Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12514/3596

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Body Image, Self-Esteem, and Attitudes Toward Sexuality in Older Adults With Chronic Illnesses
(Springer, 2025) Özbay, H.; Utli, A.; Filoğlu Ersü, N.
This study aimed to examine the effect of the association between body image and self-esteem levels on attitudes toward sexuality in older adults with chronic illnesses. The research was descriptive, cross-sectional, and correlational. The study sample comprised 1,004 people over the age of 65 who visited family health centers in a province in the east of Türkiye. The Older Person’s Description Form, the Body–Cathexis Scale, the Rosenberg Self-Esteem Scale Short Form, and the Sexual Attitude Scale for Elderly People were used for data collection. For the data analysis, Pearson’s r correlation test, simultaneous multiple linear regression, and binary logistic regression were employed. The mean age of the participants was 69.97 ± 5.74 years, and 66.9% were between 65 and 74 years of age. Furthermore, 53.8% of the participants were male and 56.2% had two chronic illnesses. It was found that the participants’ age, body image, and self-esteem explained 84% of the total variance in their permissive attitudes toward sexuality. Furthermore, as the age of the older adults with chronic illnesses increased, there were negative effects on their permissive attitudes toward sexuality. However, as their body image and self-esteem levels improved, there was a positive effect on their permissive attitudes toward sexuality. These findings will be of benefit in encouraging and developing sexual health in older adults with chronic illnesses. © The Author(s) 2025.
Evaluation of Cardiac Functions in Neonates With Hypoxic Ischemic Encephalopathy
(Taylor and Francis Ltd., 2025) Sero, L.; Tuncel, D.; Talay, M.N.; Karaca, M.S.; Gul, O.; Okur, N.
Introduction: The aim of our study was to evaluate the role of cardiac markers in determining prognosis in newborns with Perinatal Asphyxia (PA). Method: Patients with a pH <7–7.15 base deficit −12> mmol/L were defined as PA. NT-proBNP, cardiac Troponin I (cTnI), creatine kinase MB levels were analyzed. Patients with excitus during follow-up were compared with patients with pathological MRI findings and cardiac markers. Results: A total of 115 infants with perinatal asphyxia were included in the study.cTnI levels was median 0.63 (min 0.1-max 4.2) ng/ml significantly higher in patients who died (p =.006). The predictive power of cTnI was evaluated and the threshold value of cTnI for predicting mortality was determined as 0.428 ng/ml with 87.5% sensitivity and 87.2% specificity. Conclusion: We found that cTnI level analyzed in the first hours of life in newborn infants with PA has value in predicting both mortality and cranial affections. © 2025 Taylor & Francis Group, LLC.
Sustainable Livelihood of Refugees in Turkey: Does Entrepreneurship Make a Difference
(IGI Global, 2025) Almohammad, D.; Durrah, O.; Inan, C.; Bek, D.R.
This study examines the impact of livelihoods dimensions on the Syrian refugees in Turkey considering the role of entrepreneurship in this nexus. A quantitative approach was used in this study, through a sample of 470 refugees scattered across Turkey. Using AMOS to analyze the data, the findings indicate that refugee environment, social networks, and training have positive impacts on refugees' livelihoods, whereas COVID-19 context is negatively associated with their livelihood. Furthermore, entrepreneurship has a promising role in improving refugee livelihood and mitigating negative impacts. These findings reinforce all policies that incentivize refugees to cover part of the cost of their lives, and therefore they may be useful in providing constructive insights for government policymakers in the refugee-hosting country, as well as for international organizations. © 2025 by IGI Global Scientific Publishing. All rights reserved.
Calcium-Mediated Mitigation Strategies and Novel Approaches To Alleviate Arsenic Induced Plant Stress
(Elsevier Ireland Ltd, 2025) Faizan, M.; Alam, P.; Iqbal, S.; Waheed, Z.; Eren, A.; Shamsi, A.; Shahwan, M.
