Browsing by Author "Nasibova, A."

Now showing 1 - 3 of 3

Advances in Nano Vaccines: Covid-19
(Bentham Science Publishers, 2023) Keskin, Cumali; Nasibova, A.; Hoseinnejhad, S.; Selimoğlu, A.; Baran, M.F.; Keskin, C.
Nanovaccines are considered a new approach in vaccination methodology specially for Covid-19 infection. Nanovaccines are more effective than conventional vaccines; Because ofhumoral and cellular immune responses which are simultaneously induced. Nano vaccines are assumed to upregulate the immune system as well as infection prevention. They are probably promising candidates for chronic autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, AIDS, and COVID-19 infectious. Based on this, we will describe the different working mechanisms of nanoparticles. In addition, applicable nano vaccines which have been approved for COVID-19 therapy Covid 19 are described. Antigen-carrying nanoparticles can affect the immune response and significantly enhance cell-T cytotoxic response. Nanoscale particles can improve vaccine efficiency because of their biomedical benefits. These properties include Small size, which allows better penetration into tumors and more half-life tumor cells. Current vaccines, however, are required to re-formulate almost because of gradual antigen modifications. More ever these vaccines do not protect against mutations and the low half-life of current vaccines due to limitations of current technologies. Nano vaccine formulation improvements have been required to induce a widespread and potent immune response. In this review, we provide an overview ofthe types and applications of nanoparticles in vaccines and their outstanding properties that made them alternatives for Covid-19 treatment. © 2023, Bentham Books imprint.
Interactions of Nanoparticles and Biological Systems
(Jomard Publishing, 2024) Keskin, Cumali; Nasibova, A.; Kavetskyy, T.; Kazımlı, L.; Keskin, C.; Bayramova, M.
This article investigates the effects of licorice root (Glycyrrhiza L.) syrup on laboratory rats exposed to ionizing gamma radiation, focusing on its potential radioprotective properties. Ionizing gamma radiation induces oxidative stress, characterized by an increase in free radicals and subsequent tissue damage, which can contribute to the development of various diseases such as neurodegenerative, cardiovascular, diabetes and kidney diseases. The body’s antioxidant defense mechanisms, including superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA), play crucial roles in combating oxidative stress. Historically recognized for its medicinal properties, licorice root may mitigate the harmful effects of radiation. The research employed Electron Paramagnetic Resonance (EPR) spectroscopy to analyze structural and functional changes in various biological systems under the influence of radiation and other stressors. This investigation aims to provide insights into the protective effects of licorice syrup, contributing to the understanding of potential therapeutic strategies against radiation-induced oxidative damage. As a continuation of the experiments, the levels of antioxidant enzymes in the rat’s erythrocytes were measured using various methods. Biochemical analyses conducted on the erythrocytes of the rats indicated positive effects of licorice syrup on the levels of SOD, CAT and MDA. © 2024, Jomard Publishing. All rights reserved.
Study of Endogenous Paramagnetic Centers in Biological Systems From Different Areas
(John Wiley and Sons Inc, 2021) Keskin, Cumali; Khalilov, R.; Abiyev, H.; Kavetskyy, T.; Trubitsin, B.; Keskin, C.; Eftekhari, A.
Plant leaves (Eldar pine (Pinus eldarica M.), fig (Ficus carica L.), and olive (Olea europaea L.)), collected in territories with different ecological conditions, of the Absheron Peninsula (Azerbaijan Republic) were studied by electron paramagnetic resonance spectroscopy (EPR). The generation of nanophase iron oxide magnetic particles in biological systems under the influence of stress factors was revealed. It was found that the process of biomineralization plays a role in the formation of biogenic iron oxide magnetic nanoparticles in plants and the generation of magnetite crystals in biological tissues, and stress factors have a stimulating effect on this phenomenon. Copyright © 2021 Aygun Nasibova et al.