Browsing by Author "Kurnuc, Fatma Zehra"

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Evaluation of Visceral Adipokines: Omentin, Vaspin, and Visfatin in Patients With Gestational Diabetes Mellitus
(Imr Press, 2024) Balsak, Deniz; Aksin, Şerif; Bozbay, Nizamettin; Balsak, Deniz; Aboalhasan, Yasmin; Kurnuc, Fatma Zehra; Batmaz, Ibrahim
Background: Gestational diabetes mellitus (GDM) is a common metabolic disorder characterized by glucose intolerance that develops during pregnancy. The underlying pathophysiological mechanisms of GDM involve complex interactions between genetic, environmental, and hormonal factors, including adipokines secreted by visceral adipose tissue. Omentin, vaspin, and visfatin are adipokines believed to influence insulin sensitivity and inflammation, though their precise relationship with GDM remains unclear. This study aimed to examine the association between these adipokines and GDM. Methods: This single-center, prospective controlled cohort study included 87 pregnant patients diagnosed with GDM via an oral glucose tolerance test (OGTT) between the 24th and 28th weeks of gestation, along with 87 control subjects without GDM. Serum levels of omentin, vaspin, and visfatin were measured using enzyme-linked immunosorbent assay (ELISA), and their association with GDM was analyzed. Results: Our results demonstrated that omentin levels were significantly higher in the GDM group compared to the control group (p = 0.012), while no significant differences were observed in vaspin and visfatin levels (p > 0.05). An omentin cut-off value of 29.0 ng/mL predicted GDM with 59.1% sensitivity and 59.1% specificity, suggesting its potential as a biomarker for GDM. Conclusions: This study underscores the unique role of omentin in GDM, in contrast to the non-significant changes observed in vaspin and visfatin levels. The elevated omentin levels in GDM patients suggest its potential as a biomarker for diagnosing and managing GDM. Further research is needed to elucidate the mechanisms through which omentin contributes to the pathophysiology of GDM.
Relationship Between First Trimester Placental Thickness and Perinatal Prognosis: a Prospective Cohort Study
(Bayrakol Medical Publisher, 2025) Yilmaz, Mehmet; Aksin, Serif; Balsak, Deniz; Aboalhasan, Yasmin; Kurnuc, Fatma Zehra; Batmaz, Ibrahim
Aim: This study aims to investigate the correlation between first-trimester placental thickness and perinatal prognosis. Material and Methods: A prospective cohort study was conducted at Siirt University Faculty of Medicine from March 2022 to March 2023 of 365 pregnant women in their first trimester (11-14 weeks of gestation). Placental volume was measured using two-dimensional (2D) ultrasound, and estimated placental volume (EPV) was calculated using Merwin's EPV Calculator app. The patients were followed until delivery, and outcomes such as gestational age at delivery, mode of delivery, fetal weight, APGAR score, fetal gender, perinatal outcomes, preeclampsia (PE), premature rupture of membranes (PROM), gestational hypertension (GHT), gestational diabetes mellitus (GDM), intrauterine growth restriction (IUGR), preterm birth, oligohydramnios, polyhydramnios, surmaturation, presentation anomaly, intrauterine death, fetal distress, and placental abruption were evaluated. Results: Data from 365 pregnant women were analyzed. The mean maternal age was 27.2 +/- 5.5 years. The distribution of placental location was 38.4% posterior, 43.0% anterior, 7.4% left sidewall and 11.2% right sidewall. No significant differences were found in placental volume measurements based on delivery mode, fetal gender, or conditions such as PE, GDM, IUGR, PROM, preterm birth, or other perinatal pathologies. Statistical analyses showed no significant association between first-trimester placental volume and adverse perinatal outcomes (p>0.05). Discussion: No relationship was found between first-trimester placental thickness and perinatal outcomes.