One worldwide environmental concern is the presence of potentially hazardous elements (PTEs) in air, soil, and water resources. Arsenic is one of the PTEs that is thought to be the most poisonous and carcinogenic. Plants exposed to arsenic may experience several morphological, physiological, and biochemical changes-even at extremely low concentrations. Arsenic toxicity to plants varies with its speciation in plants (e.g.] arsenite, As(III); [arsenate, As(V)), with the kind of plant species, and with other soil parameters affecting arsenic accumulation in plants, according to new study on arsenic in the soil-plant system. Arsenic stress modifies metabolic cascades in plants at different developmental stages by affecting the pattern of gene expressions mediated by small non-coding RNAs (micro-RNAs), which are essential for plant adaptation to oxidative stress and play a key role in the moderation of numerous cellular processes. In this review, we investigated the impact of calcium (Ca2 +) on the toxicity of arsenic in plant and soil environments. Plant grown with arsenic exhibited enhanced arsenic uptake, increased oxidative stress and growth inhibition. Arsenic toxicity modulates carbohydrate, lipid, and protein metabolism along with DNA structure. Role of Ca2+, Ca channels and Ca sensors to signaling pathways also described briefly. A worldwide issue for humanity is the poisoning of soil ecosystems by arsenic. Its toxicity, tolerance, and phytoremediation of polluted soils utilizing calcium were the main points of the recent review, which also highlighted the significant mechanisms of arsenic in soil-plant systems. © 2025 Elsevier B.V.
A Silent Threat To Children's School Road Safety in Türkiye: the Impact of Stray Dog Attacks
(Elsevier B.V., 2025) Karadas, H.; Dag, A.
The aim of this study is to reveal the effects of stray dogs on school road safety and to provide practical suggestions for solving the problem. The study was conducted in schools located in residential areas where stray dogs are densely populated in Mardin. Phenomenology design, one of the qualitative research methods, was used in the study. The study was conducted with the participation of stakeholders in seven different schools, including central and village schools. In Türkiye, it has been determined that stray dogs endanger children's road safety to school and prevent equal opportunities in education. Research results show that stray dogs negatively affect the safety of not only students but also other stakeholders of the school. According to the results, stray dogs cause fear, panic, stress, reluctance to school, lack of self-confidence in students and other stakeholders in psychological terms, and chasing, falling and getting injured, biting and traffic accidents in physical terms. Stray dogs cause different negative effects such as preventing students and other school stakeholders from accessing the school, causing students to be absent, affecting the school's course operation, spreading infectious diseases and creating visual pollution in the environment. In the context of these results, it can be said that adopting stray dogs first and taking the dogs that are not adopted to shelters will contribute to school road safety. © 2025 The Authors
Snoring and Apnoea: a Sign of an Underlying Disease and Its Treatment
(Springer International Publishing, 2023) Sarı, N.; Muluk, N.B.
The term sleep-disordered breathing (SDB) applies to a range of conditions which impact numerous branches of medical science. The range extends from primary snoring, via upper airway resistance syndrome (UARS), to obstructive sleep apnea/hypopnea syndrome (OSAH). The most commonly encountered manifestation of SDB is snoring. Sometimes, snoring does not signify disease, or may be the result of a modifiable factor (a blocked nose, being overly tired, agents that cause central nervous depression, sleeping in a particular way). It may also be due to both disease and another non-pathological factor. The definition of apnea is a pause in breathing with a duration of at least ten seconds. Apnea in the context of OSA is linked to a cessation in the mechanical events of respiration (i.e.] thoracic movement). Central apnea is not associated with chest wall movement, but it is seldom seen. Mixed apnea refers to a derangement in respiration consisting of initial central apnea followed by obstructive apnea. Hypopnea involves a degree of lessened ventilation but with ongoing mechanical effort to breathe, and lasting a minimum of ten seconds. Obstructive sleep apnea syndrome (OSAS) is by definition a longstanding condition affecting sleep in which the airway keeps becoming partly or totally blocked and thus the flow of air ceasing, in spite of the continuation of muscular effort supporting ventilation. The intermittent obstruction keeps causing arousal in patients and thus interrupts their sleep. Diagnosis and treatment of OSAS are reviewed. © Springer Nature Switzerland AG 2023.
