Browsing by Author "Dogan, Yusuf"

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Activated Carbon-Coated Iron Oxide Magnetic Nanocomposite (ionps@ctac) Loaded With Morin Hydrate for Drug-Delivery Applications
(Frontiers Media Sa, 2024) Dogan, Yusuf; Ozic, Cem; Ertas, Erdal; Baran, Ayse; Rosic, Gvozden; Selakovic, Dragica; Eftekhari, Aziz; Doğan, Yusuf
Cancer is a major disease that affects millions of people around the world every year. It affects individuals of all ages, races, and backgrounds. Since drugs used to treat cancer cannot distinguish between cancerous and healthy cells, they cause systemic toxicity along with serious side effects. Recently, controlled drug-release systems have been developed to reduce the side effects caused by anticancer drugs used for treatment. Morin is an anticancer drug with a flavonol structure. It has been extensively researched for its antioxidant, anti-inflammatory, antitumoral, and antibacterial properties, especially found in Chinese herbs and fruits, and its multiple positive effects on different diseases. In this study, a nanocomposite with magnetic properties was synthesized by coating biocompatible activated carbon obtained using the fruits of the Celtis tournefortii plant on the surface of iron oxide magnetic nanoparticles. Characterization of the synthesized activated carbon-coated iron oxide magnetic nanocomposite was confirmed by Fourier transform infrared, scanning electron microscopy, energy-dispersive X-ray spectrometry, X-ray diffraction, dynamic light scattering, zeta potential, and vibrating sample magnetometry. The cytotoxic effects of the drug-loaded magnetic nanocomposite were examined in HT-29 (colorectal), T98-G (glioblastoma) cancer cell lines, and human umbilical vein endothelial cell (HUVEC) healthy cell line. The morin loading and release behavior of the activated carbon-coated iron oxide magnetic nanocomposite were studied, and the results showed that up to 60% of the adsorbed morin was released within 4 h. In summary, activated carbon-coated iron oxide magnetic nanocomposite carriers have shown promising results for the delivery of the morin drug.
Evolotion Barley Genotypes in Multi-Environment Trials by Ammi Model and Gge Biplot Analysis
(Parlar Scientific Publications (p S P), 2019) Oral, Erol; Kendal, Enver; Kilic, Hasan; Dogan, Yusuf; Doğan, Yusuf; Oral, Erol; Kendal, Enver
The uniformity of genotypes are significant for crop breeding program decisions to improve new varieties. The AMMI (Additive main effects and multiplicative interaction) analysis and Genotype x Environment Interaction (GEI) is make to estimation grain yield and understands GxE interaction patterns by researches as differential ranking of variety yields in multi-environment trials. Therefore, fifteen barley advanced line and six national cultivars and four foreign varieties (registered in abroad) were used in the study. The experiments were performed according to a complete randomized block design with four replications at five environments during two years. The stability and superiority of genotypes for yield and other traits were determined using AMMI and GGE biplot analysis. Factors (G, GE, and GEI) were found to be highly significant (P < 0.01) for grain yield. AMMI analysis indicated that the major contributions to treatment sum of squares were environments (98.52%), GE (0.45%) and genotypes (1.02%), respectively, suggesting that grain yield of genotypes were effected environmental conditions. The GGE biplot indicated that PCA 1 axes (Principal component) was significant as P<0.01 and supplied to 49.36% of complete GxE interaction. The AMMI indicated that G8 and G23 desirable and stabile genotypes for grain yield in multi-environment. Moreover, E2 and E5 (irrigated environments) were high yielding, while E3 (drought stress) low yielding as forecast. On the other hand, GGE biplot indicated that three group were occurred among traits, first group (GY: grain yield, CC: crude cellulose, CD: cold damage), second group (PC:, HVV: hectoliter weight, TGW: thousand grain weight, SH: seed humidity), third group (LOD: lodging, PH: plant height, HT: heading time). Moreover: the study showed that G3, G6, G7, G8, G13 and G21 were the best genotypes both grain yield and other traits. The results of AMMI model and GGE biplot indicated that G8 is suitable to recommend for release and G23 desirable origin for yield stability and G7 valuable source for quality to use in barley breeding program.
Zinc Oxide Nanoparticles for Sustainable Agriculture: a Tool To Combat Salinity Stress in Rice ( Oryza Sativa) by Modulating the Nutritional Profile and Redox Homeostasis Mechanisms
(Elsevier, 2025) Dogan, Yusuf; Alam, Pravej; Sultan, Haider; Sharma, Renuka; Soysal, Sipan; Baran, Mehmet Firat; Faizan, Mohammad; Doğan, Yusuf
The use of nanoparticles (NPs) as an amendment to reduce salt toxicity has gained much attention. Keeping in mind, this research work was done to evaluate the effect of zinc oxide NPs (ZnO-NPs) to mitigate the salt stress in rice (Oryza sativa) plant. Rice plants were subjected to salt stress (150 mM of NaCl) at 15 days of sowing through the soil. ZnO-NPs were characterized by Scanning electron microscopy (SEM), Transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR) and were applied foliar at concentration of 100 mg/L for five consecutive days (26-30 DAS). The results confirmed the salt toxicity and reduced shoot length (27 %), root fresh weight (31 %), SPAD chlorophyll (29 %), net photosynthetic rate (24 %), and nitrogen (N), phosphorus (P), potassium (K) and zinc (Zn) uptake by 9 %, 11 %, 13 % and 17 % respectively, while salinity increased the activity of antioxidant enzymes, proline, hydrogen peroxide (H2O2), and malondialdehyde (MDA) content in rice plants. However, in plants grown under salt stress, foliar application of ZnONPs significantly improved growth, photosynthesis, nutrient uptake and antioxidant enzymes activity. Beside, ZnO-NPs reduced salinity-induced oxidative stress by lowering H2O2 and MDA content. Therefore, our research showed that ZnO-NPs is useful and efficient in encouraging growth and lessening salinity stress in rice plants.