Browsing by Author "Kuyucu, Yunus Emre"

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Relationship Between Lymph Node Metastasis and Lymph Node Density and Preoperative Neutrophil-Lymphocyte Ratio in Patients Undergoing Radical Cystectomy
(UROONKOLOJI BULTENI-BULLETIN OF UROONCOLOGY, 2021) Kölükçü, Engin; Atılgan, Doğan; Kuyucu, Yunus Emre; Unsal, Velid; Özbek, Latif Mustafa
Objective: This study aimed to evaluate the relationship between the preoperative neutrophil-lymphocyte ratio (NLR) and lymph node metastasis and lymph node density after radical cystectomy in patients with invasive urinary bladder cancer. Materials and Methods: Data of 89 patients who underwent radical cystectomy were examined. Our study included only cases with stage 2 urothelial bladder cancer. They were classified according to the lymph node status based on the surgical specimen. Patients with negative results were classified as group 1 and those with positive results as group 2. Patients in group 2 were further evaluated in two subgroups according to their lymph node density. Accordingly, group 2A consisted of patients with lymph node density of <20%, and group 2B involved those with lymph node density of ≥20%. Groups were compared statistically according to NLR. Results: Of the patients, 71 (79.8%) were male. The patients’ mean ages and neutrophil and lymphocyte counts were 67.36±8.64 years, 6.89±3.02 K/µL, and 3.08±2.18 K/µL, respectively. NLRs of groups 1 and 2 were 2.80±2.25 and 4.59±2.97, respectively. The relationship between group 1 and 2 tumors was significant (p=0.008). NLR values were 3.82±2.49 and 5.20±3.25 in groups 2A and 2B, respectively. However, no significant relationship was found between these values (p=0.235). Conclusion: Although no positive correlation was found between NLR and lymph node density, we think that this inflammation marker is an invaluable parameter to predict lymph node metastasis
Citation - WoS: 7
Citation - Scopus: 6
Protective effects of dexmedetomidine on ischaemia-reperfusion injury in an experimental rat model of priapism
(Andrologia, 2021) Unsal, Velid; Kölükçü, Engin; S. Parlaktaş, Bekir; Kölükçü, Vildan; Fırat, Fatih; Deresoy, Faik A.; Katar, Muzaffer; Kuyucu, Yunus Emre
The study aimed to investigate the effects of dexmedetomidine against ischaemia-reperfusion injury occurring after priapism in a model of induced-priapism in rats. A total of 18 male rats were randomised into three groups. Group 1 was the control group. A priapism model was performed rats in Group 2 and then ischaemia-reperfusion injury was evaluated. Group 3 had similar procedures to the rats in Group 2. Rats in Group 3 additionally had 100 μg/kg dexmedetomidine administered intraperitoneally immediately after reperfusion. Blood and tissue samples were analysed. Biochemical analysis of blood samples revealed a decrease in the levels of the pro-inflammatory cytokines including interleukin-1 beta (IL-1 Beta), interleukin-6 (IL-6), and tumour necrosis factor-alpha (TNF-alpha) in Group 3 compared to Group 2 (p:.04, p:.009 and p:.009, respectively). Similarly, the highest malondialdehyde (MDA) level was in Group 2 (p:.002). The levels of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities were significantly higher in Group 3 than that of Group 2 (p:.037 and p:.045, respectively). Direct microscopic examinations revealed positive changes in desquamation, oedema, inflammation and vasocongestion scores in Group 3 compared to Group 2 (p:.007, p:.008, p:.007 and p:.006, respectively). Dexmedetomidine has a protective effect against ischaemia-reperfusion injury in penile tissue.
Citation - WoS: 1
Citation - Scopus: 1
Possible Protective Effect of Remifentanil Against Testicular Ischemia-Reperfusion Injury
(Walter de Gruyter GmbH, 2024) Katar, Muzaffer; Gevrek, Fikret; Fırat, Fatih; Unsal, Velıd; Tapar, Hakan; Karaman, Tugba; Kuyucu, Yunus Emre
Objectives: This study aims to evaluate the protective effi- cacy of remifentanil against testicular ischemia-reperfusion injury. Methods: The study included 24 male rats. The rats were randomized into three groups: Group 1 was the control group. Group 2 was subjected to a testicular torsion/ detorsion model. Group 3 underwent similar procedures and additionally received remifentanil (0.6 μg/kg/min) intrave- nously for the first 20 min of reperfusion. Blood samples were taken for biochemical analyses, and orchiectomy was performed for histopathologic examination. Results: Biochemical analysis of blood samples showed a significant increase in antioxidant enzyme activity, including superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in Group 3 compared to Group 2 (p:0.004 and p:0.002, respectively). There was a dramatic decrease in the levels of proinflammatory cytokines, including interleukin-1 beta (IL-1 Beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in Group 3 compared to Group 2 (p:0.001, p:0.046, and p:0.004, respectively). Similarly, malondialdehyde (MDA) levels decreased in Group 3 compared to Group 2 (p:0.004). Histopathologic examination of Group 3 rats showed positive changes in inflammation, hemorrhage, edema, and conges- tion levels compared to Group 2 (p<0.001). Similarly, there was a positive effect on the Johnsen and Cosentino score in Group 3 compared to Group 2 (p:0.001 and p<0.001, respectively). Conclusions: In our study, it has been documented that remifentanil protects against testicular ischemia-reperfusion injury.