Attitudes of Health Sciences Students in Turkey Towards Individuals With Different Sexual Orientations
(Womens Health & Action Research Centre, 2025) Deger, Vasfiye B.; Kacan, Havva
Study was planned in a descriptive design to examine how the empathic tendencies of students in the Faculty of Health Sciences affect their attitudes toward individuals who have different sexual orientations and was conducted with seven hundred and six students. The data collected online using the Student Information Form, Empathic Tendency Scale (ETS) and Attitudes Toward Lesbian and Gay Men Scale (ATLGS). Participants' mean scores were 62.98 +/- 18.79 on the ESS and 29.02 +/- 10.75 on the ATLGS. When the correlation between ETS and ATLGS scores was analyzed, a positive and moderate (p<0.05) correlation (r = 0.62) was found between ETS and ATLGS scores. These scores were moderate and the correlation between ETS and ATLGS scores was significant (F=438.585; p<0.05). Empathic disposition explained 38.3% of the total change in ATLGS level (R2=0.383) and increased ATLGS level (B=0.620). It was found that as students' empathic skills improved, their homophobic attitudes decreased.
Gynaecological Cancer Awareness and Healthy Lifestyle Behaviors of Women Aged 20-65 Years: a Descriptive Cross-Sectional Study
(Womens Health & Action Research Centre, 2025) Yasar, Beril Nisa; Seker, Sevda Arslan
For both individual and community health, women's health is vital. In particular, gynecological cancers can be prevented or treated by adopting healthy lifestyles, raising awareness, and detecting them early. This study aimed to identify levels of gynecological cancer awareness and healthy lifestyle behaviors among women aged 20-65 years. There were 251 women in the descriptive cross-sectional study. The Gynecological Cancers Awareness Scale (GCAS), the Descriptive Characteristics Form, and the Healthy Lifestyle Behavior Scale-II (HLBS-II) were used to gather data. The data was analyzed using the Pearson's correlation test, multiple linear regression, and descriptive statistics. The average HLBS-II score was 123.53 +/- 20.75, while the average GCAS score was 149.64 +/- 21.30. The HLBS-II and GCAS scores showed a statistically significant positive correlation. Women knowledgeable about early diagnosis methods scored 10.758 times higher on the GCAS, while women familiar with vulvar self-examination scored 11.016 times higher. Employed women had a mean HLBS-II score 6.124 times higher than non-employed women (p<0.05). Women's awareness of gynecological cancer was high, but they also had moderately good lifestyle choices. To raise awareness and promote healthy lifestyle choices, healthcare professionals are advised to take part in health-promoting initiatives.
The Performance of the Naples Prognostic Score in Predicting One-Year Mortality and Major Adverse Cardiovascular Events After Transcatheter Aortic Valve Implantation in Patients With Severe Aortic Stenosis
(Polish Cardiac Soc, 2025) Gitmez, Mesut; Guzel, Tuncay; Kis, Mehmet; Coskun, Ferhat; Isik, Mehmet Ali; Aktan, Adem; Ertas, Faruk
Background: Existing risk scores for transcatheter aortic valve implantation (TAVI) may not fully capture patient complexity. Combining nutritional and inflammatory markers, the NPS (the NAPLES prognostic score) might improve outcome prediction. Aims: This study investigated the associations of the NPS with one-year mortality and major adverse cardiovascular events (MACEs) in TAVI patients. Material and methods:This retrospective analysis included 222 patients with severe aortic stenosis who underwent TAVI. The NPS was calculated based on the serum alb & uuml;min concentration, cholesterol concentration, lymphocyte/monocyte ratio, and neutrophil/lymphocyte ratio. The patients were subsequently categorized into two groups: the low-NPS group (NPS 0-2) and the high-NPS group (NPS 3-4). Results: A high NPS was significantly associated with increased one-year mortality (4.8% vs. 23.7%; P <0.001) and MACE rates (7.2% vs. 35.9%; P <0.001). Cox regression analysis demonstrated that a high NPS was an independent predictor of both mortality (HR, 5.94; 95% CI, 2.03-17.37; P = 0.001) and MACEs (HR, 5.09; 95% CI, 2.15-12.02; P <0.001). Conclusions: The NPS emerged as a potential predictor of long-term mortality and MACEs in TAVI patients. Further validation through larger, multicenter, studies is warranted.This research contributes valuable data on the role of the NPS in TAVI risk stratification.
