to work abroad as nurses (p < 0.05). Conclusion: The increasing prevalence of unemployment anxiety and migration tendencies among nursing candidates requires the evaluation of policies aimed at increasing the number of nursing graduates in Turkey.Article Citation - WoS: 1Citation - Scopus: 2A retrospective descriptive study of NANDA-I nursing diagnoses used by midwives working in obstetrics and gynecologic service: An example from south-eastern Turkey(Wiley Online Library, 2023) Yeşil, Yeşim; Baran, Leyla; Department of Midwifery/ Ebelik Bölümü; Department of Social Services/ Sosyal Hizmet BölümüPurpose: This study aims to identify NANDA-I nursing diagnoses that midwives working in obstetrics and gynecologic service use while managing the electronic nursing care process. Methods: This retrospective study was conducted in a descriptive way to evaluate electronic care plan records of 3025 patients staying in obstetrics and gynecologic service between April 1, 2020. and April 1, 2021. Diagnoses in the records of the electronic care process were digitalized by two faculty members. Then, NANDA-I nursing diagnoses used by midwives were identified. NANDA-I nursing diagnoses used by midwives were identified. Findings: It was determined that diagnoses in care plans documented from the system within the 1-year period fell into eight domains and 10 classes, and 5819 diagnoses were given in total. The most frequent diagnoses given in obstetrics and gynecologic service were "acute pain" and "risk for bleeding." Conclusion: Findings of this study revealed that nursing care records in obstetrics and gynecologic service did not have a large number of diagnoses and interventions. Implications for nursing practice: Care plans directly reflect the contribution of the care to the patient. Consequently, midwives being aware of and recording nursing diagnoses while giving care will ensure a standardized language and visibility in care. More coverage of midwifery-related diagnoses in the midwifery curriculum will make NANDA-I nursing diagnoses more visible in midwifery as well.Article Citation - WoS: 1Citation - Scopus: 1The effect of frailty levels of older individuals on their mental well-being and depression levels(Wiley, 2024) Ayik, Derya Bicak; Bıçak Ayık, Derya; Cengiz, Zeliha; Isik, Kevser; Department of Midwifery/ Ebelik BölümüBackground: Frailty has become an important public health issue. This study was conducted to determine the effect of frailty levels of older individuals on their mental well-being and depression levels. Methods: This descriptive cross-sectional study was conducted with a total of 325 older individuals aged 60 years and over. A demographic questionnaire form, the FRAIL Frailty Scale, the Warwick-Edinburgh Mental Well-Being Scale, and the Geriatric Depression Scale-Short Form were used to collect data. Data were evaluated using the SPSS 25.0 package program. Number, percentage, mean, standard deviation, Chi-square, correlation, and multiple regression analyses were used. Results: The mean age of the older individuals was 69.56 +/- 7.75 years, and the variables of age, education level, income status, the person they were living with, regular medication use, forgetting to take medication, urinary incontinence, hospitalisation, and accidents were found to affect both frailty and depression (P < 0.05). There was a positive correlation between frailty and depression (r: 0.460, P < 0.001) and a negative correlation between mental frailty and well-being (r: -0.391, P < 0.001). Socio-demographic variables, depression, and mental well-being had a 40% effect on frailty (P < 0.001). Conclusion: Depression status and mental well-being level are related to frailty, so negativity in one of them negatively affects the other. In line with these results, it is recommended to determine the level of depression and mental well-being of older individuals with high risk of frailty, and according to the results of the research, to provide care and support regarding the predictors affecting frailty.Article Citation - WoS: 9Citation - Scopus: 11The therapeutic effect of hesperetin on doxorubicin-induced testicular toxicity: Potential roles of the mechanistic target of rapamycin kinase (mTOR) and dynamin-related protein 1 (DRP1)(Elsevier, 2022) Erdem Güzel, Elif; Kaya Tektemur, Nalan; Erdem Güzel, Elif; Department of Midwifery/ Ebelik BölümüClinical utilization of doxorubicin (DOX), which is a commonly used chemotherapeutic, is restricted due to toxic effects on various tissues. Using hesperetin (HST), an antioxidant used in Chinese traditional medicine protects testis against DOX-induced toxicity although the molecular mechanisms are not well-known. The study was aimed to examine the possible role of the mechanistic target of rapamycin kinase (mTOR) and dynamin 1-like dynamin-related protein 1 (DRP1) in the therapeutic effects of HST on the DOX-induced testicular toxicity. Rats were divided into Control, DOX, DOX + HST, and HST groups (n = 7). Single-dose DOX (15 mg/kg) was administered intraperitoneally and HST (50 mg/kg) was administered by oral gavage every other day for 28 days. Total antioxidant status (TAS), histopathological evaluations, immunohistochemistry, and gene expression level detection analyses were performed. Histopathologically, DOX-induced testicular damage was ameliorated by HST treatment. DOX reduced testicular TAS levels and increased oxidative stress markers, 8-Hydroxy-deoxyguanosine (8-OHdG), and 4-Hydroxynonenal (4-HNE). Also, upregulated mTOR and DRP1 expressions with DOX exposure were decreased after HST treatment in the testis (p < 0.05). On the other hand, DOX-administration downregulated miR-150-5p and miR-181b-2-3p miRNAs, targeting mTOR and mRNA levels of beclin 1 (BECN1) and autophagy-related 5 (ATG5), autophagic markers. Furthermore, these levels were nearly similar to control testis samples in the DOX + HST group (p < 0.05). The study demonstrated that HST may have a therapeutic effect on DOX-induced testicular toxicity by removing reactive oxygen species (ROS) and by modulating the mTOR and DRP1 expressions, which have a critical role in regulating the balance of generation/elimination of ROS.Book Part Yenidoğanda Özel Uygulamalar II Bebek Masajı Refleksoloji(Anadolu Nobel Tıp Kitabevleri, 2020) İçke, Sibel; İçke, Sibel; Department of Midwifery/ Ebelik BölümüRefleksoloji bebeklerde ve her yaşta etkili olabilecek bir uygulamadır.
