Interactions of Nanoparticles and Biological Systems

Abstract

This article investigates the effects of licorice root (Glycyrrhiza L.) syrup on laboratory rats exposed to ionizing gamma radiation, focusing on its potential radioprotective properties. Ionizing gamma radiation induces oxidative stress, characterized by an increase in free radicals and subsequent tissue damage, which can contribute to the development of various diseases such as neurodegenerative, cardiovascular, diabetes and kidney diseases. The body’s antioxidant defense mechanisms, including superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA), play crucial roles in combating oxidative stress. Historically recognized for its medicinal properties, licorice root may mitigate the harmful effects of radiation. The research employed Electron Paramagnetic Resonance (EPR) spectroscopy to analyze structural and functional changes in various biological systems under the influence of radiation and other stressors. This investigation aims to provide insights into the protective effects of licorice syrup, contributing to the understanding of potential therapeutic strategies against radiation-induced oxidative damage. As a continuation of the experiments, the levels of antioxidant enzymes in the rat’s erythrocytes were measured using various methods. Biochemical analyses conducted on the erythrocytes of the rats indicated positive effects of licorice syrup on the levels of SOD, CAT and MDA. © 2024, Jomard Publishing. All rights reserved.