Green Synthesis and Characterization of Silver Nanoparticles Using Anchusa Officinalis: Antimicrobial and Cytotoxic Potential
(Dove Medical Press Ltd, 2025) Keskin, Cumali; Aslan, Seyhan; Baran, Mehmet Firat; Baran, Ayse; Eftekhari, Aziz; Adican, Mehmet Tevfik; Mohamed, Ali Jimale
Objective: Anchusa officinalis L. (A. officinalis) is a herbaceous traditional medicinal plant used in the treatment of some diseases. The presence of its medicinal properties suggested that A. officinalis (AO) leaf extract could be used as a coating agent for the environmentally friendly production of silver nanoparticles (AgNPs). Methods: The synthesized biogenic silver nanoparticles (AO-AgNPs) were characterized using different techniques. The antimicrobial activity of AgNPs against common bacterial pathogenic strains was determined by the minimum inhibitory concentration (MIC) method. The presence of phytochemicals was determined by LSMS/MS. The MTT assay was used to investigate AO-AgNPs' cytotoxic activity in malignant (LnCap, Caco2, MDA-MB2, A549) and healthy (HEK-293) cell lines. Results: LC-MS/MS analysis detected the presence of rich phytochemicals that may be responsible for reduction reactions. Biogenic AO-AgNPs exhibited effective inhibition of the growth of pathogenic microorganisms at low concentrations. The most effective antimicrobial activity was measured as 0.5 mu g/mL MIC against S. aureus, E. coli, and C. albicans. Moreover, AO-AgNPs showed significant inhibition on the growth of cancerous cell lines, especially at a concentration of 25 mu g/mL. On the contrary, it was determined that the inhibition rate decreased in the growth of healthy cell lines due to the increase in concentration. The lowest EC50 values were determined as 15.15 mu g/mL in A549 cells. Conclusion: The obtained results showed that AO could be an important source for the synthesis of AgNPs. Especially their ability to inhibit the growth of antibiotic-resistant pathogenic bacteria at low concentrations compared to common antibiotics indicates that AOAgNPs can be used as biomedical agents in various areas. Moreover, their suppressive effect on cancerous cell lines showed that they have the potential to be used as an anticancer agent, but due to their proliferative effect on healthy cell lines, care should be taken in determining the appropriate dose.
A Simplified Analytical Modeling Approach for the Structural Analysis of Massive Masonry Structures
(Univ Estadual Maringa, Pro-reitoria Pesquisa Pos-graduacao, 2025) Unay, Ali Ihsan; Kutlu, Izzettin; Soyluk, Asena
This paper, presents a simplified analytical modeling approach to determine the structural behavior of historical buildings. Analytical modeling is a digital tool for determining the behavior of masonry buildings under the influence of dynamic and static loads. In the analytical modeling process, different types of elements are involved to represent buildings. Due to the complex geometrical features of historical buildings, it is significant to the preference for convenient elements. Mardin Great Mosque was discussed and analyzed for the selection of convenient element preferences. Three different mosque models were built and analyzed by using three different element types (frame, shell, solid). In the findings of the paper, the values at the same points on the models were compared. When the first natural vibration period was examined, the first model is 0.76sec, the second model is 0.76sec, and the third model is 0.71sec. In addition, considering the base shear under dead load, 98.35% similarity was observed. As a consequence of the geometrical features of historical buildings, inappropriate definitions and inconvenient element preferences emerge the results questionable. Therefore, to be able to manage the analytical modeling process effectively requires accurate and appropriate definitions of the elements to be preferred.
Low-Intensity Extracorporeal Shock Wave Therapy and Platelet-Rich Plasma: Effective Combination Treatment of Chronic-Phase Peyronie's Disease
(Iniestares, S.a., 2025) Ergun, Muslum; Sagir, Suleyman
Objective: This study aimed to investigate the effectiveness, safety and outcomes of the combination therapy of low-intensity extracorporeal shockwave therapy (Li-ESWT) and platelet-rich plasma (PRP) for the treatment of chronic-phase Peyronie's Methods: The clinical outcomes of patients diagnosed with Peyronie's disease and treated with Li-ESWT combined with PRP at our clinic between January 2018 and January 2024 were retrospectively reviewed and analysed. Twenty-three patients were excluded based on inclusion criteria, leaving 26 patients for the retrospective analysis. Each patient received three sessions of PRP and six sessions of Li-ESWT. The treatment regimen involved sessions administered twice weekly over a period of 3 weeks, followed by 1-week post-treatment follow-up. The patients were then monitored for 24 weeks. Result: After treatment, no significant reduction in average plaque size was observed. However, a statistically significant average improvement of 10 degrees was noted for penile curvature. Among the patients, 14 (53.8%) reported satisfaction with the treatment outcome, and 12 (46.2%) expressed dissatisfaction. No significant adverse effects were observed at the injection sites or in the areas subjected to Li-ESWT post-procedure. Conclusions: The combination of Li-ESWT and PRP is effective and safe for the treatment of chronic-phase Peyronie's disease.
