Browsing by Author "Karadağ, Musa"

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Determination of Volatile Organic Compounds in Different Parts of Hibiscus Syriacus L. by Spme/Gc-ms Method
(2024) Baran, Ayşe; Güneş, Zübeyir; Baran, Ayşe; Güneş, Zübeyir; 16.03. Department of Medical and Aromatic Plants / Tıbbi ve Aromatik Bitkiler Bölümü; 16. School of Vocational Higher School of Kızıltepe/ Kızıltepe Meslek Yüksekokulu; 01. Mardin Artuklu University / Mardin Artuklu Üniversitesi
Aromatic plants are plants with a wide range of traditional uses. One of the areas of medical use is their consumption for nutritional purposes. Aromatic plants have been used for thousands of years for their preservative and medicinal properties and for enhancing the aroma and flavor of foods. Hibiscus species L. are among the aromatic plants widely used in Türkiye. Studies have shown that Hibiscus species L. have antiinflammatory, antibacterial, antifertility, antifungal, antioxidative, antihypertensive, and hypoglycaemic effects. The use of aromatic plants for therapeutic purposes for centuries has made their compounds the research subject. Gas chromatography-mass spectroscopy (GC-MS) was combined with solid phase microextraction (SPME) to determine volatile organic compounds. Twenty-nine volatile organic compounds were determined from different parts of H. syriacus L. species. The compounds with the highest content are carvacrol, thymol, eucalyptol, and linalool. The compounds with the highest ratios determined in the flower, seeds, leaves, and buds of Hibiscus syriacus L. were carvacrol (57.93 %), carvacrol (31.50 %), thymol (44.53 %) and carvacrol (54.54 %), respectively.
Evaluation of Antioxidant, Cytotoxicity and Antimicrobial Effects of Achillea Millefolium (YARROW) and Determination of Phytochemicals
(2025) Atalar, Mehmet Nuri; Öziç, Cem; Tel, Ahmet Zafer; Baran, Mehmet Fırat; Arslan, Sevki; Karadağ, Musa; Mensure,
Achillea millefolium (A. millefolium) is one of the medicinal plants growing naturally in Anatolia and widely used in the treatment of many diseases, especially infectious diseases and digestive diseases. In this study, the determination of phenolic compounds, antioxidant, cytotoxic, and antimicrobial effects of plant extract of traditional A. millefolium were investigated. Phenolic compound analysis of the extract of the yarrow plant obtained with methanol was carried out by liquid chromatography-electrospray ionization-tandem mass spectrometry (LC–ESI–MS/MS). Antimicrobial effect was determined by the minimum inhibitory concentration (MIC) method and cytotoxicity analyses were carried out on androgen-dependent prostate cancer cells (LNCaP), human embryonic kidney 293 cancer cell lines (HEK293), and colorectal adenocarcinoma (CaCO-2) cell lines by the MTT method. Total antioxidant capacity was determined by the DPPH free radical scavenging activity determination method. In the determination of antimicrobial activity, it was tested on gram-positive Bacillus subtilis (B. subtilis.), gram-negative Escherichia coli (E.Coli) and Candida albicans (C. albicans) fungi. Among total phenolics, chlorogenic acid, caffeic acid, and salicylic acid were detected in high amounts. In the tests, the highest cytotoxic effect was shown on the LNCaP cell line, and the highest antimicrobial effect was shown on B. subtilis.