Browsing by Author "Baran, M.F."

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Advances in Nano Vaccines: Covid-19
(Bentham Science Publishers, 2023) Keskin, Cumali; Nasibova, A.; Hoseinnejhad, S.; Selimoğlu, A.; Baran, M.F.; Keskin, C.
Nanovaccines are considered a new approach in vaccination methodology specially for Covid-19 infection. Nanovaccines are more effective than conventional vaccines; Because ofhumoral and cellular immune responses which are simultaneously induced. Nano vaccines are assumed to upregulate the immune system as well as infection prevention. They are probably promising candidates for chronic autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, AIDS, and COVID-19 infectious. Based on this, we will describe the different working mechanisms of nanoparticles. In addition, applicable nano vaccines which have been approved for COVID-19 therapy Covid 19 are described. Antigen-carrying nanoparticles can affect the immune response and significantly enhance cell-T cytotoxic response. Nanoscale particles can improve vaccine efficiency because of their biomedical benefits. These properties include Small size, which allows better penetration into tumors and more half-life tumor cells. Current vaccines, however, are required to re-formulate almost because of gradual antigen modifications. More ever these vaccines do not protect against mutations and the low half-life of current vaccines due to limitations of current technologies. Nano vaccine formulation improvements have been required to induce a widespread and potent immune response. In this review, we provide an overview ofthe types and applications of nanoparticles in vaccines and their outstanding properties that made them alternatives for Covid-19 treatment. © 2023, Bentham Books imprint.
Effects of Zno Nanoparticles and Ethylenediamine-N,n Acid on Seed Germination of Four Different Plants
(John Wiley and Sons Inc, 2019) Doğaroğlu, Z.G.; Eren, Abdullah; Eren, A.; Baran, M.F.
The release of nanoparticles and biodegradable chelating agents into the environment may cause toxicological and ecotoxicological effects. The aim of this study is to determine the ecotoxic effects of zinc oxide (ZnO) nanoparticles and ethylenediamine disuccinic acid (EDDS) on most cultured four plants. The durum wheat, bread wheat, barley, and rye are exposed to 5 mL 10 mg L−1 ZnO nanoparticles and 10 mg L−1 EDDS in the seed germination stage. Results show that these different plant species have different responses to ZnO nanoparticles and EDDS. The germination percentage of bread wheat and rye decreases in the application of ZnO nanoparticles while the germination of durum wheat and barley increases as much as in radicle elongation and seedling vigor. While ZnO treatment causes a decrease in bread wheat and rye germinated rat in the range of 33–14.3%, respectively, there is no change in germination rate of these plants at EDDS treatment. In addition, EDDS treatment positively affects barley germination rate. In conclusion, it is clear that ZnO nanoparticles have more toxic effects on bread wheat and rye than EDDS, while barley is positively affected by ZnO nanoparticles and EDDS. © 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Green-Synthesized Nanoparticles for Biomedical Sensor Technology
(Elsevier, 2024) Keskin, Cumali; Baran, M.F.; Ipek, P.; Eftekhari, A.; Keskin, C.; Atalar, M.N.; Alma, M.H.
Sensor technology is an integral part of the many cost-effective and efficient factors possible in modern medical devices. Biosensors have good potential as they are easy, scalable, and effective in manufacturing processes. Nanotechnology has become one of the promising technologies applied in all fields of science. Biotechnologically produced metallic nanoparticles (NP) attract attention in scientific applications and technology platforms due to their extensive applications in biomedical and physiochemical fields. In recent years, the side effects caused by the use of synthetic drugs and the medical and economic problems caused by them have made the use of plants popular again. Ecofriendly, nontoxic metal-based NPs (such as gold, silver, palladium, manganese, and zinc) smaller than 100nm in size can be synthesized with extracts obtained from plants by different methods. As the sizes and shapes of NPs change, the physical, chemical, bioactive, optical, electrical, catalytic, and toxicity properties of the particles also change. Biological synthesis, also known as green synthesis, is a practical method to obtain NPs easily and ecologically without the need for high pressure, high-temperature values, and toxic chemicals. Green synthesis of NPs is carried out using different biomaterials such as bacteria, fungi, yeast, viruses, microalgae, and plant biomass/essence. Plant-mediated biosynthesis of metallic NPs occurs through biomolecules containing organic functional groups in the plant. Nanobiosensors, analytical devices combining a biologically sensitive element with a nanostructured transducer, are widely used for the molecular detection of biomarkers associated with the diagnosis of diseases and the detection of infectious organisms. Nanobiosensors show certain advantages over laboratory and many field methods due to their inherent specificity, simplicity, and rapid response. In this study, advancements in the development of nanobiosensors are illuminated. Considering all these aspects, it can be said that nanobiosensors enable diagnostic tools with increased sensitivity, specificity, and reliability for medical applications. © 2025 Elsevier Inc. All rights reserved.
Miracle Plants of Turkey: Their Use in Traditional as Well as Modern Medicine
(CRC Press, 2024) Yıldıztekin, M.; Çelebioğlu, B.; Kartal, B.; Baran, M.F.; Kanber, S.; Yıldıztekin, F.
Plants have been utilized in a variety of ways throughout history due to the broad-spectrum or particular components they contain. The mentioned parts are traditionally utilized as raw materials in the treatment of ailments or the creation of medications. The Food and Agriculture Organization of the United Nations (FAO) defines medicinal plants as ‘plants that are medicinal and therapeutic to humans for the aim of avoiding diseases, maintaining health, and healing disorders’. Plants used in folk medicine are the first healing approach employed by individuals living in rural areas. The challenges and costs of receiving modern treatments, as well as insufficient medical treatments, have all contributed to the formation of this predicament. In terms of plants used in traditional medicine, Turkey has a particularly rich flora. When compared to global averages, Turkey has a greater rate of plant use in traditional medicine. Locals employ medicinal herbs to treat a variety of ailments. Examples of main areas of application include cardiovascular diseases, endocrine system abnormalities, respiratory system diseases, urinary system diseases, internal diseases, dermatological diseases, digestive system diseases, muscle and joint problems, and cancer cases. The type of plant and the portions used vary depending on the ailment being treated; traditional medicines are prepared in a variety of ways, such as brewing, boiling, chewing, mashing, or water suspension. Given that Turkey’s cultural heritage extends back to ancient times, it is critical to collect and record all of this rich information from the past to the present. Plants used in traditional folk medicine in various parts of Turkey were brought together in this study, with the goal of revealing how and which ailments our country’s diverse plant species are used to treat. © 2025 Taylor & Francis Group, LLC.