Breaking Misconceptions: Assessing the Quality of Youtube Videos on Penile Fracture With Validated Scoring Tool
(Mre Press, 2025) Sagir, Suleyman; Ertek, Mehmet Sirin; Toktas, Izzettin
Background: The main objective of this research was to evaluate the effectiveness of YouTube videos related to penile fracture by applying established rating systems. Methods: A descriptive investigation was carried out by browsing YouTube for videos related to "Penile fracture". Out of a total of 108 videos that were found, 47 were deemed eligible for inclusion in the analysis. The features and substance of the videos were assessed utilizing the adjusted DISCERN tool, the criteria from the Journal of the American Medical Association (JAMA), and the Global Quality Scale (GQS). Statistical analysis was performed using SPSS 22.0 software, with a significance level of p < 0.05. Results: High-quality videos, as classified by GQS, had more views, likes, and comments than lower-quality videos; however, these differences were not statistically significant (p > 0.05). In contrast, videos with detailed and accurate content had significantly higher view counts (approximately tenfold) and more likes (approximately twofold) than poor-content videos (p < 0.05). A strong positive correlation was found between content analysis scores and DISCERN (r = 0.815, p < 0.001), JAMA (r = 0.781, p < 0.001), and GQS (r = 0.722, p < 0.001). Videos made by urologists and surgeons demonstrated superior quality across all measured criteria in comparison to those crafted by individuals without healthcare backgrounds (p <0.001). Conclusions: The quality of YouTube content addressing penile fracture exhibits a wide range, with content generated by healthcare experts standing out for its high quality. It is imperative for medical professionals to actively engage in disseminating accurate health information on these platforms.
Green Synthesis of Fe3o4-Crataegus Tanacetifolia (Lam.) Biochar Magnetic Nanocomposites for Adsorption of Naproxen
(Wiley-v C H verlag Gmbh, 2025) Solmaz, Alper; Turna, Talip; Baran, Ayse
In this study, naproxen (NPX), one of the emerging contaminants was removed by green synthesizing Fe3O4 coated magnetic biochar nanocomposites (Ct-BMNCs) synthesized from Crataegus tanacetifolia Lam. (Ct) wastes. The characteristics of Ct-BMNCs was examined by x-ray diffraction (XRD), scanning electron microscopy (SEM), energy dispersive x-ray (EDX), Fourier transform infrared spectroscopy (FTIR), thermogravimetry-differential thermal analysis (TGA-DTA), dynamic light scattering (DLS), zetasizer, Brunauer-Emmett-Teller (BET) UV-Vis spectroscopy, and pH point of zero charge (pHpzc). With batch adsorption tests, the effects of pH (4-11), amount of adsorbent (2.5-80 g L-1), time, and initial concentration (3.125-200 mg L-1), and thermodynamic analysis was performed. Also, kinetic and isotherm models and error functions were used. Accordingly, the pHpzc and average surface charge were 5.68 and +11.7 mV, respectively. Moreover, the reaction was exothermic, and the most suitable models were Pseudo-second-order and Freundlich (R2:0.999). Also, qmax was 30.12 mgNPX/gCt-BMNCs. Accordingly, Ct-BMNCs are quite effective in removing NPX.
The Ameliorative Effects of Hesperidin in Rats Developed Hepatotoxicity With Deltamethrin
(Mashhad Univ Med Sciences, 2025) Karabekir, Seda Cetinkaya; Sozen, Mehmet Enes; Ayan, Ilknur Cinar; Savas, Hasan Basri; Cuce, Gokhan; Kalkan, Serpil
Objective(s): Deltamethrin (DLM) is a widely used insecticide in agriculture; however, exposure to it can lead to serious health problems. This study aimed to evaluate the protective effects of hesperidin (HSP), a natural antioxidant, against DLM-induced liver toxicity. Materials and Methods: Thirty-two male Wistar Albino rats (250-300 g, 4 months old) were divided into four groups. The control group received 1 ml of corn oil via oral gavage for 30 days. The DLM group received 1.28 mg/kg DLM in corn oil for 30 days. The DLM+HSP 100 mg/kg and DLM+HSP 300 mg/kg groups received 1.28 mg/kg DLM followed by 100 mg/kg or 300 mg/kg HSP in distilled water, respectively, 30 min after DLM administration for 30 days. Liver tissues were examined histopathologically. Masson's trichrome staining and PCR assessed fibrosis. Caspase 3 and 9 expressions in liver tissues were determined by immunohistochemistry and PCR. Biochemical analyses were conducted on serum samples. Results: HSP supplementation led to a dose-dependent decrease in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. DLM exposure decreased antioxidant capacity, while HSP supplementation increased it dose-dependently. Histopathological evaluations showed increased liver damage in the DLM group, while HSP administration reduced liver toxicity. Masson's trichrome staining and analysis of collagen I (COL1A1) and collagen III (COL3A1) gene expression revealed increased fibrosis in the DLM group, which was attenuated with HSP treatment. Conclusion: The potential prevention of DLM-induced liver toxicity and apoptosis by HSP may be an alternative protective strategy.
The Predictive Value of the Cha2ds2-Vasc Score in the Development of Contrast-Induced Nephropathy After Endovascular Intervention in Peripheral Artery Disease
(Elsevier Science inc, 2025) Evsen, Ali; Aktan, Adem; Kilic, Raif; Isik, Mehmet Ali; Yalcin, Abdulaziz; Guzel, Tuncay; Ozbek, Mehmet
Background: Contrast-induced nephropathy (CIN) is a frequent complication of endovascular interventions for peripheral artery disease (PAD). It is linked to renal dysfunction, extended hospital stays, increased cardiovascular events, and higher mortality rates. The CHA2DS2-VASc score, widely utilized for assessing cardioembolic risk and guiding anticoagulation therapy in nonvalvular atrial fibrillation, encompasses risk factors that overlap with those of CIN. This study investigates whether the CHA2DS2-VASc score can predict CIN in PAD patients undergoing endovascular interventions. Methods: The study included 754 consecutive PAD patients who underwent endovascular procedures at 2 centers. Each patient's CHA2DS2-VASc score was calculated and categorized into low (<3) and high (>= 3) groups. Patients were retrospectively monitored for CIN development and divided into CIN-positive (CIN+) and CIN-negative (CIN-) groups. Univariate and multivariate regression analyses were performed to identify independent predictors of CIN, and a significance level of P < 0.05 was used for all statistical analyses. Results: Of the 754 patients, 178 (23.6%) developed CIN, with 151 (84.8%) occurring in the high CHA2DS2-VASc score group (P < 0.001). The CHA2DS2-VASc score was significantly higher in the CIN(+) group compared to the CIN(-) group (P < 0.001). Regression analysis identified the CHA2DS2-VASc score (odds ratio [OR]: 1.574, 95% confidence interval [CI]: 1.2981.907, P < 0.001), baseline creatinine (OR: 2.296, 95% CI: 1.580-3.335, P < 0.001), and hemoglobin (OR: 0.915, 95% CI: 0.844-0.992, P < 0.001) as independent risk factors. A CHA2DS2-VASc score cutoff of 2.5 predicted CIN with 85% sensitivity and 42% specificity. Conclusion: The CHA2DS2-VASc score is an independent predictor of the development of CIN in patients with PAD undergoing endovascular intervention.
Temporal Focal Modulation Networks for Sleep Stage Scoring
(Springer, 2025) Zan, Hasan
Accurate sleep stage scoring is crucial for diagnosing and treating sleep disorders, yet traditional manual methods are time-consuming and susceptible to variability. While recent advancements in machine learning and deep learning have enhanced automated sleep stage detection, many approaches still rely on handcrafted features and encounter limitations when processing full-night data. In this paper, we introduce a novel many-to-many classification framework that leverages a temporal focal modulation network for efficient and accurate sleep stage scoring. Our model, SleepFocalNet, processes full-night single-channel EEG signals and predicts sleep stages for all epochs simultaneously. SleepFocalNet is composed of three key components: a convolution block for local feature extraction, a focal modulation block for long-range temporal modeling, and a classification block for final predictions. We evaluated SleepFocalNet on Sleep Heart Health Study (SHHS), SleepEDF-20, and SleepEDF-78 datasets, achieving state-of-the-art performance. On SHHS, SleepFocalNet attained an accuracy of 0.888 and an F1-score of 0.815. On SleepEDF-20, it obtained an accuracy of 0.885 and an F1-score of 0.836. On SleepEDF-78, it outperformed other models with an accuracy of 0.855 and an F1-score of 0.800. This study represents the first application of temporal focal modulation networks in sleep stage scoring. Additionally, we conducted an extensive analysis of various network configurations to assess the impact of different architectural choices on performance. The results validate the potential of our approach to enhance the reliability and scalability of automated sleep stage scoring, offering a robust alternative to existing methods.
Myricetin Promotes Migration and Prevents Palmitate-Induced Apoptosis in Cultured Tenocytes Through Ampk-Dependent Pathways
(Academic Press inc Elsevier Science, 2025) Lim, Do Su; Ahn, Sung Ho; Cho, Wonjun; Gwon, Hyeon Ji; Ko, Jun Hwi; Pyo, Min Kyung; Jung, Tae Woo
Myricetin (Myr), a flavonoid present in vegetables and fruits, has been shown to ameliorate inflammation and oxidative stress in various disease models. However, the effects of Myr on hyperlipidemic tenocytes have not been studied. Herein, we aimed to investigate the effects of Myr on the features of tendinopathy in cultured tenocytes under hyperlipidemic conditions. Reactive oxygen species (ROS) were detected by DCFDA. Hydrogen peroxide (H2O2), malondialdehyde (MDA), and caspase 3 activity were quantified via matched assay kits. Apoptotic cells were detected via TUNEL staining. Proteins investigated in this study were evaluated through Western blotting. Treatment with Myr enhanced tenocyte migration and prevented apoptosis, inflammation and oxidative stress in palmitate-treated tenocytes. Myr treatment increased the phosphorylation of AMPK, and the expression of PGC1 alpha and FGF2. siRNA targeting AMPK abrogated the effects of Myr on palmitate-treated tenocytes. However, FGF2 siRNA reduced the impacts of Myr on only cell migration and ECM signaling. These in vitro results suggest that Myr promotes tenocyte migration and ECM signaling via AMPK/FGF2 signaling and attenuates apoptosis through the AMPK-mediated suppression of inflammation and oxidative stress in hyperlipidemic tenocytes. This study sheds light on therapeutic strategies for treating obesity-related tendinopathy.
Traditional Care Practices Known And/Or Used by Different Ethnic Groups for Newborns During the Postpartum Period
(BMC, 2025) Deger, Vasfiye Bayram; Butun, Ahmet
BackgroundTraditional care practices play a significant role in shaping care provided to newborns across different ethnic groups. Understanding traditional care practices is crucial for integrating culturally sensitive approaches into modern healthcare systems. This study aims to fill the gap in the literature regarding the different traditional care practices across ethnic groups. The aim of this study was to determine the traditional beliefs and practices of women from different ethnic groups living in Mardin regarding newborn care.MethodsThis study is a descriptive cross-sectional study. The sample consisted of women from four ethnic groups who volunteered to participate in the study with at least one child living in Mardin, Turkey. Snowball and convenience sampling methods were used to recruit participants. The study was completed with 188 Assyrian, 197 Turkish, 181 Arab, and 175 Kurdish women. In total, 741 women participated in this study. Data were collected between 18 December 2023 and 14 June 2024. The data were collected face-to-face using a questionnaire. The data were analysed using SPSS for Windows 22.0.ResultsThis study identified significant differences in traditional care practices across four ethnic groups (Assyrian, Turkish, Arab, and Kurdish). Traditional care practices regarding umbilical cord care, swaddling the baby, alleviating gas pain, preventing neonatal jaundice, care for canker sores, and alleviating diaper rash were identified. Assyrian participants were more likely to apply salt to the umbilical cord (14.9%), while Arab participants rarely used this practice (0.6%). Traditional practices for relieving gas pain included drinking herbal teas such as anise, fennel, linden, and cumin. Rubbing and rubbing breast milk on the abdomen, patting on the back, and massaging were other practices for alleviating gas pain. Arab participants were more likely to use anise tea to alleviate gas pain (75.1%), while Kurdish participants preferred fennel tea (22.3%). Practices regarding alleviating diaper rash included applying saturated fat, olive oil, and powder. Arab participants were more likely to apply olive oil for diaper rash (45.9%), while Assyrian participants commonly used dry earth ('H & ouml;ll & uuml;k'). These results highlight the cultural diversity in newborn care practices and underscore the importance of culturally sensitive healthcare interventions.ConclusionThis study highlighted the significance of traditional care practices in newborn care across four ethnic groups. There are many differences between ethnic groups regarding traditional care practices during the postpartum period. Understanding such differences is crucial for developing culturally sensitive interventions that support maternal well-being and enhance health outcomes for both mothers and infants.
The Role of Mid-Trimester Bun and Creatinine Assessment in Predicting Preeclampsia: Retrospective Case-Control Study
(Mdpi, 2025) Kavak, Ebru Celik; Akcabay, Cigdem; Demircan, Meryem; Batmaz, Ibrahim; Sanli, Cengiz; Senocak, Ahmet; Kavak, Salih Burcin
Background and Objectives: Preeclampsia (PE) is a major cause of adverse perinatal outcomes. Early diagnosis of pregnant women at risk of PE can facilitate disease prevention and management. However, the presence of different phenotypes of the disease complicates its prediction. In particular, the challenges in the early diagnosis of term PE cases necessitate research on PE prediction in the second and third trimesters. This study aims to examine the association between PE development and mid-trimester blood urea nitrogen (BUN), serum creatinine, and the BUN/creatinine ratio in pregnant women. Materials and Methods: This retrospective case-control study was conducted on women diagnosed with PE. Pregnant women who underwent routine biochemical blood tests between the 18th and 24th weeks of gestation and subsequently gave birth at our hospital between January 2022 and May 2023 were categorized into three groups. Accordingly, healthy women who had term deliveries were classified as Group 1 (150 cases), women diagnosed with PE were classified as Group 2 (58 cases), and those diagnosed with severe PE were classified as Group 3 (44 cases). Results: There were no significant differences in age, gravidity, parity, body mass index, or gestational week at blood sampling between the patient and control groups (p > 0.05). When comparing the mean blood urea nitrogen, serum creatinine, and BUN/creatinine ratios, a significant difference was observed between the control group and those who developed PE (p = 0.001, p < 0.001, and p = 0.031, respectively). Univariate analysis revealed a significant association between BUN levels and PE development (OR 1.083; 95% CI, 1.031-1.139; p = 0.002). A stronger association was observed between serum creatinine levels and PE development (OR 112.344; 95% CI, 11.649-1083.416; p < 0.001). However, no significant association was found between the BUN/creatinine ratio and PE in univariate analysis (OR 1.003; 95% CI, 0.979-1.028; p > 0.05). Mid-trimester BUN and serum creatinine levels were significantly higher in patients who developed PE and severe PE. The AUC value for the BUN parameter in predicting PE was 0.614 (AUC 0.614; 95% CI, 0.539-0.689; p = 0.002). A BUN cut-off value of 16.2 mg/dL predicted disease development with a sensitivity of 52.9% and a specificity of 74%. Similarly, the AUC value for the serum creatinine parameter in predicting PE was 0.644 (AUC 0.644; 95% CI, 0.574-0.751; p < 0.001). A serum creatinine cut-off value of 0.58 mg/dL was able to predict disease development with 37.2% sensitivity and 88% specificity. No significant AUC value was obtained for the BUN/creatinine ratio (p > 0.05). Conclusions: Our findings indicate that elevated BUN and serum creatinine levels measured during the mid-trimester (18-24 weeks) are associated with an increased risk of developing preeclampsia.

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